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Dean Pomerleau

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About Dean Pomerleau

  • Birthday 11/12/1964

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  1. Dean Pomerleau

    Levine Phenotypic Age Spreadsheet

    Ron, So perhaps, like it does with testosterone, CR push MCV in a direction that is associated with negative health outcomes in the "normal" population. For example, perhaps elevated MCV is a early biomarker of certain cancers. But when elevated due to benign causes like CR or fasting, elevated MCV might not be predictive of bad outcomes - or at least one can hope. --Dean
  2. Dean Pomerleau

    Levine Phenotypic Age Spreadsheet

    Thanks Al. What seems strange is why, given the study you cite (in which higher MCV was associated with lower mortality, at least in men), the Levine Phenotypic Age equation suggests MCV is positively correlated with phenotypic age (i.e. higher MCV implies higher age). Perhaps the Levine approach to estimating age from biomarkers isn't as good as Ron suggests. And unfortunately, long lifespan is compatible with impaired cognitive performance, both of which may result from (or at least correlate with) elevated MCV. --Dean
  3. Dean Pomerleau

    Levine Phenotypic Age Spreadsheet

    Maybe... [1] ---- [1] J Am Geriatr Soc. 2013 Jan;61(1):84-9. doi: 10.1111/jgs.12066. Epub 2013 Jan 10. Relationship between mean corpuscular volume and cognitive performance in older adults. Gamaldo AA(1), Ferrucci L, Rifkind J, Longo DL, Zonderman AB. Author information: (1)Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224, USA. Alyssa.Gamaldo@nih.gov Comment in J Am Geriatr Soc. 2013 Jan;61(1):155-7. OBJECTIVES: To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time. DESIGN: Longitudinal. SETTING: Sample from the Baltimore Longitudinal Study of Aging (BLSA). PARTICIPANTS: Eight hundred twenty-seven participants from the BLSA (mean age 67, range 50-96). MEASUREMENTS: Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin, and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function, and global mental status. RESULTS: High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with high rates of decline on tasks of global mental status, long delay memory, and attention, even after adjusting for potential confounders. CONCLUSION: The findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. Anemia and inflammation do not appear to explain the relationship between MCV and cognition. Further research is needed to clarify the mechanisms behind this association. © 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society. DOI: 10.1111/jgs.12066 PMCID: PMC3555566 PMID: 23301873 [Indexed for MEDLINE]
  4. Dean Pomerleau

    Levine Phenotypic Age Spreadsheet

    I tried it. My phenotypic age was 10 years younger than my actual age (54 -> 44). My phenotypic age would have been a lot lower (~40) if my MCV wasn't elevated (105), which as far as I can tell is almost a universal side effect of CR. --Dean
  5. The backpack version (which is basically the same system as Todd and I bought but packaged slightly differently) has many more and more positive reviews. What I found was that (like the "meh" reviewer), the cooling effect of the circulating water was just ok until I dampened the tee shirt I was wearing underneath. With a damp shirt, the vest will keep the entire surface of my upper torso at a constant 55-58degF for several hours. I think the advantage of the circulating ice water system is that it will keep you consistently cooler for longer than the Techkewl vest. But that may not be enough of an advantage to make it worthwhile to spring for the new vest, especially if you are satisfied with the Techkewl performance. --Dean
  6. Dean Pomerleau

    Cholesterol paradox

    A new, large retrospective cohort study [1] (popular press article) found statin users were more than twice as likely to develop type-2 diabetes compared with people who had a similar risk profile for heart disease but didn't take statins. The diabetes risk increased to 3x for those who had been taking a statin for more than two years. Here is a graph of diabetes risk over time (days) between the two groups: One more thing to consider when contemplating statins for elevated serum cholesterol which is unresponsive to lifestyle interventions. At the very least it would seem statin users should monitor their blood glucose and take steps to reverse the trend if it starts to become elevated. --Dean ------------- [1] Diabetes Metab Res Rev. 2019 May 24:e3189. doi: 10.1002/dmrr.3189 Statin users have an elevated risk of dysglycemia and new-onset-diabetes. Zigmont VA(1), Shoben AB(2), Lu B(2), Kaye GL(3), Clinton SK(4), Harris RE(1), Olivo-Marston SE(1). OBJECTIVE: Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patterns. METHODS: A retrospective cohort study was conducted among individuals with indications for statin use (n = 7064). To examine elevated glycosylated hemoglobin (>6.0%), logistic regression with inverse probability weighting was used to create balance between incident statin users and nonusers. To evaluate the risk of NOD development, Cox PH models with time varying statin use compared NOD diagnoses among statin users and nonusers. RESULTS: A higher prevalence of elevated HbA1c (PD = 0.065; 95% CI: 0.002, 0.129, P = 0.045) occurred among nondiabetic incident users of statins. Additionally, statin users had a higher risk of developing NOD (AHR = 2.20; 95% CI: 1.35, 3.58, P = 0.002). Those taking statins for 2 years or longer (AHR = 3.33; 95% CI: 1.84, 6.01, P < 0.001) were at the greatest risk of developing NOD; no differences were observed by statin class or intensity of dose. CONCLUSION: As lifestyle programs like the Diabetes Prevention Program are promoted in primary care settings, we hope physicians will integrate and insurers support healthy lifestyle strategies as part of the optimal management of individuals at risk for both NOD and cardiovascular disease. The relationships between statin use and glycemic control should be evaluated in large cohort studies, medical record databases, and mechanistic investigations to inform clinical judgment and treatment. © 2019 John Wiley & Sons, Ltd. DOI: 10.1002/dmrr.3189 PMID: 31125480
  7. Todd S, Glad to hear you are having good luck with CompCooler vest. I continue to use mine for a couple hours each day and it is holding up very well. One thing I learned to do is to blow out any remaining water in the female couplers on the ice bag before putting it back in the freezer after a cooling session. Otherwise it freezes inside the coupler and makes it hard to attach next time. --Dean
  8. Dean Pomerleau

    TMAO & Cardiovascular Disease

    Then it seems unnecesssary to worry about it. That may be the case. But if there is little to no evidence you are choline deficient, and pretty reasonable evidence that extra dietary or supplementary choline may be deleterious (via TMAO), then do you really believe the best strategy to mitigate risk is striving to add more choline to your diet, particularly since heart disease is one of your primary personal concerns? --Dean
  9. Dean Pomerleau

    TMAO & Cardiovascular Disease

    Oversight. From the USDA table cited above, legumes on average appear to have on average around ~35mg choline / 100g, with soy beans and other soy products somewhat higher. --Dean
  10. Dean Pomerleau

    TMAO & Cardiovascular Disease

    Is there any good evidence that a whole food plant-only diet with sufficient calories can and does lead to choline deficiency? Based on Michael's crazy supplement regime, he seems to think some form of choline supplementation is necessary or at least prudent for vegans, but I see very little evidence to support this assertion. Per Jack Norris' reading of the literature (here) the DRI for choline was set based on a single study which found people developed signs of choline deficiency (i.e. markers of fatty liver / liver dysfunction) when placed on a diet for six weeks that had less than 50mg of choline per day. Their deficiency was corrected by a diet with ~500mg of daily choline, so they set the DRI at ~500mg. But that begs the question of how much choline is actually needed to avoid deficiency. In fact, one very small study (n=4) Jack cites showed that 138mg/day in 70kg men reversed their markers of choline deficiency in only 10 days. So the true daily requirement may be much less than 500mg. I've been eating a healthy vegan diet without any choline supplementation for 15 years and my liver shows no sign of fattiness, and my liver enzymes (ALT/AST) are well within the normal range. The 2008 USDA update to their nutrition database included data on the choline content of many common foods. Here is an interesting graph from that update (from this pdf) : Missing from the graph are Nuts and Seeds, which from the data in the report look to come in around 50mg choline per 100g. Per this graph, a diet with a mere 3lbs (1350g) of fruits and veggies, 3.5oz (100g) of nuts and seeds, and 3.5oz (100g) of whole grains would contain ~525mg of choline, right around the (dubious and likely inflated) DRI. So unless I'm missing something, the USDA database and my own personal experience as a vegan suggests that a healthy plant-only diet should easily provide all the choline we need, without requiring choline supplements or animal product consumption, thereby alleviating the worry about TMAO formation. So am I missing something? --Dean
  11. Dean Pomerleau

    Must we throw out the blue zones?

    A = Adventists in both acronyms.
  12. Dean Pomerleau

    Who would live longer?

    I too would bet on Michael, for the simple reason that over the next several decades he is very likely to have the inside track on emerging SENS rejuvenation technologies. This coupled with his strong motivation to try them as a result of an unusually acute aversion to his own mortality, means Michael will likely outlive us all, if he doesn't die early trying interventions before they are fully vetted. --Dean
  13. Dean Pomerleau

    Must we throw out the blue zones?

    Fascinating Mikii,I hadn't realized just how shaky some of the Blue Zone data may be. Here are interesting passages from the paper you pointed to (my emphasis) : And: This reminds me of the suspicious around Jean Calment's identity and age, which we discussed here. I find all this to be good reason for skepticism about so-called "Blue Zone" longevity and claims about the lifestyle habits of the oldest old. --Dean
  14. Dean Pomerleau

    Whole Body Vibration Therapy for Bone Health

    Gordo, Tom, Todd S and I had a protracted discussion and DIY testing of the WBV machine we purchased in order to assess the potential for adverse side effects. See posts here, here, here, here, here, here, here, here, here, here and especially the hands-on testing discussed here, here, here and here and summed up here, here and here from earlier in this thread for discussion. Bottom line - using the machine we purchased for <10min per day wearing shoes and using a variety of standing postures (e.g. knees bent) seems well in line with the vibration protocols that have been shown to have health benefits in controlled studies, and still be safe. In particular, our measurements showed that the g-force at our head was well below the ISO guidelines, even for many hours of exposure. --Dean
  15. Dean Pomerleau

    Whole Body Vibration and glucose control

    Tom, Yes. I posted about this study on the whole body vibration thread yesterday. Dean