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Gordo

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  • Birthday 07/22/1974

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  1. Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755196/ Abstract Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging-related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti-aging modulator that can play a role in the treatment of aging-related diseases. This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA-65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi-nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above-mentioned formulations were statistically significantly higher compared to those of the untreated cells. In particular, in order of importance with respect to telomerase activation from highest to lowest, 08AGTLF, OA, Nutrient 4, TA-65, MA, Nutrient 3 and Nutrient 2, triggered statistically significant increase in telomerase activity compared to the untreated cells. 08AGTLF reached the highest levels of telomerase activity reported to date, at least to our knowledge, increasing telomerase activity by 8.8 folds compared to untreated cells, while Nutrient 4 and OA were also potent activators (4.3-fold and 5.9-fold increase, respectively). On the whole, this study indicates that the synergistic effect of nutrients and natural compounds can activate telomerase and produce more potent formulations. Human clinical studies using these formulations are required to evaluate their mode of action. This would reveal the health benefits of telomerase activation through natural molecules and would shed new light onto the treatment of aging-related diseases
  2. Moderna's COVID-19 Vaccine Shines In Clinical Trial November 16, 20207:00 AM ET Even better than the Pfizer vaccine but perhaps most importantly, does not have the very difficult cold storage requirements of the Pfizer vaccine (Moderna vaccine is good for 30 days at normal freezer temps).
  3. Gordo

    Hello from a new member

    Seeing that you already linked to a Fontana resource in your post above, you should also review this: We have more info now on "how much is too much" as well as what biomarkers likely indicate you are doing things well (or not).
  4. I don't know if this is too preliminary for "celebrations" but everyone is reporting this news today: Pfizer, BioNTech Say Their COVID-19 Vaccine Is More Than 90% Effective "Today is a great day for science and humanity," Albert Bourla, Pfizer's chairman and chief executive, said in a statement. "We are reaching this critical milestone in our vaccine development program at a time when the world needs it most with infection rates setting new records, hospitals nearing over-capacity and economies struggling to reopen." Pfizer expects to seek broad U.S. emergency use authorization of the vaccine for people aged 16 to 85. To do so, it will need to have collected two months of safety data on around half of the study's roughly 44,000 participants, expected in late November. "I'm near ecstatic," Bill Gruber, one of Pfizer's top vaccine scientists, said in an interview. "This is a great day for public health and for the potential to get us all out of the circumstances we're now in." The company did not break down exactly how many of those who fell ill received the vaccine. Still, over 90% effectiveness implies that no more than 8 of the 94 people who caught COVID-19 had been given the vaccine, which was administered in two shots about three weeks apart. The efficacy rate is well above the 50% effectiveness required by the U.S. Food and Drug Administration for a coronavirus vaccine. To confirm its efficacy rate, Pfizer said it will continue the trial until there are 164 COVID-19 cases among participants. Given the recent spike in U.S. infection rates, that number could be reached by early December, Gruber said.
  5. I hadn't looked at the daily new cases (US) in a while, man its looking pretty ugly right now: Matt - good to hear you and your family recovered so fast!
  6. Cellular immunity to SARS-CoV-2 found at six months in non-hospitalised individuals This study is nice because they looked at people who were infected but asymptomatic or only mild infection, and they found that everyone had robust t-cell immunity 6 months after infection. Study size was small though and used healthcare workers which may not be a good representation of the general population (healthcare workers might have repeated exposure). 2nd November 2020 Cellular (T cell) immunity against SARS-CoV-2 is likely to be present within most adults six months after primary infection, a new pre-print on bioRxiv suggests. The research from the UK Coronavirus Immunology Consortium (UK-CIC), Public Health England and Manchester University NHS Foundation Trust demonstrates robust T cell responses to SARS-CoV-2 virus peptides at this timepoint in all participants following asymptomatic or mild/moderate COVID-19 infection.
  7. 11,000 patient study: Remdesivir is “a total dud” … Fauci channeled grants and billion dollar orders to Gilead then pushed $3000 drug as the “standard of care” …
  8. Johns Hopkins Researchers Identify Immune System Pathway That May Stop COVID-19 Infection
  9. https://amzn.to/37iQ2nC Amazon algorithm recommended it to me, has great reviews (including from medical doctors). Was able to download it for free from Amazon's lending program (which I didn't know existed until today) it seems pretty well written. Screen shot of supplement recommendations :
  10. Thats what I'm talkin' about, spread a little more terror everywhere you go like Saul and get more people thinking about their own mortality. ;)
  11. Interesting chart! They have the same for other countries too, just click "change country", source I hadn't heard the news that the second wave was over already 😉 Excess mortality
  12. It is sounding like the vaccine may be a tough sell: https://www.cnbc.com/2020/10/01/coronavirus-vaccine-trial-participants-exhaustion-fever-headaches.html “Coronavirus vaccine trial participants report day-long exhaustion, fever and headaches — but say it's worth it” And each new survey that comes out seems to show fewer and fewer people saying they will get the vaccine. Arg, if that’s the case this thing will very likely be here permanently, but maybe that was always in the cards... On a personal note, the sour economy finally caught up to me, I was part of a big layoff announcement today at the small company I’ve been working for the last 15 years (I didn’t even have kids when I started there, now I’ve got one in high school). Fun times we live in.
  13. Your take is probably wrong. Don’t want to go in circles rehashing what has already been hashed. A summary of evidence is here. You might also enjoy: Latitudinal variation in lifespan within species is explained by the metabolic theory of ecology “Latitude and lifespan were positively correlated in 85% of the species, although the relationship was statistically significant in only 39% of the cases. It is worth noting that under a null model without a latitudinal gradient in lifespan, the chances of obtaining 85% positive slopes are exceedingly small (χ2 = 27.597, P < 0.0001). Moreover, for all species with significant regressions, lifespan increased with latitude. As discussed below, it appears that much of this latitudinal variation may be explained by temperature using the MTE.“
  14. From what I’ve read t-cell immunity may be just as important if not more so to determining population vulnerabilities. So if they were only looking at SARS-CoV-2 antibodies the study may not be that useful.
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