InquilineKea

I swear Vadim Gladyshev did a presentation on measuring differing aging rates between tissues (in terms of metabolomic diversity) and I think he showed that more rapidly dividing cells age faster/accumulate more "strange" metabolites, but the ones that divide more slowly should presumably accumulate more protein aggregates/lipofuscin that can't be diluted too?

Wow, this goes on with intuition (I wouldn't touch PUFAs myself), but I thought PUFAs (in the population) are associated with lowered mortality? [simply b/c so much of the population still dies from heart disease]. How many studies show that more PUFAs increase [or at least don't decrease] mortality?

https://www.longefy.com/ I don't agree with all of his recommendations, but he's definitely sensitive to a lot of the newer recommendations/research that isn't commonly found elsewhere (*yet)

Wao, low cholesterol increases risk of hemorrhagic stroke - https://www.sciencedaily.com/releases/2019/04/190410163018.htm. asians are particularly susceptible https://www.nytimes.com/2019/04/10/well/live/very-low-cholesterol-may-increase-stroke-risk.html https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjxkfiC1p_uAhUEVd8KHb1eAzUQFjAAegQIARAC&url=https%3A%2F%2Fwww.economist.com%2Fgraphic-detail%2F2021%2F01%2F16%2Fjapanese-people-may-have-gained-longevity-by-balancing-their-diets&usg=AOvVaw3Bco0NfVB58tsDisIQIxLP though like https://n.neurology.org/content/94/11/e1112

EVEN APPLES https://inews.co.uk/inews-lifestyle/food-and-drink/carrots-apples-lettuces-microplastic-contamination-explained-455905

Centenarians (and their offspring) tend to be more likely to have HDLs of 100 and LDLs in their 50s...

Alex K. Chen So should I eat more saturated fat if I have low ldl 1 · Reply · 1w Mike Lustgarten Alex K. Chen That's not as easy to answer without more info. Are your arteries free and clear, CAC score = 0? What are the leading causes of death for LDL < 100, and how can you track those diseases to make sure that any change that you make is going in the right direction? Your blood test data is mostly reflective of youth, but there is room for improvement. I'm not sure that sat fat or LDL would be the place to start. 1 · Reply · 1w Olafur Pall Olafsson Alex K. Chen I agree with Mike in that it's hard to say. I do not agree with him on the optimal LDL being that high, I think it's far below 100 mg/dl. However if your level is very low then I think it's more important to watch your HDL level. If your HDL level is also kind of low then maybe a bit of extra saturated fat would be more beneficial than harmful because it would likely elevate your HDL too not just your LDL and that is in many ways more important unless you have high LDL levels. The HDL/LDL ratio is very important because the HDL participates in reverse cholesterol transport and can basically partially reverse calcification of the vascular system if it's high. Also it is important to focus on oxidation and inflammation since it's predominantly oxidized LDL that gets stuck on the insides of the vasculature and inflammation drives that process through increasing foam cell formation. 1 · Reply · 1w Alex K. Chen Yeah, high saturated fat in a low oxidation/ inflammation environment might be ideal ESPECIALLY bc if incorporated into cell membranes it also guards against oxidation 1 · Reply · 1w Alex K. Chen You want your cell membranes to have high saturation 1 · Reply · 1w Mike Lustgarten Olafur Pall Olafsson Ha, I only agree that LDL < 100 is optimal if you have CVD, and then lower LDL is better. There's no data for all-cause mortality risk that shows < 100 for LDL is optimal, at any age group. 1 · Reply · 1w Mike Lustgarten Alex , whatever changes that you make, log them, and see what impacts your biomarkers. You're young and most of your biomarkers reflect that, so it's minor tweaks to get it all perfect and keep it there for decades. Knowing what impacts what in terms of the diet-biomarker link takes a bit of time. 2 · Reply · 1w Olafur Pall Olafsson FYI my LDL level is super low so my HDL/LDL ratio is even slightly higher than 1. I haven't been convinced in trying to raise my LDL level but I would like my HDL a little higher still so I am quite relaxed on intake of saturated fat because it should raise both my HDL and my LDL and with such low levels as mine the resulting higher HDL might be more optimal. 1 · Reply · 1w Mike Lustgarten It's easy for me to have LDL that low, too, and when considering the ACM data, that scares me. I don't want to avoid CVD but then die from cancer or a bad infection, both of which are more likely with LDL < 100, when compared with somewhat higher values. 1 · Reply · 1w Olafur Pall Olafsson Mike Lustgarten Maybe the relationship with cancer and infections is related, since both could be caused by suboptimal immune responses. In any case I'm curious to find out what explains this relationship with low LDL. Hopefully we won't have to wait too long for more answers. 1 · Reply · 1w Alex K. Chen Has Peter attia written about it · Reply · 1w Olafur Pall Olafsson Regarding infections, I just checked my notes and see that there is some evidence of cholesterol possibly playing a protective role against inflammation during infections. Mike Lustgarten you're going to like this. It may help dampen the responses to endotoxins. http://pmid.us/8450032 However HDL cholesterol seems to work for this purpose so it may be better to focus on raising HDL than LDL if the latter is very low. http://pmid.us/1930690 I mean if there is some significant effect of low cholesterol on immunity then it is likely the total cholesterol rather than LDL in particular that is responsible for it. If true then an unusually high HDL might protect against an unusually low LDL in this respect. PUBMED.NCBI.NLM.NIH.GOV Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death - PubMed Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death - PubMed 1 · Reply · 1w Mike Lustgarten Ha, Olafur I wrote about the LDL, HDL and LPS connection in my book, so I'm well aware! My average HDL over the past 5 years is in the mid-40s, and I'm working on getting it into the 50's again for my next blood test next week. 1 · Reply · 1w Alex K. Chen Does blood cholesterol correlate with membrane cholesterol index · Reply · 1w Olafur Pall Olafsson Alex K. Chen "Does blood cholesterol correlate with membrane cholesterol index" I am not sure. Blood cholesterol levels influence the membrane composition of platelets and erythrocytes but those two cell types lack a nucleus so they are not reflective of most other cells in the body. http://pmid.us/8740244 I think the membrane cholesterol is mostly under genetic control in other cells. I don't remember seeing studies on the influence of blood cholesterol on membrane cholesterol index but I can't say I have looked into that in the past specifically. PUBMED.NCBI.NLM.NIH.GOV Influence of cholesterol-lowering on plasma membrane lipids and function - PubMed Influence of cholesterol-lowering on plasma membrane lipids and function - PubMed · Reply · 1w Write a reply…

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It also helps improve glycanage markers too

ubiome is dead and mike lustgarten is negative on viome (not to mention that viome doesnt even report species abundance)

eggs and diabetes => https://www.pcrm.org/news/health-nutrition/egg-consumption-increases-risk-diabetes Idk if it's controlled in teh right ways

Uh doens't selenium decrease longevity? I mean, 300ug is associated with increased mortality. 100/200ug/day with slightly decreased mortality. But it's just ridiculously easy to get selenium from other sources.

Some exposures are just plain much more risky than others - if you have a bunch of liquid touching a flexible plastic, it ISN'T a good thing. Also if it's encased in plastic, it's also NOT a good thing. Vegetables touching plastic polyethylene bags I'm less concerned about. That plastic kind of looks like the plastic that's used in potato chips, and those have been associated with MASSIVE microplastic contamination

Aren't you concerned about microplastics in those natto packets?

Does anyone know if it's possible to even tell if one has had an asymptotic flu infection? I don't even remember the last time I was sick - I think late 2017 was the last time I actually did have a runny nose and all the associated symptoms of a cold.. And before that, it might have been, uh, 2011? I definitely spammed Quora questions about it in 2011, but I think like the fact that I haven't had to even use a neti pot/nasal rinse in a LONG TIME is indicative of SMG Also, isn't it possible for there to be too much zinc/for zinc to bioaccumulate? I do sense that out of ALL of the heavier minerals/elements, it's the healthiest, probably the only one that you're better off having more of.