corybroo

A measurable effect on one marker of aging is described in Presence of specific lipids indicate tissue aging and can be decreased through exercise, study shows One type of lipid, the bis(monoacylglycero)phosphates (or BMPs) was found in higher concentrations in older animals (mice & men were tested). In their testing subjects who selected for one hour a day of exercise, the level of BMPs was decreased. The good news is it’s a reversible change. The bad news is it’s only of the many changes associated with aging.

Scientists uncover a missing link between poor diet and higher cancer risk A research team from the National University of Singapore (NUS) has unearthed new findings that may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet. The research team first studied patients who are at a high risk of developing breast or ovarian cancers because they inherit a faulty copy of the cancer gene—BRCA2—from their parents. They demonstrated that cells from such patients were particularly sensitive to the effects of methylglyoxal, which is a chemical produced when our cells break down glucose to create energy. The study showed that this chemical can cause faults in our DNA that are early warning signs of cancer development. Prof Venkitaraman said, "Our research suggests that patients with high methylglyoxal levels may have higher cancer risk. Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker. Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer." [Emphasis added] The study's first author, Dr. Li Ren Kong, Lee Kuan Yew Fellow from N2CR, added, "We started the study aiming to understand what factors elevate risk in families susceptible to cancer, but ended up discovering a deeper mechanism linking an essential energy consumption pathway to cancer development. These findings raise awareness of the impact of diet and weight control in the management of cancer risks." the research team's work also revised a longstanding theory about certain cancer-preventing genes. This theory—called the Knudson's 'two-hit' paradigm—was first formulated in 1971, and it was proposed that these genes must be inactivated permanently in our cells before cancer can arise. The NUS team has now found that methylglyoxal can temporarily inactivate such cancer-preventing genes, suggesting that repeated episodes of poor diet or uncontrolled diabetes can 'add up' over time to increase cancer risk.

How about individual organ trajectory? Stanford Medicine-led study finds way to predict which of our organs will fail first A study of 5,678 people, led by Stanford Medicine investigators, has shown that our organs age at different rates — and when an organ’s age is especially advanced in comparison with its counterpart in other people of the same age, the person carrying it is at heightened risk both for diseases associated with that organ and for dying. “We can estimate the biological age of an organ in an apparently healthy person,” said the study’s senior author, Tony Wyss-Coray, PhD, a professor of neurology and the D. H. Chen Professor II. “That, in turn, predicts a person’s risk for disease related to that organ.” [Instead of a single estimate of biological age for an individual} “We can estimate the biological age of an organ in an apparently healthy person,” said the study’s senior author, Tony Wyss-Coray, PhD, a professor of neurology and the D. H. Chen Professor II. “That, in turn, predicts a person’s risk for disease related to that organ.” distinct numbers for each of 11 key organs, organ systems or tissues: heart, fat, lung, immune system, kidney, liver, muscle, pancreas, brain, vasculature and intestine. “When we compared each of these organs’ biological age for each individual with its counterparts among a large group of people without obvious severe diseases, we found that 18.4% of those age 50 or older had at least one organ aging significantly more rapidly than the average,” Wyss-Coray said. “And we found that these individuals are at heightened risk for disease in that particular organ in the next 15 years.” Only about 1 in 60 people in the study had two organs undergoing aging at that fast clip. But, Wyss-Coray said, “They had 6.5 times the mortality risk of somebody without any pronouncedly aged organ.” While there was some modest aging synchrony among separate organs within any person’s body, that person’s individual organs largely went their separate ways along the aging path. The researchers found that the identified age gaps for 10 of the 11 organs studied (the only exception being intestine) were significantly associated with future risk of death from all causes over 15 years of follow-up. Having an accelerated-aging organ (defined as having a 1-standard-deviation higher algorithm-scored biological age of the organ than the group average for that organ among people of the same chronological age) carried a 15% to 50% higher mortality risk over the next 15 years, depending on which organ was affected. People with accelerated heart aging … were at 2.5 times as high a risk of heart failure Those with “older” brains were 1.8 times as likely to show cognitive decline over five year

You can decide which to delve into deeper. Personally, I'd rather have the choice given to me.

Does your exercise program change over time? I’m asking because I’ve seen a number of articles claiming that HIIT training is associated with longer telomere length. For example, Here’s Why HIIT Workouts May Be Best for Your Body — and Brain HIIT tends to burn more calories in a shorter period of time than other forms of exercise and can help speed up weight loss. [This would raise the question of whether it’s HIIT or lower excess of calories that is providing the benefit. CB] At the end of a 26-week study period, individuals who did aerobic or strength training saw no change in telomere length. The HIIT group saw a “two-fold” increase in length.

I’d say this study answers the question “When should you start calorie restriction?” with TODAY, at least for adults. It found that benefits of a lower calorie, healthier diet start even after the majority of an age cohort has died. Study shows obese flies live longer on a diet at any age Old, obese flies get healthier and live longer if put on a diet, University of Connecticut researchers report on Dec. 8 in PNAS. Fruit flies live short and fast—the lifespan of flies raised on a high-calorie diet is less than 80 days, while the longest-lived on a low-calorie diet can reach 120 days. In this study, they looked specifically at male flies. Young flies switched from a high-calorie to a low-calorie diet at 20 days old lived very long lives, similar to the flies fed a low-calorie diet from day one. What surprised the researchers was that switching the flies' diet to a low-calorie one remained a reliable way to extend lifespan even for old flies in ill health. [The older insects] had a higher death rate than flies raised on the low-calorie diet. But when the surviving high-calorie flies were switched to a low-calorie diet at 50 or even 60 days (when most of the high-calorie flies had already died) their metabolisms changed, their death rate plummeted, and their lifespans lengthened. [Emphasis added CB] "The remarkable finding of this study is that even after living a significant portion of their lives on a high-calorie diet, flies can gain the benefits of life span extension by simply switching to a low-calorie diet," Graveley says. Since many basic metabolic pathways in fruit flies are shared with humans, this study suggests that human metabolism may respond the same way, and individuals eating a high-calorie diet could benefit from reducing their calorie intake in old age.

I’d gotten used to the “They’re everywhere” headlines such as How microplastics are infiltrating the food you eat Most of these articles mention potential risks and conjectures about the affect on human health. So the following article caught my attention. Effects in humans are still unproven but the findings reported in the article make such effects seem more plausible. Nanoplastics promote conditions for Parkinson's across various lab models, study shows Nanoplastics interact with a particular protein that is naturally found in the brain, creating changes linked to Parkinson's disease and some types of dementia. "Parkinson's disease has been called the fastest growing neurological disorder in the world," said principal investigator, Andrew West, Ph.D., professor in the Department of Pharmacology and Cancer Biology at Duke University School of Medicine. "Numerous lines of data suggest environmental factors might play a prominent role in Parkinson's disease, but such factors have for the most part not been identified." nanoparticles of the plastic polystyrene—typically found in single use items such as disposable drinking cups and cutlery—attract the accumulation of the protein known as alpha-synuclein. West said the study's most surprising findings are the tight bonds formed between the plastic and the protein within the area of the neuron where these accumulations are congregating, the lysosome.

New research finds that 14-hour fasting improves hunger, mood and sleep Eating in a ten-hour window is associated with higher energy and mood and lower hunger levels Despite some IF advocates commonly promoting restrictive eating windows as low as six hours, findings detailed in the abstract show even eating within a less restrictive window of ten hours still has positive health benefits, such as changes in mood, energy and hunger. Dr. Sarah Berry, from King's College London and chief scientist at ZOE, said, "This is the largest study outside of a tightly controlled clinic to show that intermittent fasting can improve your health in a real world setting. What's really exciting is that the findings show that you don't have to be very restrictive to see positive results: a ten-hour eating window, which was manageable for most people, and improved mood, energy levels and hunger. We found for the first time that those who practiced time-restricted eating, but were not consistent day to day, did not have the same positive health effects as those who were dedicated every day. "

I started with Vital Balance by Lane and posted last year. Transformer is also very good.

Research was done on Drosophila to take advantage of their shorter life span and so may not apply to mammals. An immune molecule that regulates aging and a living organism's lifespan Researchers at Washington University in St. Louis recently identified an immune molecule that could play a key role in modulating the process of aging and the duration living organism's lifespan. They specifically tried to understand the potential role of the protein IM33 and its analog SLPI in mice, in controlling the aging of mice and other mammals. When the team knocked down this gene in the immune cells of fruit flies, they found that this increased the level of reactive oxygen species and altered the composition of microbiota in their gut. This resulted in oxidative stress and in an imbalance in bacterial composition (i.e., dysbiosis), which in turn reduced their lifespan. The researchers found that knocking down this gene also caused sleep disturbances, which have also been associated with aging and a shorter lifespan. "This is a proof-of-concept study demonstrating that an evolutionarily conserved immune molecule can serve as a messenger, conveying information between the brain and gut to regulate different levels of aging and control lifespan," Xu said. "We suggest that peptidoglycan signaling, a conserved immune pathway, in the neuron could be a potentially novel target to slow down aging," Xu added. testing the role of meningeal Slpi in mice will help determine whether this is a shared mechanism throughout evolution and provide additional supportive evidence for future translational studies.

While roaming around the web today, I came across LANAP (Laser-Assisted New Attachment Procedure) which was new to me. This is a procedure to treat periodontal disease. Does anyone have any familiarity with it? Thanks Some references: Immediate Effects of Laser-Assisted New Attachment Procedure (LANAP) on Human Periodontitis Microbiota The LANAP surgical treatment protocol, but not conventional ultrasonic root debridement alone, immediately suppressed red and orange complex periodontal pathogens below culture detection limits in most deep human periodontal pockets. The Clinical and Microbiological Effects of LANAP Compared to Scaling and Root Planing Alone in the Management of Periodontal Conditions Both nonsurgical periodontal therapies were proven effective in patients with chronic periodontal disease; however, LANAP was associated with a greater reduction in pocket depth and improved clinical outcomes, associated with a significant decrease in the amount of Porphyromonas gingivalis. The clinical results included a decrease in periodontal pocket depth, bleeding on probing, and dental plaque, with LANAP having better overall outcomes than SRP alone. Tooth Retention and Clinical and Radiographic Long-Term Results Among Patients Treated with the Full-Mouth Laser-Assisted New Attachment Procedure (LANAP): A Case Series There are limited long-term treatment results for patients who receive full-mouth laser-assisted new attachment procedure (LANAP). Clinical changes in iPD were more significant among premolars and molars when followed up for a period of less than 7 years. Tooth retention after full-mouth LANAP treatment was favorable in this cohort of private practice patients.

The one time I tried jellyfish, I was overwhelmed by its chewiness. I'd asked the clerk in the store how it tasted, and she said "crunchy". I thought no way! So I bought some. I now believe that as a non-native English speaker she confused the words "crunchy" and "chewy". I recall it as otherwise rather bland.

Reinforcing Ron’s point, this article talks about a specific gene but many of our genes are similarly modulated by other genes as well as the environment. Usually we find a gene that protects or promotes some condition and then by examining the exceptions find other genes that affect (and possibly eliminate) the output of the first gene. Kidney disease gene found to also have a protective mutation increased risk of kidney disease due to a dangerous genetic mutation that creates a hole in the kidney cells, but Vanderbilt University Medical Center (VUMC) researchers have now discovered a protective genetic mutation that covers the hole to eliminate the risk. immediate and broad implications for kidney health because people with both the disease-causing and protective mutation are not at increased risk.

An interesting opinion on the Blue Zones: - What they ate might not be so important. Not only the count of centenarians would be affected, but also calculations of the average life span for the entire population would be reduced as fewer super centis appear. Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud Instead of the usual drivers of unusual longevity, found that in the US, the lack of vital registration increases remarkable longevity. In the UK, Italy, Japan, and France, the predictors are poverty, high crime rates, worse health, and fewer 90+ people. Also, supercentenarian birthdates are concentrated on the first of the month and days divisible by 5. One graph showing the impact of complete birth registration Per capita rate of attaining supercentenarian status across US states, relative to the introduction of complete-area birth registration.

I saw an article about China’s chatbot’s response to a question about the origin of Covid: It seems to have figured out that everyone has been looking in the wrong place. 🙃 Meet Ernie, China’s answer to ChatGPT China’s leading artificial-intelligence (ai) chatbot, which was released to the public on August 31st, reckons that covid-19 originated among American vape users in July 2019; later that year the virus was spread to the Chinese city of Wuhan, via American lobsters.