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  1. Is there a thread here for that? Meaning one of anguish? Ok, maybe this. Just wondering if anyone here feels like blubbering and moaning about that sad sack of world shit that is the anti-aging movement. I mean, like a bowel movement, is anyone here still disappointed that your sagging face skin is still melting down your neck, or will be soon, and your tired eyes, you’re getting uglier, you’ll be drooling onto your walker rails soon, right, just like gramps, nothing against him, of course, poor thing, aged to death right on time just like we are, with all those loud science promises, pro-misses, all those poor sad sticky bone joints, oh you can’t jump high anymore, too bad, oh you can’t leap happily now without pain, too bad, oh you can’t run hard and with abandonment anymore because well — eNtRoPy and whatever happened to your pretty face, anyway, and your shy beautiful smile, you were so harmless and cute, so young with your easy grace, that smooth hopeful glide to your step — easy now you look like fucking Aunt Ruthless now today, aging right on schedule, we called her Aunt Ruthless, like ruthless about hope, ruthless about lost joy, ruthless about nothing science, oh, I don’t know, hopeful about anything, Aunt Ruthless, anything, are you hopeful about anything at all in the anti-aging department of science? Name something. One little thing. One glimmer even. With me here? I mean, after skimming or half-reading or outright ignoring and deleting in anguish and frustration (and sometimes: Hatred) literally thousands of Al Pater’s emailed scientific studies about calorie restriction or rodents or fucking c. Elegans or more promising Petri dish studies ... I mean, they’re so foundational! And Game-changing! More studies required! Right, all these more studies studies required are done, who gives a flip about vitamin k or should I eat more guava or less okra or is it all too sugary, and is tofu eating my brain, it’s been decades, people, listen — all ten of you — Are any of you ten disappointed that you’re still growing old and literally nothing has happened in science to change that? Your SENS donations went where? To whom? Why? How many more “foundational companies” shall be formed to study, what, go into ... to ... what? Zzzz ... what was it anyone was trying to accomplish? Human lifespan extension? To relieve one iota of human suffering? These questions are just rhetorical, no need to refute my words line by line on this — I say just hi in this space to rant Rant pointlessly about what a shit bag of nothing we were all sold by this stupid “longevity” movement, or whatever it was, empty promises, promises now, stuck, I’m sure, in let-us-now-conquer COVID-19 for the next sixteen decades ... yeah I just hate that it’s been more than a decade and my knee is still off forever from that one bad landing lolz and we were promised rejuvenation or regeneration, or what was it again? literally they’re still working on sheep cartilage in sheep knees ... for the past, what, decade, two decades
  2. Might be helpful to revisit Camus’ The Plague. Covid seems a good example of Camus’ idea that life is pretty much absurd. We find little justice regarding who gets to live and who must die from this virus. No meaning is to be derived. Wishful thinking doesn’t help, miracle cures won’t work and real cures — slow-paced science — aren’t anywhere near us. Life is fleeting, fragile — lives are ephemeral. Nothing saves us — not wealth, not dreams of lifespan extension, education can’t shield us from mindlessly stupid microscopic pathogens. Yet we forget this, don’t we? We’re surprised to discover we’re vulnerable, too, that our healthy lifestyles, our calorie restriction, our devoted exercise, all our careful attention to micronutrients and obscure little anti-oxidant rich berries or whatever — none of it provides sufficient immunity. Are we surprised? So what are we supposed to do, Camus asks of us. Care, he says. Care about each other, help one another in the face of blind absurdity. The novel’s hero, Dr. Rieux, accepts the stupidity of all this useless suffering, death, and meaninglessness. Yet he battles on, pointlessly, with courage and heroism. Camus’ Dr. Rieux, does he remind me of Dr. Fauci? Dr. Rieux treats his patients only because he sympathizes with their undeserved plight. Our own shared undeserved plight. All of us have this plague, we live in it, we will get it no matter how much we wash hands and wear masks, gloves, no matter how much social distancing we practice, in the end it gets us. If not this plague then the next. Or death. We don’t deserve it, but it doesn’t matter, and little about these lives we live make much sense. What we may do, though, is give a damn about each other during the time we have remaining.
  3. Sthira

    Trying to find ways to eat more turmeric

    Nice thing about wearing homemade tie dye is when I spill curry I can’t tell, it’s just part of the overall thing. This happened today
  4. ^ Because shanty towns don’t exist in Sweden
  5. bEcUz I nEeD mOaR guVmENt tO pRoTecT mUh MeAt
  6. Thank you, this was brilliant. And if this isn’t a call to humanity to stop eating animals including fish then I don’t know what is. But since people are too stupid and greedy to listen or change behavior, we’ll have to create a new military arm, like a Bio Force.
  7. Wait wait... Is anyone here actually on calorie restriction? If so, have you increased your food intake? I am CRed and have been eating more calories — more fruits, vegetables, legumes, nuts, seeds, olive oil — I’m in process of upping my BMI from 18 to ... If anyone else out there is on CR, what are you doing?
  8. Dean, I’m not real interested in arguing for the sake of it, as it appears you may be doing. The gist here is Fahy tried this protocol on himself, with the aim of regrowing his thymus. Evidently his success led him (during the course of many years and working within the confines of a severely limited budget) to try the protocol on some older males with atrophied thymuses. Here in this published work he’s showing limited success at in that preliminary venture. Go ahead and throw your shade, argue all you want on this backwater site; but my point, as clearly expressed above and ignored, is that this is the type of experimentation that’s gonna be necessary to in order to advance longevity science. Advancement will occur through the efforts of those actually trying things. Even if Dean on the CR Forum doesn’t like it. Since you appear so well-versed in regrowing involuted thymuses, perhaps you should send Fahy et al your advice and insights? I mean, they’ve devoted more than a decade to it, but maybe you know more.
  9. Longevity science has a history of being ignored, marginalized, underfunded, mocked by the real scientists doing the important science. s/ Should I be surprised, though, to see that tradition reflected in here of all places? Gentle reminder that you’re posting on a Calorie Restriction Society Forum. And CR or CRON or CRAN in the bodies of CRONnies or CRANnies or whoever you are is one big ole self-induced behavioral experiment in under-eating, while not-knowing much “science” about anything human at all: “FAQ How Many Calories Should I Eat? What's My Goal Weight? What's My Setpoint? What "%CR" Am I? “By Michael R, June 6, 2017 in CR Practice Setpoint “People starting CR would very much like to have definitive, hard-and-fast answers to these questions, and unfortunately, there just isn't any way to give one in free-living humans! No one can tell you the exact point at which you're "on CR" or what "%CR" you are. These are guidelines and principles for entering the "CR continuum." And we don’t even know if this continuum (and I’m on it, for sure, I’m experimenting with CR at 20% for years now...) we don’t know if this is a healthy program, an unhealthy program — we don’t know much. Will I live a longer, healthier life because I’m eating less? And we’ll never know because the conventional science you desire is just too limited. My point here in this stuffy old room is that it’s gonna take revolutionary people creating new windows — taking risks, stepping outside boundaries, doing work that will be sidelined and mocked by the establishment for more years. Advances in longevity science are gonna require best-effort attempts that sometimes simply must be “...Relatively short-term, heterogeneous, multi-pronged intervention. Small test population. No control group. Post hoc analysis based on dubious surrogate endpoint...” because what else was Fahy supposed to do here? With limited funding and support? Should they have given up? Or just do the best they could have done within this harsh desert of limited funding? The only reason this study doesn’t meet the high standards you desire is due to lack of funding. Think Fahy didn’t want to create the best possible effort to regrow the involuted human thymus? He didn’t have the hundreds of millions required. You get what you pay for, and now you get less and so you throw stones. Did any of you contribute to this work? Or have you contributed to any budding, revolutionary human longevity science? I get it if you can’t because you’re poor. But if you’ve got it, did you donate something? Can you now support someone else attempting something revolutionary that still may not meet your exacting standards? Sure, throw shade on budding efforts — reminder that SENS is budding — mock it, disparage the people doing what’s necessary to try to help you. Part of tired out old tradition. And really — evidently claiming Fahy spent a decade of his life for clickbait or some speculative biotech stock gains — I mean, wow... You should be ashamed, frankly. We should invite Fahy for an AMA here. de Grey: “Public enthusiasm for new advances is a key ingredient in influencing policy-makers to stimulate follow-up work with suitable funding, and it can be achieved far faster now that interested non-specialists can explore new research autonomously and can also be appealed to directly by scientists.”
  10. Wow, I’m surprised at such breezy dismissals of an actual anti-aging study in real, live and healthy human beings. Isn’t this what we want? To slow, stop, reverse human aging? Shouldn’t any paper that states “....we conducted what may be the first human clinical trial designed to reverse aspects of human aging...” capture your attention and admiration? Your imagination should be stimulated for what good things may be ahead in this young field (that’s obviously so egregiously underfunded and under supported). The recombinant human growth hormone (rhGH) Fahy used in this work was targeted “to prevent or reverse signs of immunosenescence in a population of 51‐ to 65‐year‐old healthy men.” From the paper: “Because GH‐induced hyperinsulinemia (Marcus et al., 1990) is undesirable and might affect thymic regeneration and immunological reconstitution, we combined rhGH with both dehydroepiandrosterone (DHEA) and metformin in an attempt to limit the “diabetogenic” effect of GH (Fahy, 2003, 2010; Weiss, Villareal, Fontana, Han, & Holloszy, 2011). DHEA has many effects, in both men and women, that oppose deleterious effects of normal aging (Cappola et al., 2009; Forti et al., 2012; Shufelt et al., 2010; Weiss et al., 2011). Metformin is a powerful calorie restriction mimetic in aging mice (Dhahbi, Mote, Fahy, & Spindler, 2005) and has been proposed as a candidate for slowing aging in humans (Barzilai, Crandall, Kritchevsky, & Espeland, 2016). Neither DHEA (Riley, Fitzmaurice, & Regelson, 1990) nor metformin are known to have any thymotrophic effects of their own.” This is a wonderful study — albeit humble and hard-fought due to funding limitations — and of course it needs replication. But like WTF.... But why aren’t you excited?! This is an effort — a decade or so in the making — in which Fahy et al “...observed protective immunological changes, improved risk indices for many age‐related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 year of treatment (−2.5‐year change compared to no treatment at the end of the study)...” I feel like this is a moment you should be supportive of these baby steps, not dismissive. This very protocol may lead to actual effective human interventions that someday gonna save yo’ hide! And. It’s. Not. In. Genetically Altered Rodents! Hey there, happy: get happier.
  11. Sthira

    How I Get Exercise... (using vr)

    Boxing in VR like that would stress the shit out of me. But I really like the idea of VR as an educational tool. ““I’m calling for investments in educational technology that will help create. . . educational software that’s as compelling as the best video game. I want you guys to be stuck on a video game that’s teaching you something other than just blowing something up.” – Barack Obama More easily learning new languages looks useful and cool, and of course space travel — have you tried Mission: ISS? Or journeyed inside a human cell? http://thebodyvr.com/ ”The Body VR: Journey Inside a Cell is an award-winning educational virtual reality experience that takes the user inside a human cell. The experience allows you to travel through the bloodstream and discover how blood cells work to spread oxygen throughout the body. You then enter one of the billions of living cells inside our body and learn how the organelles work together to fight deadly viruses...” I like the looks of Sharecare... https://www.oculus.com/experiences/rift/1656800021020362/ Guess I’m probably going to have to get an Oculus Quest when I’ve enough time and money. Thanks for the reminder.
  12. Sthira

    Eat more jellyfish poop

    About 1:15 minutes into this slightly goofy interview, ( https://youtu.be/GL6dasaA9e0) Dr. Steven Gundry (The Plant Paradox) says: “We can actually extend our lifespan to things that people can’t even imagine. And it actually has to do not with you and me and what we conceive of as our bodies, but it turns out that 90% of all the cells that make you and me, me, are actually non-human cells. They’re bacteria, viruses, funguses, worms that live in us and on us. “And the shocking thing is that 99% of all the genes that make up you and me are non-human genes. They’re bacterial and viral genes. And what we’ve completely missed from the human genome project is that we have actually very few genes. And our genes are about 99% the same as a chimp or a gorilla. And we’re very different from chimps or gorillas. Yet we have virtually the same genes. What makes us different is actually the bacteria and viruses that live inside us. You can actually show when humans evolved from the other great apes, that our bacteria actually changed. We can actually identify that point in time, that the bacteria made us rather than our genes made us.” A moment later he says: “As shocking as it may seem most of what happens to us is determined by the state and the variation of the bacteria primarily in our gut. I’ll give you an example. You can take a bowel movement from an obese individual and feed it to a skinny rat. Skinny rats love to eat poo. Those skinny rats will become fat. Because the bacteria have actually manipulated their feeding habits. They actually send text messages to the brain to go look for foods that they would not otherwise consume that those bacteria want. We can actually, there was a cool study in ... a woman marathon runner in England a couple of years ago who developed very severe infection in her colon called c. Difficile... And the modern treatment for this is a fecal transplant, taking poop from somebody else and shoving it up your ass. And you try to get a fecal transplant from a family member because believe it or not family members tend to share their bacteria. I share a lot of bacteria with my dogs and they share with me. So they found a cousin for her and she got the fecal transplant, and everything went well, her c. Difficile went away, we go into why that happened. In the next year, this marathon runner gained 32 pounds without changing anything. And it turns out her niece, cousin, was actually about 32 pounds overweight. And so she was inoculated with obesogenic bacteria. And her bacteria, these little one celled organisms, controlled her behavior...” So why not drink pond koi poop? Or eat Geoducks? Geoducks live 160 years. We should shove their poop up our bums and obtain their longevity bacteria. If I surround myself with hundreds of pet Tuataras here in my apartment, if I share their eating patterns, their bacteria, their viruses and worms, will I live as long as the Tuatara? I could develop a taste for Lamellibrachia tube worms, their poop and bacteria. Some of you here have nice houses and big yards, even orchards and farms: adopt tortoises, and eat their poo. The oldest known specimens of arctic sponges are 1,550 years old. Sponge soup? Yum. I’ll post a recipe. Turritopsis nutricula jellyfish might be the only animal in the world to have discovered the fountain of youth. Since it’s capable of cycling from a mature adult stage to an immature polyp stage and back again, there may be no natural limit to its life span. Because they are able to bypass death, the number of individuals is spiking. “We are looking at a worldwide silent invasion (of Turritopsis nutricula jellyfish),”says Dr. Maria Miglietta of the Smithsonian Tropical Marine Institute. I have a solution. Eat them. Not only will humanity stop the silent invasion, but we’ll also live forever.
  13. Sthira

    Biosphere 3

    Has anyone here been to Biosphere 2? I haven’t, but In briefly reading some of its history, the entire project seems a little heartbreaking. (Is that the right word?) ...So much seemingly lost potential in so many areas of basic planetary and human health related inquiry.... Several books exist about the project, can anyone (who has actually read one) recommend one? I wonder what happened to all of the Biosphere 2 crew members (other than just Allen and Walford)? Would initiating a new, Biosphere 3 project help the human longevity movement in any way you imagine? I smell an Elon Musk-like odor of wealthy interest...
  14. “...The biggest mistake professionally successful people make is attempting to sustain peak accomplishment indefinitely. “How can I overcome this tendency? The Buddha recommends, of all things, corpse meditation: Many Theravada Buddhist monasteries in Thailand and Sri Lanka display photos of corpses in various states of decomposition for the monks to contemplate. “This body, too,” students are taught to say about their own body, “such is its nature, such is its future, such is its unavoidable fate.” At first this seems morbid. But its logic is grounded in psychological principles—and it’s not an exclusively Eastern idea. “To begin depriving death of its greatest advantage over us,” Michel de Montaigne wrote in the 16th century, “let us deprive death of its strangeness, let us frequent it, let us get used to it; let us have nothing more often in mind than death.” Yoga practice ends in savasana, the corpse pose. Savasana (to lay there, be still, relax) is called the most difficult yoga pose. We practice dying individually and collectively; savasana ultimately signifies the death of the universe.
  15. Sthira

    Olive oil? Healthy or not?!

    Nice reminder. I'm digging this from Amphora: https://amphoranueva.com/store/index.php?p=product&id=213 Chilean Coratina "Harvest Date: May 2018 Biophenols: 645 FFA: .19 Perox: 6.3 Oleic: 79.5 A wonderfully fruity Chilean Oil! This Coratina has classic notes of green banana and apple peel. Viscous with a jolt of pungency on the back end. An excellent choice for folks looking for a high phenol oil with a kick!"