Michael Rae - Supplements and CR - Continued
---------------------------------------------

Tier system:
o     Get a couple multiples of the new RDA via supplement and food
o     Disease - unless youre genetically inclined to particular 
      disease, dont supplement
o     If you do supplement for avoiding suspectibility to disease, 
      make it look as much like real food as possible.

Avoiding disease risk isnt going to gain you a lot of time.  If we 
wipe out heart attacks and cancer, and all the other major killers, youll 
only get 15 years or so. CR will almost certainly yield less.

Two possibilities:
o     Use supplements to avoid free radical damage in mitochondria


DHA (long chain omega-3) may be bad idea for mitochondrial free 
radical reasons.

How to actively reduce mito free radical damage?

CR rodents produce fewer free radicals. Complex 1 in mitochondria not 
accepting as many electrons in CR rodents. De Grey says electrons are 
spit out through cell surface.

Hagen and Ames have reported lower MT free radical production when rats 
supplemented by R+LA.

Michael thinks R+LA may have some promise in 600 - 1200 mg. Dont *seem* 
likes doses that will kill you. It doesnt last long in our blood - Michael 
takes it 6 times a day.

Very expensive.

Wont be as effective as CR.

Metaformin - Given to rodents, appears to extend median and maximum 
lifespan to the same extent as 30% CR. It inhibits complex 1 in vivo and 
in vitro in rodents.

Metaformin can induce a life threatening lactic acid buildup, lactic 
acidosis. R+LA may do the same thing, in high doses.

Doesnt recommend taking Metaformin at this time. Too new results, and 
potential grave side effect.

ALCAR - Not so afraid that it will increase mitochondrial free radical 
production. Doesnt look like this happens in experimental studies.  Not 
a conservative supplement, but probably wont extend life.

Glycation is another reasonable possible cause of aging

But the glycation reversal supplements work early in the glycation process, 
and so are pretty worthless. What we need to deal with is AGE formation  
- *Advanced* Glycations Endpoints.

If you have good blood sugar, dont bother taking ginseng or chromium 
picolinate. They work at the wrong spot on glycation - too early so dont 
help with AGEs.

Beniformin - May also be good at reducing AGEs.

Hes pessimistic on ALT-711. Doesnt do what you want, and has side effects.