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  1. mikeccolella

    Colonoscopy Pro and Con

    https://www.healthline.com/health-news/dreading-colonoscopy-other-effective-tests-for-colon-cancer-032015#1 see the above or the other reference wrt to my rationale here. Bottom line fobt every year is as effective as a colonoscopy every ten years. If your 15 year risk is like mine 4.3% then the probality that you will get colon cancer is remote and doing a fobt each year protects you just as well as the invasive and possibly dangerous procedure that you expose yourself too when an fobt yearly will likely never send you to the gastro doc to have a sharp tool shoved up your ass, medicines that are dubious etc. if the unlikely positive result is that there is blood in your stool then one takes the risk and goes to the gastro doc and gets his colonoscopy. But certainly each individual makes their choices as they see fit
  2. mikeccolella

    Colonoscopy Pro and Con

    The big unknown of course is what are the long term consequences of having this intervention done. A hose up your ass, laxatives drugs to sedate etc. We do know that punctures occur and can be deadly. We might find in the long run that similar to prostrate screening more harm is being done than good. People tend to focus on colonoscopy = lower risk of getting colon cancer. True but who knows what the real risks are in the long run. I believe in the, first do no harm approach, when possible,. Another point is that the non intervention fecal blood test looks almost as effective at preventing colon cancer mortality as a colonoscopy. That’s why after having two colonoscopies I now simply do the blood test annually. See graphics comparing the the various screenings in the article
  3. mikeccolella

    Colonoscopy Pro and Con

    https://www.bmj.com/content/367/bmj.l5515 these guidelines suggest NO screening for colorectal cancer in low risk people. You heard that right None nada!!
  4. Yes I agree that is what they claim. I was surprised that I had above average deep sleep according to their analysis, but I’m skeptical. I don’t often feel particularly rested, unlike 10 years ago and more, and that held true when they claimed I was getting above average deep sleep.
  5. I tried the 1st one and found it to be totally useless. I returned it after using it for thirty days. I had no problem getting a refund, so Giving it a try makes sense.
  6. https://doi.org/10.1111/acel.13028 metformin and growth hormone reverses aging in humans. Bio markers of aging were reversed and that is big news indeed. Even cr in rats doesn’t do that.
  7. https://www.ahajournals.org/doi/10.1161/JAHA.119.012865 just published and me thinks a good study because they controlled for so many confounders that are often associated with plant based eaters. IAC, the association was as you might expect the more whole plant foods that are eaten the lower the cardiovascular mortality as well as overall mortality
  8. mikeccolella

    Cholesterol paradox

    My own experience which I’ve reported here several times is this. high 35-40% fat raises my Hdl by about a 1/3, cuts triglycerides in half and has zero effect on my ldl when compared to a low fat diet ~ 12-15% The fat thing is still an issue for some and of course high fat diets tend to injure the endothelial tissue by causing chronic issues with flow mediated dilation. Of course this will effect some more than others such as smokers, sedentary folks, junk foodies, diabetics etc. wine is an excellent accompaniment with high fat meals and may partly explain the French paradox.
  9. Tom I have not tried such a diet. To me it sounds insane! I suppose the Inuit ate something like it? Not sure, but generally it’s just weird and I don’t like weird because I want something that’s been shown to be safe in the long run. That’s why I don’t like prescription drugs most r not tested for a lifetime and so we really don’t know their effects.plant based diets have been a mainstay of human evolution and therefore something not weird. We don’t have any evidence like that for ketogenic diets
  10. mikeccolella

    TMAO & Cardiovascular Disease

    I agree with you Dean; however I’ve found it challenging to eat a vegan diet and to get 550 mg. Which MR says is likely insufficient! Not sure what he’s basing that on. You didn’t mention legumes? How come? I’m eating 4 oz of broccoli, ounce of nuts, cabbage, collards, cup of lentils and cup of chickpeas, mushrooms, whole grains like wheat bran, oats etc and I still only get 388 mg. The egg pushes me up over 500. Me thinks your on to something Dean. This 550 mg. Of Choline just does not ring true.
  11. mikeccolella

    TMAO & Cardiovascular Disease

    http://www.clevelandheartlab.com/blog/what-your-gut-says-about-your-heart/ for now I am simply going to follow the above advice of the Cleveland clinic. The whole plant thing advantage seems to be based on gut microbes and this some other substances. As for choline one egg a day should be fine and at 150 mg of choline will push me above 500 mg. I will eat eggs from a woman I know personally who sells them and considers them pets and treats them accordingly. They don’t mention it in the above for some reason but elsewhere they recommend balsamic vinegar, grape oil, red wine and EVOO. I will continue with 8 oz of wine with evening meal and add some balsamic vinegar for the 3,3-Dimethyl-1-butanol
  12. mikeccolella

    TMAO & Cardiovascular Disease

    Maybe a dumb question but is vegan choline less problematic strictly considering TMAO or no??
  13. Omg Saul this is so totally true in my case. I have posted numerous times how much more fulfilling a low fat diet is from a hunger perspective. When I cut out the fat I feel almost challenged by how much I can eat! I always assumed it was the fiberous foods replacing the fatty foods that explained. The sheer volume of food also. But this adds another aspect that may be a factor.
  14. mikeccolella

    Should we all be drinking wine?

    https://time.com/4070762/red-wine-resveratrol-diabetes/?utm_source=facebook.com&utm_medium=social&utm_campaign=social-share-article&utm_content=20190806 I have tested the post prandial effect of red wine several times. It is just one more positive effect. The stuff is excellent medicine imo,
  15. mikeccolella

    Must we throw out the blue zones?

    Hype is the name of the game. Nothing new under the sun. It’s basically the same old bullshit recycled over and over again by this person or that person trying to get published or sell a book etc. Yes there are some basic facts like sleep hygiene, eat your veggies, exercise moderate CRON and don’t smoke, and drink moderately. That’s about it folks and the aging process will take its toll and the best we can do at this point ain’t a whole lot! God Bless Michael Rae cause he is realistic on this point and works for a real solution. The rest is weak ass medicine to say the least.