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Everything posted by Matt

  1. Some numbers to possibly explain why I've been able to maintain a higher body body weight at a lower calorie intake in recent years? I've read that T4 is usually stable up until older ages, but I've seen trend downwards over several years. When I last got it measured, it was close to the CR group in WUSTL study, but they they were close to 60 years old. Serum fT4: Reference: 9.8 - 23.1 22.9 (2005) - start of strict CRON 20.2 (2005) 20.8 (2007) 19.2 (2007) 18 (2013) 13.9 (2016) - TSH 1.6 I saw a steady decrease in fT3 from 5.5 to 4.6 but never got it tested in 2016. I've been keeping a closer track to my calorie intake by measuring everything I eat. Some days are really low, but that's just because I forgot to input the data. I eat the same foods every day anyway, so it's probably similar to fully tracked days. A few days missing as I was unable to forgot to track but some are just due to adjusting sleeping pattern . I've not seen any weight loss at all... but I expected as much as I buy the same amount of food every week and I eat the same thing almost every day. So it seems to be true that I can now maintain a much higher weight at the same calorie intake as I was at when I first started CRON.
  2. As some of you probably know, I've been on a *CRON* diet since around 2005, but prior to that for 2 years I was removing sugar, sweets, fizzy drinks from my diet, and I was adding more nutritious cereals and fruit to my diet. This resulted in significant weight loss even before I adopted CRON and more carefully tracked my weight and everything else. In 2005, my weight dropped to around 104 lbs or a BMI of 16. I was eating approximately 1550 k/cal per day and measured my food intake and calories every day. I did increase my weight after 6 years of very strict CR, and then a few years later my BMI decreased again to around 17.5 and remained there for some years. And now in 2019, my BMI is around 18.5 and my calorie intake is between 1500-1600 k/cal per day. BMI has stayed the same for years. I eat pretty much the same thing every day. I've measured my calorie intake multiple times very carefully to make sure I'm not eating more than than I think I am, and it consistently comes in around 1500-1600 Calories. And there were some days it was much less! Has this happened to anyone else? I'm more curious about people who have been on CR for years. I now seem to be much more resistant to losing weight than when I first started. On the one hand, I'm aware of research saying that mice on CR that are able to hold onto weight tend to do better. On the other, I'm wondering if I could push CR a bit harder. But with my calorie intake already quite low, that also concerns me.
  3. Matt

    Studying "Boredom" - what it is, what it means

    I really don't even know when the last time I've felt bored... It was probably when I was a child or teenager. I always find something interesting to read about, watch, play, or do. I like simple things, a simple life and no drama. I don't need to go out all the time to keep my mind stimulated. In fact, I've been shielded and living at home with the parents for months now and I've actually not left the house. I too eat the same thing every day and never get bored of it. In fact, I REALLY look forward to my food, especially what I eat for breakfast. People are like: "do you ever get bored of eating the same thing every day?" And like Dean and probably some others here, I don't. I noticed how a lot of my old friends from my previous job would complain about boredem a lot on Facebook. The same people who'd criticize me for not going out and getting drunk with them all the time (I don't drink). Which I thought was kinda funny... I just have so many things that interest me... But I can even sit still in the garden and be totally fine as well. I haven't been bored in a really long time.
  4. This was a really great episode... πŸ™‚ You might remember he as Starbuck in Battlestar Galactica. "I have built my career on the foundation of my favorite genre, Science Fiction. So this episode we dive into something that, when I heard about it, immediately captured the side of me that loves to ponder the possibilities of the future!"
  5. You have to go right back to the beginning... Maybe I stopped responding because you didn't respond to my follow up questions? You mean by going to Oxford or London? I don't remember the circumstances, but it was probably more to do with lack of money at the time than anything else. I barely had any work at the time. I have met people in IRL that I've spoken to online, but I've also had some reciprocal effort and communication from them. We barely ever even spoke to each other. But even so, I still didn't have the money to be using it on travelling at the time.
  6. Matt

    Path to Longevity (new book) by Luigi Fontana

    Low LDL-C and mortality from cancer, and all-cause mortality has been discussed so many times around here and on the CR email lists. The drop in cholesterol can occur even 10-years prior to cancer diagnoses and it's not that low LDL it'self is the cause, but a preclincial marker of a disease and ill health (even if it hasn't become apparent yet). A drop in cholesterol in response to CR is a normal response to CR and that doesn't elevate cancer risk. It's like the increased risk of hemorrhagic stroke from having low LDL-C. But when you have very low blood pressure and have extremely low levels of chronic inflammation (as people on CR have) this increased risk is ameliorated. Plus you are protected from ischemic stroke. @Michael R, @Dean Pomerleau Any comments on this?
  7. Matt

    Path to Longevity (new book) by Luigi Fontana

    The oldest rhesus monkey ever recorded (at least 43 years old) died. 😞He was on a CR diet. Luigi says that he was 42, but he was 43 in 2017. When Luigi says "he died recently" - I don't know if that means like back in 2017 or as recent as 2020.
  8. Roy Walford 1924-2004) was an esteemed professor of pathology at University of California, Los Angeles School of Medicine, a leading advocate of calorie restriction for life extension and health improvement, and a crew member of Biosphere 2. This interview which never aired publicly was filmed at UCLA on June 7, 1991 just prior to his leaving the university and joining up with several other scientists at Biosphere 2 near Tucson. *Filmed by-Barry Conrad
  9. Matt

    Roy Walford 37 Minute Interview

    Old segment featuring Roy Walford and Lisa. Roy seemed to be quite slow here in his speech... He already diagnosed with ALS at this point? He was 76 years old here.
  10. He does ask a lot of questions.. When I've tried to communicate with him and ask some back, he almost never responds. πŸ˜‰ Must be artificially intelligent 😎
  11. Matt

    CR Conference Videos

    There is so many hours of video footage of interesting presentations by CR Society members as well as researchers who studied calorie restriction over the years, but I'm surprised that they still aren't accessible at all. I don't know about you, but we don't even own a DVD player anymore, so I can't even go back and watch the one I do have either. I wonder if the conference videos will ever be uploaded onto YouTube or something? Or at least available online for digital download? Who owns the footage?
  12. Matt

    Roy Walford 37 Minute Interview

    I started at 18, you telling me I won't live to 140 with just CR? 😨 But yeah, he still had good reason to be that optimistic back then I think. But I'm still personally optimistic that in some people it will be really effective and someone starting at a young age could reach 120 and beyond. I still believe! πŸ˜›
  13. The UK government are looking at the connection between vitamin D and mortality from COVID-19. https://www.theguardian.com/world/2020/jun/17/uk-ministers-order-urgent-vitamin-d-coronavirus-review "It comes amid growing concern over the disproportionate number of black, Asian and minority ethnic people contracting and dying from the disease, including a reported 94% of all doctors killed by the virus." I wonder if we're experiencing a reduction in mortality due to higher levels of vitamin D? Sounds simplistic, but I hope they get an answer soon. Maybe things could get much worse in the winter months.
  14. My blood pressure is usually around 90/60 for the past 18 years or so. I don't see why it would be a problem if you aren't having any symptoms from it. Maintaining life-long low blood pressure is likely to be a very good thing for people on CR and protective against hemorrhagic stroke (sometimes associated with very low cholesterol.) I measured my fathers blood pressure: he's 65 years old and his BP is about 100/60. His total cholesterol is around 160. My sister also has a BP of about 100/60 and she's a couple years younger than me. Even before CR mine was around the same: 100/60.
  15. It's been years since I was properly sick but last night I went to bed and I had that scratchy throat feeling like one gets at that the start of an infection. My sister had the same thing a few days ago. Maybe she must've brought it here when she visited. So anyway, I emptied out 2 x 50 mg zinc picolinate capsules and mixed it ketchup and just swallowed it. Didn't drink anything for a bit... And then before I went to bed, I gargled some matcha and sliced up some garlic cloves to chew on. Fell asleep and got only 4 hours sleep (probably a bit anxious...) and it was still there but hadn't gotten worse. Repeated the same thing again, did some work for 2 hours and then fell back to sleep. Fortunately, when I woke up after a few hours, the scratchy feeling and mild soreness had gone away. I read that only 10% of people have sore throat as a symptom of COVID-19. So perhaps it's not that... I wouldn't normally get sick in the summer if I ever am. But I feel fine now.
  16. How is your wife doing now, Gordo? Hope things have improved since... Did she get test results back to see if it's COVID?
  17. Covid-19 news: Lockdowns prevented 3.1 million deaths in Europe An estimated 3.1 million deaths due to covid-19 were prevented by lockdowns and other coronavirus social distancing measures across 11 countries in Europe including the UK, according to a modelling study published in Nature. 470,000 deaths were averted in the UK alone, the researchers who did the study told the Guardian. Read more: https://www.newscientist.com/article/2237475-covid-19-news-lockdowns-prevented-3-1-million-deaths-in-europe/
  18. Matt

    Thread of monumental disappointment

    I'm more optimistic about the idea of extending average lifespan significantly over the next 10 years than I was just a few years ago. The tools available now are far better than what was available for much of the time that Aubrey and others have been saying we'll be able to slow or reverse aging. Some of these tools, although not perfect, have only been available in the last few years (CRISPR for example.) I can understand the skepticism though! I've lost count on how many times I've heard a baldness cure is only 5 years away or how we'll be growing new teeth in 5 years. It's always 5 years away. But as Drewab said... society is changing more rapidly. So is technology and medicine. What is still slow though is the FDA and other organizations that slow down progress. IMO, senolytics seem a lot more promising to me in the near term than NMN. Speaking of Senolytics... I came across this over on Reddit recently. Do you want to look young? πŸ˜€ A little blurry as the presentation was streamed, but the data from the clinical study looks interesting. And it's available in September.
  19. Matt

    Blood Pressure

    Mice that are on CR and are able to maintain a higher level of body fat on the diet live longer. You should NOT aim for a BMI below 14. The only advice I will ever give to you is that you increase your BMI above 19 and that you eat a healthy diet. Stop obsessing over your body fat levels and your body weight. And don't do calorie restriction. Aim to be healthy in your mind and your body.
  20. Matt

    Blood Pressure

    Assuming you have a normal adult body weight, you calculate your calories from your ad lib intake and reduce from there. Biomarkers are helpful to gauge whether or not things are going in the right direction that would normally happen on the diet. Why can't you just go by weight? In 2005 I had a BMI of 16 and ate 1550 K/CAL per day. In 2020 my BMI is just over 18.5 and I eat 1500 K/CAL per day. There are days when I eat even less than 1500. At a higher weight I still have a low body temperature (35.5 degrees C), low blood pressure (90/60), low heart rate (50 bpm), low HbA1C (4.8% last measurement), lowish testosterone (not super low, but low end of normal), low cholesterol, usually a CRP that is under 1 mg/L, and other biomarkers indicating that I'm CR'd. These are all helpful in being somewhat of a guide. The percentage of CR doesn't matter at all, it's whatever you can do SAFELY. I'm not any less CR'd that I was back in 2005, it's just my body has become far more resilient to weight loss.
  21. Matt

    Blood Pressure

    This is not true. CR is not about body weight. My BMI is around 18.5, I'm 5ft 7" and I eat 1500 k/cal per day. There are many days when I eat even less - but I seem to be more resilient to weight loss than I used to be.
  22. Matt

    BBC - To live longer eat less

    Yeah, that's an article from 2017.. I wonder if Sherman or any of the rhesus monkeys from the NIA study are still alive now?
  23. Matt

    How sustainable is a CRON lifestyle?

    Nice to hear from you, April! πŸ™‚ I hope to see you blogging again sometime in the near future!
  24. And based on the current IFR in the UK (1.45%, based on antibody testing) that number doesn't seem far-fetched at all considering over 30,000 deaths outside of London and ONLY 5% of the population having caught COVID-19. 1 in 12 people with the infection end up in the hospital. And hospitals were not overwhelmed due to the lock down. He predicted 500,000 if NOTHING were done and we took minimal action against the spread of the virus. The whole country has been on lock down and 2 million at high risk people have been shielded and not left their house at all for many weeks.