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About Gordo

  • Birthday 07/22/1974

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  1. Gordo

    A CR Garden

    I’ve been inspired by this guy’s “food forest” (he is in the same climate as me too):
  2. Gordo

    A CR Garden

    My plant based paw paw omelette. 3 trees officially planted 😉 and looking good, 11 small seedlings growing in pots, and dozens of seeds in the fridge for next year...
  3. That’s a nice list of companies in the field.
  4. Regarding metformin and exercise - in D. Sinclair's latest interviews, he has been saying the he pulses metformin and exercise on different days. I don't know his exact schedule, but I think he said something like metformin every day during the week, but not taken on weekends, where he then hits the gym hard for like 4 hours or more. I don't know, sounds a little goofy to me but there may be something to be said for not taking ANY medication every day...
  5. Anorexia is pretty hard for most people to understand, its not just wrong thinking, but a severe mental illness that requires intensive treatment and this forum is probably not a great place to get help. That said, there is some interesting active research in this area that you may benefit from: https://hopkinspsychedelic.org/anorexia Anorexics do not age well from what I've seen, expect severe bone issues, fractures, and osteoporosis. In CR circles, many used to think "the more CR the better" but this has been proven false. Fontana talked about this in a recent lecture you may be interested in: 13:44 Talks about calorie restriction studies in primates 25:30 talks about CALERIE study in humans 29:02 specifically mentions the CR Society and shows a before/after pic and biomarkers of one member 36:55 talks about the importance of increasing adiponectin and especially the importance of reduced core body temperature as a biomarker for longevity 38:00 skeletal muscle profile on CR, importance of downregulation of IGF-1 43:40 Side effects of chronic severe CR - how to know if you are overdoing CR 44:30 It is NOT TRUE that the more CR the better. Talks about study showing how 40% CR did not result in increased longevity for 2/3rds of the subtypes of mice tested. 20% CR is optimal for many strains of mice. Biomarkers are key for determining what the optimal CR level is. You must have sufficient energy to promote longevity. 46:15 Used to think it was just about the calories, but now we know that is NOT true. Composition of diet is important, meal timing is important - CR with eating all day does not result in longevity in mice (50:00) 51:10 Discusses ongoing human intermittent fasting clinical trial 53:40 Importance of low protein / methionine restriction for longevity independent of CR (blocks tumor development) 59:25 You should eat around 10% protein ("a calorie is not a calorie", "stay away from low carb or ketogenic diets") 1:04:20 Talks about the gut microbiome. Diet reliably and rapidly changes the gut microbiome, protein intake and fiber are key, the more diversity of vegetables you eat the better your gut microbiome, which results in reduced inflamation (related to short chain fatty acids). Eat legumes, whole grains, and lots of vegetables. 1:10:50 Your gut microbiome impacts your physiologic response to CR 1:13:00 Describes other pieces of the health/longevity puzzle he will talk about in a future lecture: exercise, breathing and rate of respiration, sleep, meditation, phytochemicals, cognitive training 1:18:00 Future of medicine is prevention. Reducing mental stress, reducing sedentary lifestyle, reducing excessive calorie intake, and eliminating poor diets are key.
  6. So if muscle mass and strength improvements were the same between these groups, what exactly is the impact of lower muscle fiber growth? CE is believed (by some) to lead to rapid muscle recovery (ESPN even wrote about this here), in theory allowing for more reps or higher weight reps in a given session or for an athlete to return to competition at a higher level of capability. This study did not actually look at that aspect of CE. It would be interesting to see what the findings would be had they put the test subjects back in the gym immediately after CE or control recovery period.
  7. Gordo

    Are all parts of the body part of metabolism?

    Probably. We know bone mass loss results from starvation, and even brains shrink: https://www.livescience.com/8293-brain-shrinkage-anorexia-reversible.html
  8. Restricting calories alone, based on the best available evidence, may only increase your lifespan by 1 year (compare Okinawan calorie restrictors to mainland Japan population wide lifespan averages). See:
  9. David Sinclair on cold exposure in a recent interview.
  10. Are you actually arguing that it is IMPOSSIBLE for a human to starve to death? It seems like you may be suffering either from brain damage or serious mental illness. I urge you to seek help before you end up in a hospital on forced feeding or dead.
  11. Gordo

    Is it possible to live without micronutrients?

    Depends on how long you are talking about, but the longest documented water only fast was just over a year, the guy was fine, but started out morbidly obese, and he DID take a multivitamin during that year without any food, so I don't think we have a good answer on how long a person could live without micronutrients. But where would you get calories from that contain no micronutrients?
  12. I hope these guys continue their experiment and provide annual updates, I'd love to see 5, 10, 20 year followups. HGH can play a medicinal role when it comes to healing, so I could see how it might be useful for reviving an organ in decline, but there are obviously trade offs as the science has shown. With people taking a lot, their hearts actually keep growing larger, which leads to disfunction eventually, and then death. But maybe lower doses are safer? Maybe with better cancer detection/treatment in the future, one could cut the growth hormone as soon as cancer is detected and before it rapidly multiplies and kills you.
  13. I'm waiting for a version that has more capabilities and the loss of deep brain stimulation seems like a setback with 2.0
  14. Also how do we know metformin is any better than other BAT activators? We'll probably never see a comparative study.