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ras

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  1. "Longevity Linked to Proteins That Calm Overexcited Neurons": https://www.quantamagazine.org/longevity-linked-to-proteins-that-calm-overexcited-neurons-20191126/
  2. ras

    Al's CR updates

    This will be of great concern to those of us who started CR relatively late in their lives. By all means keep us posted, Al!
  3. " "Zullo and colleagues2 [have uncovered] an unexpected link between the nervous system and ageing. They show that overall neuronal excitation is a major determinant of lifespan, and that it is higher in short-lived individuals and lower in the long-lived. The authors also characterize some of the molecular players in this effect, and tie it to a well-known regulator of lifespan: signalling by the hormone insulin or by insulin-like growth factor 1 (IGF1)." The full news article is here. --Richard Schulman
  4. ras

    Theories of aging

    [Moderator's Note: I moved this post by ras to this thread started by corybroo since they are both covering the same article - DP] This article on theories of aging will not surprise CRS members. Nevertheless, it's a a worthwhile read: https://www.realclearscience.com/articles/2019/10/01/new_theories_for_why_we_age_111123.html
  5. ras

    Al's CR updates

    This post today of Al's ("Exercise degrades Bone in Calorie Restriction") is very concerning. I'm assuming similar effects accrue to humans. The previous concerns among CR practitioners, if I recall correctly, were that CR could cause bone fragility. That exercise doesn't counterbalance the effect but instead makes matters worse is an even greater concern. Informed comments and relevant research would be appreciated.
  6. Many thanks to Saul, corybroo, and Sibiriak for their comments. The suggestions of follow-up on HIIT and telomere length will definitely be pursued. But now I'm wondering whether telomere length is really a reliable marker for biological age. If not, what are we to make of the Nature / Aging Cell study I posted in this forum today?
  7. Nine healthy subjects who took a three-drug cocktail for a year seem to have reversed their biological ages by 2 1/2 years, as indicated by changes to their epigenetic clocks. The news write-up in Nature is here.
  8. In this blog post, I attempt to describe some recent research in the benefits of dietary restriction and exercise. The blog post is aimed at an educated but largely non-technical audience. Most of the content will be familiar to members of this forum. Nevertheless, comments are invited, because I hope to publish such updates several times a year. Suggestions regarding topics and treatment would be welcome.
  9. I think the "take home" message for the obese is to both right-size calories as well as optimize the microbiome (at least as much as this can be done at this early stage of research into the subject). Here's a short article from Nature Research:
  10. This fascinating article describes the relationship between your immune system and your microbiome and how important this is in terms of what you digest, what you don't, and whether you become obese: https://www.theatlantic.com/health/archive/2019/08/inflammations-immune-system-obesity-microbiome/595384/
  11. The latest issue of Nature reports that "Genetic and pharmacological inhibition of ACMSD boosts de novo NAD+ synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function." The abstract is available here for non-subscribers. A related complete article by the lead author of the Nature report is available here for download. According to its abstract: "Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan."
  12. Two recent posts (one by Al Pater, the other by me) suggest that time-boxing (eating within a limited time window) may be a superior health and longevity strategy. Both studies aren't strictly applicable to CR Society Society members, who are likely neither obese nor mice, but certainly suggestive. The Al Pater post (an obesity study, posted and emailed today, September 13th) found that daily fasting did a better job of preserving lean muscle mass than intermittent fasting. My post (on September 6th) reported that, for mice, "increasing time between meals improved the overall health of male mice and lengthened their lives compared to mice that ate more frequently" and "showed that mice who ate one meal per day, and thus had the longest fasting period, seemed to have a longer lifespan and better outcomes for common age-related liver disease and metabolic disorders.” Some of our younger members may be able to stomach one big meal a day. Older members may find that if they try this, they will become GERD cases. For these members, a time-box method may be more appropriate (e.g., confining the day's eating within a time box of two to eight hours maximum). -Richard Schulman
  13. " A group of scientists from the NIA [National Institute on Aging], the University of Wisconsin-Madison and the Pennington Biomedical Research Center in Louisiana found that increasing time between meals improved the overall health of male mice and lengthened their lives compared to mice that ate more frequently. Perhaps even more surprisingly, the health benefits were seen regardless of what the mice ate or how many calories they consumed." Excerpted from an article in USA Today, which may be read here. -Richard Schulman Founders Broadsheet
  14. https://www.genengnews.com/gen-news-highlights/aging-cells-rejuvenated-when-hydrogen-sulfide-gives-splicing-factors-a-lift/81256109
  15. Good non-technical article on what's wrong with p=.05: https://newfoodeconomy.org/nutrition-research-statistics-problem/ -Richard Schulman Editor, https://foundsbroadsheet.com
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