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  1. But - This particular eating schedule, EOD, has been promoted for humans by a number of authors/researchers (Krista Varaday for one). The fact that some folks will only start past youth would *probably* just make even less effective. But this particular rodent strain tends to compensate more on eating days, humans maybe not as much. Randy
  2. For me this is an important paper teasing CR from eating schedules. Does any one know the amount of CR of the EOD group? Is this the same strain that Matson used in 2003 that ignited the whole IF thing in the blogosphere. Randy
  3. Really enjoyed the interview and hearing some real science, although much above my pay grade. What I came away with: 1. Contrary to the claims of a lot of bloggers it probably takes 3 -4 days fasting to amp up autophagy in humans. 2. Blown away by all the nuances/details that are known and unknown about autophagy. 3. Rats are, indeed, much, much more sensitive to fasting/Cr than humans. Rats can lose up 20% body weight after a 48 fast. 4. Interesting details on a number of autophagy mimetics. 5. Thought the exercise increases autophagy in the nervous system not just muscle tissue but Rhonda seemed to deny this. (I thought)? 6. Guido does two 5 day fast a year.
  4. randyf

    Saturated fat - a skeptic's view

    I agree that the sat fat controversy is interesting. Found this piece, all all places, from the paleo mom blog and was impressed with the balanced presentation. https://www.thepaleomom.com/saturated-fat-healthful-harmful-or-somewhere-in-between/. She starts off giving sat. fat a break but when the article is said and done the take away is far more con than pro. I like the article cause it's a good review on sat fat from a number of different evidentury lines. I look forward to listening to Masterjohn's presentation. He's an interesting fellow. As I recall as a graduate student, he felt lousy eating a standard good diet. After discovering Weston Price and adopting his ancestral diet ideas his physical woes were resolved. He's been try to give scientific credence to Price's ideas since. Randy
  5. Saul - I'm not doubting that you are in keytosis. In fact I'm fascinated. Your experience is consistent with the rat data. Remember the rats eating a high carb diet produced 30% more keytones than the rats not on CR but eating a classic keytotic diet. Rats eating a CR keytotic diets even produce more I thought this research finding in rats was really interesting. Folks could greatly increasse keytones (and hopefully with the associated neuro benefits) without having to eat a low carb diet. What I am interested in, if you care to tell, is what your macronutrient profile is? Thanks Randy
  6. But what the results do show is that rodents on a Low calorie High carb low Fat diet increase keytones by 4x. Also the low calorie high carb group produced 33% more keytones than the group eating a higher calorie ketogenic diet.. I don't know your diet other than your descriptions over the years. But you know CFP rations of what you eat. This shouldn't be a mystery. And keep in mind that the soluble fiber is partially digested to fat, insoluble fiber is 0 calories (I think?). From what I've seen simple carbs, even in a full calorie healty, balanced diet, are nothing to worry about. Even less so in a health balanced low calorie diet
  7. Saul wrote in another post: ********* Also unclear is the optimal macronutrient (carb/protein/fat) ratios: I used t think that I was on a high carbohydrate diet -- since I, like most of us, eat mostly raw vegetables. While (technically) I was correct -- soluble and insoluble fiber are complex carbohydrates -- what is meant by "carbohydrates" in these ratios is understood to be simple carbs (such as sugar, starch, sugar alcohols, etc.). By this more correct, definition, my diet is actually low carb, low protein, high fat -- a ketotic diet. This was verified with bloodwork -- my serum ketone measurement showed that I have "ketosis" (this is because the test is usually performed on diabetics, for which it is a serious complication). ********** Low calorie diets irrespective of carbs, fats, protein significanly increase serum keytone bodies. In fact rodents on Low Calorie High Carb Low Fat diet produce More keytones than rodents on full calore classic ketogenic diets (high fat, very low carb low protein diets) http://www.nutrition.../content/1/1/11 See figure 4 below. Four diets were compared: Standard diet - calorie unrestricted Standard diet - calorie restricted Ketogenic diet - calorie unrestricted Ketogenic diet - calorie restricted Note that the Standard diet (high carb/low fat) with Restricted calories produced More hydroxybutyrate than the Ketogenic (low carb/high fat) Unrestricted calorie diet. Figure 4
  8. Hey Saul, We go back a ways, close to 2 decades for me on the old email list. Always admired your CR disipline and consistentcy and in awe of anyone that cam pump an eliptical on max resistance for more than a minute much less an hour. We also share an interest in meditation. But I still disagree - Seyfried was specially refering to a 600 - 800 Kcal diet. VLCD have a specific meaning in the literature and Seyfried was not being sloppy.
  9. VLCDs are generally conceived as temporary regimes designed for rapid weight loss or some specific therapeutic purpose. In contrast, CR is generally conceived as a very long-term regime designed to slow the biological aging process and increase lifespan/healthspan. It seems to me that even "severe CR", if it is a long-term regime, would in most cases involve more calories/day than a VLCD. Neither myself or Seyfriedd were suggesting that 600Kcal/day for a continual CR program. Death would eventually result. I was responding to Saul's comment that it was unclear to what Seyfried meant by *very low calorie diet*. I was just pointing out that this is clear. A VLCD diet, in the literature, refers to a human diet of 600 -800 Kcals and that's what Seyfried was meant. Once again the point of Seyfried, papers is that *certain results* in rodents from moderate CR can only be reproduced in humans by severe calorie reduction or fasting. Regards Randy
  10. Hi Saul, I disagree. *Very low calorie diet in humans* typically refers to 600 - 800 calories a day. That's severe CR. And fasting, of course, is 0 calories https://en.wikipedia.org/wiki/Very-low-calorie_diet Regards Randy
  11. Thomas Seyfried published a paper suggesting that rodents are much more sensitive to CR (in certain regards) than humans. He suggested that moderate rodent CR is equivalent to severe CR/Fasting in humans. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513228/ Randy
  12. My point, better stated, is that even if autophagy doesn't return to base line levels after refeeding from a longer fast - So what? Until some real world problems are demonstrated, the best evidence I"ve seen (from Longo's work) is very positive. Haven't seen any downsides. And that includes folks on chemo after 4 days fasts. Thanks Randy
  13. Thank you Randy! Appreciate the link and great hearing from you. Are you perhaps referring to 5 minutes in, where he seems to characterize the mechanism of stem cell regeneration in prolonged fasting ( or his FMD version of that) to be apoptosis rather than classic autophagy, followed by proliferation during the re-feeding phase? If so, while an interesting distinction and worthwhile subject, the mechanism of action for stem cell changes is another matter than the concern raised above that autophagy resumption is delayed on re-feeding with fasts > 24 hours, and has been demonstrated to increase susceptibility to and harm from intracellular organisms. Whatever the mechanism it is not so much a matter of how it works - or even all the benefits autophagy - but rather the downside of longer complete fasts. Please let me know if you were referring to another part of the interview! Yes that's what I was referring too. My point being that even if long term fasting decreases autophagy there still *might* be very signifcant benefits as reported by Longo in a number of his recent papers. Randy
  14. In a recent interview Valter Longo down played the value of autophagy in his 4 day fasting schemes. I found that interesting and unexpected. Here's the interview: Apologizes for not specifying exactly where he makes that observation, but I know its there cause it caught me by surprise. Randy
  15. Thanks for those details. As for me, when I'll do it (if I do it), I'll skip the higher calorie day and go straight to 5 days of lower calorie intake. My understanding (and correct me if I'm mistaken) is that the food portion is solely to make this process less painful without (much?) reduction in benefit. The calories don't add any benefits it just does't subtract too much. A straight fast would as good or better.