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Everything posted by ras

  1. " "Zullo and colleagues2 [have uncovered] an unexpected link between the nervous system and ageing. They show that overall neuronal excitation is a major determinant of lifespan, and that it is higher in short-lived individuals and lower in the long-lived. The authors also characterize some of the molecular players in this effect, and tie it to a well-known regulator of lifespan: signalling by the hormone insulin or by insulin-like growth factor 1 (IGF1)." The full news article is here. --Richard Schulman
  2. ras

    Theories of aging

    [Moderator's Note: I moved this post by ras to this thread started by corybroo since they are both covering the same article - DP] This article on theories of aging will not surprise CRS members. Nevertheless, it's a a worthwhile read: https://www.realclearscience.com/articles/2019/10/01/new_theories_for_why_we_age_111123.html
  3. ras

    Al's CR updates

    This post today of Al's ("Exercise degrades Bone in Calorie Restriction") is very concerning. I'm assuming similar effects accrue to humans. The previous concerns among CR practitioners, if I recall correctly, were that CR could cause bone fragility. That exercise doesn't counterbalance the effect but instead makes matters worse is an even greater concern. Informed comments and relevant research would be appreciated.
  4. Nine healthy subjects who took a three-drug cocktail for a year seem to have reversed their biological ages by 2 1/2 years, as indicated by changes to their epigenetic clocks. The news write-up in Nature is here.
  5. In this blog post, I attempt to describe some recent research in the benefits of dietary restriction and exercise. The blog post is aimed at an educated but largely non-technical audience. Most of the content will be familiar to members of this forum. Nevertheless, comments are invited, because I hope to publish such updates several times a year. Suggestions regarding topics and treatment would be welcome.
  6. Many thanks to Saul, corybroo, and Sibiriak for their comments. The suggestions of follow-up on HIIT and telomere length will definitely be pursued. But now I'm wondering whether telomere length is really a reliable marker for biological age. If not, what are we to make of the Nature / Aging Cell study I posted in this forum today?
  7. I think the "take home" message for the obese is to both right-size calories as well as optimize the microbiome (at least as much as this can be done at this early stage of research into the subject). Here's a short article from Nature Research:
  8. This fascinating article describes the relationship between your immune system and your microbiome and how important this is in terms of what you digest, what you don't, and whether you become obese: https://www.theatlantic.com/health/archive/2019/08/inflammations-immune-system-obesity-microbiome/595384/
  9. Two recent posts (one by Al Pater, the other by me) suggest that time-boxing (eating within a limited time window) may be a superior health and longevity strategy. Both studies aren't strictly applicable to CR Society Society members, who are likely neither obese nor mice, but certainly suggestive. The Al Pater post (an obesity study, posted and emailed today, September 13th) found that daily fasting did a better job of preserving lean muscle mass than intermittent fasting. My post (on September 6th) reported that, for mice, "increasing time between meals improved the overall health of male mice and lengthened their lives compared to mice that ate more frequently" and "showed that mice who ate one meal per day, and thus had the longest fasting period, seemed to have a longer lifespan and better outcomes for common age-related liver disease and metabolic disorders.” Some of our younger members may be able to stomach one big meal a day. Older members may find that if they try this, they will become GERD cases. For these members, a time-box method may be more appropriate (e.g., confining the day's eating within a time box of two to eight hours maximum). -Richard Schulman
  10. The latest issue of Nature reports that "Genetic and pharmacological inhibition of ACMSD boosts de novo NAD+ synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function." The abstract is available here for non-subscribers. A related complete article by the lead author of the Nature report is available here for download. According to its abstract: "Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan."
  11. " A group of scientists from the NIA [National Institute on Aging], the University of Wisconsin-Madison and the Pennington Biomedical Research Center in Louisiana found that increasing time between meals improved the overall health of male mice and lengthened their lives compared to mice that ate more frequently. Perhaps even more surprisingly, the health benefits were seen regardless of what the mice ate or how many calories they consumed." Excerpted from an article in USA Today, which may be read here. -Richard Schulman Founders Broadsheet
  12. https://www.genengnews.com/gen-news-highlights/aging-cells-rejuvenated-when-hydrogen-sulfide-gives-splicing-factors-a-lift/81256109
  13. The NY Times has a general-interest-level article on the crucial role the cell nucleolus plays in aging: https://www.nytimes.com/2018/05/20/science/nucleolus-cells-aging.html?rref=collection%2Fsectioncollection%2Fscience The technical article is here: https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30063-1 - Richard Schulman Editor, https://foundersbroadsheet.com
  14. Good non-technical article on what's wrong with p=.05: https://newfoodeconomy.org/nutrition-research-statistics-problem/ -Richard Schulman Editor, https://foundsbroadsheet.com
  15. Some nice, unexpected PR on behalf of CR brainpower: https://www.quantamagazine.org/decades-old-graph-problem-yields-to-amateur-mathematician-20180417/ -- Richard Schulman, Editor, Founders Broadsheet
  16. The European Union recently published a report claiming that organic food is better for your brain: http://tinyurl.com/ydyukhgu Inasmuch as some of the European Union's scientific findings have been politicized (e.g., its ban on genetic foods, without evidence), I wanted to get a second opinion on the subject. A Scientific American blog is excellent for this purpose: http://tinyurl.com/jzsc9w5 My present take is that much more research is called for -- fine-grained research regarding specific pesticides, their application levels at the farm, and the relative facility of consumers flushing them away with running water.
  17. ras

    sex-restriction and longevity

    This article explains why men should try to tamp down testosterone after they've sown their wild oats: http://nautil.us/issue/49/the-absurd/why-men-dont-live-as-long-as-women
  18. Hang in, there aging calorie restricters. Help may be on the way (eventually, alas): http://tinyurl.com/zy5hnj8 ("DNA-editing breakthrough could fix 'broken genes' in the brain, delay ageing and cure incurable diseases" -- Independent [uK])
  19. Here is the press release from the University of Birmingham, where the research took place: http://tinyurl.com/hd3qoog
  20. Answer: apparently not, because of methodological bias in most of the studies. The few studies not biased don't show the supposed beneficial J-curve of modest alcohol consumption. Popular summary: http://www.eurekalert.org/pub_releases/2016-03/joso-imd031616.php The full article: http://dx.doi.org/10.15288/jsad.2016.77.185 Is wine, red or otherwise, an exception? The study above does not address that question, but the odds against a wine benefit seem longer than they were before. -Richard Schulman
  21. Hey, tipplers! This article suggests it's time for you to get out on the running track, or other aerobic equivalent, to prevent or remediate, damage done to your topside. http://www.huffingtonpost.com/dr-douglas-fields/alcohol-brain-damage_b_3857430.html
  22. While statins reduce the risk of arterial plaque rupture, it is now known that they also accelerate aging and presumably mortality. The widespread prescribing of statins, e.g., by Britain's NHS, needs to be reconsidered, given that risks in some, though not all, cases may outweigh the benefits. News article: http://tinyurl.com/pmc22bv Pub Med abstract: http://www.ncbi.nlm.nih.gov/pubmed/26224580 Full article: http://ajpcell.physiology.org/content/ajpcell/early/2015/07/23/ajpcell.00406.2014.full.pdf -ras
  23. I'm sorry to hear, Dean, that you're so exercised by cow farts. It's well known that more people worldwide die from the cold than from heat, so maybe, to warm things up, farmers should feed their cows more cabbage and baked beans. It's important not to confuse philosophical arguments for veganism, with science. Carbon dioxide is not a pollutant; it's what makes plant life possible. No CO2, no vegans (or anyone else)! More CO2, up to about four times present levels, increases agricultural productivity. That's more food, for less cost, for the world's hungry as well as the rest of us. Global warming hysteria is a project of "progressive" politicians to increase their power by securing top-down control of energy use. That constitutes most of the economy. "Progressive" politicians want to control what you do and how much of it you use because they know what's best for you, including what food you eat, what tests you have, what drugs you get, and when it is time to take you off life support. To achieve this, the U.S. and European Union governments -- a far wealthier, more powerful, more coercive interest group than Exxon -- have massively corrupted much of the climate science community through selective funding. In return, scientists on the government dole have been active in falsifying climate data and in blocking and even criminalizing dissenting scientists' research and publications. Lysenkoism has come to the U.S. Hundreds of billions of tax dollars that could be more usefully spent on longevity research and combating underdeveloped sector diseases are instead being wasted on subsidies to uneconomic alternate-energy boondoggles. Despite this huge expenditure, even its supporters concede that the effect of these efforts will be a small fraction of one degree centigrade per decade. A completely useless expenditure that makes Egyptian pyramid building look productive by comparison! It's not clear either that, from a health standpoint, veganism is the way to go, rather than a plant-centered diet with modest inputs of animal protein. The traditional health-field warnings against red meat consumption may be misplaced. See the article "Red meats: Time for a paradigm shift in dietary advice" at http://www.sciencedirect.com/science/article/pii/S0309174014001922#. - Richard Schulman