Jump to content

Matt

Member
  • Content Count

    195
  • Joined

  • Last visited

Everything posted by Matt

  1. Matt

    Oldest Man 111

  2. Roy Lee Walford, M. D. was a professor of pathology at University of California, Los Angeles School of Medicine, a leading advocate of calorie restriction for life extension and health improvement, and a crew member of Biosphere 2. This is a rare unedited interview with him during his tenure at Biosphere 2 discussing longevity research especially his caloric restriction plan. (interview filmed by Barry Conrad).
  3. Maybe not, we'll see soon. So far the symptoms seem mild but she only just woke up with it a few hours ago. Since she has had chest infections before and is constantly on azithromycin (takes it daily), it might not be the virus. She also takes hydroxychloroquine every day too for lupus. I'm just slightly annoyed really cos she ignores the warnings and advice from the NHS, the government... and me when I keep telling her she has to stay at home. Yet she takes me nan who has COPD (not emphysema as I thought..) to the shops twice a day to get things like the newspaper and things that are not essential. So then I have the anxiety about this and constantly have to be careful. I've not even been out of the house in 2 weeks now. If she wasn't leaving the house, it'd make life a bit easier.
  4. My mother has to get tested for coronavirus in just over an hour. She feels like she has a chest infection, pains when taking deeper breaths feels hot (but not fever), and tired. I told her a million times that she should not be leaving the house but she wouldn't listen to me. Anyway, after getting told this news... she gets off the phone and goes into the kitchen and starts putting the dishes, forks, and spoons away in the drawers. Touching everything... 😞 I asked her why she is doing this knowing she might have the virus.. she said: "I didn't think..." And I'll have completely run out of food by tomorrow. I have nothing.
  5. I've only just started to grow some of my vegetables and greens but the fruit trees have hundreds of flowers already and hopefully will get a good harvest from them this year. I'm considering sticking to fruits that I have to peel (like an Avocado) and eating a lot of root vegetables like sweet potato, carrots, and canned baked beans, olive oil etc. For the time being, I'm gonna be more reliant on a multivitamin and not have the variety I normally get from the store. But if I do buy anything from the store, I'm going to make sure that I wash it better than I normally do. Is regular hand soap I wash with okay? As long as it's removed after rinsing, there isn't much risk?
  6. Coronavirus Ravages 7 Members of a Single Family, Killing 4 The matriarch of the large New Jersey family died Wednesday night without ever knowing that her two oldest children had died before her. Article here: https://www.nytimes.com/2020/03/18/nyregion/new-jersey-family-coronavirus.html
  7. Two Women Fell Sick From the Coronavirus. One Survived. By Sui-Lee Wee and Vivian WangMarch 13, 2020 阅读简体中文版閱讀繁體中文版Leer en español The young medical professionals, who worked long hours on the front lines in Wuhan, first came down with fevers. Within weeks, both were in hospital beds, hooked up to IVs or oxygen machines. Deng Danjing Xia Sisi THE YOUNG MOTHERS didn’t tell their children they had the coronavirus. Mama was working hard, they said, to save sick people. Instead, Deng Danjing and Xia Sisi were fighting for their lives in the same hospitals where they worked, weak from fever and gasping for breath. Within a matter of weeks, they had gone from healthy medical professionals on the front lines of the epidemic in Wuhan, China, to coronavirus patients in critical condition. https://www.nytimes.com/interactive/2020/03/13/world/asia/coronavirus-death-life.html
  8. @DHL Didn't you see the research I posted with regards to beta-glucan preventing cytokine storm and preserving the integrity of lungs in animals infected with H1N1? This Coronavirus kills people by causing a cytokine storm late in infection. Beta-Glucan modulates the immune system in humans the same way it does in animals. This is shown by research conducted in humans. Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide. The aim of these experiments was to investigate the potential antiviral effect of Saccharomyces cerevisiae beta-glucan on the pneumonia induced by swine influenza virus (SIV). Forty colostrum-deprived 5-day-old piglets were randomly divided into four groups of 10. The 20 pigs in groups 1 and 2 were administered Saccharomyces cerevisiae beta-glucan orally (50 mg/day/pig; En-Bio Technology Co., Ltd) for 3 days before SIV infection and those in groups 3 and 4 were given culture medium/diluent alone. Groups 1 and 3 were inoculated intranasally with 3 ml of tissue culture fluid containing 2 x 10(6) tissue culture infective doses 50% (TCID(50))/ml of SIV and those in groups 2 and 4 were exposed in the same manner to uninfected cell culture supernatant. The microscopic lung lesions induced by SIV infection (group 1 pigs) were significantly more severe than those induced by infection in animals pre-administered beta-glucan (group 3) (P < 0.05). Significantly more SIV nucleic acid was detected in the lungs of pigs experimentally infected with SIV only (group 1) at 5, 7 and 10 days post-inoculation (dpi) compared with lungs from pigs pre-administered beta-glucan and infected with SIV (group 3) (P < 0.05). The concentrations of interferon-gamma (IFN-gamma) and nitric oxide (NO) in bronchoalveolar lavage fluid from pigs pre-administered beta-glucan and infected with SIV (group 3) were significantly higher than for any other group at 7 and 10 dpi for IFN-gamma, and at 5, 7 and 10 dpi for NO (P < 0.05). Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV-infected pigs. These findings support the potential application of beta-glucan as prophylactic/treatment agent in influenza virus infection. PMID: 15030604 Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro and in vivo. LEM directly inhibited influenza virus growth in vitro at early phases of infection, possibly at the entry process of viral particles to host cells. We also found that the nasal administration of LEM increased the survival rate of infected mice, and this was likely due to the direct action of LEM on viral growth. The oral administration of LEM showed prolonged median survival time of infected mice. Histological analysis revealed that the moderate bronchiolitis was observed in infected mice by the oral administration with LEM, and the extent of alveolitis was dramatically reduced. The orally LEM-administered mice showed a rapid activation of IFN-β gene expression upon influenza virus infection. These results suggest that the immunopotentiation activity of LEM on type I IFN pathway represses the virus spread to distal alveolar regions from peribronchiolar regions which are primary infection sites in the mouse model. We propose that LEM has anti-influenza virus activities through the direct action on viral growth and stimulatory activity of innate immunity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992414/ Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis. In a separate set of experiments, survival was monitored for 7 days after CLP. beta-Glucan treatment led to a significant increase in survival rate (63% in glucan-treated rats vs 38% in saline-treated rats). Administration of the beta-glucan inhibitor abrogated beta-glucan's survival benefit (50%). After CLP, plasma TNF-alpha, IL-1beta, and IL-6 concentrations were increased in control animals. When beta-glucan was administered, it completely blocked the elevation of TNF-alpha, IL-1beta, and IL-6. Administration of beta-1,3-D-glucanase suppressed glucan-induced decrease in cytokines. https://www.ncbi.nlm.nih.gov/pubmed/17414422 Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise (humans) BYBG significantly (P < 0.05) altered total and classic monocyte concentration and expression of CD38, CD80, CD86, TLR2, and TLR4 on monocyte subsets. BYBG also significantly increased CD4+ and CD8+ T cell concentration and the exercise response of CCR7+/CD45RA- central memory (TCM) cells. Likewise, BYBG significantly (P < 0.05) altered serum IFN-γ and IL-2, and LPS-stimulated IFN-γ, IL-2, IL-4, and IL-7. Taken together these data support the hypothesis that oral BYBG supplementation modulates the expected exercise response for individuals of average fitness. https://www.frontiersin.org/articles/10.3389/fphys.2017.00786/full Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. n E1, BG was associated with a 37% reduction in the number of cold/flu symptom days postmarathon compared to placebo (p = .026). In E2, BG was associated with a 32% increase in salivary IgA (p = .048) at 2 hr after exercise compared to placebo. In summary, the present study demonstrates that BG may reduce URTI symptomatic days and improve mucosal immunity (salivary IgA) postexercise. https://www.ncbi.nlm.nih.gov/pubmed/23927572
  9. I included plenty of references in all my posts regarding beta-glucans and AHCC. They did not use anywhere near these doses and have shown good effects on clearing chronic viral infections (including hpv) and preventing them.
  10. Living with my parents, on the one hand, they sound as if they are taking it seriously, on the other, no one is truly taking it seriously. Kids are still in school, coming over here most days in the week. Brother works at a hotel as a driver and goes into many cars every day and has been over here a few days this week. Sister comes over every day to help my dad as he just had hernia surgery. My mum back and forth to the shops with her mother every day (who has chronic lung issues) and my mum's friend comes over every weekend. I guess I will not escape this. I wish I lived on my own at this point so I could self isolate and limit my exposure but it seems impossible. Everyone is panic buying now too. Riots in stores. everywhere. I went shopping this morning at 6 am and it was super quiet and stores were stacked full, but by mid-morning apparently everything was stripped again. The stores need to start rationing food.
  11. Beta Glucan from oatmeal is different and is a weak immune system modulator relative to yeast-derived glucans. AHCC also helps protect the lungs from damage and preserves the epithelial integrity in the lungs according to this study: https://www.ncbi.nlm.nih.gov/pubmed/17056815 "young C57BL/6 mice were supplemented with 1 g AHCC/(kg body weight x d) for 1 wk prior to and throughout infection with influenza A (H1N1, PR8). Supplementation increased survival, decreased the severity of infection, and shortened recovery time following intranasal infection with flu, as determined by the recovery of body weight and epithelial integrity in the lungs. There's been research in animals and humans AHCC. I did a review of that research here: http://www.crvitality.com/2018/07/ahcc-benefits-and-side-effects/
  12. A few days ago I shared a study on how Beta-Glucans prevented excessive damage from inflammation and infection in the lungs from H1N1 (swine flu). Here is another study using an extract from Shiitake mushrooms, which also contain beta-glucans. It significantly reduces alveolitis and lung damage in mice infected with Influenza. Beta-Glucans modulate the immune system. Excessive inflammation and fibrosis seem to be killing people infected with this new virus. Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity Takahiro Kuroki,1 Sangjoon Lee,2 Mikako Hirohama,3 Tomohiro Taku,1 Michiko Kumakura,1 Takahiro Haruyama,3 Kyosuke Nagata,3 and Atsushi Kawaguchi1,2,3,* Author information Article notes Copyright and License information Disclaimer Go to: Abstract Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro and in vivo. LEM directly inhibited influenza virus growth in vitro at early phases of infection, possibly at the entry process of viral particles to host cells. We also found that the nasal administration of LEM increased the survival rate of infected mice, and this was likely due to the direct action of LEM on the viral growth. The oral administration of LEM showed prolonged median survival time of infected mice. Histological analysis revealed that the moderate bronchiolitis was observed in infected mice by the oral administration with LEM, and the extent of alveolitis was dramatically reduced. The orally LEM-administered mice showed a rapid activation of IFN-β gene expression upon influenza virus infection. These results suggest that the immunopotentiation activity of LEM on type I IFN pathway represses the virus spread to distal alveolar regions from peribronchiolar regions which are primary infection sites in the mouse model. We propose that LEM has anti-influenza virus activities through the direct action on viral growth and stimulatory activity of innate immunity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992414/
  13. More interesting information on zinc supplements, zinc ionophores, and Quercetin. Part of the protocol for treating the virus in South Korea is to use zinc ionophores like hydroxychloroquine.
  14. Just an anecdote on Facebook from a Doctor that I want to share: Coronavirus (COVID-19) update: I haven't posted much other than memes lately, but as a primary care physician practicing in Tarzana, I wanted to give you my experience, and information that I know to be true. I won't mention hand washing or sanitizers, or things that everyone obviously knows, as there is plenty of information about this already. I have two patients right now with CV, one hospitalized, and one not, and am close to a third patient. Essentially, 14 men went on a ski trip to Northern Italy. All have become ill, and all 14 have tested positive for CV. Of the 14, 4 needed to be hospitalized, and of the 4 patients, 3 are very ill as I write this. One had a significant pre-existing medical condition. The other 3 did not, and are relatively young. The news today out of Northern Italy is not good. I have practiced for over 30 years, and have seen it all, or so I thought. Nothing has worried me like this. I recommend to all who read this that you avoid going to large group events such as sporting events, and concerts. I believe that all schools should be closed immediately and classes conducted online, which is relatively simple. I know that so far, children infected with CV have done relatively well, but they might come home and hug Grandpa, who won't do so well. Avoid contact with others as much as possible. CV in the United States is at a relatively early stage, but it won't last there for long. Make sure you have any medications you need, as well as supplies, but panicking hurts all of us. My biggest hope is that I am totally wrong, and that you will all wonder in a few weeks what the hell I was talking about. But I have a pretty good track record, and I think you should take steps now to protect yourselves and your family. There is little cost to taking extra precaution right now, and the earlier, the better. Feel free to share. Sam Fink, M.D. Fellow, American College of Physicians
  15. 10 mg/day of zinc is not going to hurt you. I don't have time to go through individual studies right now, but higher doses of 100 mg/day + of zinc have been tried for months with no issues. It takes a while before you start causing an imbalance. When I was correcting a zinc deficiency a few years back, acne responded much better to 100 mg/day than 50 mg/day at first. I've maintained a lower dose of 50 mg every other day or 22 mg/day of zinc picolinate for 3 years now and have no issues. I've not been sick at all with any infection either since taking it. No viral infections at all for me even though my 7 nephews and nieces bring things back all the time to the house and the rest get sick. I shared my story here: Regarding zinc toxicity: High levels of intake by humans[edit] Zinc has been used therapeutically at a dose of 150 mg/day for months and in some cases for years, and in one case at a dose of up to 2000 mg/day zinc for months.[7][8][9][10][11] A decrease in copper levels and hematological changes have been reported; however, those changes were completely reversed with the cessation of zinc intake.[9] However, zinc has been used as zinc gluconate and zinc acetate lozenges for treating the common cold[12] and therefore the safety of usage at about 100 mg/day level is a relevant question. Thus, given that doses of over 150 mg/day for months to years has caused no permanent harm in many cases, a one-week usage of about 100 mg/day of zinc in the form of lozenges would not be expected to cause serious or irreversible adverse health issues in most persons. https://en.wikipedia.org/wiki/Zinc_toxicity And a study regarding zinc absorption: At the end of four weeks, hair, urine and erythrocyte zinc levels rose significantly during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. https://www.ncbi.nlm.nih.gov/pubmed/3630857
  16. I recommend checking out this channel below. The person giving out the information is Roger D. Seheult, MD. He works in Pulmonology.
  17. Matt

    Oldest Man 111

    I actually think that some people on CR will do better, especially when combined with new medical technologies and drugs that'll come along in the next few decades. It's likely to be genetic in this man's case, and it's really impressive compared to many supercentenarians I've seen over the years, but why couldn't CR mimic this effect? Even on something like the eyes? CR helps maintain good glucose metabolism (completely prevention of diabetes), and maintaining good proper folding of proteins and preventing degradation of them. CR appears to enhance the expression of many genes implicated in longevity in centenarians: it acts on the IGF-1/insulin signaling pathway, boosts SIRT1, FOXO3A, boosting autophagy, and reducing expression of genes involved in inflammation. CR also results in profiles of thyroid hormones that go in the same direction as what is seen in familial longevity, but only a stronger effect and more representative of a CR'd state. I've looked at some of the research on families who are 'predisposed to longevity' the results from Fontana's group is far more impressive when you look at the numbers. If none of these longevity markers that are found in centenarians have anything to do with their longevity, then everything we know has to be wrong. And the reason for their longevity (despite knowing that more active variants of these genes alter lifespan in animals also) is still unknown. I feel like I'm one of the very few people here that is still optimistic about the effects of CR on human aging. 🙂 I really can see many of us who started earlier in life being able to reach 100-115. The average person lives to about 80 years old, while the oldest lived to 122. There is clearly a lot of room left in the system for optimizing for the vast majority of people. The best way to optimize our biology and genes to resemble a person or animal that is phenotypically predisposed to extreme longevity is by doing CR.
  18. This study is not in humans but one of the ways the virus is killing people is by damaging the lungs and causing fluid build upi, and this is similar to what H1N1 did in humans. "Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV-infected pigs." Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide. The aim of these experiments was to investigate the potential antiviral effect of Saccharomyces cerevisiae beta-glucan on the pneumonia induced by swine influenza virus (SIV). Forty colostrum-deprived 5-day-old piglets were randomly divided into four groups of 10. The 20 pigs in groups 1 and 2 were administered Saccharomyces cerevisiae beta-glucan orally (50 mg/day/pig; En-Bio Technology Co., Ltd) for 3 days before SIV infection and those in groups 3 and 4 were given culture medium/diluent alone. Groups 1 and 3 were inoculated intranasally with 3 ml of tissue culture fluid containing 2 x 10(6) tissue culture infective doses 50% (TCID(50))/ml of SIV and those in groups 2 and 4 were exposed in the same manner to uninfected cell culture supernatant. The microscopic lung lesions induced by SIV infection (group 1 pigs) were significantly more severe than those induced by infection in animals pre-administered beta-glucan (group 3) (P < 0.05). Significantly more SIV nucleic acid was detected in the lungs of pigs experimentally infected with SIV only (group 1) at 5, 7 and 10 days post-inoculation (dpi) compared with lungs from pigs pre-administered beta-glucan and infected with SIV (group 3) (P < 0.05). The concentrations of interferon-gamma (IFN-gamma) and nitric oxide (NO) in bronchoalveolar lavage fluid from pigs pre-administered beta-glucan and infected with SIV (group 3) were significantly higher than for any other group at 7 and 10 dpi for IFN-gamma, and at 5, 7 and 10 dpi for NO (P < 0.05). Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV-infected pigs. These findings support the potential application of beta-glucan as prophylactic/treatment agent in influenza virus infection.
  19. Matt

    Oldest Man 111

    It's really impressive how sharp his mind is for being almost 112. He looks 30 years younger, too!
  20. I have that brand of AHCC but only keep it at hand for when I think I need it. I frequently take beta-glucan from NOW Foods (taking 5 capsules per day right now ) as AHCC can be a bit expensive. Here's a bit more information from a couple of articles I wrote on AHCC and Beta-Glucan for immunity. 🙂 http://www.crvitality.com/2018/07/ahcc-benefits-and-side-effects/ http://www.crvitality.com/2019/01/beta-glucan-vs-ahcc/
  21. TL;DR Since I started on zinc picolinate I've not caught any viral infection, and it's the longest time I've not had one (at least in recent years). My skin also cleared up very nicely after taking zinc, within days I noticed a huge difference. Nothing worked before to stop the acne. Other little issues I was having also completely went away. I already mentioned my issues with magnesium and zinc in my blog posts, but I just want to share it here in case someone comes across it. When I first started doing CR, it felt like I was almost completely immune to any bugs going around. Sometimes I would go years without catching a cold or the flu, and then somewhere along the line things changed. In the last few years, I noticed I was getting sick just like everyone else. Every year, I'd develop a cold or what felt like the flu. They also seemed to be a lot worse than what I remembered having before. So at some point, I started developing acne (I really became a teenager again), athletes foot, and other skin issues. I think I also experienced some diffuse hair loss, but my hair is thick anyway, and therefore took me a long time to notice. During that winter I developed 3 colds, and then a burst eardrum. Although, despite being a large perforation and saying I needed an operation, it healed very fast, which was quite unusual apparently. Eventually, I figured that I might be deficient in zinc. Normally I wouldn't be so complacent and track my nutrient intake or I'd just take half a multi in previous years and do just fine. However, I know that even tracking and getting enough through diet doesn't always guarantee there won't be an issue... as my experience with magnesium a long time ago had shown me. So I started taking Zinc. Within days of taking 100 mg zinc picolinate, my skin and acne started to heal. I continued taking this amount for probably one or two months if I remember correctly, before lowering the dose to 50 mg per day and then 22 mg sometime after that. Anyway, I just wanted to share this in case someone else experiences it. I have heard of many raw foodists/vegans having issues with these two minerals and even some people on CR showing signs of mild zinc deficiency. I'm a lot more careful again now about ensuring I get what my body needs by more closely tracking nutrient intake, staying on top of supplementing where necessary. I couldn't understand that despite my super healthy lifestyle I was having these issues, especially with acne! Something that my diet had completely stopped many years ago. And with regards to getting sick a lot, I put that down to just having 7 nieces and nephews always running around here and bringing germs back lol.
  22. Matt

    Fernando Gabriel current diet

    Fernando, you really should get advice from your DOCTOR and follow it. We don't advocate starving yourself and going to these extremes. This forum is NOT about weight loss and trying to get as skinny as possible.
  23. Matt

    Fernando Gabriel current diet

    Forget what Zeta said. You should not be doing CR.
  24. Fernando, I don't think CR is for you at all. Get yourself to a healthy normal weight and don't obsess over calories.
  25. Matt

    Starting my CR journey (yet again)

    Maintaining a higher level of fat mass is actually a positive predictor of longevity within the CR group in animals. Strains of mice that had not adapted well to CR and lost too much fat had no longevity benefit or reduced lifespan. https://www.ncbi.nlm.nih.gov/pubmed/21388497 Ideally, you'll want to restrict calories enough so that you're not losing more than 1 pound per week. Don't think of this as a race to get to the lowest weight possible, but a journey that you'll go along where your health will be improved by the dietary changes you make in addition to the (slow) weight loss from CR. So, my advice is just to look at how many calories you're currently consuming and factor in your activity level and then start restricting slowly and see how your body responds. As I mentioned on here before, when I first started serious CR I could only just maintain a BMI of about 16 eating 1550 K/cal per day. Now at 35 I am able to maintain a BMI of close to 19 eating around 1500-1600 Calories per day. My body is remarkably resistant to losing weight these days... Look at biomarkers as you're doing CR and as long as you see the same pattern as people on CR, you're going in the right direction. CR is not about getting skinny. CR is not about trying to maintain the lowest amount of muscle or fat to survive. You do need a baseline of how many calories you're eating and keep track fairly often of how much you're eating in the early stages at the very least.
×