BrianMDelaney

I've seen the gallstone risk mentioned by no one by Longo. It makes some theoretical sense, but I don't know whether there's any evidence for it.

Hey everyone, I posted the following at the CRON-o-Meter forum [1] as a desired feature, but I thought I'd post it here in case anyone has creative work-arounds. 1. People who travel around the globe a lot from west to east may want to be able to add leap days when they cross the Date Line (or subtract them, if going east to west). I've had this problem several times now. 2. People who experiment with non-24-hour-day eating cycles may want to add or subtract days from a calendar month. Obscure needs, I know. But it would be cool to be able to add or subtract extra days from a calendar month. There are other solutions, of course, such as ignoring the need to have one's current day be the calendar day. But that seems like a pain. Does anyone have any creative work-arounds? Are there other nutrition analysis programs that allow for the addition or subtraction of days from a calendar month? Brian [1] https://forums.cronometer.com/discussion/1776/adding-leap-days/p1?new=1

Hey gang, Mark Mattson claimed, at the Longo conference, that "all" the CR studies in rodents are really time-restricted eating studies, since the CR'd rodents are fed one time every 24 hours, and eat all the food given to them quickly. I'm virtually certain that there are a couple studies showing CR via two or three meals throughout the day had health benefits, but my PubMed searches are drawing blanks. Can anyone locate one of these studies? Thanks, Brian

I'm at Longo's conference, which starts today. http://gero.usc.edu/fasting-conference/ Anyone in our group also attending? 1. I'll of course report on any significant findings. 2. Please fire off any questions you'd like me to get answers to. Brian

Mech., did you go? Any cool insights you could share?

McCoy, great idea about getting the complete list of ingredients. Has someone here purchased Prolon and can tell us? Thanks, Brian

Mccoy, thanks for the great discussion. Just noting that I agree with Mike's concern above. I also want to submit that many people digest nuts badly (partly because they may be chewing them too little). This means that the amount of protein in dietary anal. software might, in effect, read low, for people, like me, who get most of their protein from nuts. I've upped my protein to 1.4 g / kg body weight based on my IGF-1 levels. I'm assuming a lot of my nut protein protein ends up in the toilet. My goal is to have IFG-1 levels in the 20th or so percentile. Brian

Hi everyone, Many people have been asking, both here and elsewhere, about the safety and efficacy of various time-restricted eating schemes. This is of particular interest to me since, for reasons that are irrelevant to most here (an unusual constellation of health challenges), I have been finding conventional CR (=the same, low energy intake per day) unworkable. Before I continue, I should emphasize that the best bet for health and longevity, based on the science we have (which is limited), is indeed conventional CR. But for those who want to try time-restricted eating, I'm wondering about the relative merits of two approaches, and I'd appreciate feedback. I've been thinking this through mostly on my own, and find myself unable to reach a conclusion. Experimental evidence is so limited, I think it's more helpful to reflect a bit on mechanisms, or even evolution. (More helpful doesn't mean very helpful, though....) Type 1: Longo/FMD. The evidence for benefit in both lab animals and humans is limited, but is at least somewhat compelling. It seems unlikely that there's any antiaging benefit per se, beyond that which would have obtained with the same overall ("longish-period averaged") reduction in calories. Type 2: "Inverted FMD". If the Longo approach involves having non-CR signaling patterns (high mTOR, IGF1, insulin, etc.) be the norm, with a sudden several-day period of CR signaling patterns being the exception, "inverted FMD" would be CR, perhaps somewhat mild, as the norm, with a several-day, or week-long period of "feast" signaling. (Credit where credit is due: James Clement is the one who suggested this pattern of eating as possibly better than the Longo pattern.) Type 1 vs. Type 2. Type 2 seems to me to be more like the pattern of eating under which we evolved – scarcity as the norm, with the occasional feast when the tribe came upon a bunch of food – but that doesn't say much about its benefits, though it might suggest that the body would be more adapted to it. Hm.... what we really need is more science on this. Does anyone here know Longo? I've emailed him a couple times and not gotten a response. A small trial comparing the two approaches could be helpful (though only slightly of course, since the main interest of many here is effect on mortality, for which we still don't have great biomarkers). Brian

Michael, Agree that Oisín Biotechnologies' approach is extremely promising (and well-done, SENS and Meth. Foundation, for helping to fund them!). For now, I'm impatient enough that I'm going to start trying some of the Rescue Elders protocols even though the evidence for efficacy and safety isn't immense. D+q seems most promising to me (cheap, likely safe, probably at least a bit helpful). Off-target effects are a concern, of course, but loss of some stem cells, and indeed any other cell type, can probably be remedied/offset within 10-15 years, with the exception of neocortical neuron loss, of course, which is the trickiest age-reversal problem we face. But I doubt d or q would knock out neocortical neurons, but of course we don't know.... I'm glad you at least have some oversight ... To the blumpkin over Ma Kardashian, there is no oversight involved in any of the group buys (aside from the obvious "oversight" of quality control: all the people involved agree about the need for careful assays of whatever we purchase (whether or not it comes from China...). Perhaps you just mean I'll be guided, in the case of d+q, by results of the small trials we're doing using diff. dosing protocols. Yes, I will be. Brian

Wow, wonderful! Things are slower over here. Just made a few phone calls. Harvest hasn't happened yet, but it will soon. Online stores should have them by the end of Oct.

Not sure what UBX0101 can do that navitoclax or dasatinib+quercetin can't do. Lots of people are already doing group buys on those at Longecity and elsewhere. I'm waiting a few weeks, but then I'll be trying d+q, to start. My strategy will be to target all the SCAPs (Senescent Cell Anti-apoptotic Pathways) possible, as long as there's reasonable rodent safety data. I wouldn't recommend this for others, of course. Waiting for human data would be the cautious approach. (TTBOMK? To The Blumpkin Over Ma Kardashian?) Brian

It's actually in the clinic now, in a loose sense: "in the clinic" means, of course, very small, "phase 0" human trials are underway. We'll have results in a matter of weeks, I'm pretty sure. (I'm not in a position to give more details yet.) Exciting times! Brian

Hi everyone, Has anyone checked with nuts.com or any other of our favorite nut sources to find out when nuts from the northern hemisphere fall harvest will be available? (Varies by nut of course.) I can report that David at Sun Organic Farm says they'll have the 2017 harvest almonds by the end of this coming week. Haag Farm has "wet walnuts" available now. Normal, shelled, dried walnuts are probably a few weeks away. Hazelnuts tend to be quite a bit later, right? Thanks, Brian

Thanks, file received! I'd still like to know whether there's a way to save a whole thread in one stroke. There's probably a back-end way to do it, but grabbing data from a database, by that would require asking an admin every time one wanted to get a copy of a thread. (Note: I can never receive personal msgs. The message-loading circular thing keeps spinning, and the msgs. never load.) Brian

Saul, will do. Meanwhile, you, or anyone who might be interested can sign up for whatever studies you want, here: http://www.rescueelders.org/ Click on "Studies" at the top. Brian