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Matt

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  • Birthday 10/21/1984

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  1. Anti-inflammatory potential of Quercetin in COVID-19 treatment SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Phylogenetic findings show more similarity of the SARS-CoV-2 virus with bat coronaviruses, and less with SARS-CoV. Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19. https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-021-00268-6 Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial Results The interim results reveal that after 1 week of treatment, 16 patients of the QP group were tested negative for SARS-CoV-2 and 12 patients had all their symptoms diminished; in the SC group, 2 patients were tested SARS-CoV-2 negative and 4 patients had their symptoms partially improved. By 2 weeks, the remaining 5 patients of the QP group tested negative for SARS-CoV-2, whereas in the SC group out of 19 remaining patients, 17 tested negatives by week 2, one tested negative by week 3 and one patient, still positive, expired by day 20. Concerning blood parameters, the add on therapy with QP, reduced LDH (−35.5%), Ferritin (−40%), CRP (−54.8%) and D-dimer (−11.9%). Conclusion QP statistically shortens the timing of molecular test conversion from positive to negative, reducing at the same time symptoms severity and negative predictors of COVID-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238537/
  2. Influenza virus also infects CD4+ and CD8+ T lymphocytes. It's not unique to COVID or HIV. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6115886 "Both CD4+ and CD8+ T lymphocytes were susceptible to influenza virus infection, and the infected CD4+ and CD8+ lymphocytes served as infectious foci for other nonpermissive or even virus-permissive cells. These data show that monocytes-macrophages and both CD4+ and CD8+ lymphocytes can become infected during the course of an immune response to influenza virus challenge"
  3. Matt

    Curious about BMI on CR

    What was your weight prior to starting your plant based diet? Your calorie intake now? Do you have signs of doing CR like low body temperature, lowering fT3 and fT4? Lower BMI range on a healthy diet is associated with the lowest all cause mortality
  4. Matt

    War in Ukraine

    A friend sent me this 4 hour interview the other day and it's worth watching to understand Putin. All 4 parts are available on YT and easy to find. Also some interesting video from Vlad Vexer
  5. Isn't what he's talking about been shown in multiple studies already with regards to vaccines that do not prevent transmission? Did anyone bother to watch the talk I shared a few months ago (it's from 2016 and by a person who is in favor of COVID vaccines). Vaccines alter the immune landscape experienced by pathogens, and hence their evolution, by targeting subsets of strains in a population, reducing the number of fully susceptible individuals, and creating or expanding classes of semi-immune hosts. The great success of vaccination against the acute childhood occurred without being undermined by pathogen evolution, but those diseases were easy targets: natural immunity was evolution-proof; all vaccination needed to do was to induce something very similar. Pathogens now under assault by vaccination are different: their natural infections induce leaky, often strain-specific immunity that usually wanes. Vaccines against these diseases will induce immunity to which natural selection has already found solutions. Evolutionary analysis is particularly warranted where vaccines are leaky, target subsets of strains or virulence determinants, involve novel technologies, or relax selection against virulence. Vaccination has been a great benefit. Continuing past successes requires evolutionary considerations at all stages of vaccine design and implementation. Andrew Read, Alumni Professor in the Biological Sciences & Director, Center for Infectious Disease Dynamics at Pennsylvania State University, visits the ASU Center of Evolution, Medicine and Public Health, to lecture on the subject of Pathogen evolution in a vaccinated World.
  6. How are you doing now since your infection with Omicron? My experience with Omicron It was a really weird viral infection for me. It was almost entirely muscle pain, and it was quite annoyingly persistent and painful at times. It felt as if I had stretched and injured my muscles. Like a muscle sprain or something. Mainly around the shoulders, arms, thighs, and hips area. I think it affects tendons and muscles. I found Quercetin and Bromelain to be very helpful. I did not experience any of the usual common symptoms though: Never had a fever, cough, runny nose, or sore throat. My appetite was completely normal and I noticed I started getting a lot hungrier during the infection. There was also something going on with my upper back but couldn't tell if it was bronchus related or muscle -- although it was quite mild and short-lasting. I was unable to get a positive test from nose or throat with the rapid antigen tests. Omicron and my family: -My brother was the first to display symptoms at home (triple vaccinated). Usual symptoms like runny nose, upper chest cold-like symptoms, night sweats, fever (1 night), sore throat, etc. Took about 4-5 days to get a negative antigen result. My mother had cold-like symptoms with upper chest, mucous, loss of smell and taste, cough (triple vaccinated and previously infected in 2020) My uncle had similar symptoms as my mum (triple vaccinated and previously infected in 2020). He was the first to tell us he tested positive, so he might've been the person who lead to the rest of us getting it days later. My grandmother (80 years old, bad COPD and other health issues) has had mild cold-like symptoms: sneezing, coughing, and general upper away symptoms. No fever. (triple vaccinated but no confirmation of previous infection despite my uncle living with her when had it before). My niece who is about 5-6 had no symptoms but tested positive. My other uncle and aunt came here to the house a day prior to my brother getting sick and they ended up testing positive 3 and 5 days later. Both triple vaccinated and were negative on antigen test within 5 days. Both mild illness from what I heard. My dad had some very mild symptoms but like me did not test positive (previously infected 2020 and triple vaccinated).
  7. Pre-infection deficiency of vitamin D is associated with increased disease severity and mortality among hospitalized COVID-19 patients Patients with vitamin D deficiency (less than 20 ng/mL) were 14 times more likely to have severe or critical case of COVID than those with more than 40 ng/mL. Strikingly, mortality among patients with sufficient vitamin D levels was 2.3%, in contrast to 25.6% in the vitamin D deficient group. https://www.eurekalert.org/news-releases/942287
  8. An update... My brother is recovering well and doesn't feel ill today. 🙂 My recovery... My muscle and joint pains lasted just over 1 day. I had some mild discomfort at the top of my back (did make me a bit anxious!), but it only lasted a few hours and then went away. Oxygen saturation is 97-99 and heart rate has been between 60-75. Throughout this, I've not felt ill at all. Haven't developed any fever, no cough, no sore throat, no runny nose. If my brother hadn't become ill, I would never have known it was COVID. Will get an antibody test in March to see how high the antibodies are. Last time in August it was 80.4 u/mL. It seems my preexisting immunity from my COVID infection in November 2020 probably helped.
  9. Found a paper this afternoon about Omicron variant and symptoms: Omicron outbreak at a private gathering in the Faroe Islands, infecting 21 of 33 triple-vaccinated healthcare workers "The most common symptoms were muscle and joint pain, fatigue, and fever, while the least common symptoms were loss of taste and smell." https://www.medrxiv.org/content/10.1101/2021.12.22.21268021v2.full?fbclid=IwAR3a1QtIEljhVNgmVxwAE_STBtUfCezjmGaI52qIUXCoP_qGJoJCDE-OPag
  10. I know he had 2 Pfizer shots but I'm not sure about his booster which he got around November. He seems to be doing okay... He told me he has a fever, night sweats, back pain, stomach issues and a sore throat. I had some weird muscle pains yesterday... they stopped me from sleeping. Not sure if it's a coincidence or what, but they felt strange... Almost as if I had worked out too much and pulled my tendons/muscles and some joint pain (feels similar to reactive arthritis I had 17 years ago after food poison). I have no other symptoms and don't feel ill. My temperature is still around 35.5. Still testing negative on lateral flow tests as well.
  11. My brother (triple vaccinated) started having night sweats last night... I suspected COVID and asked him to do a test... and yup, it's positive on the lateral flow test. We live in the same house as well, so I've probably already been exposed. I did a lateral flow test, but it was still negative after 25 minutes waiting. Hopefully I can avoid it.
  12. Antibody response 18 months after SARS-CoV-2 infection in vaccinated and unvaccinated individuals Unvaccinated recovered individuals were found to test positive for anti-S-RBD antibodies 18 months post-infection. No cases of reinfection were reported in these individuals despite the emergence of multiple mutant strains that brought about several waves of infection. Most recovered individuals also tested positive for anti-NCP antibodies at 18 months post-infection. Therefore, the current study demonstrates that immunity conferred by SARS-CoV-2 infection lasted longer as compared to vaccination. Although the antibodies are boosted significantly post-vaccination, this response is short-lived. https://www.news-medical.net/news/20220124/Antibody-response-18-months-after-SARS-CoV-2-infection-in-vaccinated-and-unvaccinated-individuals.aspx
  13. Coronavirus Cross Immunity 18 Years After Infection with SARS-COV-1 This small but important study shows that SARS-COV-1 infection created memory cells that are activated after 18 years.
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