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  1. Synchrotron-based study finds a high-fish diet may not be bad for you A synchrotron-based study led by University of Saskatchewan (USask) researchers shows that the chemical form of mercury found in the brains of people who ate a lot of fish over a lifetime is completely different from the mercury form found in the brains of people who were poisoned. However, a large exposure to this mercury species resulting in poisoning is hugely different than low level exposure from a diet of fish containing naturally low levels of mercury [Emphasis added] "The form of mercury in the brains of the two fish-consuming individuals is essentially unchanged from the form found in fish," said George. "There were no neuropathological consequences apparent in the Seychellois and neither had known neurological deficits that could be linked to mercury exposure." But there were striking differences found in the brains of subjects poisoned with organic mercury, which contained mixtures of mercury compounds, including significantly elevated levels of mercury selenide compared with low-level exposures. Selenium has a complex relationship with mercury, said George. Depending on the species of mercury, and whether selenium enters the body before or after exposure, it can cancel or increase the toxicity of mercury. "There have been some papers that suggest that it is safe to eat fish with high levels of mercury if the selenium content exceeds that of mercury, but it does not appear to be nearly that simple," said George. "I would advise against eating anything that contains high levels of mercury."
  2. Perhaps our beliefs about who is most at risk are not up to date with the evolving virus. COVID mortality age patterns changed significantly during pandemic Between March 2020 and October 2021, the age pattern of COVID mortality changed in a striking fashion, with rates significantly dropping for those 80 and older and profoundly increasing for those 25 to 54. "This could reflect several factors," she says. "For one, vaccine coverage is much higher among the elderly." In addition, many younger people went back to working in person and to doing other activities that increased their COVID exposure risk Data for every group [race and ethnicity CB] showed the same trend; death rates rose for younger people and decreased for older people, leading to more total years of life lost and a substantial decrease in life expectancy overall.
  3. Not a bad guess Gordo. In the following from PubMed, AOR is Adjusted Odds Ratio CB Female gender is associated with long COVID syndrome: a prospective cohort study Female gender was independently associated with long COVID syndrome at multivariable analysis (AOR 3.3 vs. males, 95% CI 1.8-6.2, p < 0.0001).
  4. corybroo

    War in Ukraine

    Stalin purged a lot of generals. Putin reportedly fancies himself a modern Stalin, so perhaps one of his goals in the war is eliminating generals he has become wary of. Perhaps they should remember the old admonition, "He who sups with the devil should have a long spoon."
  5. Model finds COVID-19 deaths among elderly may be due to genetic limit on cell division Your immune system's ability to combat COVID-19, like any infection, largely depends on its ability to replicate the immune cells effective at destroying the SARS-CoV-2 virus that causes the disease. The average person's immune system coasts along pretty good despite this limit until about 50 years old. That's when enough core immune cells, called T cells, have shortened telomeres and cannot quickly clone themselves through cellular division in big enough numbers to attack and clear the COVID-19 virus Importantly, he added, telomere lengths are inherited from your parents. "Depending on your parents and very little on how you live, your longevity or, as our paper claims, your response to COVID-19 is a function of who you were when you were born," he said [I have doubts about the above claim because some interventions appear to modify telomere length. For example, “Certain lifestyle factors such as smoking, obesity, lack of exercise, and consumption of unhealthy diet can increase the pace of telomere shortening, leading to illness and/or premature death.” Telomeres, lifestyle, cancer, and aging CB]
  6. Why is anyone talking about "cases?" These variants are asymptomatic or milder than the current flu for most, why is The WHO not sounding a flu warning and calling for flu vaccine mandates? They're watching cases because after the sentence you selected was this statement "But he said it was "too soon to know whether these new sub-variants can cause more severe disease than other Omicron sub-variants."" Are you stating with absolute certainty (asymptomatic or milder than the current flu for most), that new variants do not present any short or long term problems for most (51%?). What level of risk would most parents find acceptable for their children? For an aging parent? Or immune compromised friend? There are a couple of new variants sweeping S Africa and surging now in the US. The US is closely watching this Covid surge for clues My hope was to increase awareness of this and let everyone choose whether to ignore it or hide out in a bunker. The definition of mild may be similar to the distinction betwee a recession and depression: If you lose your job, I'd call that a recession but if I lose mine, then it's a depression. ‘Better Than Omicron’ Is Still Pretty Bad
  7. It may be premature to celebrate the end of Covid S.Africa's daily COVID cases soar 50% in one day amid new surge World Health Organization chief Tedros Adhanom Ghebreyesus on Wednesday said that two Omicron sub-variants, BA.4 and BA.5, were behind the surge in cases in South Africa. But he said it was "too soon to know whether these new sub-variants can cause more severe disease than other Omicron sub-variants." The South African government on Thursday retracted its earlier announcement stating school children were no longer required to wear masks. The withdrawal came 16 hours after the health ministry dropped the requirement for school children to wear masks. [16 hours is not long enough for the dropped requirement to have much, if any, effect. Just an unfortunate coincidence. CB] When the Next Covid Wave Breaks, the US Won’t Be Able to Spot It All the indicators suggest the US is likely poised for a new surge of Covid; in some parts of the country, that surge may already be arriving. But in our zeal to declare the pandemic over, we may have maneuvered ourselves into a position where it is now harder to detect a coming wave. “More and more, the relaxation of public health requirements, mandates, has placed responsibility on the individual and the employer,” says Saskia Popescu, an infectious-disease epidemiologist The seven-day moving average calculated by the US Centers for Disease Control and Prevention stood at 42,605 cases last week, which was 35 percent higher than one week earlier. The number of counties that score high and medium on the CDC’s “community levels” map both increased last week.
  8. Thanks for the link Ron, I see the statement there CDC data also show that Americans, regardless of age group, are far more likely to die of something other than COVID-19. Even among those in the most heavily impacted age group (85 and older), only 13.3 percent of all deaths since February 2020 were due to COVID-19. However, that compares covid with *all* deaths. I looked for a head to head comparison of covid and flu and found this site: https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/coronavirus-disease-2019-vs-the-flu which has this section [bolding added for emphasis] which recognizes that the statistics are fluid, but currently find Covid to be far more serious than the flu. Coronavirus vs. Flu Deaths­ COVID-19: Current COVID-19 deaths* Flu: The World Health Organization estimates that 290,000 to 650,000 people die of flu-related causes every year worldwide. The COVID-19 situation continues to change, sometimes rapidly. Doctors and scientists are working to estimate the mortality rate of COVID-19. At present, it is thought to be substantially higher (possibly 10 times or more) than that of most strains of the flu. *This information comes from the Coronavirus COVID-19 Global Cases map developed by the Johns Hopkins Center for Systems Science and Engineering. BTW, the Current COVID-19 deaths linked above shows that in less than three years there have 6,230,212 covid deaths. That's over 2M a year vs the 290,000 to 650,000 flu deaths every year.
  9. If you (very reasonably) expect appeasement to work as well in this century as it did in the previous, then on the present course, WW III is inevitable. The only alternative is some sort of internal change in Russia where political strife avoids the total devastation of nuclear war. Indeed, nearly twenty years ago, the book Stalin’s Last Crime New Study Supports Idea Stalin Was Poisoned was published. The book suggests that warfarin, a tasteless, colorless blood thinner, was added to his wine and was the cause of the extensive stomach hemorrhaging. Also contributing to his demise was his planned physicians purge that left those near him afraid to be the one who called for a doctor. One doctor later reported his interrogation was interrupted when they starting asking for medical advice for treating Stalin’s condition. The True Story of the Death of Stalin Of course, far more details are known to Putin and I’ve read that his security is vastly better than Stalin’s so there is not much hope for a small convulsion. Look how Hitler was willing to destroy everyone and everything around him to delay the inevitable. History makes scary reading at present.
  10. Only 29% of hospitalised COVID-19 patients fully well one year on: Study The [UK] study involving more than 2,300 people also found that women were 33 per cent less likely to fully recover than men. The study looked at the health of people who were discharged from 39 British hospitals with COVID-19 between March 2020 and April 2021, then assessed the recovery of 807 of them five months and one year later. Just 26 per cent reported a full recovery after five months, and that number rose only slightly to 28.9 per cent after a year, according to the study published in the Lancet Respiratory Medicine journal. The most common long COVID symptoms were fatigue, muscle pain, poor sleep, slowing down physically and breathlessness.
  11. A low-calorie diet alters the gut microbiome and delays immune aging A calorie-reduced diet can not only delay the development of metabolic diseases, but also has a positive effect on the immune system. … this effect is mediated by an altered gut microbiome, which slows down the deterioration of the immune system in old age transplanting the diet-altered microbiota, glucose metabolism improved and fat deposition decreased. In addition, mass cytometry showed that the level of specific memory T and B cells was also reduced. "This indicates delayed immune senescence," the investigation has so far only been conducted with the microbiome of one person and that the experiments will have to be repeated with additional subjects to confirm the results.
  12. Hi Cory,

    Would you be willing to share with me your longevity strategy and/or supplement regimen??

    I'm wondering if you are on rapamycin along with other prescriptions??

    I had been hesitant to use rapamycin yet since I had concerns on that it hardens arterial plaque - certainly stabilizes it, but my goal was to keep it soft and eliminate it with vegan eating and vitamin K.



    1. corybroo


      I'm not taking any supplements.  My longevity stategy is follow Michael Pollan: “Eat food.  Not too much.  Mostly plants.”  Where the first part rules out many things found in SAD and the second part means as much CR as I do.  It helps me to remember Michael Rae's post from long ago, "The Myth of the Good Calorie".  I am near vegan.

      Also I exercise, typically with HIIT.  I don't know if the people swimming in the lanes beside notice any difference on my High Intensity laps, but I sure feel it.

      Sorry not to be more help, 


  13. Multiple treatments to slow age-related muscle wasting Rapamycin and CR have additive effects. Researchers led by Professor Markus Rüegg at the Biozentrum of the University of Basel have demonstrated in mice that both calorie restriction and the drug rapamycin have a positive effect on aging skeletal muscle. "Contrary to our expectations, the treatments do not redundantly converge at mTORC1," emphasizes Ham. "While we could understand that calorie restriction would have beneficial effects beyond mTORC1 suppression, it was incredibly surprising to us that rapamycin, an mTORC1 inhibitor, further slowed muscle aging in calorie restricted mice, where mTORC1-activating nutrients are available for just a few hours each day." [I assume everyone saw the articles about limited benefit of time restricted feeding in humans. I suspect the stricter restriction of the rats “nutrients are available for just a few hours a day” is much more severe than the humans in this trial. Year-long study shows time restricted diets offer no benefit “limit their eating to the hours of 8am to 4pm” CB] In calorie-restricted mice treated with rapamycin, the beneficial effects were therefore additive, with mice displaying significantly better muscle function than mice receiving either treatment alone.
  14. Sometimes the numbers are obviously manipulated. Here's a comparison of variability in deaths per million for the US and Russia.
  15. Zinc in a good diet appears to be helpful, at least in vitro. Common dietary supplements could protect against COVID, common winter illnesses We have known for years that food supplements containing zinc can enhance immunity to severe, viral and chronic infections and their potentially grave consequences. The researchers found that the consumption of zinc alone achieves a relatively low cellular content. To enhance the effect, they combined the zinc with flavonoids—polyphenolic compounds found in many fruits and vegetables. They also added copper in order to prevent an ionic imbalance and improve the treatment's effectiveness. Such a product will be safe, natural, and effective against several types of viruses, including new mutations and variants