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  1. So called “junk DNA” may affect aging and cancer. Potential role of 'junk DNA' sequence in aging, cancer A research team … recently identified a DNA region known as VNTR2-1 that appears to drive the activity of the telomerase gene, which has been shown to prevent aging in certain types of cells. Knowing how the telomerase gene is regulated and activated and why it is only active in certain types of cells could someday be the key to understanding how humans age, as well as how to stop the spread of cancer. "Almost 50% of our genome consists of repetitive DNA that does not code for protein," Zhu said. "These DNA sequences tend to be considered as 'junk DNA' or dark matters in our genome, and they are difficult to study. Our study describes that one of those units actually has a function in that it enhances the activity of the telomerase gene." "Our findings are telling us that this VNTR2-1 sequence contributes to the genetic diversity of how we age and how we get cancer," Zhu said. Subsequently, they conducted a study that looked at the length of the sequence in DNA samples taken from Caucasian and African American centenarians and control participants in the Georgia Centenarian Study, a study that followed a group of people aged 100 or above between 1988 and 2008. The researchers found that the length of the sequence ranged from as short as 53 repeats -- or copies -- of the DNA to as long as 160 repeats. "It varies a lot, and our study actually shows that the telomerase gene is more active in people with a longer sequence," Zhu said. there were relatively few centenarians with a short VNTR2-1 sequence as compared to control participants. However, Zhu said it was worth noting that having a shorter sequence does not necessarily mean your lifespan will be shorter, because it means the telomerase gene is less active and your telomere length may be shorter, which could make you less likely to develop cancer. experiments that found that deleting the DNA sequence from cancer cells -- both in a human cell line and in mice -- caused telomeres to shorten, cells to age, and tumors to stop growing.
  2. corybroo

    Olive oil? Healthy or not?!

    Dr. Gregor mentioned a new site True Health Initiative In one of the articles there, How Much Fat Should We Have in Our Diet? the author states My own lab has a paper in press showing acute improvement in endothelial function with genuine EVOO, and acute impairment with bargain-brand olive oil. So the difference between high and low quality olive oil is not magnitude, but direction.
  3. MedicalXpress reports a study on postprandial inflammation: Landmark study shows inflammation after meals varies dramatically among healthy adults 1,002 healthy adults taking part in the PREDICT research program to come into the team's research clinic for a day. They were all given two standardized meals to eat, each containing precise amounts of fat, carbohydrate, fiber and protein: breakfast (a muffin and a milkshake) and lunch four hours later (a muffin). The researchers took blood samples from the participants before the breakfast meal and at nine points throughout the day. The researchers found that the levels of inflammation after eating varied widely between participants, including identical twins, even though everyone had the same meals at the same intervals. People with more body fat and greater body mass index (BMI) were more likely to have higher levels of inflammation after eating … Levels of inflammation also tended to be higher in males than females, and in older participants than younger ones. [The study recommendations reinforce what has been frequently advised in the various CR fora.] Control unhealthy blood fat responses by choosing whole foods that are higher in fiber and lean protein, increasing your intake of healthy omega-3 fats from sources like fish, nuts and seeds, and reducing your overall body fat Control unhealthy blood sugar responses by choosing foods containing complex carbohydrates and fiber, such as whole grains, fruit and vegetables, and limiting sugary processed foods and sodas Reduce inflammation after eating by choosing foods that are high in 'anti-inflammatory' bioactive molecules such as polyphenols, found in colorful fruits and vegetables and other plant-based foods
  4. Ø But did you look at the video itself? Yes, I started by watching the entire video and its style caused me to wonder if PV had an agenda. Looking that up led to the numerous reports of previous falsehoods by PV. Ø What's false and misleading about it? I wasn’t present on the five dates that “the staff member pretended to be a nurse on Tinder and went on five dates with Charlie Chester“ and so can not say what is distorted because I’m not privy to what was actually said. I suspect there will be a number of lawsuits over this and will watch to see the outcome of those. The quote above came from Project Veritas founder wants to sue Twitter for defamation over recent suspension
  5. I saw this comparison vaccine efficacy:
  6. Actually, I looked at several sources before posting the above. I did a google search for "project veritas reliable?" and received numerous results for repeated PVA supplying false and misleading information. Granted that some of the accusations against PVA are based on informants recanting testimony, eg , Project Veritas and Illegality, I often apply the rule "Fool me once..."
  7. Is project veritas reliable? The American Federation of Teachers does not seem impressed with their work: BACKGROUNDER - PROJECT VERITAS Let us hope that they've learned not to doctor videos as they paid settlements for doing so in the past: Litigation settlement payment: Litigation filed by Juan Carlos Vera of ACORN was settled by Project Veritas for $100,000; Vera objected to violations of state recording laws and sought damages for the impact of the deceptively edited videos
  8. Instead of a comparison of excess deaths for the US across time, MedicalXpress summarizes a comparison across five large European countries. The calculations make covid-19 look like a distraction from a much larger (and totally) ignored problem. COVID-19 not the sole cause of excess U.S. deaths in 2020 By the year 2017, the United States was already suffering more excess deaths and more life years lost each year than those associated with the COVID-19 pandemic in 2020 "It is not commonly recognized how far we have fallen behind our European counterparts in mortality and survival," To make age-specific comparisons of U.S. and European [Germany, England and Wales together, France, Italy, and Spain] mortality from 2000 to 2017, Preston and Vierboom used data from the Human Mortality Database to create three indexes. [1) ratio of age-specific death rates, 2) calculate number of excess deaths, 3) calculate Years of Life Lost] Even more striking was the mortality comparison between the U.S. and those five European countries when using the measure known as "years of life lost." This accounts for the age at which death occurs, giving more weight to death at a younger age. Source article: Excess mortality in the United States in the 21st century Age-specific death rates which show a sharp deterioration in the US position since 2000. Applying European age-specific death rates in 2017 to the US population, we then show that adverse mortality conditions in the United States resulted in 400,700 excess deaths that year. these excess deaths entailed a loss of 13.0 My of life. [For comparison] the mean loss of life years for a person dying from COVID-19 in the United States is 11.7 y. Multiplying 377,000 decedents by 11.7 y lost per decedent gives a total of 4.41 My of life lost to COVID-19 in 2020, only a third of the 13.02 million life years lost to excess mortality in the United States in 2017 … the comparison is so much sharper for YLL than for excess deaths [because] COVID-19 deaths in 2020 occurred at much older ages, on average, than the excess deaths of 2017. Fig. 1A shows the ratio of US death rates to the mean of death rates in the five European countries (the “European standard”), by age, in 2000, 2010, and 2017. Fig. 1B shows the age pattern of excess deaths, deaths that would not have occurred if the United States had the age- and sex-specific death rates of the European standard. Fig. 1C presents estimates of years of life lost (YLL) as a result of higher US mortality.
  9. Less sugar, please! New studies show low glucose levels might assist muscle repair skeletal muscle satellite cells, key players in muscle repair, proliferate better in low glucose [skeletal muscle satellite cells are named based on their anatomic location between the myofiber plasma and basement membranes. They have been described as “myogenic stem cells given their ability to self-renew in addition to producing differentiated progeny” Skeletal muscle satellite cells, a special type of stem cell that resides between the two layers of sheathing, the sarcolemma and basal lamina and envelops myofiber cells in individual muscle fibers, have been found to be particularly important. When myofiber cells are damaged, the satellite cells go into overdrive, multiplying and finally fusing with myofiber cells. This not only helps repair damage, but also maintains muscle mass. they noticed that higher levels of glucose had an adverse effect on the rate at which [skeletal muscle satellite cells] grew [The team notes] may have significant implications for how we might keep our muscles healthier for longer.
  10. MedicalXpress has an article about how the name a patient is given affects the choices made by the patient. How your doctor describes your medical condition can encourage you to say 'yes' to surgery when there are other options 1,308 people from five countries, some with and without shoulder pain, who were randomly allocated to read one of six hypothetical scenarios. The only difference between the scenarios was the medical term used by the health professional Health professionals use a variety of terms for [pain at the front of one of their shoulders which is made worse by lifting the arm and lying on it], including "subacromial impingement syndrome," "rotator cuff tear," "bursitis," and "rotator cuff related shoulder pain." The terms doctors use vary so widely because it's currently impossible to pinpoint the exact cause of most shoulder pain, even with the help of sophisticated technology such as magnetic resonance imaging (MRI). We found people told they had a "rotator cuff tear" wanted shoulder surgery the most. Those told they had "bursitis" (inflammation of a fluid-filled sac in the shoulder) wanted surgery the least. People told they had a rotator cuff tear had 24% higher perceived need for surgery than those told they had bursitis. Based on this, the authors estimate More than 20,000 potentially unnecessary shoulder surgeries are performed in Australia each year, which we estimate to cost over A$200 million per year. There's a type of abnormal breast cells that can build up in the milk ducts called "ductal carcinoma in situ." For many people, these cells are low-risk and won't grow, or grow so slowly they'll never cause harm. Using the terms "cancer" or "carcinoma" to describe this condition elicits strong negative reactions from patients, and increases their desire for more aggressive treatments, including surgery. For patients with these low-risk cells, surgery, radiotherapy and/or hormonal treatments may not improve overall survival. They found similar results for conditions like acid reflux, pink-eye, and polycystic ovary syndrome. Perhaps one of the benefits of a second opinion is a different set of words. A personal favorite in wording was McDonald's Quarter Pounder. I've often wondered how many 4 Ouncers would have sold.
  11. I agree with Ron: Mutate faster does not make sense unless something is making the genome less stable and the environment is tolerant of experiments. As Saul noted, selection is faster in a new environment in the sense that the original form will be more quickly displaced by some new variant that has even the slightest advantage over the original.
  12. Education is becoming one of the leading determinants of longevity.
  13. Claims that meritied debunking. Politifact 15 wackiest covid-19 claims
  14. The news reports seemed to be focused on three or four variants. This chart of variant lineages shows there are far more than four.
  15. Possible way to mitigate until vaccination Vitamin B6 may help keep COVID-19's cytokine storms at bay In their paper, she and her fellow researchers pointed out growing evidence showing that vitamin B6 exerts a protective effect against chronic illnesses such as cardiovascular diseases and diabetes by suppressing inflammation, inflammasomes, oxidative stress and carbonyl stress. Kumrungsee explained that thrombosis (blood clotting) and cytokine storm (hyper inflammation) might be closely linked to the severity of COVID-19. Vitamin B6 is a known anti-thrombosis and anti-inflammation nutrient. Vitamin B6 … levels always drop in people under chronic inflammation such as obesity, diabetes and heart diseases.