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Golden Seven

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  1. Greetings, I recently found out via 23 and Me that I have two copies of the ApoE4 gene, which makes my risk for developing Alzheimer's disease much, much higher than average. I'm 50, male, and, fortunately, I think, I've been on a mildish version of CRON for 15 years. Do any of you know if there are studies looking at ApoE4 status and CRON, either in mouse models, or in humans? From what I know about CRON it's a reasonable guess that I should be somewhat protected against Alzheimer's, but I've been looking closely at some studies from Australia showing that people with TWO copies of the ApoE4 might not benefit from many of the things that benefit others, not moderate drinking, not even exercise (but the research is limited). Having two copies of ApoE4 is a very strange condition (though not extremely rare: 1.7 % of the population has it). Anyway, I'm thinking about going on a more severe version of CRON (gradually, and carefully). But I'm just wondering whether the research supports it. See, for example: http://www.brainhealthhacks.com/2011/02/16/alzheimer%E2%80%99s-disease-omega-3-and-exercise-the-complexity-of-treatment/ which suggests fish oil might help, but quotes a researcher saying exercise might actually be BAD! Thanks, Golden
  2. Golden Seven

    CR for those with two ApoE4 alleles?

    Thank you so much for the detailed replies! Great reading. I'm a little over my head here, but I'm starting to think more severe CR is probably a very good idea for me (and for most people!). I read the article about Sirt1 and Alzheimer's (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911635/). Doesn't resveratrol upregulate Sirt1? Might that be a good thing to try for people genetically predisposed towards Alzheimher's? Thanks again for the interesting ideas, Golden