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  1. I went back and listened to that. First, he's talking about mice, though one would think its conserved between humans and mice. Second, I think he may be referring to their gluconeogenic behavior Though again, I'm not entirely sure.
  2. It bugs me that Longo equates intermittent fasting with skipping breakfast and implicitly eating dinner. He points out that eating food later in the day (dinner) disrupts sleep and increases risk for cardiovascular disease, cancer, and is a negative risk factor for mortality. Therefore, intermittent fasting = eating dinner = increased risk factors for disease. I recognize the human behavior that leads to this pattern (eat after work, late at night), but I don't understand how he makes that leap on the physiology that intermittent fasting must mean eating late at night and the associated risk factors therein. If NAD+ follows a circadian pattern and peaks mid-day, why isn't he suggesting then that people who follow an intermittent fasting pattern skip breakfast, but eat mid-day? A person would be done with digesting well before any sleep.
  3. arwin77

    Report from CR Conference

    Great news. I was at another conference and couldn't make it. At certain points during boring/meaningless presentations, I wished I could watch a CR conference webcast. I look forward to picking up the DVDs.
  4. Google the concept: "Surfing the Urge". It is a willpower technique used in various settings such as quitting smoking. Once you reset your circadian rhythm to 2 meals a day, it becomes no problem because your body has been conditioned. It's the issue of having the willpower to get from Point A to B.
  5. arwin77

    re: Indispensable Amino Acid (IAA) requirements

    Thanks. There was no problem w/ the passage, other than I wanted to compare this reference vs. other references w/ different EAA/IAA recommendations. On my side, the referenced thread shows a reference [ix] (as noted in the .jpg attached to the first posting here). The [ix] points to [ix] Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr. 2003 Jul;78(1):131-6.
  6. Read this superb write-up by Michael. Wanted to know where this DRI for the Amino Acids came from? Am I missing something, because I (think) I pulled the cited source and it seems to be about B12 status. Interested in the source of this data: Thanks in advance for any help.
  7. arwin77

    Dean's Current Diet

    Dean: Thanks for your updated routine. The data dump is always interesting. What I wondered while reading this write-up is do you ever have issues eating this much quantity in a single meal? Vegetables, for example, are typically nutrient dense, high fiber and filling. Physiologically, I don't think I could even eat this much in a single meal, or I would be forced to eat it slowly over ~3 hours. Thanks
  8. arwin77

    Biomarker - Cortisol

    Yes. Thanks for such a comprehensive response. I appreciate it.
  9. arwin77

    Biomarker - Cortisol

    I'm wondering if anyone has thoughts about the appropriate upper limit for diurnal (morning) serum cortisol in CR. I know it's supposed to be high, but I'm having trouble finding appropriate benchmarks. My concern is -- how high? And are there corresponding biomarkers that one might correlate with cortisol being too high such as glucose? I seem to only find salivary. Also, if anyone has any conversion (salivary --> serum) that might be helpful. Thanks very much!
  10. arwin77

    topic forum request

    pls add a forum section dedicated to CR recipes. thx.