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Gordo

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About Gordo

  • Birthday 07/22/1974

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  1. Gordo

    The Impact Of The Microbiome On Lifespan

    I think this could be really important: Gut microbiome pattern reflects healthy ageing and predicts survival in humans https://www.nature.com/articles/s42255-021-00348-0 Wilmanski, T., Diener, C., Rappaport, N. et al. Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nat Metab 3, 274–286 (2021). https://doi.org/10.1038/s42255-021-00348-0 Abstract (emphasis mine) The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. In older age (over ~80 years), healthy individuals show continued microbial drift towards a unique compositional state, whereas this drift is absent in less healthy individuals. The identified microbiome pattern of healthy ageing is characterized by a depletion of core genera found across most humans, primarily Bacteroides. Retaining a high Bacteroides dominance into older age, or having a low gut microbiome uniqueness measure, predicts decreased survival in a 4-year follow-up. Our analysis identifies increasing compositional uniqueness of the gut microbiome as a component of healthy ageing, which is characterized by distinct microbial metabolic outputs in the blood. Here is a link to the studyfinds write up on the above study: Gut feeling: This could be the key enjoying a long, healthy life
  2. Gordo

    Post a picture of what you just ate

    Harvard study says 2 fruits, 3 vegetables ‘right’ number of daily servings for a longer life I mostly just liked the picture which resembled what I ate yesterday for lunch. 😉
  3. Gordo

    Sci Fi Movie and Book Recommendations

    I thought they were both amusing, but liked "Map" better. Interestingly, I remember Map paying homage to Groundhog Day by mentioning it, but not Palm Springs (maybe I was falling asleep and missed it, haha). Anyone watching WandaVision? I guess there is "sort of" a time travel element to that series. Its entertaining, but the last episode went a little too Disney for me with all the witch nonsense.
  4. Castration is probably not worth a possible extra 6 months of life 😉
  5. Gordo

    Sci Fi Movie and Book Recommendations

    Have not seen Palm Springs, but I will check it out. I love the genre.
  6. Gordo

    Sci Fi Movie and Book Recommendations

    If you like amusing temporal anomaly movies, check out "The map of tiny perfect things".
  7. Gordo

    Sci Fi Movie and Book Recommendations

    Watched it tonight, it was amusing. My wife and son had fun pointing out things that were changing in the background as time was altered 😉
  8. Yea I am alarmed by big tech censorship, they have gone too far and yet too many seem to be OK with this. It's all good until you are the one that is censored, or the people you enjoyed interacting with disappear. Media/social companies banning politicians, even celebrities now, that they don't like? Seems hard to believe this is happening in America. Good to see some countries are actually fighting for free speech.
  9. Gordo

    Sci Fi Movie and Book Recommendations

    I generally hate time travel in movies, I have this saying "time travel ruins everything" haha, but I'll check it out. Have you seen Tenet?
  10. Gordo

    What floss do you use?

    I have the same issue, which is why I switched to the flosser thingys, because its way easier -- you can bite down on it to push the floss between the teeth. I just wash and reuse them until they break, so a single bag is basically a lifetime supply.
  11. As stated in a similar thread, there are a LOT of really low quality studies/analysis of BMI with regard to longevity. These have been discussed in these forums many times. The higher quality the study, in particular when they look at never smokers and do REALLY LONG follow up to ENSURE no one with disease impacted the analysis, they find the ideal BMI is between 20-22. among healthy never smokers with exclusion of early follow-up, and 1.05 (1.04 to 1.07; I2=97%, n=198) among all participants. There was a J shaped dose-response relation in never smokers (Pnon-linearity <0.001), and the lowest risk was observed at BMI 23-24 in never smokers, 22-23 in healthy never smokers, and 20-22 in studies of never smokers with ≥20 years’ follow-up. But how this changes for the elderly is still a bit of a mystery as far as I know, for example some here believe higher BMI may be beneficial after age 80 or so, frailty can be a serious risk factor for the elderly, and having "excess reserves" to burn if/when you are very sick could also save your life.
  12. So it's good for the brain, it clears out scenescent cells, AND lengthens telemeres? I'm surprised there isn't more enthusiasm... Wonder what it costs to do this? Human ageing process biologically reversed in world first
  13. The tide seems to be turning where I live. I was driving through downtown last night, streets completely packed with cars. Every restaurant I could see into was completely full, no masks, no extra distance between tables, every table filled. Not sure if this is partly because my town has a big hospital and tons of medical personnel all of which are probably already vaccinated? All the teachers are also vaccinated now too. Or maybe people have just had enough and they are going back to normal regardless? I think in a few more months the economy should start really booming again. I wonder if we are going to see inflation starting to become a concern a year from now.
  14. There are a LOT of really low quality studies/analysis of BMI with regard to longevity. These have been discussed in these forums many times. The higher quality the study, in particular when they look at never smokers and do REALLY LONG follow up to ENSURE no one with disease impacted the analysis, they find the ideal BMI is between 20-22. among healthy never smokers with exclusion of early follow-up, and 1.05 (1.04 to 1.07; I2=97%, n=198) among all participants. There was a J shaped dose-response relation in never smokers (Pnon-linearity <0.001), and the lowest risk was observed at BMI 23-24 in never smokers, 22-23 in healthy never smokers, and 20-22 in studies of never smokers with ≥20 years’ follow-up. But how this changes for the elderly is still a bit of a mystery as far as I know, for example some here believe higher BMI may be beneficial after age 80 or so, frailty can be a serious risk factor for the elderly, and having "excess reserves" to burn if/when you are very sick could also save your life.
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