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About Gordo

  • Birthday 07/22/1974

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  1. Thanks for posting, I had not heard of this device but now I want one! Do you actually have one and if so, how long have you been using it and in what ways do you think it has benefitted you? I'm wondering if you can get the EEG, respiration, and heart rate data off of the device? (I'm thinking of possible uses in addition to its deep sleep improvement or sleep analysis features, to further justify the expense). Also wondering if the device is "open" for hacking/development, for example I see strong potential for use as a tool to gain consciousness while dreaming (i.e. "lucid dreaming") through auditory or visual cues when REM sleep is detected though EEG and/or heart rate (possible improvement over existing lucid dream masks). I'll contact its manufacturer about my ideas...
  2. Gordo

    Going complete vegan

    Only with respect to iron (in which case there was no problem found and I need no supplement nor do I have too much). For something like b12, DHA, D3, zinc or iodine it seemed silly to do testing, because the testing itself costs more than the supplements and you'd have to keep testing every year as nutrient requirements and bodily function change with age. If you limit your supplementation to recommended amounts (avoid excessive doses), there is little risk of taking too much even if you were already receiving enough in your diet (If I'm getting decent sun exposure and its Summer, I don't take D3, I take b12 only once a week, zinc only 2-3 times a week). "when one (apparently) explores and understands nature better, does the nature itself offer the opportunity to fight nature?" Well humans are part of nature, so the answer is of course, yes. We may have been guided since the beginning of life on Earth by basic survival but now we've already moved beyond that in many respects and have the capability to mess with the genetic code itself, replace or remove failing organs, rejuvenate cells, modify hormones and disrupt physiological processes. It seems reasonable to me to think that we will achieve radical life extension eventually despite the formidable hurdles encountered thus far.
  3. Can We Become Immortal? The Quest to Live Forever Through Technology Several promising projects involving robotics, genetics, cryonics, 3D printing and more are in the pipeline seeking to make the idea of living forever plausible. By Kashyap Vyas Link to article from October, 15th 2018 Humans have always been looking for ways of not having to die. It is an instinct as strong as survival to extend our lifespan and eliminate diseases from the face of humanity. As unrealistic and incomprehensible as the idea might seem, researchers have forever been focusing their efforts on cheating death and leading invincible lives. There have been countless experiments, studies, and investigations into this theory that have prompted scientists to design ingenious ways of not just extending our lives, but eliminating the concept of death altogether. Bina48 is a robotic very primitive representation of you that can incorporate the characteristics and unique eccentricities of your being into a new form. According to the latest experiment dedicated to Bina48, the robot is being loaded with inexhaustible information. Source: iBina48/Twitter This information is being derived from the interviews held between Bina Rothblattand Bruce Duncan. This robot has been the subject of an experiment for more than a decade where scientists have been trying to make it more social and smarter. 2017 made Bina48 the first robot in history to ever successfully complete a university level course and the following year has only proved to be more victorious for the robot. This robot experiment is just one amongst countless that have been initiated in a bid to live forever! Another study revealed by the futurologist Dr. Ian Pearson reveals that human beings are quite close to becoming “immortal,” i.e., they are likely to achieve the ability to “not die” ever. According to Dr. Pearson, there are various ways of living forever but only if we can make it till 2050. Some of the methods that he listed are as follows: Body Part Renewal: With the help of genetic engineering, your body parts can be rejuvenated. Also, scientists are working towards creating human body parts and organs with the help of 3D printers that are loaded with living cells. It can help in replacing the old and withered body parts with healthy ones. Start your life in an Android body: Another way to live a longer life is to link your mind with a machine and start living in the cloud. According to Dr. Pearson, you can easily hire an Android in 2050 like you hire a car these days and transfer your consciousness to it. For example, the current status of sex dolls is almost like humans, and they are likely to achieve a form closer to humans in the next 30 years. Biomedical Technology The biomedical technology has also made several advances toward reverse the aging process. According to a statement issued by Daily Express, “From enhancing certain proteins which protect cells from aging to extending telomeres – fragments of DNA which cap both ends of each chromosome and protect against the wear and tear of natural aging – scientists have tried to halt the aging process.” Hence, there is a lot of hope for humans to live forever. Cryonics Cryonics is also an excellent option for human beings who want to achieve immortality. Through this process, people can be frozen in liquid nitrogen with a hope to be safely revived and defrosted. Although there is no proof of this concept, yet it is hoped that there would be enough scientific advancements in the future to revive such bodies so that they can start reliving a normal life. Alcor Life Extension Foundation has put forward an approach in which the brain of a person would be removed before his/her death and will be treated with a chemical fixative and a cryoprotective agent. Brain preservation there is still a lot of is technically possible according to a neuroscientist Kenneth Hayworth, but he says that research needed. Swap Your Body with An Android Avatar Dmitri Itskov, a Russian billionaire and a former media tycoon, has founded the 2045 Project. In this project, he is trying to find possibilities to replace human bodies with their robotic avatars that would be uploaded with all the content of their human counterparts. The ultimate goal of this project is to extend the lives of human beings by hundreds or even thousands of years. Itskov’s overall ambition is to create a utopia where people can be free from their corporal selves and can spend their time on spiritual and intellectual growth. Recently, Dmitri also unveiled a sophisticated robot that was a replica of his own head. It was designed by the pioneer in robotics named David Hanson. There would be as many as 36 motors in the head that ought to create exceptional realism or in other words, an exceptional Android. Source: 2045 Initiative The final aim is to create a full human Android body that can jump, run, walk and behave exactly like a human being in the future. This will help people to live longer and healthier lives. Transferring Your Consciousness to An Artificial Body A new startup called Humai wants to help people live forever by transferring their consciousness to an artificial body. The CEO of this company, Josh Bocanegra believes that the team in his startup will create its own human being in the next 30 years. ROBOTICS Two Humanoid Robots Discuss the Fate of Humanity In his words, "We’re using artificial intelligence and nanotechnology to store data of conversational styles, behavioral patterns, thought processes and information about how your body functions from the inside-out. This data will be coded into multiple sensor technologies, which will be built into an artificial body with the brain of a deceased human. Using cloning technology, we will restore the brain as it matures." As can be seen, countless initiatives and experiments have been started to date and continue popping up to increase the life of humans and make them “immortal.” Humans continue striving to achieve the impossible and have dedicated their careers to making this dream happen. Irrespective of the approach taken by different scientists and researchers to avoid the inevitability of death, their long-term goals are pretty much aligned - make humans live forever! Only future holds the truth of this dream while efforts in this direction continue.
  4. Gordo

    Going complete vegan

    "Nature" does not want you to have longevity, better to kill you off shortly after reproduction and parenting are done, to give more resources to your offspring and theirs 😉 Also you can survive on almost anything, there is a show called "Freaky Eaters" (also on YouTube) that shows people who have been living for years on the strangest, hyper-limited diets (nothing but french fries, nothing but pizza, nothing but cheeseburgers, there was a woman drinking over 4000 kcal a day of soda (30 cans a day, and didn't get especially fat either by the way). See: https://www.youtube.com/results?search_query=freaky+eaters I don't consider myself "vegan" by the way. I like to tell people I eat a plant based whole food diet. I do eat non-vegan foods about once a week (occasional dairy item, or small portion of salmon). I believe it's what you do 90% of the time that matters as far as health is concerned, and the exceptions aren't going to make any significant difference if they are minor and infrequent. You will know how well your regime is doing by your biomarkers of health and aging indicators compared to others - and those don't lie 😉 I think some people get so obsessed with diet tweaks that they end up damaging their health with anxiety and anti-social behavior. There is MUCH more to longevity than what or how you eat. If you have a lousy marriage or no friends or poor sleep, you aren't likely to have longevity for example.
  5. Gordo

    Going complete vegan

    I think the 2 main supplements recommended for vegans are also generally recommended for non-vegans too, so I don't consider that a major factor. B12 is so cheap its almost free, only needs to be taken once a week or even less frequently. DHA - most meat eaters don't get the recommended amount because they don't eat a lot of salmon/oily fish. Fish generally have pretty high levels of contamination: https://www.epa.gov/fish-tech/national-lake-fish-tissue-study-results-and-data https://scripps.ucsd.edu/news/study-finds-toxic-pollutants-fish-across-worlds-oceans https://www.consumerlab.com/answers/is-fish-oil-safe/fish-oil_contamination/ Is this worse than the contaminants in plant foods? I don't know... But its easy enough to get dha from a vegan supplement, and this is likely a superior source than fish oil supplements which are more likely to go rancid and contain pcbs. Eating meat & dairy can spike your growth factors and other cell signaling which may not be optimal for longevity, especially for men. The longest lived people group ever documented (as far as I know) are CA Adventists, and their diets have been studied. For men, the vegan diet was optimal for longevity, for women, pesco-vegetarian was best. Table 4 Associations of Dietary Patterns With All-Cause and Cause-Specific Mortality From a Cox Proportional Hazards Regression Model Among Participants in the Adventist Health Study 2, 2002–2009 Characteristic Deaths, Hazard Ratio (95% CI) All-Cause Ischemic Heart Disease Cardiovascular Disease Cancer Other All (N = 73 308), No. of deathsa,b 2560 372 987 706 867  Vegetarian   Vegan 0.85 (0.73–1.01) 0.90 (0.60–1.33) 0.91 (0.71–1.16) 0.92 (0.68–1.24) 0.74 (0.56–0.99)   Lacto-ovo 0.91 (0.82–1.00) 0.82 (0.62–1.06) 0.90 (0.76–1.06) 0.90 (0.75–1.09) 0.91 (0.77–1.07)   Pesco 0.81 (0.69–0.94) 0.65 (0.43–0.97) 0.80 (0.62–1.03) 0.94 (0.72–1.22) 0.71 (0.54–0.94)   Semi 0.92 (0.75–1.13) 0.92 (0.57–1.51) 0.85 (0.63–1.16) 0.94 (0.66–1.35) 0.99 (0.72–1.36)  Nonvegetarian 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference] Men (n = 25 105), No. of deathsa 1031 169 390 273 368  Vegetarian   Vegan 0.72 (0.56–0.92) 0.45 (0.21–0.94) 0.58 (0.38–0.89) 0.81 (0.48–1.36) 0.81 (0.53–1.22)   Lacto-ovo 0.86 (0.74–1.01) 0.76 (0.52–1.12) 0.77 (0.59–0.99) 1.01 (0.75–1.37) 0.89 (0.69–1.15)   Pesco 0.73 (0.57–0.93) 0.77 (0.45–1.30) 0.66 (0.44–0.98) 1.10 (0.73–1.67) 0.60 (0.39–0.93)   Semi 0.93 (0.68–1.26) 0.73 (0.33–1.60) 0.75 (0.43–1.32) 1.15 (0.65–2.03) 1.03 (0.62–1.71)  Nonvegetarian 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference] Women (n = 48 203), No. of deathsa,c 1529 203 597 433 499  Vegetarian   Vegan 0.97 (0.78–1.20) 1.39 (0.87–2.24) 1.18 (0.88–1.60) 0.99 (0.69–1.44) 0.70 (0.47–1.05)   Lacto-ovo 0.94 (0.83–1.07) 0.85 (0.59–1.22) 0.99 (0.81–1.22) 0.85 (0.67–1.09) 0.93 (0.75–1.17)   Pesco 0.88 (0.72–1.07) 0.51 (0.26–0.99) 0.90 (0.66–1.23) 0.86 (0.61–1.21) 0.81 (0.58–1.15)   Semi 0.92 (0.70–1.22) 1.09 (0.60–1.98) 0.93 (0.64–1.34) 0.85 (0.56–1.30) 0.97 (0.64–1.47)  Nonvegetarian 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference] 1 [Reference]
  6. kpfleger - cold exposure can be used to improve sleep (that's what I do), this is also discussed in the cold exposure thread (search that thread for "sleep"). This can result in very deep restorative sleep which boosts immune function. Its funny because just yesterday the company I work for sent out an email to all employees promoting the flu shot (its free, no copay, go get it)... A long-lasting flu shot that you'd only have to get once every 5-10 years could be on its way The hope is that such a broad-spectrum vaccine also could protect against rare but potentially deadly pandemics The most vexing thing about the annual flu vaccination is that it's annual. The most vexing thing about the annual flu vaccination is that it’s annual. You have to get it every year, and many people don’t do so. In fact, the Centers for Disease Control and Prevention recently reported that only 2 out of 5 Americans have received the shot so far this flu season. Wouldn’t it be easier if a flu shot were a once-in-a-lifetime event, or even once or twice in a decade? Public health officials see that as a potential game-changer. “If we had an effective universal vaccine, it would take a huge dent out of health-care costs [and] disruption of work, school attendance and social activities,” says William Schaffner, a professor of medicine at Vanderbilt University and medical director of the National Foundation for Infectious Diseases. “It could change the entire way we prevent influenza.” The idea no longer seems so elusive, says Barney Graham, deputy director of the vaccine research center at the National Institute of Allergy and Infectious Diseases. Modern molecular technology enables scientists “to design things at atomic resolution,” which “really wasn’t possible until the last few years,” says Graham, who is trying to develop what scientists call a universal, or long-lasting, vaccine. Several groups of scientists, including Graham’s, have reported progress toward a vaccine that could protect against flu permanently with a single injection or with a shot given every five to 10 years. Either approach would be a big advance over current practice, which requires health officials to predict major flu viruses nine months in advance so manufacturers can adjust the vaccine each year. With a universal vaccine, “we wouldn’t have to worry about that,” Schaffner says. “Each year we could go after people who hadn’t been vaccinated before. It could be a year-long, daily vaccination activity, not just focused in the fall.” The hope is that such a broad-spectrum vaccine also could protect against rare but potentially deadly pandemics. “It would be the single most important thing we can do in public health today,” says Michael Osterholm, a professor of public health and the director of the Center for Infectious Disease Research and Policy at the University of Minnesota. While flu can strike anyone, it is most dangerous for the very young, the elderly and the chronically ill. Globally, seasonal flu epidemics produce 3 million to 5 million cases of serious disease every year, resulting in 250,000 to 500,000 deaths, according to the World Health Organization. Symptoms include fever, dry cough, headache, muscle and joint pain, severe malaise, sore throat and runny nose. The two major types of seasonal influenza viruses that can infect humans are A and B. Type A viruses, which are constantly changing, are the ones usually responsible for yearly epidemics. Scientists classify type A viruses into subtypes based on the combinations of the two molecules that cover the surface of the virus, hemagglutinin and neuraminidase. Vaccines work by stimulating the production of antibodies against pieces of the virus. A universal vaccine would need to provoke antibodies that bind to “conserved” regions of the virus – that is, areas that stay the same and are common to most flu viruses. Currently, seasonal vaccines are designed to respond to the hemagglutinin head, which changes every year. Researchers are using different strategies that target the common areas. Two groups working separately, for example, are focusing on hemagglutinin’s stem, or stalk, which, unlike the head, doesn’t change. To do so, each team had to first figure out how to stabilize the stalk after lopping off the head. (The head is removed because it draws key immune system cells – those needed to make antibodies – away from the stem.) Each using a different approach, the teams have found a way to anchor the stem once the head is eliminated. Another team built an entirely new virus in the lab by using recombinant DNA techniques, then designed a vaccine based on its conserved elements. “We hope that by doing that, our immune system will remember the conserved regions . . . so that changes in the head won’t matter,” says Peter Palese, chair of the microbiology department at the Icahn School of Medicine at Mount Sinai in New York. Finally, another group has developed an experimental multiyear vaccine based on the genetic sequences of flu strains that have appeared in the past century. These researchers believe it is unrealistic to assume that any experimental vaccines, including theirs, will last a lifetime without requiring an update; thus, they are reluctant to predict the effectiveness of their own beyond five to 10 years – but even that would be an improvement over having to get an annual shot. “We can go back in history and make vaccines that protect against all the variants for the last 100 years,” says Ted Ross, director of the Center for Vaccines and Immunology at the University of Georgia’s College of Veterinary Medicine. “That doesn’t mean we can do 100 years in the future, but we still can prevent a lot of disease. We just don’t know when and if one approach will have longer staying power than another. We’ll find out.” While animal studies of various prospective vaccines are promising, it probably will be years before researchers start testing them in humans. Still, public health officials are excited. The idea of a universal vaccine seemed a pipe dream until recently. “But now, or very soon, it may no longer be a flight of fancy,” Schaffner says. “Some very impressive scientific efforts are underway to make this real.’” ‘I can’t rewrite history’: She didn’t think a flu shot was necessary — until her daughter died at 12 Sorry kids: Docs urge flu shots, not nasal spray, this year Flu nose spray doesn’t work for kids and needles are more effective, U.S. health panel says
  7. Could be linked to the rise in obesity and diabetes: https://www.telegraph.co.uk/news/0/rise-obesity-diabetes-could-exacerbate-future-flu-pandemics/
  8. The flu vaccine also commonly causes Soreness, redness, and/or swelling from the shot Headache Fever Nausea Muscle aches
  9. I just want to clarify that I’m not an “anti-vaccine” person at all, I just don’t find the science compelling (yet) for the current flu vaccine (I’ve read that better vaccines are in the works and look more promising). Also in light of Siberiak‘s link above I think it’s worth looking at the PRIOR most recent Cochrane review on flu vaccines: https://www.ncbi.nlm.nih.gov/pubmed/20614424 WARNING: This review includes 15 out of 36 trials funded by industry (four had no funding declaration). An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size. Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines. The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies. The content and conclusions of this review should be interpreted in light of this finding. That review also described risks from getting the vaccine by the way (which are tiny, but not non-existent).
  10. I don’t think flu shots are worth it and I never get them, latest Cochran’s review: https://www.ncbi.nlm.nih.gov/pubmed/29388196
  11. I'm a huge proponent of deep restorative sleep. I'll have to check out that book, I like the reviews.
  12. This wasn't the focus of the study, but these researchers discovered a synergy in mice between calorie restriction and BAT stimulation for beneficial heath outcomes. I guess this is not surprising since we know BAT activation is hampered by obesity. Lab Invest. 2018 Sep 26. doi: 10.1038/s41374-018-0120-x. [Epub ahead of print] Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis. Poekes L1, Gillard J1, Farrell GC2, Horsmans Y3, Leclercq IA4. Author information Abstract Nonalcoholic steatohepatitis (NASH) is the form of nonalcoholic fatty liver disease that can evolve into cirrhosis. Lifestyle modifications achieving 10% weight loss reverse NASH, but there are no effective approved drug treatments. We previously identified defective adaptive thermogenesis as a factor contributing to metabolic syndrome and hepatic steatosis. We have now tested whether increasing nonshivering thermogenesis can improve preexisting NASH in mice. In high-fat diet-fed foz/foz mice with established NASH, treatment with β3AR agonist restored brown adipose tissue (BAT) function, decreased body weight, improved glucose tolerance, and reduced hepatic lipid content compared to untreated counterparts, but had no impact on liver inflammation or on nonalcoholic fatty liver disease activity score (NAS). Similarly, β3AR agonist did not alter liver pathology in other steatohepatitis models, including MCD diet-fed diabetic obese db/db mice. Caloric restriction alone alleviated the hepatic inflammatory signature in foz/foz mice. Addition of a β3AR agonist to mice subjected to caloric restriction enhanced weight loss and glucose tolerance, and improved liver steatosis, hepatocellular injury, and further reduced liver inflammation. These changes contributed to a significantly lower NAS score such as no (0/9) animals in this group fulfilled the criteria for NASH pathology compared to eight out of ten mice under caloric restriction alone. In conclusion, β3AR agonist counteracts features of the metabolic syndrome and alleviates steatosis, but does not reverse NASH. However, when coupled with weight loss therapy, BAT stimulation provides additional therapeutic advantages and reverses NASH. PMID: 30258096 DOI: 10.1038/s41374-018-0120-x
  13. An interesting look at cold induced cognitive impairment (and how to prevent it). Unclear what type of cinnamon was used, but they also used green tea extract which performed better than either pepper or cinnamon when it comes to markers of BAT activation: Int J Hyperthermia. 2018 Sep 13:1-10. doi: 10.1080/02656736.2018.1511835. [Epub ahead of print] Pepper and cinnamon improve cold induced cognitive impairment via increasing non-shivering thermogenesis; a study. Pandit C1, Sai Latha S1, Usha Rani T1, Anilakumar KR1. Study Link Abstract Despite an understanding that a major effect of cold exposure is a fall in core body temperature which is responsible for the observed decrements in the performance, it is surprising that thermogenic supplements are seldom evaluated to verify if they can aid in improving the performance during cold exposure. Following evidence from our previous study indicating the ability of pepper and cinnamon to improve coldendurance, we investigated further here if the improved endurance had advantages in real time where they could positively affect cognitive performance (assessed by Novel object test) when exposed to cold in albino wistar rats. In order to delineate if the observed improvement if any, was due to their cognitive enhancing ability or thermogenic potential, distinctive room temperature (RT) and cold temperature (CT) groups were used. Cold exposure impaired cognitive performance which improved following treatment with both the spices. We noted an increased rate of cold adaptive thermogenesis in CT treated group as evidenced by an elevated norepinephrine, free fatty acid levels in blood, increased expression of UCP1 in brown adipose tissue, the net effect being a decreased fall in the core body temperature. Absence of any notable effect in these parameters in the RT treated group ascertained that at least in the current experimental set up the observed improvement in performance in CT treated group is due to the thermogenic potential of the spices alone. In conclusion, our results demonstrate that the cognitive impairment caused by exposure to cold can be effectively countered by agents with thermogenic potential. KEYWORDS: Spices; cold stress; learning and memory; non-shivering thermogenesis; novel object test PMID: 30208750 DOI: 10.1080/02656736.2018.1511835
  14. J Therm Biol. 2018 Oct;77:137-144. doi: 10.1016/j.jtherbio.2018.08.016. Epub 2018 Aug 23. Sex difference in cold perception and shivering onset upon gradual cold exposure. Kaikaew K1, van den Beukel JC2, Neggers SJCMM2, Themmen APN2, Visser JA3, Grefhorst A2. Author information Abstract To maintain a thermal balance when experiencing cold, humans reduce heat loss and enhance heat production. A potent and rapid mechanism for heat generation is shivering. Research has shown that women prefer a warmer environment and feel less comfortable than men in the same thermal condition. Using the Blanketrol® III, a temperature management device commonly used to study brown adipose tissue activity, we tested whether the experimental temperature (TE) at which men and women start to shiver differs. Twenty male and 23 female volunteers underwent a cooling protocol, starting at 24 °C and gradually decreasing by 1-2 °C every 5 min until an electromyogram detected the shivering or the temperature reached 9 °C. Women started shivering at a higher TE than men (11.3 ± 1.8 °C for women vs 9.6 ± 1.8 °C for men, P = 0.003). In addition, women felt cool, scored by a visual analogue scale, at a higher TE than men (18.3 ± 3.0 °C for women vs 14.6 ± 2.6 °C for men, P < 0.001). This study demonstrates a sex difference in response to cold exposure: women require shivering as a source of heat production earlier than men. This difference could be important and sex should be considered when using cooling protocols in physiological studies. KEYWORDS: Cold temperature; Sex characteristics; Shivering; Skin temperature; Thermogenesis; Thermosensing PMID: 30196892 DOI: 10.1016/j.jtherbio.2018.08.016 ____________________________________________________________ FYI: I noticed there are quite a few used Blanketrol machines on eBay (sort by distance) some are quite cheap. It would be fun to have one of those!
  15. Ya think? He sends out a "miserable narcissist" vibe to me. He's on prescription anti-depressants "not because he needs them", but because he's trying to feel better (despite being a 30 something millionaire with total freedom: no wife or kids or house). He spends his time reading cheesy regurgitated self help books, he hires women for sex, "but they aren't prostitutes". In his previous interview, he had a girlfriend but was "polyamorous" - based on the new interview it looks like that didn't work out 😉 He is looking for the perfect drug to become superhuman - yea, that doesn't usually end well.