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  1. I have read that there is a trade off when it comes to growth hormone and IGF-1 & Longevity . Growth hormone and IGF-1 enhance muscle and cognitive performance but this comes at a cost: longevity. Reduced growth hormone and IGF-1 increase lifespan by increasing the expression of genes involved in stress resistance but at an expensive cost when it comes to muscles and brain. What good is it to live longer if the price is muscular frailty & decreased cognition? How do CR members arrive at a compromise.