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About Gordo

  • Birthday 07/22/1974

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  1. Yea, not sure mild cold exposure has any direct impact on BDNF/brain health, but there are some interesting potential new ways to boost BDNF/neurogenesis/brain health, see this recent patent
  2. Gordo

    Blood sugar levels?

    The 180 lbs. guy at 5% fat would have to have far more muscle mass than the 110 lbs. person at 5% fat, and excess glucose is stored as glycogen in muscle, so its possible the muscular person would have the better blood sugar level, especially if muscle glycogen levels are depleted by exercise. This doesn't necessarily mean better health or longevity though. Plus there are things you can do to improve blood sugar besides gaining muscle mass (like cold exposure, eating lower glycemic index foods, exercise optimizations, maybe even taking metformin, etc)
  3. Gordo

    Bottle of Lies

    I'd like to know more, but my first reaction was same as Ron's above, doesn't sound very plausible that this is a huge problem in the U.S. or there would be massive lawsuits already, and if/when that happens the problem will resolve itself. In the meantime, you will find that healthcare professionals pick generics over brand names for their own personal use: http://freakonomics.com/podcast/how-to-save-1-billion-without-even-trying-a-new-freakonomics-radio-podcast/
  4. https://www.accuweather.com/en/health-wellness/most-active-flu-season-since-2003-is-already-wreaking-havoc-in-the-us/644427 Most active early flu season since 2003 already ‘wreaking havoc’ in US I got a flu shot this year 😉
  5. Gordo

    The Ultimate Purpose of Life

    Since I believe our universe was created/designed (which is a view shared by those who believe in the simulation hypothesis as well by the way) I suppose there could be several purposes to life: 1) Try to figure out who the creator is or was. This may involve looking for clues and/or “Easter eggs” that the creator deliberately left for us to discover. 2) Explore all of creation - this goes hand in hand with #1 above. Exploration, doing and seeing things you’ve never done or seen before (even better if it’s something no other human has done or seen before) invigorates one’s spirit. There also seems to be an innate desire in mankind to “spread out” which has led to covering this earth, but will also lead to leaving this planet as well. It’s a big universe, maybe there is other intelligent life out there, we need to find out. Hopefully interstellar communication or even travel is possible. If there is no other intelligent life beyond earth, maybe it is our destiny to “make it so”. 3) Create. Producing something of value to someone else is very satisfying, therefore it is likely to be a part of our purpose. Creating is required to fulfill the other purposes of life. 4) Share / document what we have learned with others, so that every discovery can be preserved and utilized by others who will carry on #1, #2, and #3 after you are gone. I do not believe “happiness” is the purpose of life, nor the pursuit there of. Happiness is an illusion, sure you can have many moments of happiness, but these are fleeting. The human brain is not capable of sustaining “happiness”. One big juicy red in season strawberry may taste amazing, but eating a big bowl of them makes you sick. Using opiates or alcohol might make you happy for a few hours, then it leads to withdrawal or worse, becoming an unproductive junkie or drunk with no happiness. I once researched the people with the highest documented IQs of all time just out of curiosity, and if I am remembering correctly, fully 7 out of the top 10 would be considered “theists", one of them, Christopher Langan, even wrote an elaborate mathematical proof of the existence of God and believes it is possible to prove not only the existence of God but of souls and an afterlife using mathematics. I thought that was pretty intriguing but must confess I never did actually dig deeper into his work or story.
  6. Gordo

    A CR Garden

    I’ve been inspired by this guy’s “food forest” (he is in the same climate as me too):
  7. Gordo

    A CR Garden

    My plant based paw paw omelette. 3 trees officially planted 😉 and looking good, 11 small seedlings growing in pots, and dozens of seeds in the fridge for next year...
  8. That’s a nice list of companies in the field.
  9. Regarding metformin and exercise - in D. Sinclair's latest interviews, he has been saying the he pulses metformin and exercise on different days. I don't know his exact schedule, but I think he said something like metformin every day during the week, but not taken on weekends, where he then hits the gym hard for like 4 hours or more. I don't know, sounds a little goofy to me but there may be something to be said for not taking ANY medication every day...
  10. Anorexia is pretty hard for most people to understand, its not just wrong thinking, but a severe mental illness that requires intensive treatment and this forum is probably not a great place to get help. That said, there is some interesting active research in this area that you may benefit from: https://hopkinspsychedelic.org/anorexia Anorexics do not age well from what I've seen, expect severe bone issues, fractures, and osteoporosis. In CR circles, many used to think "the more CR the better" but this has been proven false. Fontana talked about this in a recent lecture you may be interested in: 13:44 Talks about calorie restriction studies in primates 25:30 talks about CALERIE study in humans 29:02 specifically mentions the CR Society and shows a before/after pic and biomarkers of one member 36:55 talks about the importance of increasing adiponectin and especially the importance of reduced core body temperature as a biomarker for longevity 38:00 skeletal muscle profile on CR, importance of downregulation of IGF-1 43:40 Side effects of chronic severe CR - how to know if you are overdoing CR 44:30 It is NOT TRUE that the more CR the better. Talks about study showing how 40% CR did not result in increased longevity for 2/3rds of the subtypes of mice tested. 20% CR is optimal for many strains of mice. Biomarkers are key for determining what the optimal CR level is. You must have sufficient energy to promote longevity. 46:15 Used to think it was just about the calories, but now we know that is NOT true. Composition of diet is important, meal timing is important - CR with eating all day does not result in longevity in mice (50:00) 51:10 Discusses ongoing human intermittent fasting clinical trial 53:40 Importance of low protein / methionine restriction for longevity independent of CR (blocks tumor development) 59:25 You should eat around 10% protein ("a calorie is not a calorie", "stay away from low carb or ketogenic diets") 1:04:20 Talks about the gut microbiome. Diet reliably and rapidly changes the gut microbiome, protein intake and fiber are key, the more diversity of vegetables you eat the better your gut microbiome, which results in reduced inflamation (related to short chain fatty acids). Eat legumes, whole grains, and lots of vegetables. 1:10:50 Your gut microbiome impacts your physiologic response to CR 1:13:00 Describes other pieces of the health/longevity puzzle he will talk about in a future lecture: exercise, breathing and rate of respiration, sleep, meditation, phytochemicals, cognitive training 1:18:00 Future of medicine is prevention. Reducing mental stress, reducing sedentary lifestyle, reducing excessive calorie intake, and eliminating poor diets are key.
  11. So if muscle mass and strength improvements were the same between these groups, what exactly is the impact of lower muscle fiber growth? CE is believed (by some) to lead to rapid muscle recovery (ESPN even wrote about this here), in theory allowing for more reps or higher weight reps in a given session or for an athlete to return to competition at a higher level of capability. This study did not actually look at that aspect of CE. It would be interesting to see what the findings would be had they put the test subjects back in the gym immediately after CE or control recovery period.
  12. Gordo

    Are all parts of the body part of metabolism?

    Probably. We know bone mass loss results from starvation, and even brains shrink: https://www.livescience.com/8293-brain-shrinkage-anorexia-reversible.html
  13. Restricting calories alone, based on the best available evidence, may only increase your lifespan by 1 year (compare Okinawan calorie restrictors to mainland Japan population wide lifespan averages). See: