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  1. Sthira

    Biosphere 3

    Has anyone here been to Biosphere 2? I haven’t, but In briefly reading some of its history, the entire project seems a little heartbreaking. (Is that the right word?) ...So much seemingly lost potential in so many areas of basic planetary and human health related inquiry.... Several books exist about the project, can anyone (who has actually read one) recommend one? I wonder what happened to all of the Biosphere 2 crew members (other than just Allen and Walford)? Would initiating a new, Biosphere 3 project help the human longevity movement in any way you imagine? I smell an Elon Musk-like odor of wealthy interest...
  2. “...The biggest mistake professionally successful people make is attempting to sustain peak accomplishment indefinitely. “How can I overcome this tendency? The Buddha recommends, of all things, corpse meditation: Many Theravada Buddhist monasteries in Thailand and Sri Lanka display photos of corpses in various states of decomposition for the monks to contemplate. “This body, too,” students are taught to say about their own body, “such is its nature, such is its future, such is its unavoidable fate.” At first this seems morbid. But its logic is grounded in psychological principles—and it’s not an exclusively Eastern idea. “To begin depriving death of its greatest advantage over us,” Michel de Montaigne wrote in the 16th century, “let us deprive death of its strangeness, let us frequent it, let us get used to it; let us have nothing more often in mind than death.” Yoga practice ends in savasana, the corpse pose. Savasana (to lay there, be still, relax) is called the most difficult yoga pose. We practice dying individually and collectively; savasana ultimately signifies the death of the universe.
  3. Sthira

    Olive oil? Healthy or not?!

    Nice reminder. I'm digging this from Amphora: https://amphoranueva.com/store/index.php?p=product&id=213 Chilean Coratina "Harvest Date: May 2018 Biophenols: 645 FFA: .19 Perox: 6.3 Oleic: 79.5 A wonderfully fruity Chilean Oil! This Coratina has classic notes of green banana and apple peel. Viscous with a jolt of pungency on the back end. An excellent choice for folks looking for a high phenol oil with a kick!"
  4. Sthira

    Drowning in kombucha

    Happy Spring, scrawny people! I'm on 15-17% CR again for the past six months, including water-only fasting stints, and I'm wondering about your take on nutrition in commercial brands of Kombucha, e.g., GT's? I've even done some kombucha fasts, oddly enough, wherein I drink only water or kombucha and don't consume anything else. When refeeding, I'm drinking hideous amounts of it, like 36-64 oz per day, and is it healthy, kombucha from the store, or should I begin the weaning process? GT's kombucha seems to round off some vitamin and nutrient deficiencies as seen in my cronometer dailies, I like it, it's delicious, it's expensive, it's habit-forming.. is it also junk food?
  5. Sthira

    How to Avoid Bonking?

    When offered the luxury, I let myself bonk for as long as I feel like it. What's my hurry? I think there's also an adjustment period we need to give our bodies when changing habits, especially if abruptly. Like I do -- sudden change is a kind of stress and the body, poor thing, it's just a mammal and it needs a moment to do whatever it needs to do. I guess the problem is when you need to rest and you cannot rest because of, well, all of ... That. I get enormous energy from fasting now, but it can be inconsistent. Ups and downs might be sharper. Way up I go with loads of sunshine for everything; then way down into sleep for maybe longer than socially acceptable.
  6. Sthira

    CRON without counting calories?

    Maybe yes maybe no: doesn't blood pressure fluctuate all the time? I guess we're looking for trends. Proud advice I took from others is that CR is a practice and not a perfect. Sounds tipsy in words maybe to say it like that, like wandering along a cliff, but I'm a perfectionist by nature so I'm easily upset when I'm not humming along at peak heights of new skill attained instantly, effortlessly. Something like that. Then I'm hard on myself when I realize oh shit I'm not living up to my tightrope-crossing standards and death is below without a net. Stress. If you're eyeballing, and you're not perfectly weighing your food down to the bitter gram with a calibrated, scale of hideous perfection, then don't beat yourself up (sorry cliche alert code red). The fact that you're trying this thing, CR or ON or whatever, the fact that you're conscious and noticing and caring enough to document is a step into canyons of many steps (sorry, I'm full of "traveling canyons east to west" cliches). Also that you weight has dropped, you notice, you care, you care enough to wonder am I practicing CR or not, and is it working to do .... whatever .... is pretty cool. At least it is here, anyway, quiet virtual corner it's become. Do Good Habits!
  7. Sthira

    The Call of the Wild

    Out of all of your great posts, Dean, I think this one is inside my top two or three favorites. Thank you.
  8. Sthira

    Purportedly Xenohormetic Phytochemicals

    How do we vegans feel about consuming mushrooms? I admit I love them ferociously, I eat them and eat them, I steam them, steam them up with guilt and olive oil, I mean, kingdom fungi are more closely related to kingdom animalia than they are to plants. ..... I wander around after the rains gathering wild mushrooms in the mist; few city folk here dare to chance it, or even notice they exist. If anyone around my ridiculous circus of a life notices I'm gathering mushrooms from the abandoned fields and busy street sides, they might say: "Aren't you AFRAID of DEATHCAPS" I'm like, nope. Do mushrooms have moms and faces and feel pain? Are mushrooms on no-no lists, dear vegans, or am I awful?
  9. Thanks for that link!! I was looking for a clear definition, i.e. "a person is CR'd iff..." You're not going to get one . Go be a lab mouse . Sorry: that's just the best we can do. Happily, you seem to have quite correctly understood the issue. I've also just pinned a FAQ post: How Many Calories Should I Eat? What's My Goal Weight? What's My Setpoint? What "%CR" Am I?. So, no one will ever ask this question ever again :) . Sorry, but I'm asking a question ever again. In that helpful pinned FAQ, we aren't allowed to post follow ups, nor quote the original text, so I'll ask here. Michael writes in FAQ: "People starting CR would very much like to have definitive, hard-and-fast answers to these questions, and unfortunately, there just isn't any way to give one in free-living humans! No one can tell you the exact point at which you're "on CR" or what "%CR" you are. These are guidelines and principles for entering the "CR continuum."" Check. Understood. Guidelines and principles. Michael writes: "If you are lucky enough to have had a clear, healthy 'setpoint' in your youth — a weight to which you tended to gravitate when you were in your early twenties, and that was within the healthy BMI range — take that as your baseline, and restrict Calories down to a level that keeps you at least 15% below that." Check. In my early twenties I was within the healthy BMI range, and my current BMI fluctuates between 10% and 20% below that. That would seem to indicate CR. But I've always been an ectomorph, says my mom, even when you were a baby, she says, you looked like a spider monkey. All arms and legs. But even now, below weight from the early twenties, I'm not sure if I'm on CR or not. Not for reasons of sickness or overexercise, I'm indeed cutting calories. Michael writes: "Wherever you start from, you need to cut Calories. Ultimately, the goal is to keep Calories lower than your physiology 'thinks' it needs, and a level of Calorie intake that only normalizes an overweight body will simply return you to the historical norm for our species, not induce the anti-aging metabolic shift that characterizes CR." For background before my question: I've been more or less honestly measuring, weighing, and entering my daily diet into COM since 2010, so I'm going on nearly eight years of focused documentation. Recording what I eat and what I do not eat (e.g., "fasting" is programmed to record into COM as "zero" calories) has become a habit. So, tallying up "Trends" in COM, clicking on "Report" for "All Time" (in an iPhone app) the zero calorie days from fasting add up to bring down the totals. My all time food intake for the past nearly eight years is "1,806 kcal consumed" versus "2,040 kcal burned" or, roughly, I'm maybe around 10% CRed, which seems about right, at least if I go by body weight from early twenties to now. My question is probably unanswerable, but who better to ask than Michael, and I'm probably not even looking for a definitive answer, just guidelines and principles, remember, but I don't think I've seen this question asked before. I'm not practicing daily cutting of calories below my BMR, which is 2040 kcal. But I'm fasting -- longer fasts (8-10 days), medium fasts (5-8 days), short fasts (1-3 days), and all of that while also "intermittent fasting" (doing one meal per day, allowing 20-hours to elapse between refeedings). Yet when I refeed from fasts, I tend to go over my BMR. I don't "gorge" but I do tend to eat around 2,500 to 3,000 kcal for a few days, more like "controlled feasting" and I'm following the "optimal nutrition" part of the equation, if that matters, eating only plants, following a Mediterranean thing, and so most of my extra calories derive from olive oil, legumes, nuts, and seeds. Recently I've started eating sardines again, too, so I've transitioned for now away from my strict vegan and vegetarian past. No dairy or meat, though, but sometimes I eat a few cans of sardines. The question is -- if I'm not practicing CR during refeeding after fasts, but sometimes going over my daily calorie requirements, am I still practicing CR? The zero calorie days bring down the overall calorie intake -- even when I'm not practicing daily CR. Can CR be spaced out in time like this, or "should" it be daily CR practiced with daily consistency over long periods of time? Sorry to be so long winded.., Like I said, there probably isn't any answer in humans to this, but I'm throwing it out there anyway, to fellow humans, while we all wait for something better to emerge from clinical trials that aims to repair the damages caused by aging, rather than this "messing-with-metabolism" CR project that we're practicing. For me, fasting seems easier long term than daily CR because although I'm doing my best to measure, weigh, and document everything I eat, I assume I'm still getting numbers wrong. Food values aren't consistent. When I fast, I know for sure that I'm cutting calories to zero. When I eat, I'm only guessing.
  10. Hmm, I realize this is a thread about intermittent fasting, which I practice, so I apologize for the swing out. Me, I've no problem with the natural flows of conversation in online discussions, especially in dead zones like this one. Have you considered a Reddit AMA, Michael, you seem to know about AI's future impact on human aging, and it might be fun in a livelier setting? Meanwhile: In eight decades of completed work in animal studies (deep bow to the animals), what changes in which parameters are relevant to aging humans? Changes consistently seen for a given intervention between mouse and human are consistent with the intervention's translatability; those that aren't weigh against it. Animal studies obviously have been of historical use in medicine, as I noted above. So the suggestion isn't that we ditch all prior work or quit paying attention to current animal studies as foundational and practical contributions. Rather, the suggestion is that humans will keep looking for different ways to reduce suffering and improve life. Animal models have taken us to a point, and soon they'll drop off and become even more irrelevant than they already are, like your horse and buggy analogies in the Dr. de Grey book. AI will be medically useful during our lifetimes because it already is; dismissing it isn't what you're asserting. Nevertheless, about animal model translatability, you write: Because it is all we've got. It's not all we've got. Robotic surgeons, for example, are here and they're not going away. I must be misunderstanding you. First, it's false. That's interesting good news. I certainly don't see AI potentiality in dark and threatening movie tones -- eek, violent sci-fi films, I hate them. I'm excited about possibilities for AI's potential use in helping to solve not only human suffering and damage repair, but also in wider issues like ecosystem degradation, species extinction, alternative energy solutions, global climate change reversals, extraterrestrial travel... From the Snopes article you linked, this: "...We are in infant stages now, but I think we will subsume AI and make it part of ourselves; better to control it. Implanting neural nets, within our brains that are connected to it, etc. Now that raises all kinds of as yet unseen “have and have not” issues. But that’s another subject for another time." Gibberish isn't helpful, that's why the chatbotting gibberish was halted. AI won't stay stuck in place. The things must crawl before they walk, though, and before their usefulness to us unfurls. And they're already here anyway. I see absolutely no way for AI to tell us how to intervene in aging in a way that would preëpt animal testing. If you ask the AI of Oz how to retard aging in humans and it replies "take 1500 mg of extract of untested plant X and microdose cyanide daily," is any sensible person going to take it without first testing it in rodents? And where is the AI going to get its data, if not from rodent studies? Then you're not looking carefully enough. Are these opinions a general SENS position? No way, right? I mean, do SENS researchers see absolutely no way for future advances in AI to assist us in how to intervene in human aging? Of course preemptions of animal models won't occur until more intelligent models develop and mature. For example, eventually Google will map out every metabolic activity that occurs within your body. Probably static at first. Like an internal Google maps, they're already working on this part. Then progress will lead to dynamics, live, as in your own personal chemical reactions that are occurring within your own body right now, we see them now. It's hard for me to imagine that this isn't one of Calico's aims. Baby steps first, though, and they ain't talking publicly because why should they? Fruit ain't ripe. SENS ain't talking to us much, either, are y'all? AI helps with healthcare because we can feed into it data from clinical trials and healthcare registries for various clinical outcomes. This is already useful, and will become more so as more and more electronic medical record data becomes mineable. That will improve cancer care and other kinds of ordinary medicine, but it doesn't help us with aging, because we have no equivalent data for aging — except in rodents, and translational studies built up from rodents. Sure, we feed these things data from clinical trials and healthcare registries until they can think for themselves. They'll be doing that, thinking independey, and hopefully into the directions we steer them, as your Snopes link suggests. One direction we may steer AI is into the repair of aging-damaged human bodies. We'll do this because we must do this -- the trillions in healthcare costs from these aging damaged baby boomers will spur faster progress.
  11. In eight decades of completed work in animal studies (deep bow to the animals), what changes in which parameters are relevant to aging humans? If few, then why, as Tom may be suggesting, continue with this model? Facebook shut down an artificial intelligence engine after developers discovered that the AI had created its own unique language that humans can’t understand. So if that's true, doors to AI models may open to supplement or supersede animal models. So, do any SENS-funded projects plan to advance or incorporate AI models? Might they in future? Given Dr. de Grey's background, ya'd think it'd be obvious, but... If so or if not, Calico seems like a promise for a progressive model, no? Perhaps you don't think so, or perhaps I'm misunderstanding this bit of darkness: I doubt many people here fail to recognize and pay tribute to the countless animals of many species who've contributed their suffering and their lives to advance human health (mice for penicillin; guinea pigs for TB; the eyes of monkeys, cats and rabbits for macular degeneration; frogs for asthma; rabbits for meningitis; dogs and pigs for kidney transplants; insulin in dogs...) But clearly there's a better way forward for both humans and wildlife, and artificial intelligence seems less cruel and perhaps more relevant. The Wizard of Oz: "Child, you're talking to a man who's laughed in the face of death, sneered at doom, and chuckled at catastrophe..." Certainly, we should face the truth about our existential situation. Now, having accepted your existential situation: what are you going to do about it? If you aren't prepared to accept that we'll all grow old and withered and sad just like our ancestors (and, for that matter, our peers), you use the best data you've got — and that's largely the eight decades of work that's been done in rodents, and the additional rodent studies that are going to keep coming down the pipes from now until we each reach Escape Velocity or the grave.Additional rodent studies? That's it? Are not AI advances in algorithms and software currently improving the quality and availability of healthcare services? Won't these continue, lol? Unless we're all drowned in filth by climate disruptions, there's little reason for that model to not replace the animal model in human medicine. Where is SENS in the AI jam? Oh, and why not citizen science amongst us science literate CR ppl to investigate "intermittent fasting?" Which parameters relevant to aging humans did we learn from eight decades of animal data? Let's use those while we muggles await Hogwarts interventions.
  12. Citizen science for human health as it relates to eating, e.g., intermittent fasting. Let's do it: https://www.zooniverse.org/projects?discipline=medicine&page=1&status=live
  13. Screw human lifespan studies; obviously they're past us. And leave alone the near-extinction non-hominoid simians and great ape brothers and sisters -- god knows we've fucked them to near oblivion anyway. Give them habitats and peace and quiet. Artificial intelligence models for human lifespan extension (like weather prediction models, idk) might be part of "a solution": you add one plus one equals two, and calculate this must be Calico's thinking? Oh The Great Oz. Or, citizen science amongst fellow geeky tinkerers. Let's do it! Meanwhile, I've toned down my own over-fasting, toned it down to one five day fast per two months, that is, and I only eat one meal per day, from 2pm to 5pm (god knows why) so I let 21 hours elapse (like numerology) between refeedings (who the hell knows if this is beneficial n1 human behavior... but it's fun and interesting and I'm aging right on schedule with everyone else around).
  14. I don't think Tom's being unreasonable, and tend to agree with him here. No, evidently "we" can't perform birth to death human lifespan studies; but we can pursue scientifically creative short term, controlled "intermittent fasting" (defined) experiments amongst honest, reasonable people who are seeking health and life extension hints. Any one of us (especially y'all retired ex-engineer types) could "easily" thunk up us some citizen science. But evidently writers here and writers there prefer waiting around for government- and academia-supported projects (projects chiefly designed for publishing success stories and bolstering personal reputations and incomes, hence "mice and other model organisms is [sic] what we've got...") If we were interested (dreaming now is sthira, oh look, y'all stand back, like dreamtime drum circle fantasies, too far out) then we could devise citizen science projects amongst like-minded, honest people. We don't. So face truth instead -- we're really lazy if honestly look within, obviously myself included, and so as a deadly consequence we'll all grow old and withered and sad just like our ancestors. Anyway, keep on beating that funding drum and we'll sit on our asses and await The Great Oz (I just rewatched Wizard of Oz, haha, and it reminds me of rodent studies and all that mainstream sciency stuff...)
  15. Sthira


    Given that he, Aaron, is presumably pleased about "$40,000/mo in revenue" (https://www.indiehackers.com/businesses/cronometer) wouldn't it be polite if he updated Cronometer? An update could offer helpful RDA rounding suggestions, like, say I enter in today's food (avocado toast, broccoli hunks, whatever) and then the program helpfully suggested specific food items to meet today's RDA? Tell us, updated Cronometer, that we need 16 goji berries today in order to achieve lev. Confession: I bought the premium version last year, go the gold, etc, and so this year I was like, uh, why, what for, it's not improving, is it, it's not changing, it looks like auto pilot gold $40,000 a month with no upgrades, and plus, I don't even notice much fun between the paid version and the unpaid version (not on an iPhone anyway -- are laptop versions better?) Aaron's probably happy with money, he's hopefully floating in the warm waters of Svalbard -- but many of us are poor skinny whining schlubs still obsessing over grams of adzuki -- so upgrade your golden goose, fine fellow, we politely suggest now. Let's send him paper letters written in ink, drop these sealed with spit and stamps into blue-not-rusting mailboxes. Old fashioned Cronometer, staid but classic, I still use it like I still listen to the Grateful Dead, and it's also mildly popular in public (try suggesting Cronometer to someone seeking truth-in-their-daily-diet, and they're like, did it, tried it, gave up on it cos it's dull). Hey Cronometer: ?