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Gordo

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About Gordo

  • Birthday 07/22/1974

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  1. Gordo

    sex-restriction and longevity

    That sounds like guru-speak, there's a lot of woo there, but I'm glad you feel great. Some would beg to differ: https://veganhealth.org/choline/
  2. Gordo

    Vegan specimens and protein

    mccoy, do you believe pumping up one's muscles (beyond just having decent healthy muscle tone) is somehow going to lead to longevity? If so, what is your basis for this belief? I haven't seen any science or even any anecdotes, to suggest this is true. Doesn't it lead to higher growth factors and T? I can see why a teenager would want this, but why would you want high growth factors after your body is already fully developed?
  3. Gordo

    CR might increase number of cancers

    The "vibe" to me is that he doesn't really know what he's talking about. Too much wrong with this clip to even get into.
  4. https://www.fiercebiotech.com/biotech/xprize-board-member-raises-100m-fund-to-tackle-aging?fbclid=IwAR27EwNiKOj6O4N7vvOktGoYnaczWVwe_nc9UH4Cm6bs4EezHKBfEazeYoU XPrize board member raises $100M fund to tackle aging by Nick Paul Taylor | Feb 5, 2019 9:20am Longevity Vision Fund founder Sergey Young (XPrize) Longevity Vision Fund has exited stealth with plans to invest $100 million in startups with aspirations to extend healthy life spans. The fund, which is linked to the founder of XPrize, will pump the money into biotechs and other longevity startups based around the world in seed to series B rounds. Sergey Young, the founder of Longevity Vision, unveiled the fund at an event in London this week. Young is the cofounder of Peak State Ventures and an innovation board member at XPrize Foundation, a nonprofit known for running competitions to incentivize advances in fields including suborbital space flight. At Peak State, Young and his colleagues invest in fields well outside of longevity, including property and education. But Young has established a foothold in the longevity space, leading to him becoming development sponsor of Longevity XPrize and a longevity partner at Bold Capital Partners. Now, Young is using his experience and connections to invest $100 million in the longevity sector. The fund will cooperate with Bold Capital, a VC fund created by XPrize founder Peter Diamandis that has backed startups in or adjacent to the longevity field such as Iota Biosciences and Insilico Medicine. Longevity Vision will get deeper into the field by investing in startups in the U.S., China and Europe that are working on therapeutics, IT products, services and infrastructure related to the goal of increasing healthy human life spans. Young wants to increase human life spans to 200 years and make the technologies that enable such advances available to 1 billion people or more. Some of Young’s collaborators publicly express more conservative goals, but either way the potential health and financial payoffs are significant. “Adding 20 to 30 healthy years on a person's life is likely to be the largest market opportunity on Earth. The convergence of genome sequencing, AI and cellular medicine will enable breakthroughs that will make 100 years old the new 60,” Diamandis said in a statement. The ability of therapeutics and other complementary technologies to power such changes in healthy life spans remains unproven, but a growing pool of investors and startups are working on the problem. For now, the sums involved remain relatively small compared to the broader biotech sector, with the $100 million Longevity Vision Fund joining Juvenescence among the bigger players.
  5. A lot of people are excited about these results. From: https://drive.google.com/file/d/1D2dLXvE9_D6pCWozovnA44obV-Un4Z8v/view
  6. https://joshmitteldorf.scienceblog.com/2019/02/05/rumors-of-age-reversal-the-plasma-fraction-cure/ Rumors of Age Reversal: The Plasma Fraction Cure Posted on February 5, 2019 I say “rumors” because there is no publication and results from just 6 rats, all of which were sacrificed for the sake of tissue biopsies. Worse, we have no announcement of what the active agent(s) were that rejuvenated the rats, so discussion of mechanisms will have to wait. I’m writing this largely from personal and scientific trust, while recognizing that even the most careful and honest scientists can deceive themselves. “You are the easiest person to fool,” Feynman warned us. Some of you may recognize the name of Dr Harold Katcher, who is one of the most prolific and best-informed among many well-informed readers commenting on this blog. I’ve known Harold for about 10 years. We came together because we have the same idea about what aging is. The difference is that I have only the evolutionary reasoning, the logical shell. Harold also has the background in biochemistry to fill in the details. Filling in the details is what he has been doing, and this week he convinced me that he has the most promising age-reversal intervention yet devised. His treatment protocol is in preliminary stages of testing, and because the ideas that he and I share are out of the mainstream, it has not been easy for him to get funding. Now that he has preliminary results, perhaps that is about to change. He is committed to bypassing the standard channel of Big Pharma, proceeding on his own with appropriate partners to assure that the the technology gets to a wide public at affordable prices–but it is early to think in these terms. The heretical idea that unites Harold’s thinking and mine is this: Aging is controlled through evolutionarily conserved mechanisms. Some of the same genes and proteins that control the rate of aging in yeast cells serve the same function in mammals, which may live a thousand times longer than yeast. This implies that aging isn’t just random damage to individual cells; rather it is tightly regulated at the systemic level. Maybe there is a central clock, or maybe there is a consensus that is reached body-wide. But in any case, there is communication, assuring that different parts of the body keep to a common schedule. The natural place to look for this communication of the age stateof the body is through signal molecules in the blood. Thus our hypothesis, Harold’s and mine, is that even an old body remembers how to be young, if only it gets the message in the appropriate biochemical language. If an old mouse were to have the blood of a young mouse coursing through its veins, the old mouse would become a young mouse. Parabiosis experiments, sewing together mice of different ages so that they share a common blood supply, originated in the 19th century, but they took a leap into the 21st century beginning in the Stanford laboratory of Irv Weissman. His students spread out to Berkeley and Harvard, and the successors to these programs are studying the rejuvenation potential of various blood plasma components. (It’s not the red blood cells or the white blood cells. It’s not any cells at all, but the proteins and RNAs and short peptides that are dissolved in the blood’s clear liquid background, called plasma.) Some of the best-known people working on this idea are Mike and Irina Conboy at Berkeley, Amy Wagers at Harvard, Tony Wyss-Coray at Stanford. Two companies (Ambrosia and Alkahest) have begun selling transfusions of young blood to wealthy old folks, brave or desperate enough to experiment on themselves with untried technology, and to pay for the privilege. Harold doesn’t have the funding or the university infrastructure that these people have, but by his report he has leapfrogged their research. He claims to have isolated the crucial molecules in young blood plasma, and that it is feasible in the not-too-distant future to synthesize them, so we’re not all running like vampires after 20-something men and women, bidding up the price of their blood. His experimental results are preliminary, but impressive. On the one hand, there are big questions that remain; on the other hand, I’ve never seen success like this from any other intervention. (The possible exception is the Mayo Clinic’s work with senolytics, extending the lives of older mice; but the two approaches are so very different and what we know about the two is so different that there is no basis for saying one is more successful or more promising than the other.) So, what were the results that we find so impressive? I’ve linked to his own chart of results, and I’ve asked Harold to tell us in his own words. I’m full of questions, but Harold tells me these will have to wait until intellectual property is secured. For some interventions, the body is made stronger and levels of tissue growth repair are restored to youthful states, but there is a cost in elevated cancer risk. This is something that will take time to determine, and perhaps working with mice would be better, since they have higher cancer rates than rats. I would guess that a fully youthful phenotype will require restoration of the thymus, which shrinks severely with age both in rats and humans. The current report doesn’t mention thymic regrowth. What would rejuvenation look like in humans? Physical strength and mental acuity are a great start. Would my eye lenses soften to youthful levels? Would I grow new discs between my vertebrae (and regain the 2″ I’ve lost in the last decade)? How about teeth and hair? I’ve read that many blood factors are transient, with a half-life of seconds to minutes. I can imagine long-term effects from epigenetic reprogramming through blood factors, but I’m surprised this could happen without a continuous IV feed. And, of course, I’m curious about the content of the elixir. Thousands of different compounds have been isolated from blood plasma, and hundreds that differ between young and old. I think of the Conboys as leaders in this field, and when I spoke to them less than two years ago, they had been unable to identify a small subset of key factors that would induce changes in the rest. Harold has said, “these factors are ‘bio-similar’ to factors already present in the blood, they work by natural means…” The bottom line I respect Harold’s caution in protecting his discovery out of the reach of Big Pharma. On the other hand, so many questions are not being addressed because his resources are limited. This is indeed a very promising start, and let’s hope that the appropriate connections come along so that further experiments can proceed without delay.
  7. This guy seems to have found the secret to running: https://medium.com/esquire/i-was-addicted-to-running-high-it-almost-cost-me-6dc539fb7ccd
  8. Gordo

    Post a picture of what you just ate

    Interesting, I stumbled across this article today about a guy who analyzed his gut microbiome 600 times: https://www.cnbc.com/2019/01/31/former-apple-engineer-analyzes-microbiome-what-he-learned.html?__source=twitter|main&fbclid=IwAR2v541R03qo-I_3m76Qarm4EJLCx0pYn62wewEsYBneWoBVSeXd5wf7Vdk He made an interesting connection between potatoes and great sleep! I eat a sweet potato pretty much every day, and also sleep well, I wonder if there really is a connection, it says: Diet can have a big impact on Sprague's sleep. He noticed that when he ate potato starch, he was able to increase the amount of a microbe called bifidobacterium, an ingredient found in many commercial probiotics, in his gut. "I learned that this microbe likes to eat a particular kind of resistant starch in potatoes, so I'd drink it about 8 hours before sleep and tested myself," he explained. "I saw a bloom (of it), and sure enough, my sleep that night was amazing." He believes it increased his levels of melatonin, which induces sleep.
  9. Gordo

    U.S. Dietary Guidelines: An Evidence-Free Zone

    1) Not impossible, just not very practical for most people. Remember that animals don't make b12, bacteria do. Some mushrooms, and fermented foods, and seaweeds contain b12. Many water supplies (rivers and lakes) contain b12. b12 is in soil, so if you grow your own vegetables or get them from a trusted organic source, you could just eat them without "sand blasting" all the dirt off (again, not a very practical solution for anyone, we wash veges to remove pesticides and dangerous bacteria as well). B12 supplementation is recommended for even meat eating, older adults. 2) Define "healthiest". We know from cohort studies which diets are likely to lead to greatest healthspan and lifespan. From a pure survival perspective, back in the day, it was most practical to kill an animal and eat it, then you could spend the rest of your time doing other important things instead of foraging for plants all day like the super muscular, vegetarian gorilla, and you don't have to store up a massive quantity of vegetables for the Winter in climates with a Winter. But "nature" pretty much wants you to be healthy enough to survive and thrive while young, have kids, raise them long enough to succeed, then its done with you and best to kill you off quickly so you don't take resources away from the younger folks with better reproductive prospects. This means pretty much anything you are going to do for maximum healthspan and/or longevity is probably going to be "abnormal" (like calorie restriction, cold exposure, or eating a plant based diet) and basically fighting against "human nature" to some degree. What diets do you know of that have been scientifically proven to reverse heart disease (the leading killer in the world)? I only know of one, the plant based diet, and it seems the more extreme you do it, the better the results. Buildup of fatty plaques can be observed with ultrasound evaluation of the carotid arteries. What dietary factors fuel cancer if/when you get it? High growth factors seem to contribute. What diet results in high growth factors? Do fully grown adults, past the age of reproduction, need high growth? No. Could this be detrimental to longevity? Yes. What diet has a proven track record of preventing cancer and boosting the immune system? Not meat. Literally thousands of plant-derived compounds are associated with a lower risk for most types of cancer when used throughout your lifetime.
  10. Yes, after doing some research it seems you are correct about that, but you can still get enough vitamin D production in Summer to last you right through the winter even at high latitudes like in the UK, this is a good read: https://www.ncbi.nlm.nih.gov/pubmed/30071636 They cite the related: https://www.ncbi.nlm.nih.gov/pubmed/20716215 If you're white, you can indeed get all the vit-d you need to make it through the winter without deficiency, but you probably won't be producing any in Winter at high enough latitudes including much of the United States and all of Canada and the UK. Genny - there are other benefits to sun exposure (in Winter or any other time), sun exposure produces nitric oxide in our bodies, benefits include dilated blood vessels which lower blood pressure and dilated coronary arteries which stop angina. As discussed above it is also a way to modulate serotonin which is important for mental health.
  11. Gordo

    Fasting ramps up metabolism

    Also: https://www.healthline.com/nutrition/intermittent-fasting-metabolism Does Intermittent Fasting Boost Your Metabolism?
  12. Gordo

    Fasting ramps up metabolism

    I was watching a video that also mentioned fasting increases metabolism which I thought was an error until I actually looked into it...
  13. https://sci-hub.tw/10.1093/gerona/glx082
  14. He never mentioned in the video that CR lead to telomere preservation. One of the studies related to meditation that was mentioned was: But here's a more recent related publication (not cited in the video):
  15. Gordo

    Is CR bad for women/fertility

    Do you have kidney disease?
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