InquilineKea

There could be concerns with mitochondrial hormesis in younger poeple - https://pubmed.ncbi.nlm.nih.gov/24874428/ Most of the research is in hearts but I'm sure it has effect in brain too

?

https://sci-hub.tw/https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30020-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0962892418300205%3Fshowall%3Dtrue => so many of the biomarkers! ===

some suggest urolithin A but it really depends on the bacteria in one's gut Max Unfried Sep 3rd at 8:02 AM What happens to Urolithin A after the gut? What's the target it is acting on? 4 replies Patrick Burgermeister 3 days ago Have you checked Andreux et al., Nat Metab 2019? Patrick Burgermeister 3 days ago Even better: Ryu et al., Nat Med 2016 Penelope Andreux 3 days ago Hi Max, Indeed I can refer you to our publication in Nat Metab. In short, UA enters the blood circulation, it is conjugated by the Phase II conjugation enzymes in the liver, undergoes active enterohepatic recirculation, before being elimination through renal and GI tract. It takes up to 4 days to completely eliminate it. The target of UA has not been identified as of today. Thanks for your interest ! Max Unfried 3 days ago Appreciate that you took the time to answer will check out your papers(Thank you for linking them Patrick)!

peptidesciences.com for Mots-C and SS-31

eg MDM2 or DNA DSB genes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/

https://www.fightaging.org/archives/2020/08/a-type-of-phosphorylated-tau-in-blood-samples-indicates-amyloid-%ce%b2-aggregation-prior-to-symptoms/

ideally some curcumin + piperine too (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335222/ ) though really i dont know of its effect size also i have green tea extract (EGCG+catechins). again they're helpful but not rapamycin-level effectiveness

(vegan here so extra vegan supplements needed) - rapamycin (5 or 10mg/week) - metformin - lithium - taurine/carnosine - creatine - CDP choline - delta/gamma tocotrienols - 6g betaine per day (ideally) to reduce homocysteine - B12 - plasmalogens (also impt for vegans) - rosemary (i just eat it straight). has carnosol, rosemarinic acid - NAC - acarbose with meals (though I often miss taking it if the meals aren't carb heavy) - luteine - glucosamine - methylphenidate (for ADHD more than aging, but appetite suppressant). IDEALLY one should supplement with selegiline, NAC, lipophilic antioxidants like tocotrienols to reduce the oxidative stress burden, also crocin) - glycine also reduces methionine metabolism [this is A LOT and I can't consistently take them ALL especially when traveling. when traveling I view the most critical supplements as rapamycin/metformin, though I should also view betaine as more critical perhaps] ==== spices: - ideally, i would also dose my foods more liberally with saffron - ideally you want some triterpenoids cloves have highest ORAC value but the chemicals are so powerful that they can be antibiotic in other contexts i've been thinking of more ginkgo [the trees live longer for a reason!] === nootropics: I have some racetams, NSI-189, etc and intend to continue trying them but they don't consistently work and don't have the effect size of stims

https://www.elysiumhealth.com/en-us/matter/oxford-study =>im sure thishas too much folate

This is interesting even though B vitamin supplementation is thought to decrease brain shrinkage (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ ). Obvs. these are both compatible (Alzheimer's and cancer are ANTI-correlated with each other). But it seems better to just supplement with betaine or trimethylglycine rather than folic acid. THOUGH maybe betaine is involved in 'blunt instrument' DNA methylation too This means I suppose I should just toss my B supplements (though I keep my B12)

https://www.medrxiv.org/content/10.1101/2020.07.07.20148098v1.full.pdf 800 mcg folic acid is only 200% of the RDA too...

https://sph.unc.edu/sph-news/only-12-percent-of-american-adults-are-metabolically-healthy-study-finds/#:~:text=Only 12 percent of American adults are metabolically healthy, study finds,-Biostatistics News, Epidemiology&text=The prevalence of optimal metabolic,weight, a new study finds.