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About Matt

  • Birthday 10/21/1984

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  1. Matt

    Reputable Online Pharmacy?

    I used to use QHI, they were really good and reliable, until an article got published in the dailymail and then they shut down (they were going since 1995?). I tried inhousepharmacy.vu, but I was a bit worried that I received finasteride in their packets without the box or leaflet and not sure if I want to chance to order other things either. Apparently, lots of people say they are fine, but I ended up getting the finasteride prescribed online from a chemist in the UK. Unfortunately, ends up being way more expensive, too.
  2. After so many promises and failures over the years, it would be nice to get a small win. I think this would help with people's confidence that we can intervene in aging and even reverse it to some extent. Investors would be more likely to start taking notice as well. I wonder if there are any plans to use multiple therapies at once? NAD boosters, Senolytics, and whatever else. I hope Aubrey is right
  3. There are better plant sources of calcium than spinach. See table 2 here: https://academic.oup.com/ajcn/article/70/3/543s/4714998
  4. An interview about some of the work Calico is involved in. By the sounds of it, the mouse study might be the most in-depth CR study with the number of things they are measuring. It'll be interesting how they can use all the data to possibly better predict whether or not CR will work based on various factors.
  5. I'm wondering you guys watched the entire video? From what I remember, most of what they talked about was clinical data in humans. Which parts of the video do you disagree with?
  6. Hi all! In case you missed it, I did an interview with David Fisher, who you probably all know! He hasn't been in the media for quite a long time and I had literally hundreds of messages from people asking about him. http://www.crvitality.com/2019/04/david-fisher-interview-calorie-restriction-2019/ I'll be looking to do some more CR-related interviews with CRONies soon. 🙂
  7. I've tried to make improvements to my sleep since listening to his interviews. I stop drinking caffeine earlier in the day and try to not shift my sleep too much in either direction. Naturally, I am a night person and fall to sleep around 4 am, so it's hard to always get perfect sleep because of the noise around the house. But most of the time I sleep well... if I'm allowed to sleep on my own schedule. One interesting thing I learned from the discussion was that you lose deep sleep if you stay awake beyond your natural bedtime. I thought you would still go through all the cycles, regardless. And it works the other way too. That was eye-opening to me and I keep it in mind now. But I still find it difficult to be strict about going to bed when I'm tired. I often find myself staying up a few hours later than my normal bedtime from watching a movie, podcast, gaming, or working. But yeah, he has some super interesting interviews. Easy to listen to as well. 🙂 I think this is one of the best discussions from the ones I've seen of him being interviewed.
  8. [Rapamycin is one of the most promising "anti-aging" drugs today. In one study, it extended the lifespan of mice by 33%. By intermittent fasting or following the keto diet, can we regulate our mTor & achieve similar results without the side effects of a drug? We reference mTor frequently on our podcast, particularly when we discuss fasting or keto and their potential for extending health & lifespan. mTor is a pathway that helps controls cell growth. In the most simplest terms: When you have high mTor activation, you promote growth in the body. When you have low mTor activation, you promote repair and maintenance.... ]
  9. At what age would one want to think about using senolytics?
  10. You should give Allicin Max (or allimax) a try when you feel you're getting a stomach bug. I don't remember exactly when I last got sick with a stomach bug, I think it was around 2009-2010. I have felt them coming on after family coming down with it, but as soon as I feel it, I would just take about 10 garlic capsules 2-3 times a day for a couple of days. Even within a few hours after taking it, I would be fine. It's never failed to help. It's been about 27 months since I've been sick with flu or a cold... the longest I've gone in many years. As I said before, I really think taking zinc picolinate has made a massive difference to my immune system.
  11. "In this episode, we discuss how sleep plays a critical role in learning and memory, in the regulation of emotions including loneliness, in the function of the immune system, preventing the formation of amyloid beta plaques in the brain and Alzheimer's disease, glucose regulation and insulin sensitivity. We also discuss how certain dietary macronutrients affect sleep, the effect of sleeping pills and alcohol on sleep, the accuracy of sleep trackers, and so much more." I haven't watched the entire interview yet but there's a lot of new information here that he hadn't talked about in previous interviews.
  12. " Abstract Lifespan extension under low temperature is well conserved across both endothermic and exothermic taxa, but the mechanism underlying this change in aging is poorly understood. Low temperature is thought to decrease metabolic rate, thus slowing the accumulation of cellular damage from reactive oxygen species, although recent evidence suggests involvement of specific cold-sensing biochemical pathways. We tested the effect of low temperature on aging in 11 strains of Brachionus rotifers, with the hypothesis that if the mechanism of lifespan extension is purely thermodynamic, all strains should have a similar increase in lifespan. We found differences in change in median lifespan ranging from a 6% decrease to a 100% increase, as well as differences in maximum and relative lifespan extension and in mortality rate. Low temperature delays reproductive senescence in most strains, suggesting an extension of healthspan, even in strains with little to no change in lifespan. The combination of low temperature and caloric restriction in one strain resulted in an additive lifespan increase, indicating these interventions may work via non- or partially-overlapping pathways. The known low temperature sensor TRPA1 is present in the rotifer genome, but chemical TRPA1 agonists did not affect lifespan, suggesting that this gene may be involved in low temperature sensation but not in chemoreception in rotifers. The congeneric variability in response to low temperature suggests that the mechanism of low temperature lifespan extension is an active genetic process rather than a passive thermodynamic one and is dependent upon genotype." https://www.sciencedaily.com/releases/2018/12/181210171847.htm https://www.sciencedirect.com/science/article/pii/S0531556518305011?via%3Dihub
  13. Matt

    98.6 F (37.0 C) is old school

    What happened to your website, Khuram? I remember reading it a long time ago, I think you had information about your diet, supplements and other things? But wow, yeah, that is very strict! @Saul What happened to Warren? It seems like a lot of people from the email lists never joined the forum...
  14. Matt

    98.6 F (37.0 C) is old school

    How many calories are you guys eating a day? My calorie intake currently is usually between 1500-1600 Calories per day. Current BMI is around 19. The thing is, for quite a while I was sort of just winging but eating the same thing every day. So I'd buy my shopping, usually the same foods, and they'd last a set number of days. But never measured everything precisely aside from the initial measurements I took. Not too long ago I thought about how I struggled to maintain a BMI above 17 on such a low-calorie intake, so maybe I was eating more than I thought. So I got out the scales, made the same food as I always do, but after measuring for 2 weeks it was pretty consistent, with the odd day actually being lower. It seems that my body has become more resistant to losing weight or I broke my metabolism 😄 I'm not that active at the moment though, mostly working on my websites while sitting down, so maybe that is a factor. Body fat percentage is between 13-14% according to the new scales we have, but not sure how accurate they're supposed to be. I did change my weight maybe a couple times, to a small degree (roughly 10-15 lbs) over the period of the last 14 years, so I'm not sure if that had anything to do with it. Or maybe it's just the fact that I've been doing the diet a really long time (but then so have many people here). Apparently, in rodents, a maintaining a higher body temperature and less fat loss were predictive of increased lifespan compared with a greater degree drop in temperature and fat. I seem to be holding onto fat pretty well, but my temperature is really low. That being said, I'm not to the point of shivering, I don't think it's ever gone below 34.9 Degrees C on my ear thermometer. An interesting study here measuring body temperature with different caloric intake levels in AN patients. Looks like they used that pill to track internal 24-hour BT. So it'll be a bit higher than other measurements we're discussing here. 1 Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011;10:629–639
  15. Matt

    98.6 F (37.0 C) is old school

    I thought most people and doctors are now using ear thermometers? I've never seen anyone measure forehead temperature. I use an ear thermometer.