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  1. corybroo

    Molecular aging midlife crisis

    Just saw the article New Study Identifies Molecular Aging "Midlife Crisis" https://medicalxpress.com/news/2019-06-molecular-aging-midlife-crisis.html Some interesting statements: molecular programs known to promote longevity do not last beyond midlife. study provides a possible new reason why human disease burden increases so sharply from the sixth decade of life onward as health-protective mechanisms disappear key biochemical events regulate the longevity of small short-lived animals ... humans appear to stop using these pathways from about 50 years of age onward a dominant role for the so-called mTOR protein complex—a mechanism that regulates numerous protective cell programs—as well as mitochondrial reactive oxygen species production. These two cellular mechanisms combined to explain about two-thirds of the molecular aging profile in humans While the key protein regulators of longevity and health-span in short-lived animals have been found for the first time to be central to human molecular aging, this new study also determined that many little-studied so-called non-protein-coding genes are involved in human aging. "We've demonstrated that the most valid of 'anti-aging' programs are naturally active in humans and for some reason stop when we reach our 50s," Dr. Wahlestedt said. "This not only provides a specific time window to now study human aging, it also indicates that these established anti-aging strategies may no longer be effective (if too active there can be side effects) and so new approaches will be needed in long-lived humans."
  2. corybroo

    Hong Kong beats the blue zones

    It's good to see improvements somewhere in the world after this news a few days ago. https://www.ajmc.com/focus-of-the-week/millennials-have-worse-health-than-gen-xers-did-at-same-age-driven-by-mental-health
  3. Medical News Today has an article Increased muscle power may prolong life which begins with "Increasing muscle strength is good, but increasing muscle power may be even better for enjoying a longer life" https://www.medicalnewstoday.com/articles/325004.php What's the difference between power and strength? "Muscle power differs from muscle strength in that it relies on generating force and velocity while coordinating movement. For example, lifting a weight one time requires strength, but lifting it several times as quickly as possible requires power." What is the benefit? "participants in quartile one had a risk of dying that was 10 to 13 times higher than that of those in quartiles three and four, while the risk for those in quartile two was still four to five times higher" How to increase power: "choose a weight that is neither easy to lift nor so immense that the person cannot lift it at all. Focus on doing 1 to 3 sets of 6 to 8 repetitions each while moving the weight as quickly as possible"
  4. Medical News Today has an article Time-restricted eating may prevent tumor growth https://www.medicalnewstoday.com/articles/324803.php study in mouse models, have found that time-restricted eating could arrest tumor growth some of the mice unrestricted 24-hour access to food, while the rest had their access to food restricted to the 8-hour window All of the mice also received injections with breast cancer cells for 3 weeks after the start of the experiment. The study results revealed that obese mice on time-restricted diets experienced much less tumor growth than mice who ate unrestrictedly. The results for obese mice on time-restricted diets were, in fact, comparable with those of the lean mice who had unrestricted access to food but received low-fat feed. researchers also found that rodents that had higher insulin levels due to the insulin pump implant had faster tumor growth than control rodents. Conversely, the mice that received diazoxide to lower their insulin levels had slower tumor growth than the control mice. researchers also found that rodents that had higher insulin levels due to the insulin pump implant had faster tumor growth than control rodents. Conversely, the mice that received diazoxide to lower their insulin levels had slower tumor growth than the control mice.
  5. Science Daily has an article "Fasting ramps up human metabolism, study shows" at https://www.sciencedaily.com/releases/2019/01/190131113934.htm "going without food may also boost human metabolic activity, generate antioxidants, and help reverse some effects of aging." "results revealed 44 metabolites, including 30 that were previously unrecognized, that increased universally among subjects between 1.5- to 60-fold within just 58 hours of fasting." " various metabolites whose quantities decline with age, including three known as leucine, isoleucine, and ophthalmic acid. In fasting individuals, these metabolites increase in level" "authors suggest that these antioxidative effects may stand as the body's principal response to fasting, as starvation can foster a dangerously oxidative internal environment. ... fasting might boost production of several age-related metabolites, abundant in young people, but depleted in old."
  6. Medical News Today has the results of the effect of cold on different strains of Rotifers. The most striking finding was that low temperature was not always positive." "The change in the median lifespan of each strain ranged from a decrease of 6 percent to an increase of 100 percent. The team also observed "differences in maximum and relative lifespan extension and in mortality rate." It also saw that in most strains, low temperature extended the "reproductive period and shortened the post-reproductive period, suggesting an extension of healthspan in most strains." It ends with the following "This means we really need to pay more attention to genetic variability in thinking about responses to aging therapies. That is going to be really important when we try to move some of these therapies into humans."
  7. Medical News Today has an article Melanoma: More evidence that antioxidants speed up tumor spread https://www.medicalnewstoday.com/articles/323574.php "Although it may be true that antioxidants protect healthy cells, a growing body of research shows that they also protect cancer cells." "show that dietary antioxidant supplementation increases metastasis in malignant melanoma," "mitochondria-targeted antioxidants do not inhibit cancer progression." "people with cancer or who have a high risk of developing it should avoid the use of antioxidant supplements."
  8. Medical News Today has an article How and why our bodies starve gut bacteria (https://www.medicalnewstoday.com/articles/323509.php) > The results of Reese and colleagues' analysis revealed that bacteria are kept on a short leash in the human gut: they have access to around 1 nitrogen atom per every 10 carbon atoms. This is much less than what free-living microbes get: 1 nitrogen atom to every 4 carbon atoms, on average. The more protein the researchers gave the mice, the more the number of gut bacteria increased. "Our findings," says David, "support the idea that we've evolved a way to keep our bacteria on a leash by leaving them starving for nitrogen." ...why the Western diet might be bad for us. When people eat too much protein, it swamps the host's ability to take up that nitrogen in the small intestine, and more of it ends up making its way to the large intestine, eliminating our ability to control our microbial communities."
  9. Medical News Today had an article about looking at the "healthy" tissue and the mutations therein. Cancer: Even healthy tissue is 'riddled with mutations' https://www.medicalnewstoday.com/articles/323392.php Based on an article at http://science.sciencemag.org/content/early/2018/10/17/science.aau3879 that I do not have access to. The researchers "sampled healthy tissue from the esophagi of nine individuals aged 20–75. None of these people had any history of esophageal cancer or other medical issues with that part of their body." Next, they carried out whole-genome sequencing to map the presence of mutated cells in these healthy samples. They found that, to their surprise, people in their 20s had hundreds of mutations in each cell. In older participants, this figure rose to more than 2,000 per cell Mutations in some genes gave the cells a competitive advantage, meaning that, as they divided and conquered, they outcompeted cells without the mutation and colonized large patches of tissue; this created a patchwork of mutant cells. I interpret this as being one of the reasons apoptosis (as generated by CR) is beneficial. My *guess* is that apoptosis is likely to go after the most different cells first. Cory
  10. corybroo

    Any Downside for One Big Meal per Day?

    Science Daily has an article https://www.sciencedaily.com/releases/2018/08/180831130131.htm Eating in 10-hour window can override disease-causing genetic defects, nurture health Although the original focus was mice with defective internal clocks, the benefits seemed to apply to normal mice as well. "As we age, our circadian clocks weaken. This age-dependent deterioration of circadian clock parallels our increased risk for metabolic diseases, heart diseases, cancer and dementia. But the good news, say the researchers, is that a simple lifestyle such as eating all food within 10 hours can restore balance, stave off metabolic diseases and maintain health. The lab next plans to study whether eating within 8-10 hours can prevent or reverse many diseases of aging, as well as looking at how the current study could apply to humans. Their website, mycircadianclock.org, allows people anywhere in the world to sign up for studies, download an app and get guidance on how to adopt an optimum daily eating-fasting cycle."
  11. corybroo

    Obesity alone does not increase risk of death

    What about the externalities of obesity? My daughter is a nurse in a stroke ICU where she and other nurses have injured their backs and knees hoisting 300 lb plus patients. Indeed, they report no longer being surprised by patients over 400 lbs.
  12. Science Daily has an article about possibly reversing aging by reducing wrinkles in the nuclear membrane. https://www.sciencedaily.com/releases/2018/05/180529103541.htm It suggests that effects of aging may be the result of the nuclear membrane developing wrinkles as we age. ... the location of our DNA inside the cell's nucleus is critically important. Genes that are turned off are shoved up against the nuclear membrane, which encases the nucleus. But with age, our nuclear membranes become lumpy and irregular, and that prevents genes from turning off appropriately. When your nuclear membrane is no longer functioning properly, it can release the DNA that's supposed to be turned off, The membrane wrinkling stems from a lack of a substance called lamin, a cellular protein that comes in various forms.
  13. Science Daily has an article about 24hr fast doubling regenerative capacity in intestinal step cells: https://www.sciencedaily.com/releases/2018/05/180503142852.htm Intestinal stem cells are responsible for maintaining the lining of the intestine, which typically renews itself every five days. After mice fasted for 24 hours, the researchers removed intestinal stem cells and grew them in a culture dish, allowing them to determine whether the cells can give rise to "mini-intestines" known as organoids. The researchers found that stem cells from the fasting mice doubled their regenerative capacity. sequencing the messenger RNA of stem cells from the mice that fasted, revealed that fasting induces cells to switch from their usual metabolism, which burns carbohydrates such as sugars, to metabolizing fatty acids. they could reproduce the beneficial effects of fasting by treating mice with a molecule that mimics the effects of PPARs. The findings suggest that drug treatment could stimulate regeneration without requiring patients to fast
  14. Science Daily has an article Calorie restriction trial in humans suggests benefits for age-related disease https://www.sciencedaily.com/releases/2018/03/180322141008.htm 15% reduction in calories slowed aging and metabolishm. 53 non-obese humans between 21 and 50 cut calories for two years. Calories reduction was monitored with the ratio of isotopes absorbed. No adverse effects found. Mood and health QoL improved. "...found that even people who are already healthy and lean may benefit from a calorie restriction regimen," support for two of the longest-standing theories of human aging: the slow metabolism 'rate of living' theory and the oxidative damage theory
  15. Science Daily has an article Physically fit women nearly 90 percent less likely to develop dementia https://www.sciencedaily.com/releases/2018/03/180315101805.htm Tests were done on Swedish women in 1968 the small (n=191) group followed for over 40 years. For me, the most striking finding was this Five percent of the highly fit women developed dementia, compared to 25 percent of moderately fit women and 32 percent of the women with low fitness. The highly fit women were 88 percent less likely to develop dementia than the moderately fit women. Among the women who had to stop the exercise test due to problems, 45 percent developed dementia decades later. The researchers do note that the women who had to stop the exercise test might have already had some underlying caridovascular issues. Still the comparison of highly fit with moderately fit (5% vs 25%) is impressive.