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About Matt

  • Birthday 10/21/1984

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  1. @aducknamedjoe Thanks JP! I'll read your article when I get a chance later today. 🙂
  2. I wouldn't call the CALERIE studies that informative for the effects of serious life-extending CR. They were more like weight loss studies and not nearly as restricted as people who took part in the Fontana studies. However, there are other positives of the CALERIE study in that they were randomized and not a self selected group. Rather than the starvation experiment, you might want to look up Biosphere 2 instead. 🙂 There is a free PDF available https://academic.oup.com/biomedgerontology/article/57/6/B211/564317 You can check out my article on CR here: http://www.crvitality.com/benefits-of-calorie-restriction/ There's a bunch of references you can look up at the bottom. Hope that helps! I'll check through the links you posted later...
  3. I've had really low cholesterol from doing CR and I never felt any negative effects from it. The numbers were: Total 2.8 (108mg/dl) HDL: 1 (39mg/dl) LDL 1.5 (58mg/dl)
  4. If you have very little inflammation and very low blood pressure, the risk of hemorrhagic stroke shouldn't be a concern with having very low cholesterol.
  5. One of the main points of the lockdown is to reduce the number of people in critical care... If there is no lockdown and no changes in the way people live and work, who is going to treat people when all the nurses and doctors are working in ICU to deal with coronavirus patients? Do you want them to work 24/7 a day with almost no end in sight for months or years? The NHS here was already running at close to capacity before a recent lockdown and the lockdown has once again worked to reduce the number of people catching the virus. The alternative (no lockdowns) would result in massive deaths from both COVID and non-COVID patients. As for masks, what about Asian countries like South Korea and Japan? A walk in South Korea where 99.99% are using masks - even outdoors. https://youtu.be/oL3SMeK2YaQ?t=317
  6. Matt

    34 years is late to start CR?

    No, you will have started younger than most people I know who have been on CR for years. I'm personally on the more optimistic side about how well CR will work, but not everyone is around here these days. David Fisher started around 35 and is doing well: http://www.crvitality.com/2019/04/david-fisher-interview-calorie-restriction-2019/
  7. Just a quick update on the coronavirus situation here. My mum has recovered now. She didn't end up going to the hospital even though it was up and down. In fact, her lungs are better than they were before getting the infection. She has had trouble walking up the stairs and getting out of breath since 2016, but that's mostly gone away now. She's taking her usual medications, but still got her taking zinc and allicin. She's been taking Azithromycin since 2016 to deal with repeated lung infections. I wonder if that antibiotic wasn't working and the shortness of breath that she's had for years was caused by an underlying lung infection that didn't go away.
  8. This is only a virtual screening of allicin, but thought I'd share: In silico allicin induced S-thioallylation of SARS-CoV-2 main protease "The overall reaction is exergonic and allyl disulfide of Cys-145 residue of Mpro is involved in a sulfur mediated hydrogen bond. The results indicate that allicin causes dual S-thioallylation of SARS-CoV-2 Mpro which may be of interest for treatment and attenuation of ongoing coronavirus infection." https://www.tandfonline.com/doi/full/10.1080/17415993.2020.1817457
  9. It's been 11 days since my mum got sick and she seems to be doing better every day now. She really turned the corner and started to improve when she started taking the zinc and allicin. Of course, I have no real way of knowing if that had anything to do with it... but her oxygen saturation was 89 and she could barely talk because she couldn't catch her breath. Even walking a few feet would make her gasp for air. I think she took about 90 allicin capsules over a period of 4 days. She took 100 mg zinc picolinate as well. Now her oxygen saturation is around 94 and her heat rate 60-70. The most interesting thing happened with her temperature... As she has lupus, her temperature normally runs quite high at about 37.0 - 37.2 Degrees C. Since she's been taking these supplements, her temperature is now more consistently at about 36.5 degrees C. We noticed the effect quite early on: every time she took them, within 30-60 minutes her temperature (fever) would drop significantly. She told me that she has *never* seen her body temperature so low in many years... Any thoughts on this? I didn't give her beta glucan as I wasn't confident enough in its effects due to her case being more complex. However, I gave my dad supplements as soon as he started to feel ill. He took Yeast beta glucan (I posted research way back on how beta glucan prevents cytokine storm and tissue damage to lungs from H1N1 and other viruses). He took a LOT of allicin throughout the day. And he took 100 mg of Zinc Picolinate per day. He was mostly over COVID-19 within a day and a half... with some tiredness and the odd fever for 1 hour or so here and there. I took the same supplements as my dad and I got over COVID-19 within about 1 day and a half. Left with a very, very mild cough. So anyway, my mum being affected with lupus, heart disease, COPD and other issues, seems to be doing a lot better and looks like she'll be fine. But it was very close and she almost ended up in hospital.
  10. Yeah, it's still much lower than it was. However, I did check her oxygen saturation level and it was 89. I checked mine and it was 99. My father's level was 98.
  11. I take 50 mg of zinc picolinate every other day as my diet often tends to be low in zinc and I went through zinc deficiency around 4 years ago (already posted about it here). But I increased to 100 mg per day for the past few days. I normally just empty the capsule of zinc onto toast (along with allicin) or even a spoon with ketchup lol, if I feel like an infection is coming on. The day I got sick, I had barely slept as I woke up really early in the morning to care for my rabbit. He has a serious infection called E.cuniculi and supportive care is almost all day long.Being stressed and not sleeping because of that probably hasn't helped. But this is the first time I've been sick in about 4 years. I've just started giving my mum zinc picolinate and allicin yesterday. Her temperature seems a bit lower now but still chest and breathing isn't great. She's coming up to 7 days, so I've bought an oxygen monitor and that'll come tomorrow. I think it's 7-14 days is when people end up in hospital. Hoping that doesn't happen... 😞 I'm taking the rest of the week off work just to make sure I get good sleep and recover properly (I work from home). Edit: She just checked her temperature again and it's now 36.9 degrees C. She said it hasn't been this low in a long time.
  12. Thanks... It's mainly my mum I'm concerned about as she has multiple health issues. Last night, not long after I posted here, I got a mild fever, shivering, muscle aches in my back near my chest, and my glands were swollen at back of my throat. Temperature went to 37.6 degrees C (quite high for me). I felt like I had a mild case of the flu. Normally, my temperature about that time of night should be around 35.1. Felt quite rough for a few hours. My smell and appetite is fine. I took a bunch of my supplements at a higher dose: 100 mg zinc picolinate, 8 beta glucan, chewed allicin capsules, and had lots of matcha green tea. Woke up this morning and fever has gone (temp at 35.5) and I feel quite a bit better already aside from a bit of tiredness from lack of sleep. One worrying symptom was feeling a bit raw in my chest but it quickly subsided and wasn't that bad. My dad got over it within a day and he took all the supplements I gave him soon as he started getting ill. His temperature was around 38.2 and dropped within a few hours to normal. Unfortunately, my mum is still not well. Her temperature this morning was 38.9 degrees C and she's been ill since Friday. I got her to take some zinc and allicin this morning and her temperature dropped to 37.6 but could be a coincidence. She's already taking vitamin D3. She's overweight, has lupus, heart issues and other health problems. 😕 I wonder if getting over it so quickly and being mild, means I'll have less antibodies and be susceptible in the near future?
  13. My mum tested positive for COVID-19 after getting sick on Friday. My dad's test was inconclusive so he had to have it done again... but had a fever for a day on the weekend. My sister just got her result back and she is positive for it. And I live with my parents... so I'm guessing I've certainly been exposed and probably have it. No symptoms though...
  14. Eyes closed and on your weakest leg? I've not found anything to say that you can significantly improve this with practice. Some people keep saying that but I've not seen anyone provide any evidence for this. I'd be happy to be proved wrong though! There might be some level of adaptation in the brain by further compensating for degradation of sensory input, but I'd be surprised if it was that significant. But I think some people are just misunderstanding what it's testing. From what I understand, this is NOT primarily about muscle strength in the leg or something like that, although it is part of it. You can't just make your legs stronger and hugely better. As people age, they lose vestibular function and equilibrium. Unless you can regenerate new hair cells, it's going to be difficult to improve on this kind of test because when you close your eyes, you're relying on proprioception, the integrity of the vestibular system, central nervous system to correctly maintain balance without the use of the visual system. The only real thing you can do here to perform well on this test is to either a) regenerate these cells or b) slow the rate of damage and cell loss (as what happens with long term calorie restriction in animals). -- "Clinically, progressive dysequilibrium of aging presents as gradually worsening balance due to age-related decline in function of the peripheral vestibular system, central nervous system, vision, and musculoskeletal system. Vestibular function testing has shown clear evidence of age-related changes in peripheral and central sites. Histopathologic changes in the vestibar sensory organs include progressive hair cell degeneration, otoconial degeneration in the otolith organs, and decreasing number of Scarpa's ganglion neurons." "Results show a highly significant continuous decrease in all counts from birth to age 100, best fit by a linear regression model. Type I hair cell counts in all three semicircular canal cristae decrease at a similar rate, significantly faster than the degeneration observed in type I hair cells of the maculae. Type II hair cell counts decline at the same rate for all 5 sensory epithelia. These normative data provide the basis for comparisons to hair cell counts made in temporal bones from subjects with known vestibular disorders" [2]. 1. Age-Related Vestibular Loss: Current Understanding and Future Research Directions https://pubmed.ncbi.nlm.nih.gov/25567421/ 2. Decreasing hair cell counts in aging humans https://pubmed.ncbi.nlm.nih.gov/11710464/
  15. That is really good. And that was with your eyes closed and not hopping around? 😄 I've repeated the test a quite a number of times now and I can normally get between 90-120 seconds. But that dropped to near 60 seconds the more I tried (without a rest), as my foot and muscles were burning lol. I've gotten quite a lot of people to do this test now and most of them fall close to where you'd expect on the graph in the original post. The ones that have been on CR for extended periods of time and who really do seem young for their age (I expected they'd do well), were able to do significantly better. This is one of the tests Roy Walford proposed checking from time to time in the book 120 Year Diet. Functional tests that decline for everyone with age and can't be as easily changed compared to something like cholesterol. But with CR, you'd expect to see a delayed deterioration. Also, I should mention , the study I referenced in the 2nd link (Normative Values for the Unipedal Stance Test with Eyes Open and Closed), used a different study design where they crossed their hands over their chest. This is much harder. I performed this test as well I'm well above what is expected for my age. Eyes closed, arms crossed, standing on weak foot: 42 s, 66 s, 44 s. Only a few seconds rest between tries though. Back to the original test (no arms crossed), this the results in children / teenagers. https://www.researchgate.net/figure/Single-leg-balance-on-stable-surface-eyes-closed_fig3_236908767