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Since I consume a negligible amount of cacao and chocolate last year (up to 15g/day) and this is less then previous years I expected to move my test data to the lower side but instead of it I now have borderline 0.2 ug/l instead of 0.13 almost 2 years ago. Maybe because I switched to cheaper noname sources due to my believe that it makes no sense to pay 2.5 prices for better ones. Or maybe the reason is in something different (I ate 1.5kg of unknown quality stuff like spices/curcuma/ginger/cynamon last months also). In any case, I was curious to find that japanese people (and probably other far east populations with rice as a staple food) do have very high cadmium (often ~40% of nephrotoxic values!) levels in the kidneys, here are a few pages on it (I hope google will allow them to be viewed): https://books.google.pl/books?id=sSoUDgAAQBAJ&pg=PA171&lpg=PA171&dq=It+is+widely+known+that+an+outbreak+of+itai-itai+disease,+a+human+disease+caused+by+local+Cd+poisoning+fromintensive+mining+operations,+occurred+in+Japan+more+than+50+years+ago&source=bl&ots=adM4kCU5R-&sig=ACfU3U0STYIwmiAGLMW16Q0gr617544_RQ&hl=en&sa=X&ved=2ahUKEwj9g-virMmFAxXJHxAIHUmNClMQ6AF6BAgmEAM (or doi of the chapter 10.1016/B978-0-12-805378-2.00013-9 is also possible to be fetched via sh) Given the fact that japanese are among the leader top for longevity the fact could be peculiar I would say.. Br, Igor

When listened to the audio version of Coleen Murphy's "How We Age" book I was surprised by an effect observed in flies, a brief on it is here https://www.scientificamerican.com/article/the-scent-of-a-calorie-wh/ https://www.cell.com/fulltext/S1534-5807(07)00064-0 I can't find the mentioned study from 2017 but it seems there are more studies about the olfactory influence on well-known regulatory paths, e.g. the refs of https://www.sciencedirect.com/science/article/abs/pii/S0962892423002349 and so on. So it could be the case that not only the meds and lifestyle stimulating the growth-related machinery could, well not cancel the CR effect in more complicated organisms like mammals but dempfer it (imho to a small degree if any) but also intense enough stimulation by some flying chemistry. Given that we assess the olfactory as a separate sense but from the buildup perspective it is rather a part of a wide sensory continuum wired into the brain the idea is completely ok but I am skeptical about the size of the effect (and easiness of CR/DR cancellation via other factors) due to the complexity of mammals in comparison with more primitive organisms - the same basic building blocks that are dealing with materia and energy transformations have less degrees of freedom due to their incorporation into much more complex structures (this is the reason we can't see 30-100% lifespan increase from CR in mammals also). Br, Igor

COVID-19 Virus Can Persist in the Body More Than a Year after Infection https://polybio.org/covid-19-virus-can-persist-in-the-body-more-than-a-year-after-infection/ "Research published today in Lancet Infectious Disease and supported by PolyBio Research Foundation provides the strongest evidence yet that the COVID virus can persist for months or years after infection. The findings, published by a UC San Francisco/Harvard Medical School team, found that proteins created by the virus were still present for up to 14 months in a quarter of people tested."

Director of the NIH, regarding long covid: "We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI [gastrointestinal] tract, to the lung." "The virus can persist in tissues for months, perhaps even years." https://www.medpagetoday.com/opinion/faustfiles/109672

After 14 days of CGM, 7 without canagliflozin and 7 with... Average glucose without: 100 Average glucose with: 97 It's not a huge obvious difference. Also I ate not the healthiest food on two days of the first week bc I wasn't at home ===== yesterday i ate 4 packs of mr tortilla and felt so K/O'd from all the fiber that I wasn't able to do amything for rest of day/next of day. it's not a huge calorie load. BG only around 95-105 for a long while after 2 days ago I ended up eating an entire pack of ezekiel bagel (960 cals). it only spiked my BG to 125 at the very end (and I had other things too). the decrease in BG the night after was lower but only around 100

https://www.urmc.rochester.edu/news/story/on-world-parkinsons-day-a-new-theory-emerges-on-the-diseases-origins-and-spread?fbclid=IwAR11CpaJbERJY4-m30gtyLOOyitIiUVj9kNAu0VEAbIEwLUM-4XchmaYGLo

It sounds plausible, yep.

Previously I did not tested shbg rather focusing on thyroid and lh,fsh,pl,t pannels. After some reading it seems this one is paired with well studied main cr pathway of insulin/igf1 - it is suppressed by igf1 that itself is increased with insulin. So my context is: - definitely CR, unfortunately paired with some weight loose in the last 3 months, I am crossing now the "low normal" bmi range - borderline hematocrit, etc; low normal leukocytes without neu/lym disporoportions, reticolocites reveals no upcoming anemic decreases - good proteinogram with a lot of albumin, I assume I have all available protein being used for desired goals, no growth etc. - from "traditional" clinical anemia signs perspective only leg weakness when going 100-200 stairs up is present in some mild degree - low protein diet, 10% and plants only, this seems forms igf1 value independently of "raw" insulin arm So the results observed are: insulin 2.3 in 1.9-23 mU/l igf1 88 in 53-215 ng/ml shbg 74.3 in 10-57 nmol/l total testosterone 208 in 150-684 ng/dl dihydrotestosterone 141.2 in 143-842 pg/ml To derive some insight on free testo or bioavailable testo (the concept is not widely agreed as important, more in a dedicated book "Controversies in Testosterone Deficiency" - Springer 2021) I used this calc https://www.issam.ch/freetesto.htm Albumin 4.9 SHBG 74.3 Testosterone 208.2 Free Testosterone 2.18 ng/dL = 1.05 % Bioavailable Testosterone 57.9 ng/dL = 27.8 % (this is with the lowest albumin I ever tested, last values were higher giving freeT 1.03-1.01%) Resuming - I would say that the expectation to have high shbg due to low igf1/insulin is observed, and lower available testosterone due to high shbg is what has to happen from all points of view (it seems a safeguarding element - so no cell growth stimulation by testo will happen when resources are low). Br, Igor

Hm, trying to listen to the stuff of https://www.youtube.com/@SeriousScience in particular so far looks like a good source of inspiration, the channel has a lot of materials of many kinds thus I can't conclude about all the stuff but it looks like a high quality popsci to do my morning salad chopping %) Br, Igor

Not a lecture but rather a roadmap of Leonard Hayflick's scientific trajectory, with lots of nuances not visible in the books and papers, I found it very interesting from many angles: Br, Igor

IMHO the situation with abnormally low LDLs originates from the approach of contextless data sciencing and creates unwanted confusion due to this. For myself I use this model to understand it (or "understand", for obvious reasons of complexity). There is a flux of materia into a sophisticated transforming machinery called liver. There is a processing capacity with optimal range of operation let's say 40-90% of approximated saturation point. With such a flux the size of exported cargoes will be determined by many factors but most of them will fluctuate close to mean values observable in the population. If we will artificially increase the flux at the input then the system will leak the extra to some other paths (if they exist and to the extent of their saturation) or will start to export lower sized cargoes, just to get rid of overload because there is no housing for it (yes, there is some and fatty liver is a sign of saturation of this backup mechanism). So actually it is pretty imaginable within the queing theory used in engineering. There is a rare exceptional share for small abnormal cargoes - genetically determined, these people will produce abnormal particles within a normal flux values but my intuitive feeling is that they account for minuscule shares of a percent. In other words - for most of the people the start of production of smaller particles is a redflag about unwanted input overload that itself is a sign that a lot of problems will come in other areas - the network of queues goes deoptimized and no one could predict where the things will start to break. No magic pill or any kind of mimicking or biohacking will help, there is no way to mimic normal traffic in a congested network, there should be incoming rate limit implemented until it will become too late and parts of the mechanism will be deformed. From this perspective it does not make a big difference if smaller particles are more atherogenous themselves, this adds to the bad prognosys but should be of concern especially for those with rare unfortunate genetics, 99.9% of other people should rethink their energy balances. Br, Igor

Not necessarily. It's a rapidly fading theory. Dense LDL particles are associated with those with more severe CVD, but by themselves do not appear to have predictive value. Low-Density Lipoprotein Size and Cardiovascular Disease: A Reappraisal | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic (oup.com)

I just tested lipids again, after a period of a bit lower fat consumption, and months after I stopped Omega-3 supplementation. Back to where I want to be: C-Total: 143 mg/dl HDL-C: 69 mg/dl LDL-C: 64 mg/dl VLD-C: 10 mg/dl Apo B: 60 mg/dl Triglycerides: 39 mg/dl Based on my experiment of 1, the low-fat diet proponents appear to be on the right track, and dietary fat/cholesterol matters in those who have not reached a saturation point. I consumed about 30g of flax daily and reduced nuts (walnuts or almonds) to about 12-14g per day. An avocado once every five days or so. Raw cacao powder of about 10g daily. This confirms my guess, based on reading the published studies, that in healthy people, Omega-3 supplementation may be detrimental to what is currently considered an optimum lipid profile.

Yet, strawberries after canagliflozin and garbanzo beans.. barely inched upward at all (I almost NEVER see this with fruit). I need repeat tests Just on inspection alone, bluebrries do seem to have simpler "matrix structure" (and less fiber) than strawberries. also they were target's. maybe costco's frozen ones may be dif

You really should differentiate sdLDL vs the other types. sdLDL is uniquely bad, other types are barely different from HDL. It's easy to get lipid subfractions, the technology is not that expensive, and all LDL measurements are confounded by fraction that's "good" vs "bad" LDL. Your results might be especially good, but we don't know until we see your lipid subfractions https://www.questdiagnostics.com/our-company/actions-insights/2017/ldl-subfractionation-testing-can-help-id-patient-risk If your LDL is of the unusually good subtype, good for you, but potentially misleading for others.

Hi McCoy! Sounds like a ketotic diet. They do make it easy to lose weight; but Luigi, in his original posts, discouraged them. (Evidence is that the lipid levels tend to be bad.) Byt maybe it work well for you. -- Saul

Thanks drewab. I'm not sure about the why, but it looks like this effect may not be specific to me: "After adjusting for age, race/ethnicity, sex, fasting status, and lipid-lowering medication use, greater epigenetic age acceleration was associated with lower TC, HDL-C, and LDL-C, and higher TG (p < 0.05)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925395/

I really appreciate the longer video here Michael. It is a bit wild to think that no foods/nutrients are significantly correlated with DunedinPACE. Nice work getting to 11th or 12th on the Rejuvenation Olympics leaderboard (even if that isn't your overall goal). How many names have been submitted? I heard it's about 4000 at this point, which would make your results pretty impressive! I don't understand why a higher LDL would result in slower aging. Intuitively this just doesn't make sense to me and it doesn't square up with the Ornish/Esselstyn studies that have reversed heart disease and had patients with very low LDL's. I know that this is obviously different than aging and all-cause, mortality, I'm just trying to square this up in my basic brain. I'll be curious to see how this shakes out with more tests. Are calories associated with DunedinPACE in your data? I commend you for your detailed testing of SFA, LDL, and Dunedin pace without "blowing up the system" as you put it.

Attempting To Slow The Epigenetic Pace Of Aging (13-Test Analysis)

Rather than isolated measurements, I'd recommend testing regularly and evaluating year-to-year changes...

Este tema es muy interesante McCoy, yo también he tenido experiencias similares. Por curiosidad, mencionas que eras bajo en carbohidratos y ligeramente alto en proteínas, ¿incluiste proteína animal o fue exclusivamente vegetal? Digo esto porque quizás la menor digestibilidad de las proteínas vegetales podría haber influido en la pérdida de masa magra 🙂

finally took 18 oz blueberries AFTER canaglifloznin, needed to test this 145 and stll increasing.. 160... 183... [this NEVER happens...] the avocado oil beyond meat i ate right before didnt do anything to stop that

it's 105/66 now, also I took the positions in a depressed position. Regardless I did get more natto [unclear if this works] and aged garlic extract and all the other BP meds... I'll see a doc mid next week, lol I wonder if it'll be in the 90s then.. 4/20 next week, 40% discount at local cannabis store... I'm also restarting vyvanse......

Gordo, The immune suppressive factor in rapa is negligible for helthy people; so it's conceivable that rapa might be interesting. I asked Matt when he gave a talk at the University of Rochester's annual aging conference, whether he thought that CR and rapa might go together. He said that he never could get funding for such a study. The dog study is possible, since it simply depends on large dog owners volunteering to allow their pet to enter the study. Since large dogs have short lifespans, there hopefully might be some useful data in not too long a time period. If, as Matt suspects, rapa appears to improve the expected lifespan and heathspan of large dogs, it would certainly be interesting. -- Saul

This spike from just diced tomatoes which usually don't spike them