Saul

Hi Dean! I actually have a salt deficient diet -- my bloodwork always shows low sodium. I exercise fairly vigorously -- but not as much as you do (I remember how much time you spent working out on the machines at the last CR Society meeting). I've never had knee pain -- but I do have a joint problem -- I swam ca. 1 mile per day, most days, for over 30 years -- I used my own (lousy) stroke. As a result, I wrecked both of my rotator cuffs. My right shoulder has been replaced by reverse shoulder arthroplasty -- so my right shoulder is made of plastic and steel. But this contraption works fine, letting me write on the blackboard in my in-person classes. The surgeon who did the surgery is Dr. Ilya Voloshin, of URMC. He also takes care of the Buffalo bills. -- Saul

My negative opinion of whole grains: Lots of calories, minimal benefit. Of course better than white bread (not saying much). Similar criticism of extra virgin olive oil: Excessive calories for minimal -- and even dubious -- benefit. -- Saul

Elon Musk is working on it. -- Saul

Hi Dean! You didn't include my whole quote, thus changing the meaning. My post made two points: There's no better way to avoid inflammation than having a good, low calorie diet of fruits and vegetables -- avoiding grains -- and practicing robust daily cardio exercise -- my CRP is almost always < 1mg/L, a sign of extremely low inflammation.

Yes; a small amount for dinner; sashimi salmon and tuna; except for Saturdays, when wife cooked fish (varying each week) is eaten with lunch (most common fish for Saturdays: wild pacific halibut, or wild carribean tuna).

I've read "Split Second" and the sequel, and in fact all the douglas e richards books, except for the chidrens' ones. He has another (adult) book coming out next week, on March 4 -- like all of them, it will be available for free on Kindle Unlimited (I'm a subscriber). -- Saul

There's no better way to avoid inflammation than having a good, low calorie diet of fruits and vegetables -- avoiding grains -- and practicing robust daily cardio exercise -- my CRP is almost always < 1mg/L, a sign of extremely low inflammation. Also, I wouldn't ignore mindfulness and meditation. You won't find these things in a vitamin pill. -- Saul

It's not a movie, but I suspect it might inspire one: I just finished reading a terrific "time-travel" sci fi ebook: "Recursion", by Blake Crouch. It's a great story -- and also presents a fascinating, and I think original, theory of the nature of time. Believe me, you'll enjoy this. It's debatable whether or not you would call the "time shifts" in the novel "time travel" -- I wouldn't. Disclaimer: I think that the "many worlds" explanation of some of the peculiarities of quantum mechanics is very plausible; but the hypothesis on the nature of time suggested in the story plot, while fascinating and I think original, is, INMHO, bullshit. But the novel is a great read -- I think the best sci fi book that I've read since the days of Van Vogt. The book is available in Amazon Kindle format for about $10. -- Saul

IMO, this effort is ofinterest: https://www.rochester.edu/newscenter/rochester-to-advance-research-in-biological-imaging-through-new-grant-470072/ -- Saul

IF you can get your medical insurer to approve it. I have excellent medical insurance; it was approved for 2 years. (The FDA approval for the drug is phrased in a way that gives insurers "an escape clause) to deny the expensive drug after two years of use). With difficulty, I obtained approval for renewals for several more years. This ended recently. Each one month supply has some extra shots in it; I've saved cylinders for the whole time, expecting to get cut off. So I'm now dosing only twice weekly. With what I've saved, I have enough for a little over 3 years. (I've checked with one of the original researchers on Forteo and other PTH (or PTHRP) peptide researchers. Twice weekly dosing should work). When I run out, I plan to purchase tymlos, a drug that binds to the same receptor (a PTHRP peptide) -- it's cheaper -- and also use it twice weekly (unless the FDA drops its escape clause for drug manufacturers). -- Saul

I use Jarrow bone up daily. I also excercise on an elliptical cross trainer with hand motion, at the maximum resistance, daily. And twice a week I take the only real bone-builder for people over 25: Forteo, injectable. -- Saul

Assuming Michael Rae is correct, my most recently measured ratio (using micromoles/nl instead of micrograms/nl) is about .1. Using the micrograms per nl, about .03. I was in the CR group tested by Luigi in that study. I seem to be lower than average in that ratio in the CR group. -- Saul

My guess: Both IGF1 and IGFBP3 are measured in ng/ml. The article indicates clearly that IGF1 is measured in ng/ml; so one would presume that the same is true for the numerator and denominator of the ratio. Michael Rae's statement about the paper seems to be false. ?? -- Saul

Actually, looking at the paper, IGF1 is measured in ng/ml, not uU/ml. So unfortunately it is unclear whether the IGF1/IGFBP3 ratio is comparing ng/ml or uU/ml of these two measurements. At least one of the reported measurements on in the article is in uU/ml -- namely insulin. Reading the paper as written, it appears that all reported measurements, except insulin, are in mg/ml -- and therefore probably also the IGF1:IGFBP3 ratio. But unfortunately, this is unclear. I might email Michael. (or Luigi). -- Saul

I don't use floss. My teeth are more widely separated, due to previous successful gum surgery. I use interdental brushes twice daily, before brushing (with an electronic rotary toothbrush). Works well. (I also keep portable interdental brushes in my back pocket, which I use after eating.) -- Saul