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  1. And add to that the fact that supplements are almost always found to be useless at best in clinical trials
  2. I wasn’t totally serious of course. That’s why there is an lol. But your points are worthy and heck it’s complicated, but IAC supplementation of any kind has rarely, very rarely been shown to confer benefit for most people and sometimes harm. but that’s generally only when megadosing which we are not discussing wrt choline I don’t think. For me I’ll just stick to a whole food, plant based diet And furthermore I’m quitting the 4 eggs a week I was eating in a desperate attempt to get enough choline. I like Dean Pomerleau’s idea of giving up on the goal of getting the rda for choline and simply eating a healthy whole food, plant based diet and getting 300ish mg of choline. I think this study lends support to Dean’s thinking on this.
  3. So taking choline supplements is probably suicidal LOL! Br J Nutr. 2019 Jul 10:1-9. doi: 10.1017/S0007114519001065. [Epub ahead of print] Dietary choline is positively related to overall and cause-specific mortality: results from individuals of the National Health and Nutrition Examination Survey and pooling prospective data. Mazidi M1, Katsiki N2, Mikhailidis DP3, Banach M4,5,6. Author information 1 Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, People's Republic of China. 2 Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. 3 Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK. 4 Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland. 5 Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. 6 Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Abstract Little is known about the association between dietary choline intake and mortality. We evaluated the link between choline consumption and overall as well as cause-specific mortality by using both individual data and pooling prospective studies by meta-analysis and systematic review. Furthermore, adjusted means of cardiometabolic risk factors across choline intake quartiles were calculated. Data from the National Health and Nutrition Examination Survey (1999-2010) were collected. Adjusted Cox regression was performed to determine the risk ratio (RR) and 95 % CI, as well as random-effects models and generic inverse variance methods to synthesise quantitative and pooling data, followed by a leave-one-out method for sensitivity analysis. After adjustments, we found that individuals consuming more choline had worse lipid profile and glucose homeostasis, but lower C-reactive protein levels (P < 0·001 for all comparisons) with no significant differences in anthropometric parameters and blood pressure. Multivariable Cox regression models revealed that individuals in the highest quartile (Q4) of choline consumption had a greater risk of total (23 %), CVD (33 %) and stroke (30 %) mortality compared with the first quartile (Q1) (P < 0·001 for all comparison). These results were confirmed in a meta-analysis, showing that choline intake was positively and significantly associated with overall (RR 1·12, 95 % CI 1·08, 1·17, I2 = 2·9) and CVD (RR 1·28, 95 % CI 1·17, 1·39, I2 = 9·6) mortality risk. In contrast, the positive association between choline consumption and stroke mortality became non-significant (RR 1·18, 95 % CI 0·97, 1·43, P = 0·092, I2 = 1·1). Our findings shed light on the potential adverse effects of choline intake on selected cardiometabolic risk factors and mortality risk.
  4. mikeccolella

    Colonoscopy Pro and Con

    https://www.healthline.com/health-news/dreading-colonoscopy-other-effective-tests-for-colon-cancer-032015#1 see the above or the other reference wrt to my rationale here. Bottom line fobt every year is as effective as a colonoscopy every ten years. If your 15 year risk is like mine 4.3% then the probality that you will get colon cancer is remote and doing a fobt each year protects you just as well as the invasive and possibly dangerous procedure that you expose yourself too when an fobt yearly will likely never send you to the gastro doc to have a sharp tool shoved up your ass, medicines that are dubious etc. if the unlikely positive result is that there is blood in your stool then one takes the risk and goes to the gastro doc and gets his colonoscopy. But certainly each individual makes their choices as they see fit
  5. mikeccolella

    Colonoscopy Pro and Con

    The big unknown of course is what are the long term consequences of having this intervention done. A hose up your ass, laxatives drugs to sedate etc. We do know that punctures occur and can be deadly. We might find in the long run that similar to prostrate screening more harm is being done than good. People tend to focus on colonoscopy = lower risk of getting colon cancer. True but who knows what the real risks are in the long run. I believe in the, first do no harm approach, when possible,. Another point is that the non intervention fecal blood test looks almost as effective at preventing colon cancer mortality as a colonoscopy. That’s why after having two colonoscopies I now simply do the blood test annually. See graphics comparing the the various screenings in the article
  6. mikeccolella

    Colonoscopy Pro and Con

    https://www.bmj.com/content/367/bmj.l5515 these guidelines suggest NO screening for colorectal cancer in low risk people. You heard that right None nada!!
  7. Yes I agree that is what they claim. I was surprised that I had above average deep sleep according to their analysis, but I’m skeptical. I don’t often feel particularly rested, unlike 10 years ago and more, and that held true when they claimed I was getting above average deep sleep.
  8. I tried the 1st one and found it to be totally useless. I returned it after using it for thirty days. I had no problem getting a refund, so Giving it a try makes sense.
  9. https://doi.org/10.1111/acel.13028 metformin and growth hormone reverses aging in humans. Bio markers of aging were reversed and that is big news indeed. Even cr in rats doesn’t do that.
  10. https://www.ahajournals.org/doi/10.1161/JAHA.119.012865 just published and me thinks a good study because they controlled for so many confounders that are often associated with plant based eaters. IAC, the association was as you might expect the more whole plant foods that are eaten the lower the cardiovascular mortality as well as overall mortality
  11. mikeccolella

    Cholesterol paradox

    My own experience which I’ve reported here several times is this. high 35-40% fat raises my Hdl by about a 1/3, cuts triglycerides in half and has zero effect on my ldl when compared to a low fat diet ~ 12-15% The fat thing is still an issue for some and of course high fat diets tend to injure the endothelial tissue by causing chronic issues with flow mediated dilation. Of course this will effect some more than others such as smokers, sedentary folks, junk foodies, diabetics etc. wine is an excellent accompaniment with high fat meals and may partly explain the French paradox.
  12. Tom I have not tried such a diet. To me it sounds insane! I suppose the Inuit ate something like it? Not sure, but generally it’s just weird and I don’t like weird because I want something that’s been shown to be safe in the long run. That’s why I don’t like prescription drugs most r not tested for a lifetime and so we really don’t know their effects.plant based diets have been a mainstay of human evolution and therefore something not weird. We don’t have any evidence like that for ketogenic diets
  13. mikeccolella

    TMAO & Cardiovascular Disease

    I agree with you Dean; however I’ve found it challenging to eat a vegan diet and to get 550 mg. Which MR says is likely insufficient! Not sure what he’s basing that on. You didn’t mention legumes? How come? I’m eating 4 oz of broccoli, ounce of nuts, cabbage, collards, cup of lentils and cup of chickpeas, mushrooms, whole grains like wheat bran, oats etc and I still only get 388 mg. The egg pushes me up over 500. Me thinks your on to something Dean. This 550 mg. Of Choline just does not ring true.
  14. mikeccolella

    TMAO & Cardiovascular Disease

    http://www.clevelandheartlab.com/blog/what-your-gut-says-about-your-heart/ for now I am simply going to follow the above advice of the Cleveland clinic. The whole plant thing advantage seems to be based on gut microbes and this some other substances. As for choline one egg a day should be fine and at 150 mg of choline will push me above 500 mg. I will eat eggs from a woman I know personally who sells them and considers them pets and treats them accordingly. They don’t mention it in the above for some reason but elsewhere they recommend balsamic vinegar, grape oil, red wine and EVOO. I will continue with 8 oz of wine with evening meal and add some balsamic vinegar for the 3,3-Dimethyl-1-butanol
  15. mikeccolella

    TMAO & Cardiovascular Disease

    Maybe a dumb question but is vegan choline less problematic strictly considering TMAO or no??