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Matt

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  • Birthday 10/21/1984

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  1. " Abstract Lifespan extension under low temperature is well conserved across both endothermic and exothermic taxa, but the mechanism underlying this change in aging is poorly understood. Low temperature is thought to decrease metabolic rate, thus slowing the accumulation of cellular damage from reactive oxygen species, although recent evidence suggests involvement of specific cold-sensing biochemical pathways. We tested the effect of low temperature on aging in 11 strains of Brachionus rotifers, with the hypothesis that if the mechanism of lifespan extension is purely thermodynamic, all strains should have a similar increase in lifespan. We found differences in change in median lifespan ranging from a 6% decrease to a 100% increase, as well as differences in maximum and relative lifespan extension and in mortality rate. Low temperature delays reproductive senescence in most strains, suggesting an extension of healthspan, even in strains with little to no change in lifespan. The combination of low temperature and caloric restriction in one strain resulted in an additive lifespan increase, indicating these interventions may work via non- or partially-overlapping pathways. The known low temperature sensor TRPA1 is present in the rotifer genome, but chemical TRPA1 agonists did not affect lifespan, suggesting that this gene may be involved in low temperature sensation but not in chemoreception in rotifers. The congeneric variability in response to low temperature suggests that the mechanism of low temperature lifespan extension is an active genetic process rather than a passive thermodynamic one and is dependent upon genotype." https://www.sciencedaily.com/releases/2018/12/181210171847.htm https://www.sciencedirect.com/science/article/pii/S0531556518305011?via%3Dihub
  2. Matt

    98.6 F (37.0 C) is old school

    What happened to your website, Khuram? I remember reading it a long time ago, I think you had information about your diet, supplements and other things? But wow, yeah, that is very strict! @Saul What happened to Warren? It seems like a lot of people from the email lists never joined the forum...
  3. Matt

    98.6 F (37.0 C) is old school

    How many calories are you guys eating a day? My calorie intake currently is usually between 1500-1600 Calories per day. Current BMI is around 19. The thing is, for quite a while I was sort of just winging but eating the same thing every day. So I'd buy my shopping, usually the same foods, and they'd last a set number of days. But never measured everything precisely aside from the initial measurements I took. Not too long ago I thought about how I struggled to maintain a BMI above 17 on such a low-calorie intake, so maybe I was eating more than I thought. So I got out the scales, made the same food as I always do, but after measuring for 2 weeks it was pretty consistent, with the odd day actually being lower. It seems that my body has become more resistant to losing weight or I broke my metabolism 😄 I'm not that active at the moment though, mostly working on my websites while sitting down, so maybe that is a factor. Body fat percentage is between 13-14% according to the new scales we have, but not sure how accurate they're supposed to be. I did change my weight maybe a couple times, to a small degree (roughly 10-15 lbs) over the period of the last 14 years, so I'm not sure if that had anything to do with it. Or maybe it's just the fact that I've been doing the diet a really long time (but then so have many people here). Apparently, in rodents, a maintaining a higher body temperature and less fat loss were predictive of increased lifespan compared with a greater degree drop in temperature and fat. I seem to be holding onto fat pretty well, but my temperature is really low. That being said, I'm not to the point of shivering, I don't think it's ever gone below 34.9 Degrees C on my ear thermometer. An interesting study here measuring body temperature with different caloric intake levels in AN patients. Looks like they used that pill to track internal 24-hour BT. So it'll be a bit higher than other measurements we're discussing here. 1 Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011;10:629–639
  4. Matt

    98.6 F (37.0 C) is old school

    I thought most people and doctors are now using ear thermometers? I've never seen anyone measure forehead temperature. I use an ear thermometer.
  5. Matt

    98.6 F (37.0 C) is old school

    I've read quite a few studies on body temperature in humans and it does appear that 37 degrees C is probably not accurate. My body temperature on CR is usually between 35.0 to 35.8 degree C. If my temperature starts going above 36.5 I feel like I have a fever. I'm guessing others around here experience the same thing.
  6. I think the benefits of occasionally getting some bitewing x rays probably outweighs the harm in my opinion. Cavities and hidden infections can cause many problems themselves, which I'd be more concerned about.
  7. Matt

    Thank you for being welcoming

    It's not just those, it happens in other communities as well... if you don't adhere to "their way". I've seen this in raw food/vegan forums as well as low carb forums. The main thing we have in common around here is CR, but even then, we all do different levels of CR and it's not even agreed upon what is actually best. We're just part of an experiment and all points are quite interesting. While I'm really skeptical about a total carnivore diet being the best approach for health and longevity, I'm still interested in seeing the results (and I say that as a vegan! lol). I heard Jordan Peterson and his daughter benefited hugely from it. They claim that their autoimmune problems went away... but I wonder if those effects were are the result of weight loss and reduced calorie intake and not the meat. If you still use Facebook, stop by in the CR facebook group.
  8. Matt

    Back to CE but...

    Well, it's been about 2 years almost, but I went from very bad immunity to very good. Just before I realized I was deficient (I was getting non-stop acne breakouts and other symptoms), I got sick 3 times in a short period of time. Once that lasted 2 weeks (felt like the flu), and two other times that were only separated by weeks. The last time I was ill, I burst my eardrum and was half deaf for months. But even before that, I was getting sick about 3-4 times a year. This was really unusual because early on when I was doing CR I rarely got sick with viral infections... I could go years without catching anything. Which form of zinc do you take? Comparative absorption of zinc picolinate, zinc citrate, and zinc gluconate in humans https://www.ncbi.nlm.nih.gov/pubmed/3630857
  9. Matt

    Back to CE but...

    Since I've been taking zinc picolinate I never get sick anymore. I've already shared my story around here when I had a zinc deficiency and kept getting colds and flu. Even with 7 nephews and nieces running around here most days, I don't catch anything. Aside from taking zinc consistently, I also take allicin max.. although I didn't feel like it helped at all when I was low on zinc. I also have beta glucan and take about 10 capsules a day if there are some nasty bugs going around here.
  10. I made quite a big update to one of my pages recently about the benefits of CR in humans. It's quite long, around 4000+ words at the moment, but still 'work in progress'. I haven't gone into CALERIE yet. Just mostly the WUSTL and a little on monkeys (I want to write more on that when the final data is in). http://www.crvitality.com/benefits-of-calorie-restriction/
  11. Good to see you around here, Brian. You should stop by the CR Facebook group some time as well! The activity has picked up a bit lately...
  12. The amount of progress made in just the last two years is making me feel a bit more optimistic. It really feels like there has been quite a shift since 2016... I just hope that we get a few "wins" and that will help build more momentum. From 2003-2015 it felt like things were moving at a snail's pace compared to the last 2 years.
  13. Matt

    PROSTATE & PSA

    I came across this article the other day http://www.urologytimes.com/prostate-cancer/5-ari-use-reduces-prostate-ca-risk-16-years "The Prostate Cancer Prevention Trial (PCPT) was a placebo-controlled, double-blind randomized controlled trial showing that using the 5-alpha-reductase inhibitor finasteride (Proscar), 5 mg daily for 7 years, could reduce the risk of prostate cancer by 25%. The trial duration was limited to 7 years of treatment and follow-up due to the substantial cost and burden of randomized controlled trials. However, some questions had emerged, such as whether the trial duration was sufficient to demonstrate the maximum benefit of finasteride. Another concern was whether the reduced risk of prostate cancer would be maintained after discontinuation of finasteride at the end of the trial." I've been taking finasteride at 1.25 mg per day for a while now. Although initially, I was taking 2.5 mg per day for a while. No side effects, thicker hair. ?
  14. Matt

    OMG! Obesity paradox stupidity

    In recent years I've been able to get away with eating significantly fewer calories and still maintain a BMI of about 19. I can now eat 1600 k/cal per day and my weight just stays the same, whereas years ago when I first started CR, this would have put me at a BMI of 17 or below.
  15. Matt

    Forum Upgrade (!)

    I really like it! It looks far more professional and inviting. The navigation/menu are not all working, though.
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