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Matt

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  • Birthday 10/21/1984

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  1. Just a quick update on the coronavirus situation here. My mum has recovered now. She didn't end up going to the hospital even though it was up and down. In fact, her lungs are better than they were before getting the infection. She has had trouble walking up the stairs and getting out of breath since 2016, but that's mostly gone away now. She's taking her usual medications, but still got her taking zinc and allicin. She's been taking Azithromycin since 2016 to deal with repeated lung infections. I wonder if that antibiotic wasn't working and the shortness of breath that she's had for years was caused by an underlying lung infection that didn't go away.
  2. This is only a virtual screening of allicin, but thought I'd share: In silico allicin induced S-thioallylation of SARS-CoV-2 main protease "The overall reaction is exergonic and allyl disulfide of Cys-145 residue of Mpro is involved in a sulfur mediated hydrogen bond. The results indicate that allicin causes dual S-thioallylation of SARS-CoV-2 Mpro which may be of interest for treatment and attenuation of ongoing coronavirus infection." https://www.tandfonline.com/doi/full/10.1080/17415993.2020.1817457
  3. It's been 11 days since my mum got sick and she seems to be doing better every day now. She really turned the corner and started to improve when she started taking the zinc and allicin. Of course, I have no real way of knowing if that had anything to do with it... but her oxygen saturation was 89 and she could barely talk because she couldn't catch her breath. Even walking a few feet would make her gasp for air. I think she took about 90 allicin capsules over a period of 4 days. She took 100 mg zinc picolinate as well. Now her oxygen saturation is around 94 and her heat rate 60-70. The most interesting thing happened with her temperature... As she has lupus, her temperature normally runs quite high at about 37.0 - 37.2 Degrees C. Since she's been taking these supplements, her temperature is now more consistently at about 36.5 degrees C. We noticed the effect quite early on: every time she took them, within 30-60 minutes her temperature (fever) would drop significantly. She told me that she has *never* seen her body temperature so low in many years... Any thoughts on this? I didn't give her beta glucan as I wasn't confident enough in its effects due to her case being more complex. However, I gave my dad supplements as soon as he started to feel ill. He took Yeast beta glucan (I posted research way back on how beta glucan prevents cytokine storm and tissue damage to lungs from H1N1 and other viruses). He took a LOT of allicin throughout the day. And he took 100 mg of Zinc Picolinate per day. He was mostly over COVID-19 within a day and a half... with some tiredness and the odd fever for 1 hour or so here and there. I took the same supplements as my dad and I got over COVID-19 within about 1 day and a half. Left with a very, very mild cough. So anyway, my mum being affected with lupus, heart disease, COPD and other issues, seems to be doing a lot better and looks like she'll be fine. But it was very close and she almost ended up in hospital.
  4. Yeah, it's still much lower than it was. However, I did check her oxygen saturation level and it was 89. I checked mine and it was 99. My father's level was 98.
  5. I take 50 mg of zinc picolinate every other day as my diet often tends to be low in zinc and I went through zinc deficiency around 4 years ago (already posted about it here). But I increased to 100 mg per day for the past few days. I normally just empty the capsule of zinc onto toast (along with allicin) or even a spoon with ketchup lol, if I feel like an infection is coming on. The day I got sick, I had barely slept as I woke up really early in the morning to care for my rabbit. He has a serious infection called E.cuniculi and supportive care is almost all day long.Being stressed and not sleeping because of that probably hasn't helped. But this is the first time I've been sick in about 4 years. I've just started giving my mum zinc picolinate and allicin yesterday. Her temperature seems a bit lower now but still chest and breathing isn't great. She's coming up to 7 days, so I've bought an oxygen monitor and that'll come tomorrow. I think it's 7-14 days is when people end up in hospital. Hoping that doesn't happen... 😞 I'm taking the rest of the week off work just to make sure I get good sleep and recover properly (I work from home). Edit: She just checked her temperature again and it's now 36.9 degrees C. She said it hasn't been this low in a long time.
  6. Thanks... It's mainly my mum I'm concerned about as she has multiple health issues. Last night, not long after I posted here, I got a mild fever, shivering, muscle aches in my back near my chest, and my glands were swollen at back of my throat. Temperature went to 37.6 degrees C (quite high for me). I felt like I had a mild case of the flu. Normally, my temperature about that time of night should be around 35.1. Felt quite rough for a few hours. My smell and appetite is fine. I took a bunch of my supplements at a higher dose: 100 mg zinc picolinate, 8 beta glucan, chewed allicin capsules, and had lots of matcha green tea. Woke up this morning and fever has gone (temp at 35.5) and I feel quite a bit better already aside from a bit of tiredness from lack of sleep. One worrying symptom was feeling a bit raw in my chest but it quickly subsided and wasn't that bad. My dad got over it within a day and he took all the supplements I gave him soon as he started getting ill. His temperature was around 38.2 and dropped within a few hours to normal. Unfortunately, my mum is still not well. Her temperature this morning was 38.9 degrees C and she's been ill since Friday. I got her to take some zinc and allicin this morning and her temperature dropped to 37.6 but could be a coincidence. She's already taking vitamin D3. She's overweight, has lupus, heart issues and other health problems. 😕 I wonder if getting over it so quickly and being mild, means I'll have less antibodies and be susceptible in the near future?
  7. My mum tested positive for COVID-19 after getting sick on Friday. My dad's test was inconclusive so he had to have it done again... but had a fever for a day on the weekend. My sister just got her result back and she is positive for it. And I live with my parents... so I'm guessing I've certainly been exposed and probably have it. No symptoms though...
  8. Eyes closed and on your weakest leg? I've not found anything to say that you can significantly improve this with practice. Some people keep saying that but I've not seen anyone provide any evidence for this. I'd be happy to be proved wrong though! There might be some level of adaptation in the brain by further compensating for degradation of sensory input, but I'd be surprised if it was that significant. But I think some people are just misunderstanding what it's testing. From what I understand, this is NOT primarily about muscle strength in the leg or something like that, although it is part of it. You can't just make your legs stronger and hugely better. As people age, they lose vestibular function and equilibrium. Unless you can regenerate new hair cells, it's going to be difficult to improve on this kind of test because when you close your eyes, you're relying on proprioception, the integrity of the vestibular system, central nervous system to correctly maintain balance without the use of the visual system. The only real thing you can do here to perform well on this test is to either a) regenerate these cells or b) slow the rate of damage and cell loss (as what happens with long term calorie restriction in animals). -- "Clinically, progressive dysequilibrium of aging presents as gradually worsening balance due to age-related decline in function of the peripheral vestibular system, central nervous system, vision, and musculoskeletal system. Vestibular function testing has shown clear evidence of age-related changes in peripheral and central sites. Histopathologic changes in the vestibar sensory organs include progressive hair cell degeneration, otoconial degeneration in the otolith organs, and decreasing number of Scarpa's ganglion neurons." "Results show a highly significant continuous decrease in all counts from birth to age 100, best fit by a linear regression model. Type I hair cell counts in all three semicircular canal cristae decrease at a similar rate, significantly faster than the degeneration observed in type I hair cells of the maculae. Type II hair cell counts decline at the same rate for all 5 sensory epithelia. These normative data provide the basis for comparisons to hair cell counts made in temporal bones from subjects with known vestibular disorders" [2]. 1. Age-Related Vestibular Loss: Current Understanding and Future Research Directions https://pubmed.ncbi.nlm.nih.gov/25567421/ 2. Decreasing hair cell counts in aging humans https://pubmed.ncbi.nlm.nih.gov/11710464/
  9. That is really good. And that was with your eyes closed and not hopping around? 😄 I've repeated the test a quite a number of times now and I can normally get between 90-120 seconds. But that dropped to near 60 seconds the more I tried (without a rest), as my foot and muscles were burning lol. I've gotten quite a lot of people to do this test now and most of them fall close to where you'd expect on the graph in the original post. The ones that have been on CR for extended periods of time and who really do seem young for their age (I expected they'd do well), were able to do significantly better. This is one of the tests Roy Walford proposed checking from time to time in the book 120 Year Diet. Functional tests that decline for everyone with age and can't be as easily changed compared to something like cholesterol. But with CR, you'd expect to see a delayed deterioration. Also, I should mention , the study I referenced in the 2nd link (Normative Values for the Unipedal Stance Test with Eyes Open and Closed), used a different study design where they crossed their hands over their chest. This is much harder. I performed this test as well I'm well above what is expected for my age. Eyes closed, arms crossed, standing on weak foot: 42 s, 66 s, 44 s. Only a few seconds rest between tries though. Back to the original test (no arms crossed), this the results in children / teenagers. https://www.researchgate.net/figure/Single-leg-balance-on-stable-surface-eyes-closed_fig3_236908767
  10. Has anyone tried the one leg static balance test? I first tried it in 2005 when I bought "The 120 Year Diet". It was the last time I tried the test until yesterday! I managed to get about 1 minute 30 seconds. My age is 35y, 11m. How well do you do? My father is 65 and managed about 5-6 seconds. My brother who is 40 managed about 15-17 seconds. They are close to what is expected for their age. Your ability to stand on one foot with your eyes closed drops sharply with age. If you're right handed, balance on your left foot. Left handed, use right foot. Stand with feet close together and lift foot about 6 inches off the ground. Don't move your foot that you're balancing on. If you try this, be safe about it! Maybe have someone around close to you while you try. A decrease in balance may indicate brain abnormalities (eyes open) and even increased mortality for those over 50 (eyes closed). As you age, there will be a loss of vestibular function and also other age-related changes take place in the central nervous system that makes it harder to balance. As people get older, they rely more on the visual system - even when eyesight is also failing. A lot of people think this is merely just practice and you need to exercise... but it's more than just stronger leg muscles. Michael and Joe try the test in the video below: https://www.medicalnewstoday.com/articles/287201 https://www.bmj.com/content/348/bmj.g2219 https://geriatrictoolkit.missouri.edu/balance/Normative_Values_for_the_Unipedal_Stance_Test_Springer-JGPT.pdf https://www.bmj.com/content/348/bmj.g2219?
  11. At the end of the year it'll be 4 years since I was last struck down ill with a cold or flu. As I've mentioned elsewhere, I will sometimes experience what seems like the beginning of a cold like a scratchy throat but it's typically gone within hours and doesn't develop further. It's about 11-12 years since I last had a full blown norovirus infection with all the symptoms. So I've not vomited in 12+ years either. I have had what seems to be the start of norovirus, but allicin has never failed to get rid of very early symptoms within hours. Typically those will be nausea and a feeling of pressure under the rib cage where the stomach is located. Could be a coincidence that I stopped getting sick since using zinc and allicin, but who knows. 🙂 I do know allicin has antiviral properties, and getting it into the stomach is pretty straight forward. But it's not been tested against norovirus? Only against stomach issues related to bacteria like h plyori, where it seems effective.
  12. Matt

    1 week of CR

    Please don't copy me. I have a small body frame and I'm only 5ft 7"
  13. Matt

    New to CR, have 4 basic questions

    Unfortunately, there is no perfect answer. We don't even know how much CR is too much. And it probably varies depending on the person as well... I can give you my own experience from started at a young age: When I was 18 years old, I removed sugar from my diet, changed bread and cereals to wholewheat, I stopped fizzy drinks, added more fruit to my diet, etc. It resulted in a weight loss drop without intentionally cutting calories. But calories were cut just by doing this. And so I count this as the first stage towards CRON. It was CR, but not intentional. I don't remember the exact numbers, but I found a notepad with my weight on them from that time and I think it was about 135-140 lbs. I'm 5ft 7" So I assume that was my set point. But I was 18 years old... not in my early 20s. After two years of that, I started a strict CRON diet and reduced my weight from something like 123-124 lbs to 104 lbs at my lowest (BMI 16.3) I maintained this for about 6-7 years an then increased to around 1700 k/cal for 2-3 years from 1550k/cal. Eventually I got to about BMI 17.5 and maintained this for a while. Gradually, my weight got to about 18-18.5 and stayed there for some years. In 2005 at 20-years-old, eating 1550 k/cal per day (measured everything) I could only maintain a BMI of 16.3 IN 2020 at almost 36-years-old, I eat 1500 k/cal per day, my BMI today is 18. But I still maintain the same CR biomarkers at a higher weight. My metabolism just seems to have slowed. I've now added in a bit more exercise 3 x per week. Ultimately, your guide should also be your blood work and seeing if it matches up what we see in people on CR. And also what weight you're comfortable being. You restrict until you feel it's too much and you're too skinny. You be objective about your own health and quality of life. You track biomarkers like thyroid, glucose, insulin, IGF-1, body temperature, cholesterol, inflammation, blood pressure and more. Are they consistent with being on CR? You won't reach the levels of the most severe CR imposed on rodents without looking extremely skinny. So in the end, it doesn't matter for most people as they would not put up with that. Personally, I would not go below a BMI of 17.5 again. That would be my limit.
  14. Matt

    New to CR, have 4 basic questions

    You're restricting from your previous ad lib intake, that is the important part and how it's CR is implemented. You reduce weight by 10-25% below your natural 'set point' or where your weight gravitates to in your early 20s, assuming you're not obese or something. This will induce the CR phenotype that is protective against diseases of aging and may extend lifespan. Two books you should read: Dr Roy Walford - 120 Year Diet Dr Luigi Fontana - The Path to Longevity It's not about weight. Although, in rodents, those in the CR group who are able to hold onto more fat when they're restricted, tend to do better and live longer. But they're still really skinny compared to ad lib controls.
  15. Matt

    New to CR, have 4 basic questions

    You would be colder (men with lower body temperature live longer and lower body temperature seems to be part of the protective effects of CR). And no, you won't always be shivering cold. My body temperature is 35.5 degrees C and I'm fine. You adapt to it. No, being young and skinny is not the same as being old and frail. I had a BMI of 16, weighing around 106 lbs. I was benching 60-70 kg. That is more than my body weight and definitely not "frail". My BMI now is about 18. Sex drive can decrease for people on CR but it's different for everyone. If you're young, you probably won't be as impacted. When I was 20 and on strict CR with a BMI of 16, my libido did not just vanish. You can see the benefits here. 😉 No, the diet is not about reaching a certain BMI. There is no good way to translate the level of restriction imposed on animals like mice and rats to humans. Ad lib intake varies a lot and so the best idea seems to be to reduce body weight by 10-15% if you're fairly skinny and up to 25% (if you're over a BMI of 25 when you start). You impose calorie restriction slowly. Drop calorie intake by 10% at a time over a long period of time. Maybe 10% drop every 3-4 months or something. No, you do not eat more calories on days you exercised. You don't "stop restricting" after weight loss. If you eat 1800 k/cal per day down from 2300, you will eventually stop losing weight and maintain. It's really up to you if you are comfortable with how you look at that point. Also take into consideration your quality of life and your blood work. You might end up below a BMI of 18, you might not. It depends on many factors. When I first started to CR, my BMI dropped to 16. Now, almost 18 years later, I can maintain a BMI of about 18 at a strict 1500 k/cal per day. In rodent experiments, CR mice are more active and are still running long after all the ad lib are dead. And no, they don't add in calories when their exercise more. You stick to the same calorie intake. It's worth doing some exercise like cardio and weightlifting. This is really up to you... it's a trade off. You stick to the same calorie intake, but if it's low enough, it will limit your muscle gains. But CR helps maintain muscle function and mass with age. If you're not compensating by increasing calories in the day(s) after intense exercise, you may lose more weight. So you accept the extra weight loss or you increase calories, thus reducing the level of restriction.
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