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  1. Today
  2. Thanks Igor and Tom for your responses in this thread. I largely agree with what you’ve posted. So with that being said, a natural question that comes from this is who do you consider to be better sources of information. A few people come to mind including the likes of Valter Longo and Luigi Fontana, while avoiding characters like David Sinclair and Andrew Huberman.
  3. Yesterday
  4. Mr Tortilla 1 net carb, VERY low calorie density, practically impossible to overeat (though gives you lots of bloating/gas). Which is FINE and I tolerate it WAY better than almost anyone but I've noticed the huge dif even w/that
  5. https://pubmed.ncbi.nlm.nih.gov/37499389/ plastic mulches.... really common contamination source in fruits/vegetables..
  6. I just finished listening to the most of his episodes during morning salad preparation. It took me many months to do so. I came to conclusion that it is a typical "amusement with a fleur of science" with 90% of useless information that nevertheless could sometimes raise curiosity about something (or about a guest) and that way feed the later search. The bad side of it - it is filled with "science supported sales" process (not only direct ads), so unprepared listener will sooner or later have a lot of b....t in his/her head. With time it became worse, both for topics and for promotions (eat more "high quality" protein for me is a 100 bulletproof red flag after reading of "Food politics" by Marion Nestle, so I dropped it completely to stay calm%)). I wonder if there is some true version of a long running really scientific podcast that could be picked and listened regularly (? https://www.scientificamerican.com/podcasts/), so far only pop-sci audiobooks are useful but they are monologs and sometimes a discussion between highly knowledgeable people could bring valuable things almost never described in a book form. Br, Igor
  7. Gee, who ever thought he was "reliable"? I listened to one episode, and immediately saw that his shtick was to take some initial findings and wildly extrapolate into confident recommendations. Worthless. Plus his recommendations fall into the completely useless and impractical category. The episode I listened to featured his supposed area of expertise, where he made a series of recommendations about exposing your eyes to various light conditions in just the "right way" - which encapsulated everything wrong with such "guru" podcasts; shaky science wildly exaggerated and claimed with 100% confidence, married to completely impractical routines that are supposedly going to benefit you. Who the F**k has the time to waste every morning on this speculative cr*p?? If you were to take seriously every recommendation from every one of these gurus, you would need not 24 hours a day, but 10,000 hours where the foot guy recommend 10 minutes of feet exercises, the back guy 15 minutes, the ear guy 7 minutes and so on for 10,000 hours of "health" routines every single day, and then comes Hubernan to add more time wasting snake oil on top of that. The hell with all those guys. All they ever do is pad their own pockets by wasting your time and attention to make money for themselves selling you nothing but a false dream. Waste of time. Another grifter, another hypester, another useless supplement pusher trying to scam you.
  8. I think the tortilla fills me enough to reduce calorie consumption AND it doesn't spike glucose (only gradual increase) did acarbose kill one glucose spike from beets?? i can try a second can..
  9. Last week
  10. https://www.amazon.com/dp/B09D1ZKXGS?psc=1&ref=ppx_yo2ov_dt_b_product_details 360 calories in 1bag, of which 24g, or 72 is non-fiber carbs. I mean I did eat 3 entire bags yesterday I can tolerate far far more fiber/bloating/gas than most people (acarbose+beans is nothing for me), but even this reaches borderline too much. Oh and I sent my microbiome sample yesterday
  11. This was just beets 2nd is the fancy riced cauliflower
  12. How about beets? in 360g of canned beets, that's like roughly a gram of betaine/TMG ==== well which methylation genes act on both homocysteine and epigenetic age?
  13. Looks like I put the CGM in the wrong place (though this is ALSO true for the CGM I found usable in the thred here). agelessrx will mail me another CGM sensor that I'll apply correctly (hopefully) for once this week - I see that they're in the fleshy part of the back of the arms. At least https://www.amazon.com/dp/B0BKR557NL?psc=1&ref=ppx_yo2ov_dt_b_product_details mission flour keto tortillas barely give me a CGM response. But beets still do. and my BP has been unusually high lately for idk what reason.. I know what I need - natto, sulfur, and beets. Idk if these will be enough.. maybe it's just a phase.. == canned beets spiked my BG by 50 points... it's not safe to eat them every day. ;/ i should test them with acarbose
  14. https://cbd.market/lazarus-naturals-cbd-oil-high-potency-unflavored-4oz-120ml-6000mg-of-cbd seems like the obvious choice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970569/ is a chinese study so caveat emptor, but says CBD + THC.. = https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.962922/full (there's smg called entourage effect) -- more cross-referenced in thread here -https://www.rapamycin.news/t/cannabinoids-cannabis-cbd-thc-can-they-slow-aging-in-strange-ways/464/3
  15. Interesting read, now it's natural to wonder whether the things he says in his podcast are reliable or not, coming from such an unreliable source.
  16. https://nymag.com/intelligencer/article/andrew-huberman-podcast-stanford-joe-rogan.html There’s an incredible amount of both backlash and support in response to this interesting (and damming) look into Andrew Huberman’s personal life including what appears to be multiple affairs and deception. It’s a very long read but is well worth it.
  17. Hm, cronometer reports for me the top contributors for today like: Paprika 592.8 mg 17% Oranges, Raw 570.2 mg 17% Honeydew Melon, Raw 513 mg 15% Apple, Fresh, With Skin 443 mg 13% Grapes, Raw 416.4 mg 12% Red Bell Peppers, Raw 405.1 mg 12% Chicory Greens, Raw 394.8 mg 12% Strawberries, Raw 355 mg 10% Dates, Dried 347.7 mg 10% Napa Cabbage, Raw 347.5 mg 10% with total 8820 mg 259% (in reality I have more, e.g. from 6 spoons of tomato passata for which cronometer has no values reported) For the sake of curiosity just selected all the leafs/greens/cruciferous stuff for a day - almost 2 grams of potassium comes from 600 grams of it. Br, Igor
  18. New glucose meter (libre 3) but now it starts at 125 (after a 770 calorie meal of banza chickpeas+kombucha 8 hours earlier) and some beets.. those were my only food in 20 hours or since 1am, though I had 2 kiwi fruit at 5 yesterday But ugh I think the first sensor may have been uncalibrated - it may have been put in a region of thicker muscle. The first sensor this year was way too low and unrepresentative of what values I got in the past... I have been feeling poorly today due to sleep deprivation.. ... And it goes to 153 when I take out the trash wtf... and still only decreasing to only 100 after nearly a day w/o food, upon which yu choi increases it. the new glucose meter makes me so paranoid. my BP has also been really unusually high lately (high BP) and I don't know what it is. It could be an all-nighter or recent rapamycin (which was the biocon type - for like 1.5 years I relied on the useless kachhela type...). But I'll test tomorrow. I was also just very low-functioning today I had chiro for much of the last few weeks. I also lost weight much of the last few weeks (after all I did restart the empagliflozin). There's a chance the all-nighter+32oz of coffee really threw my results off *that* much but I'm not betting on it it's the agelessrx canagliflozin trial now, and they don't want you to be taking acarbose or metformin in the trial (over the next week). B/c my blood glucose levels are so high by their CGM, it's too risky to try normal carb heavy foods so I'll rely on vegetables and fats to get me through the next week... [it's still possible that high carb is healthiest *only* with -flozins]
  19. I relatively eat a lot of potatoes, bananas and beans, but according to MyFitnessPal, this accounts to less than 1500mg of the 3500. I wonder if some people here take potassium supplements? It is hard to get 2000mpg K supplements by caplets. Going in powder might be a better option; 10g of potassium bicarbonate brings you 3906mg according to this one not offered as a supplement, but for cooking; https://www.amazon.ca/Bicarbonate-Food-Grade-Crystalline-Elos-Premium/dp/B09ZTPGBX8/ref=sr_1_6?crid=3OBYKM8AXYZ76&dib=eyJ2IjoiMSJ9.mNqQFo_CrZAF7JCvauupNNLeK0VZYpW8RBga5x34aNyzbYAHqxBaj5ChePjxsHOWUL-026X4F_NltXuDOqBrjO7qvYQ_OH9n9V0wJAk2oVBmdH92GLrwSxBhjE9TR9B4FS9bNDg14FdVIfhzMWP3jvIy4vbAG8N28GDbvC5KBlwM5lLHHGohVAxQNQGAlDJoQbADgeIXwYjznq7Lo0jDXljKzNyrxlRuL0SKyR-sunBjKKawNvGR-9DRegJIvockeNx8g4GqnAOyyKKbg7pJvCMm3nNsMLsEakGJnw6qW_8.AKHwvpA333rJooKBBS2qNHjFKv34DS5LxvW8Rx-0gzc&dib_tag=se&keywords=potassium+powder&qid=1711324337&sprefix=potassium+powder%2Caps%2C107&sr=8-6 But it would be my 7th regular powder to take lol! Or I could use it in my cooking if K doesn't get destroyed by the heat...
  20. The study has been cited by Dr. Gil Carvalho, according to him the results are apparently negative but there might be some confounding factors not examined. All in all, his conclusions are that there is not much study material yet to issue an unfavourable verdict.
  21. I got two boxes of sweet green salad last night, but also 16oz green tea, 32 oz of coffee and I think the coffee made me VERY uncomfortable the next day. That might be 400 mg of caffeine according to chatgpt Also a lot of fried tofu but I'm prolly not eating for 24 hours New CGM tomorrow. I need to do a bit more CGM if I am to replace MUFAs with carbs which is probably healthier for me
  22. Just realized.. My RDW went down A LOT in 3 days last year.. this could have been bc I was overdosing on B12 for a period of time then.. Also my DunedinPACE might vary a lot bc I binged on A LOT of nuts in the days prior to my test.. now that Ezekiel bread and keto culture bread is safe for me, I have much lower need to binge on them.. this might also take my LDL cholesterol down too
  23. Hm, for the reasons unclear for me just decided to look again into the original paper this thread started with. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630957/ They used rather a therapeutic dosage for their experiment: To get to the human data I used this https://www.jkom.org/upload/31-3 01 [01-07].pdf which for a 60kg human is close to 5g daily dose, no idea if it will create serum concentrations close to the observed in the young people. Also there is an interesting addition by authors: That could be interesting because they do not reveal the reasons they are noting) I personally do not want to eat 5g of taurine daily to increase the gradient enough that it will help to push the taurine to the brain areas because I have 2-2.5 times the lab normal range (however reliable the norm is in this case) with a "small tongue of a teaspoon" dose (I assume 200-300mg) of it. But invention of a kind of molecular "jit/kanban" for it will make it more attractible. As well as other molecules that were promising but after decades still producing results almost indistinguishable from nothing. Br, Igor
  24. This is an interesting proposition. I suppose the short answer is that we do not know and are unlikely to know anytime soon. You are correct that many drugs are just plain dangerous to everyone and that they are risky regardless of who you are (with your mention of fat burners, ephedrine comes to mind). There are a number of people, like Michael Lustgarten, that have diagnosed hypothyroidism and have taken Levothyroxine for very extended periods of time. But this is a hormone naturally found in the body, so it seems biologically safer... in my opinion. It is interesting that these hormones are also mentioned, given that the body naturally produces them. Perhaps it's neutral or less harmful to take these hormones given that the are least found in the body. I do wonder about people who take these hormones and are diligent about monitoring them (and keep things well within the normal range). I always find it impressive when some individuals (like Michael Lustgarten or Paul McGlothin) are able to maintain relatively high levels of testosterone. This has not been my experience as my levels trend towards lower... though I'm more or less okay with it. As a point of interest, here were my levels a few weeks ago with I them tested (14.5 nmol/L which is 418 ng/dl for my American friends). At the end of the day, my speculation is that there are probably a plethora of drugs/medications/interventions that work counter to the effects of CR, but that there is probably not a lot of data on them.
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