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About Gordo

  • Birthday 07/22/1974

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  1. I didn't do a deep dive into that article, but I think that topic has been discussed here before. In some cases, study organisms dying from cancer is actually a positive sign, if you live long enough, eventually you are going to get cancer, dying from cancer indicates that you did NOT die from everything else, such as the number one killer -> heart disease. So you can't look at cancer alone without looking at total mortality. I believe numerous mouse model cold exposure studies posted in this thread showed increased longevity. There are also some studies noted in this thread that seem to conflict with assertions made in that article, specifically I'm thinking of the one Dean posted: [1] Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13860-4. doi: 10.1073/pnas.0900300106. Epub 2009 Jul 30. Latitudinal variation in lifespan within species is explained by the metabolic theory of ecology. "To summarize, in species that span a wide range of latitudes, the within-species longevity is pretty strongly correlated with how far north (or south, in the southern hemisphere) an individual lives. That is, cooler environments → increased lifespan across a huge range of land, freshwater and marine species. Although less compelling because it wasn't an interventional study, the wide range of species which exhibited a longer lifespan in cold climates is suggestive, particularly when linked with the evidence discussed here that people's HbA1c improves in winter months." It is interesting that your cancer paper points out a difference between men and women. I have noted previously, that the top 3 countries where MEN specifically live the longest are Switzerland, Hong Kong, and Iceland. But I'm not convinced country (or states within a country) comparisons are valid at all. What Americans are doing extensive cold exposure? Most are in climate controlled environments pretty much 24/7 all year. You might look at outdoor workers, but then you have confounding issues - blue collar workers in general don't live as long. I think its harder than most people think to determine what average temperature a person is exposed to, it would actually make for a great study, have people wear temperature monitors 24/7 for a year and compare results from country to country. Some "tropical" places like Costa Rica, actually get pretty cool especially in the evenings and have frequent rains, and it is not common to have central heating there (I just googled the 10 day forecast in San Juan and every single night its mid 60's temps overnight and rain daily). I don't see much of a pattern in cancer rates by state: https://worldpopulationreview.com/state-rankings/cancer-rates-by-state Other than the northern states of South Dakota and Iowa having the lowest cancer rates. Similarly life expectancy by state seems pretty mixed: https://worldpopulationreview.com/state-rankings/life-expectancy-by-state You've got Hawaii and California with high life expectancy, but you also have Minnesota and much of the Northeastern states with high marks.
  2. TechKewl cooling vest still going strong after all these years. My beard keeps getting more gray though ;). Its a good time to do cooling experiments where I live 😉 Some fun articles: Queen Naked Mole Rats induce BAT activated thermogenesis even in warm temps, but subordinate naked mole rats do not this is of interest to me because if they could figure out why/how the queen does this maybe humans could too. Integrating Mortality Risk and the Adaptiveness of Hibernation: we tested the hypothesis that longevity was positively correlated with the hibernation season duration (the time spent between immergence and emergence from the hibernaculum or den) across 82 different mammalian species. We found that longevity increased significantly with hibernation season duration, an effect that was particularly strong in small hibernators (<1.5 kg) especially for bats. These results confirm that hibernation not only allows mammals to survive periods of energy scarcity, but further suggest that activity time budgets may be selected to reduce mortality risks according to life history pace. Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study: These guys found that prenatal cold exposure resulted in longer telomeres (with the opposite being true of heat exposure) "Consistently, prenatal temperature exposure below the cold threshold (5.0°C) was associated with longer cord blood telomere length" and they speculate that this could impact longevity and disease susceptibility later in life. A dose of experimental hormesis: When mild stress protects and improves animal performance: Here we review how hormesis studies have revealed animal performance benefits in response to changes in oxygen, temperature, ionizing radiation, heavy metals, pesticides, dehydration, gravity, and crowding. And how almost universally, hormetic responses are characterized by increases in performance that include either increases in reproduction, longevity, or both. And while the field can benefit from additional mechanistic work, we know that many of these responses are rooted in increases of antioxidants and oxidative stress protective mechanisms; including heat shock proteins. There is a clear, yet not fully elucidated, overlap between hormesis and the preparation for oxidative stress theory; which predicts part of the responses associated with hormesis.
  3. Gordo

    Organ Donation

    Thanks for that clarification, what I was really thinking but didn't write was that it seemed like based on what I've read, the longer term health risks post procedure for surviving donors are lower from a liver donation vs. kidney (i.e. The liver grows back and you are good to go, vs. missing a kidney and making your other one work harder and having higher risk of complications because of that). As for the impact on me from my wife donating a liver... I guess I'd just have to take care of her for several weeks and cancel the travel we have booked but that seems petty and insignificant in the grand scheme. In the unlikely event that she were to die or suffer long term injury the impact would be huge (we have two grade school kids, she also is the one in the family with a steady job, health insurance, and a pension, while I am the self employed one with no benefits). I wonder if you can buy a few million in life/disability insurance before the procedure and cancel it afterwards if all goes well? Maybe that would at least mitigate the financial risk aspect. I know at the end of the day saving a life takes precedence and its what I would hope someone would do for us, so it makes sense to do it. I support her in it. I would do the same. If I could start a donation chain maybe I could even take her place (assuming a matching donor in the chain could help her cousin, as I don't have the right blood type).
  4. Gordo

    Organ Donation

    Wondering if anyone has any thoughts about living liver donation? My wife's cousin needs a liver transplant, and apparently no one else among her relatives is both qualified as a living donor, and has A+ blood type except for my wife. She wants to do it. It makes me nervous. Looking into the stats, it seems liver donation may be less risky than kidney donation. Risk of death for the donor is 1 in 300, liver should just grow back, but they also have to remove the gall bladder as part of the procedure (not something I would voluntarily want to do, having had mine removed already, but I guess not the end of the world either). Requires a one week hospital stay and up to 8 weeks recovery, fatigue for up to 3 months. In my research, it looks like about 25% of people waiting for a liver transplant die while waiting. Flip that around and I guess you could say she has pretty good odds, 75% chance of getting a donor liver without my wife having to do it, if she just waits. I'm told she is #18 on the list to receive a transplant, which is pretty high priority (moved up this week after being hospitalized in extreme pain). Her cousin is pretty young (30's), doctors aren't sure what caused the liver failure (she does not drink, and does not have hepatitis, those are the two main causes of liver disease generally). Not really sure if, without knowing the cause, the transplanted liver would also be likely to fail? What would you do in this situation? It's a difficult decision from my perspective, but my wife has no hesitation about it, she wants to proceed and just considers it almost like an obligation to do what she can to help her cousin.
  5. Gordo

    Puzzling over approach and calorie paramaters

    Best meta-analysis of BMI I've seen is: https://www.bmj.com/content/353/bmj.i2156.abstract BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants BMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i2156 (Published 04 May 2016)Cite this as: BMJ 2016;353:i2156
  6. I saw this t-shirt being advertised on the worldometer site today, and it reminded me of this thread:
  7. Gordo

    Puzzling over approach and calorie paramaters

    I think you should consider the wider body of evidence before you adopt any potentially ill conceived ideas from the past. Truthfully most of the hard core calorie restrictors from this group and elsewhere have abandoned the older classic practices involving super low BMIs (<19), some developed health problems, frailty, osteoporosis, bone fractures. Some of the people who say they do CR have weirdly high BMIs too, I don't know, all I'd suggest is that you do a lot of research. One of the founding members and leaders here (who no longer participates here) wrote a pretty good book The CR Way (which ironically doesn't even mention calories much if at all, and warns people not to drop below a 20 BMI). The so called "Godfather of Calorie Restriction" Roy Walford died at age 79. There is a good thread here you might want to read:
  8. I enjoyed this latest Mathew Walker interview:
  9. That is a lie, see: https://www.projectveritas.com/news/settling-acorn-lawsuit/
  10. I have a bag of nibs that I just can't seem to get through, those things are pretty hard to eat 😉
  11. I like your car crash analysis 😉. So for me, I basically just felt a little "off kilter" for most of the day after getting the J&J vaccine, and tired. I was back to normal the next day. I never had a fever or any serious side effects, I didn't even have any pain at the injection site. Also note that I had heard a report on NPR that said people who do vigorous workouts on the day they get the vaccine, had better immune responses and higher long term antibody protection than people who did not. So I took that info and kind of went nuts, haha, I did 3 different HIIT workouts from YouTube, pullups, crunches, bike riding, and a hike down and back up a mountain the day I got the shot. So that might be why I felt tired, haha! Now in contrast, my wife got the Moderna vaccine, everything was pretty nominal after the first shot, but after the second shot, she felt sick for 3 days (mostly just tired, but also a little nausea and feverish). She still went to work, but most of her coworkers took a sick day after they got their second shot.
  12. Of course 2 days after I get the J&J vaccine it's use is now halted, haha: Don't 'overinterpret' decision to pause J&J Covid vaccine over rare clotting issue, Dr. Scott Gottlieb says I'm wondering if this could be that "accidentally went directly into blood stream" issue discussed previously in this thread? (the FDA expert thinks its just a very rare auto-immune response). 6 cases out of 6.8 million? I wonder what the odds are on non-vaccinated people getting a blood clot? This seems like a pretty weak reason to stop using the vaccine. UPDATE: The question about the background rate of these conditions is addressed in this morning's press conference: around the 20 minute mark, background rate for this type of blood clot is 2-14 people per 1 million population, but that is with normal platelet count, the unusual thing here apparently is the combination with low platelet count. They did not see such cases with the Pfizer/Moderna vaccines. A doctor on the call followed up at the end and asked "Well what's the background rate for people with low platelet count?" and the answer was "We don't know" 😉 but severe headaches and leg pains that start 6 days to 21 days after receiving the vaccine should lead a doc to check for low platelet counts and treat accordingly.
  13. True, but sending it back to bats only (or Wuhan labs only) would be a pretty good outcome 😉
  14. That's an interesting perspective, so by this logic, is it fair to say you believe mass vaccination will make the pandemic even worse? Given the preliminary results so far, I disagree, in fact I think it's actually the opposite. The more unvaccinated people out there, the greater the chances of mutation and spread over time. Even the J&J vaccine seems to stop the spread of the worst known variants. I'm optimistic that we can eradicate it with mass vaccination, but only time will tell. I share those concerns. And things just seem to be heading further off tilt/unhinged with time.