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Gordo

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  • Birthday 07/22/1974

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  1. Gordo

    Living for millions of years is possible

    I'm skeptical of their (unexplained) lifespan estimates, but interesting content nonetheless, you would think mars' interior should be teeming with life unless Earth is some miraculous exception (given that Mars' surface was carved out by water and water is very likely below the surface).
  2. I like this development, prior criticisms of AI often mentioned things like the previous generation chess algorithms which really just did massive number crunching, we've now moved beyond that, with neural type learning, and the kicker is that this approach is actually superior to the massive number crunching approach, and even seems to be "creative" in some sense, able to teach humans new things. I also like that they have now turned their attention to using this technology to solve health related problems (how exactly they will do that, I'm not sure). https://news.yahoo.com/deepmind-apos-alphazero-now-showing-190000147.html DeepMind's AlphaZero now showing human-like intuition in historical 'turning point' for AI Sarah Knapton , The Telegraph•December 6, 2018 Demis Hassabis the co-founder and CEO of DeepMind - DeepMind More DeepMind’s artificial intelligence programme AlphaZero is now showing signs of human-like intuition and creativity, in what developers have hailed as ‘turning point’ in history. The computer system amazed the world last year when it mastered the game of chess from scratch within just four hours, despite not being programmed how to win. But now, after a year of testing and analysis by chess grandmasters, the machine has developed a new style of play unlike anything ever seen before, suggesting the programme is now improvising like a human. Unlike the world’s best chess machine - Stockfish - which calculates millions of possible outcomes as it plays, AlphaZero learns from its past successes and failures, making its moves based on, a ‘nebulous sense that it is all going to work out in the long run,’ according to experts at DeepMind. When AlphaZero was pitted against Stockfish in 1,000 games, it lost just six, winning convincingly 155 times, and drawing the remaining bouts. The AlphaZero team at work Credit: DeepMind More Yet it was the way that it played that has amazed developers. While chess computers predominately like to hold on to their pieces, AlphaZero readily sacrificed its soldiers for a better position in the skirmish. Speaking to The Telegraph, Prof David Silver, who leads the reinforcement learning research group at DeepMind said: “It’s got a very subtle sense of intuition which helps it balance out all the different factors. “It’s got a neural network with millions of different tunable parameters, each learning its own rules of what is good in chess, and when you put them all together you have something that expresses, in quite a brain-like way, our human ability to glance at a position and say ‘ah ha this is the right thing to do'. “My personal belief is that we’ve seen something of turning point where we’re starting to understand that many abilities, like intuition and creativity, that we previously thought were in the domain only of the human mind, are actually accessible to machine intelligence as well. And I think that’s a really exciting moment in history.” AlphaZero started as a ‘tabula rasa’ or blank slate system, programmed with only the basic rules of chess and learned to win by playing millions of games against itself in a process of trial and error known as reinforcement learning. It is the same way the human brain learns, adjusting tactics based on a previous win or loss, which allows it to search just 60 thousand positions per second, compared to the roughly 60 million of Stockfish. Garry Kasparov playing against Deep Blue in 1997 Credit: Rex Features More Within just a few hours the programme had independently discovered and played common human openings and strategies before moving on to develop its own ideas, such as quickly swarming around the opponent’s king and placing far less value on individual pieces. The new style of play has been analysed Chess Grandmaster Matthew Sadler and Women’s International Master Natasha Regan, who say it unlike any traditional chess engine. ”It’s like discovering the secret notebooks of some great player from the past,” said Sadler. Regan added: “It was fascinating to see how AlphaZero's analysis differed from that of top chess engines and even top Grandmaster play. AlphaZero could be a powerful teaching tool for the whole community." Garry Kasparov, former World Chess Champion, who famously lost to chess machine Deep Blue in 1997, said: “Instead of processing human instructions and knowledge at tremendous speed, as all previous chess machines, AlphaZero generates its own knowledge. “It plays with a very dynamic style, much like my own.The implications go far beyond my beloved chessboard." The new analysis was published yesterday in the journal Science, and the DeepMind team are now hoping to use their system to help solve real world problems, such as why proteins become misfolded in diseases such as Parkinson’s and Alzheimer’s. The new results suggest that it could come up with new solutions that humans might miss or take far longer to discover. DeepMind CEO and co-founder Demis Hassabis said: “The reason that tabula rasa was important is because we want this to be as general as possible. The more general it is across the games the more likely it will be able to transfer to real world problems. Like protein folding. “Protein folding has always been our number one target. I’ve had that in mind for a long time, because its a huge problem in biology and it will unlock a lot of other things like drug discovery. "In chess AlphaZero works not because it’s looking further ahead but because it understands the position better. It’s generalising from past experience. It’s almost like intuition in the same way a human grandmaster would think about it, it's evaluation of the current situation is better. And if you’re evaluation is better then you don’t have to do as much calculation.” Prof Silver added: “Historically there has been this amazing mismatch between the things that humans can do and the things that computers can do. “With the advent of powerful machine learning techniques we’ve seen that the scales have started to tip and now we have computer algorithms that are able to do these very human-like activities really well.”
  3. Gordo

    CR vs. common illness

    Slightly off topic for this thread, but there was some interesting news this week related to the above: https://www.telegraph.co.uk/science/2018/12/04/blood-test-detect-cancer-within-just-10-minutes-developed-scientists/ A new blood test that sounds very promising that can supposedly detect any type of cancer you may have lingering about your body. As for longevity and frequency of illness - I don't know, but at least one supercentenarian I read about claimed to have never been sick a day in his life. I would think having a super immune system would certainly help you achieve longevity.
  4. Gordo

    UCL Human Cognition Calorie Restriction Study

    I just took the test, one part was pretty crazy. Yea, I'm not sure what they are really going after, but I would think aptitude (IQ) would play a pretty big role in how you perform on this test, and there is no "before vs. after" diet change being done. They didn't ask about age, gender, height, weight, sleep or any other potentially confounding variables. I'm not sure what this study is really all about, there must be something they are hiding, haha. They seem to have put a lot of work into setting up the testing platform... They pretty much only ask you to describe in detail what you ate and when, for the day you are taking the test, and you have to take it in a specific 4 hour evening window. You are also supposed to take the test twice on different days, not more than 7 days apart, so I'm thinking there could be some potentially interesting data to mine there related to food choices and test performance or timing of eating and test performance when comparing your first result to the second result. I don't know if the second test will be identical to the first one, if so, you might do better the second time just because you are familiar with the test and its instructions.
  5. Gordo

    UCL Human Cognition Calorie Restriction Study

    Eh, all the participant info sheet says is "You have been chosen to take part in this study because you are a healthy adult (18-60 yrs) who has already begun either the 5:2 diet or a continuous calorie restriction (daily calorie restriction of between 15-25%) diet.". Still isn't clear if you are expecting fat people who have been trying to lose some weight (reduced calories for the last 4 weeks) or healthy non-overweight people who eat 15-25% less than the average person of the same age, gender, and height? Or maybe its 15% less than you ate immediately before starting your calorie restricted diet? Or maybe you are looking for hard core calorie restrictors that are in the 15-18 BMI range? Or maybe you don't really care and hence don't feel like defining your own criteria? 😉 Either way, I like puzzles, I'm in! Haha.
  6. https://www.cell.com/cell/fulltext/S0092-8674(18)31500-9?fbclid=IwAR1xelMsqAYbATAbpdvgS1IwqtRGMSmdHrFvZmWF-d8b9nOJZO8vs3AEZmk Secretin: An Old Hormone with a Burning Secret Most theories of meal-induced thermogenesis involve a gut-brain-brown adipose tissue axis driving sympathetic nervous system-mediated thermogenesis. Li et al. demonstrate that secretin released by the gut after a meal binds to abundant receptors in brown adipose tissue to stimulate thermogenesis, inhibiting food intake and thereby suggesting a novel role for secretin regulating satiety.
  7. Gordo

    UCL Human Cognition Calorie Restriction Study

    "restricting their daily calorie intake by at least 15%" 15% of what?
  8. Gordo

    UCL Human Cognition Calorie Restriction Study

    You didn't define what you consider "daily CR lifestyles". I think the biggest factor impacting executive function is sleep.
  9. "It's best to ask your doctor how to work off all that turkey and dressing" Seriously? 😉 Michael, whats going on with your voice?
  10. Gordo

    Back to CE but...

    Where I live it seems some kind of nasty cold has been hitting everyone. My wife and kids all got it, I was optimistic, but as soon as they got better, I went down hard, had a fever for 3 continuous days and the worst sore throat of my life, pretty much lost the ability to talk, swallowing was excruciating. I think it was probably strep throat. Anyway, I don't do CE unless I'm 100%, but I don't think there is any evidence that it compromises the immune system, that's a myth: https://www.verywellhealth.com/does-cold-weather-cause-the-cold-or-flu-770379
  11. He just published this very nice lecture yesterday. 13:44 CR in primates 25:30 talks about CALERIE study 29:02 he specifically mentions the CR Society and shows a before/after pic and biomarkers of one member (who is this?) 36:55 talks about the importance of increasing adiponectin and especially the importance of reduced core body temperature as a biomarker for longevity 38:00 skeletal muscle profile on CR, importance of downregulation of IGF-1 43:40 Side effects of chronic severe CR - how to know if you are overdoing CR 44:30 It is NOT TRUE that the more CR the better. Talks about study showing how 40% CR did not result in increased longevity for 2/3rds of the subtypes of mice tested. 20% CR is optimal for many strains of mice. Biomarkers are key for determining what the optimal CR level is. You must have sufficient energy to promote longevity. 46:15 Used to think it was just about the calories, but now we know that is NOT true. Composition of diet is important, meal timing is important - CR with eating all day does not result in longevity in mice (50:00) 51:10 Discusses ongoing human intermittent fasting clinical trial 53:40 Importance of low protein / methionine restriction for longevity independent of CR (blocks tumor development) 59:25 You should eat around 10% protein ("a calorie is not a calorie", "stay away from low carb or ketogenic diets") 1:04:20 Talks about the gut microbiome. Diet reliably and rapidly changes the gut microbiome, protein intake and fiber are key, the more diversity of vegetables you eat the better your gut microbiome, which results in reduced inflamation (related to short chain fatty acids). Eat legumes, whole grains, and lots of vegetables. 1:10:50 Your gut microbiome impacts your physiologic response to CR 1:13:00 Describes other pieces of the health/longevity puzzle he will talk about in a future lecture: exercise, breathing and rate of respiration, sleep, meditation, phytochemicals, cognitive training 1:18:00 Future of medicine is prevention. Reducing mental stress, sedentary lifestyle, excessive calorie intake, and poor diets are key.
  12. https://insights.ovid.com/crossref?an=00005768-900000000-96766 Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality Abstract Purpose Resistance exercise (RE) can improve many cardiovascular disease (CVD) risk factors, but specific data on the effects on CVD events and mortality are lacking. We investigated the associations of RE with CVD and all-cause mortality, and further examined the mediation effect of body mass index between RE and CVD outcomes. Methods We included 12,591 participants (mean age 47 years) who received at least two clinical examinations 1987-2006. RE was assessed by a self-reported medical history questionnaire. Results During a mean follow-up of 5.4 and 10.5 years, 205 total CVD events (morbidity and mortality combined) and 276 all-cause deaths occurred, respectively. Compared with no RE, weekly RE frequencies of one, two, three times or total amount of 1-59 minutes were associated with approximately 40-70% decreased risk of total CVD events, independent of aerobic exercise (AE) (all p-values <0.05). However, there was no significant risk reduction for higher weekly RE of more than four times or ≥60 minutes. Similar results were observed for CVD morbidity and all-cause mortality. In the stratified analyses by AE, weekly RE of one time or 1-59 minutes was associated with lower risks of total CVD events and CVD morbidity regardless of meeting the AE guidelines. Our mediation analysis showed that RE was associated with the risk of total CVD events in two ways: RE had a direct U-shape association with CVD risk (p-value for quadratic trend <0.001) and RE indirectly lowered CVD risk by decreasing BMI. Conclusion Even one time or less than one hour/week of RE, independent of AE, is associated with reduced risks of CVD and all-cause mortality. BMI mediates the association of RE with total CVD events. Popular Press: https://www.msn.com/en-us/health/fitness/less-than-one-hour-of-weightlifting-a-week-may-reduce-risk-of-heart-attack-and-stroke/ar-BBPHbSz?OCID=ansmsnnews11 Less than one hour of weightlifting a week may reduce risk of heart attack and stroke New US research has found that lifting weight for less than an hour a week could reduce the risk of heart attack or stroke by 40 to 70 percent. Carried out by researchers at Iowa State University, the new large-scale study looked at 12,591 participants with an average age of 47 years. The researchers assessed the participants' level of resistance exercise using self-reported questionnaires, and investigated the possible association between this type of exercise and three health outcomes: cardiovascular events such as heart attack and stroke that did not result in death, all cardiovascular events including death, and death from all causes. The findings, published in the journal Medicine and Science in Sports and Exercise, showed that resistance exercise reduced the risk for all three health outcomes included in the study. Engaging in a total of 1 to 59 minutes of weightlifting per week, split over either one, two, or three sessions, was associated with a 40 to 70 percent reduced risk of experiencing a cardiovascular event. Similar results were also found when looking at the risk of death from cardiovascular events and death from all causes. However, four sessions a week or spending more than an hour weightlifting did not bring any additional benefit, the researchers found. "People may think they need to spend a lot of time lifting weights, but just two sets of bench presses that take less than 5 minutes could be effective," said author Duck-chul Lee. [Gordo: This is what I've suspected for years, that you really only need about 5 minutes of exercise per day if done right, particularly so if you are already a very healthy eater who doesn't need to burn off excess calories with exercise] The results, which are some of the first to look at the relationship between resistance exercise and cardiovascular disease, also showed that benefits of the exercise are independent of running, walking or other aerobic activity, meaning that even if individuals do not meet the recommended guidelines for aerobic physical activity, weight training alone may be enough to lower the risk of cardiovascular diseases. The researchers noted that resistance exercise is not as easy to incorporate into a daily routine as aerobic exercise, with Lee suggesting a gym membership to give individuals access to weights and more options for resistance exercise. In a previous study Lee also found that people with a gym membership exercised more. However, although the current study did look specifically at use of free weights and weight machines, such as those found in a gym, Lee added that any resistance exercises or muscle-strengthening activities will still bring benefits. "Lifting any weight that increases resistance on your muscles is the key," Lee said. "My muscle doesn't know the difference if I'm digging in the yard, carrying heavy shopping bags or lifting a dumbbell."
  13. https://www.sciencedaily.com/releases/2018/11/181106104247.htm Family tree of 400 million people shows genetics has limited influence on longevity Study of huge Ancestry.com pedigree set suggests similar life spans between spouses may have inflated previous estimates of life span heritability Date: November 6, 2018 Source: Genetics Society of America Summary: Although long life tends to run in families, genetics has far less influence on life span than previously thought, according to a new analysis of more than 400 million people. The results suggest that the heritability of life span is well below past estimates, which failed to account for our tendency to select partners with similar traits to our own. Share: FULL STORY How long you live has less to do with your genes than you might think. Credit: © Sondem / Fotolia Although long life tends to run in families, genetics has far less influence on life span than previously thought, according to a new analysis of an aggregated set of family trees of more than 400 million people. The results suggest that the heritability of life span is well below past estimates, which failed to account for our tendency to select partners with similar traits to our own. The research, from Calico Life Sciences and Ancestry, was published in GENETICS, a journal of the Genetics Society of America. "We can potentially learn many things about the biology of aging from human genetics, but if the heritability of life span is low, it tempers our expectations about what types of things we can learn and how easy it will be," says lead author Graham Ruby. "It helps contextualize the questions that scientists studying aging can effectively ask." Ruby's employer, Calico Life Sciences, is a research and development company whose mission is to understand the biology of aging. They teamed up with scientists from the online genealogy resource Ancestry, led by Chief Scientific Officer Catherine Ball, to use publicly available pedigree data from Ancestry.com to estimate the heritability of human life span. Heritability is a measure of how much of the variation in a trait -- in this case life span -- can be explained by genetic differences, as opposed to non-genetic differences like lifestyle, sociocultural factors, and accidents. Previous estimates of human life span heritability have ranged from around 15 to 30 percent. "Partnering with Ancestry allowed this new study to gain deeper insights by using a much larger data set than any previous studies of longevity," said Ball. Starting from 54 million subscriber-generated public family trees representing six billion ancestors, Ancestry removed redundant entries and those from people who were still living, stitching the remaining pedigrees together. Before sharing the data with the Calico research team, Ancestry stripped away all identifiable information from the pedigrees, leaving only the year of birth, year of death, place of birth (to the resolution of state within the US and country outside the US), and familial connections that make up the tree structure itself. They ended up with a set of pedigrees that included over 400 million people -- largely Americans of European descent -- each connected to another by either a parent-child or a spouse-spouse relationship. The team was then able to estimate heritability from the tree by examining the similarity of life span between relatives. Using an approach that combines mathematical and statistical modeling, the researchers focused on relatives who were born across the 19th and early 20th centuries, finding heritability estimates for siblings and first cousins to be roughly the same as previously reported. But, as was also observed in some of the previous studies, they noted that the life span of spouses tended to be correlated -- they were more similar, in fact, than in siblings of opposite gender. This correlation between spouses could be due to the many non-genetic factors that accompany living in the same household -- their shared environment. But the story really started to take shape when the authors compared different types of in-laws, some with quite remote relationships. The first hint that something more than either genetics or shared environment might be at work was the finding that siblings-in-law and first-cousins-in-law had correlated life spans -- despite not being blood relatives and not generally sharing households. The size of their dataset allowed the team to zoom in on longevity correlations for other more remote relationship types, including aunts and uncles-in-law, first cousins-once-removed-in-law, and different configurations of co-siblings-in-law. The finding that a person's sibling's spouse's sibling or their spouse's sibling's spouse had a similar life span to their own made it clear that something else was at play. If they don't share genetic backgrounds and they don't share households, what best accounts for the similarity in life span between individuals with these relationship types? Going back to their impressive dataset, the researchers were able to perform analyses that detected assortative mating. "What assortative mating means here is that the factors that are important for life span tend to be very similar between mates," says Ruby. In other words, people tend to select partners with traits like their own -- in this case, how long they live. Of course, you can't easily guess the longevity of a potential mate. "Generally, people get married before either one of them has died," jokes Ruby. Because you can't tell someone's life span in advance, assortative mating in humans must be based on other characteristics. The basis of this mate choice could be genetic or sociocultural -- or both. For a non-genetic example, if income influences life span, and wealthy people tend to marry other wealthy people, that would lead to correlated longevity. The same would occur for traits more controlled by genetics: if, for example, tall people prefer tall spouses, and height is correlated in some way with how long you live, this would also inflate estimates of life span heritability. By correcting for these effects of assortative mating, the new analysis found life span heritability is likely no more than seven percent, perhaps even lower. The upshot? How long you live has less to do with your genes than you might think. Story Source: Materials provided by Genetics Society of America. Note: Content may be edited for style and length. Journal Reference: J. Graham Ruby, Kevin M. Wright, Kristin A. Rand, Amir Kermany, Keith Noto, Don Curtis, Neal Varner, Daniel Garrigan, Dmitri Slinkov, Ilya Dorfman, Julie M. Granka, Jake Byrnes, Natalie Myres, Catherine Ball. Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating. Genetics, 2018; 210 (3): 1109 DOI: 10.1534/genetics.118.301613
  14. Gordo

    Clinton's Stack

    The most common reason for using melatonin supplements is to encourage sleep when sleep problems exist, the additional mention of using a sleep mask and ear plugs add to this concern (potential lack of deep sleep and/or proper sleep environment). Sleep problems are a red flag indicating long term health and longevity are at risk. Maybe taking a melatonin supplement and wearing masks/plugs is just as good a method as alternative ways of improving sleep, I don't know, but suspect not:
  15. I was being facetious because it’s a goofy question. Let’s say you concocted the perfect blend of nutrient dense low calorie foods, and let’s say you get your RDA of everything on 400 calories- ok, so what? You still need another 1600 calories give or take to survive assuming you don’t stay in bed all day, hence by definition you cannot have optimal nutrition without adequate calories, so the question really becomes- how many calories are required to have optimal health. If you look at people who put this to the test, they often have bone density problems so maybe that’s one way to zero in on an answer (if you have osteoporosis you probably aren’t doing something right), another factor might be susceptibility to infectious disease. You could also just look at the massive meta studies on BMI as a reasonable guideline for an optimal range with regard to mortality.
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