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About Gordo

  • Birthday 07/22/1974

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  1. % men out of workforce due to illness is still below the levels from 1993 to about 2007, which left me wondering why did women shoot up more than men? Apparently women get "long covid" at four times the rate of men? https://www.theguardian.com/society/2021/jun/13/why-are-women-more-prone-to-long-covid
  2. Wow, this is interesting, it is apparently ILLEGAL in China to say "the zero covid policy is not sustainable" and the UN's Tedros' account was censored as a result: from:
  3. Hope that is mutually beneficial but already there are reports of exploitation and corruption. And they have badly mismanaged their domestic economy by restricting capital markets and causing extreme malinvestment in housing. It will be interesting to see what happens next... In the meantime, zero covid policy is going off the rails:
  4. And yet Hong Kong (i.e China without communism) and Taiwan (sort of China without communism) are FAR more prosperous. And the median income in China is considered far below the poverty line in the US. Hmmmm...
  5. They allowed Communism to happen too, despite the fact that it has failed everywhere its ever been tried 😉 Even some on the left are starting to express outrage (good!) : https://www.thewrap.com/bill-maher-twitter-censorship-you-failed/amp/
  6. I could see the CCP deciding to kill people off immediately after infection to limit the spread (/sarc): https://www.cnn.com/2022/05/03/china/shanghai-morgue-care-home-resident-intl-hnk/index.html 😉 'What is going on in Shanghai': Horror as elderly man taken to morgue in body bag -- while still alive By Jessie Yeung, CNN Updated 6:37 AM ET, Tue May 3, 2022 Shanghai resident mistakenly sent to morgue while still alive 00:41 (CNN)An elderly Shanghai resident was mistakenly declared dead and taken to a morgue in a body bag, in the latest sign of dysfunction in the Covid-stricken city where millions of people remain under government-enforced lockdown.
  7. You should edit the title of this post to "no advantage to intermittent fasting with calorie restriction vs. calorie restriction alone for weight loss" as that was what was actually reported in the link. Furthermore, its worth noting that while not statistically significant, the intermittant fasting group actually DID lose more weight on average: "Those who were intermittent fasting lost an average of 8 kilograms from baseline (about 17 pounds), compared to the 6.3 kilograms (just under 14 pounds) lost by the control dieting group—a difference that wasn’t statistically significant." But the real problem with "dieting studies" is that nobody actually follows the guidelines making them all pretty questionable. If anyone from this obese group actually followed the guidelines, they wouldn't have lost 14 lbs in a full YEAR they probably would have lost >50 lbs.
  8. When fear hits hysteria levels, very strange things happen, and the more controlling a government is, the worse the outcome:
  9. Article from her website referenced at the end of the video: https://www.foundmyfitness.com/topics/cold-exposure-therapy Introduction The use of cold exposure to promote good health is an ancient practice, dating back many centuries. In modern times, cold exposure is used primarily to reduce muscle soreness and promote muscle recovery after physical activity. However, regular cold exposure may also improve glucose and lipid metabolism, decrease inflammation, enhance immune function, and improve cognitive performance. The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor. Hormesis triggers protective mechanisms that provide protection from future, more harmful stressors. Despite the presumed benefits associated with cold exposure, it does pose some risks, especially in unsupervised or uncontrolled conditions. See our overview of cold exposure safety concerns at the end of this article. This article provides an overview of cold exposure modalities as well as the physiological responses, health effects, and safety concerns associated with the practice. Cold exposure modalities Common cold exposure modalities include cold water immersion, local cryotherapy, and whole-body cryotherapy. Cold-water immersion involves submerging one's body in water typically at or below 59°F (15°C). Local cryotherapy generally involves placing ice packs on specific areas of the body, such as joints or muscles. Whole-body cryotherapy involves exposure to cold air for a few minutes at temperatures as low as -289°F (-178°C), typically in a cryotherapy chamber, wearing protective garments on the extremities. Cryotherapy chambers must be colder than water because thermal conductivity, the rate at which heat is transferred, differs between water and air. The thermal conductivity of water is 25 times greater than air, so humans lose body heat up to five times more quickly in water compared to the same temperature in air.[1][2] Physiological responses to cold exposure Exposure to cold temperatures induces a range of acute physiological responses, collectively referred to as the cold shock response. The goal of the cold shock response is to reduce heat loss and increase heat production.[3][4] Exposure to cold temperatures induces a range of acute physiological responses, collectively referred to as the cold shock response. With repeated exposure, the body becomes habituated to cold, diminishing the cold shock response.[5][6][7] A study in healthy young men investigated the effects of habituation to the cold shock response. Participants underwent brief cold-water immersion sessions at 50°F (10°C) on the first and fifth day of the study, and immersion sessions at 59°F (15°C) on the intervening days. On the fifth day, the cold-exposed group showed a 49 percent decrease in respiratory frequency and a 15 percent decrease in heart rate response to 50°F (10°C) exposure compared to the first day at the same temperature.[8] Norepinephrine release Integral to the cold shock response is the release of norepinephrine, a hormone and neurotransmitter produced in the adrenal glands and some regions of the brain. Norepinephrine increases heart rate, activates thermogenesis (the production of heat), constricts blood vessels, and modulates immune function.[9][10] Norepinephrine release can also activate peroxisome proliferator-activated receptor gamma coactivator 1-alpha, or PGC-1 alpha, a key regulator of genes involved in energy metabolism.[11][12] PGC-1 alpha participates in glucose and fatty acid metabolism, muscle fiber remodeling, mitochondrial biogenesis (the production of new mitochondria), and thermoregulatory function.[13] A study in healthy young men investigated the effects of hormone release after hour-long immersion sessions in water temperatures of approximately 90°F (32°C), 68°F (20°C), and 57°F (14°C), with one week separating each exposure. Whereas water immersion at warmer temperatures (90°F [32°C)]) and (68°F [20°C]) did not activate norepinephrine release, immersion at a colder temperature (57°F [14°C]) increased norepinephrine by 530 percent, dopamine by 250 percent, and energy expenditure by 350 percent, compared to pre-immersion levels.[14] A separate study found that immersion in cold water at 50°F (10°C) for an hour increased plasma norepinephrine by approximately 84 percent (compared to immersion for just two minutes), suggesting that exposing the body to cold for prolonged periods may elicit greater norepinephrine release.[15] However, long cold exposure durations of one hour may not necessarily be required to induce norepinephrine release. A long-term study compared healthy women who immersed themselves in cold water at 40°F (4.4°C) for 20 seconds to those who received whole-body cryotherapy for two minutes at -166°F (-110°C). In both groups, plasma norepinephrine increased 200 to 300 percent. Those levels dropped, however, over the course of an hour after the exposure.[16] Habituation does not appear to affect the release of norepinephrine, but it does increase the activity of brown adipose tissue (described below), which is involved in nonshivering thermogenesis (described below).[16][17] See the section "Cold exposure affects aspects of brain function" below for information about the role of norepinephrine in brain health. Cold shock protein induction During the cold shock response, cell membranes lose their fluidity, nucleic acids and proteins become destabilized, and protein synthesis stalls due to impaired ribosomal function.[18] Cold shock proteins, a large family of highly conserved proteins that are induced by various cellular stressors such as cold exposure, DNA damage, and hypoxia, ameliorate the harmful effects of cold.[19] Notable cold shock proteins include cold‐inducible RNA binding protein, which promotes cell survival and activates antioxidant enzymes under conditions of mild hypothermia (89.6°F [32°C]), and RNA binding motif 3, or RBM3, which may be neuroprotective. RBM3 binds to RNA to increase protein synthesis at neuronal dendrites, a part of the neuron that communicates with synapses, thus facilitating regeneration of damaged neurons.[20][21][22] [23][24] [25][26] See the section "Cold exposure affects aspects of brain function" below for more information about RBM3. Mitochondrial biogenesis Mitochondrial biogenesis is the process by which new mitochondria are produced. It is one of the principal beneficial adaptations to endurance exercise.[27][28] Many factors can activate mitochondrial biogenesis, including exercise, cold shock, heat shock, fasting, and ketones. As mentioned above, mitochondrial biogenesis is regulated by the transcription factor PGC-1α. Increased mitochondrial biogenesis within skeletal muscle is associated with greater aerobic capacity and performance and reduced risk factors for various diseases.[29] Cold water immersion after endurance exercise increases PGC-1 alpha concentrations in skeletal muscle, and studies in both mice and humans suggest that mitochondrial biogenesis is increased upon cold exposure.[30][11][31][32] For example, a study in healthy young men found that post-exercise cold water immersion increased several mitochondrial proteins in skeletal muscle. Within three minutes of completing vigorous aerobic exercise, the men immersed one leg in a 50°F (10°C) water bath for 15 minutes while keeping their other leg at room temperature without cooling treatment. Levels of p38 MAPK and AMPK (proteins involved in cellular signaling of mitochondrial biogenesis), PGC-1 alpha, and mitochondrial respiratory complex proteins 1 and 3 increased in the cold-exposed leg, compared to the one at room temperature.[12] Thermogenesis Cold exposure increases metabolic heat production through a process called thermogenesis. There are two types of thermogenesis: shivering and nonshivering. Shivering thermogenesis, as its name implies, involves shivering to produce heat. During shivering, skeletal muscles undergo repeated, rapid contractions that produce little net movement and instead, produce heat.[33] Nonshivering thermogenesis generates heat in the absence of shivering by unique mechanisms in both skeletal muscle and adipose (fat) tissue depots. These processes involve uncoupling electron transport from ATP synthesis and repetitive, non-productive transport of ions across the adipose cell membrane.[34] [35][36] Brown adipose tissue activation Mammals have three types of adipose (fatty) tissue – white, brown, and beige – and they play different roles in the body in terms of heat production. The primary roles of white fat are the storage of excess lipids in the form of triglycerides and the release of free fatty acids for energy. The primary role of brown fat is thermogenesis.[37] Beige fat, which resides within white fat tissue stores, can adopt either storage or thermogenic properties based on environmental conditions.[38][39] Brown and beige fat are responsible for nonshivering thermogenesis. Rodents possess both brown and beige fat cells, while humans are thought to have beige fat cells primarily. The remainder of this article will use the term "brown fat" to refer to thermogenic tissues. Early research suggested that brown fat was present only in newborns where it served as a means to protect against heat loss. However, recent research has identified active brown fat in adults, typically following cold exposure. For example, a study in which healthy young men were exposed to cold for two hours a day for 20 days found that brown fat volume increased 45 percent and cold-induced total brown fat oxidative metabolism increased more than twofold.[17] These findings suggest that cold exposure can increase brown fat activity and may increase energy expenditure to improve metabolic health. Cold exposure also increases brown fat activity in people with little to no detectable brown fat mass. In a study involving healthy men who were exposed to warm or cold temperatures for two hours, researchers identified cold-activated brown fat in approximately half of the participants but not in the remainder. At 81°F (27°C), energy expenditure differed little among the two groups. But after two hours of cold exposure at 66°F (19°C), energy expenditure increased in both groups, even though muscle shivering among the participants was negligible. Cold-induced thermogenesis was 252 calories per day in the brown fat-positive men and 78.4 calories per day in the brown fat-negative men. The researchers posited that the increase in energy expenditure in the brown fat-negative men was attributable to previously undetected brown fat or separate thermogenic mechanisms.[40] The researchers also measured repeated cold exposure in a subset of the men identified as having little to no brown fat activity. Half of the participants were exposed to cold at 63°F (17°C) for two hours every day for six weeks while the others maintained their usual lifestyles without cold exposure. Among those exposed to cold, thermogenesis increased by approximately 58 percent compared to baseline levels, coinciding with a loss of approximately 1.5 pounds (0.7 kilograms) in fat mass. None of these changes were observed in the non-cold-exposed group.[40] The continuous activation of brown fat may aid in fat loss, but more studies are needed to determine the extent to which brown fat can be activated to achieve clinical improvements in weight loss. The activation of brown fat upon cold exposure may improve glucose and insulin sensitivity, increase fat utilization, and protect against diet-induced obesity, however. Studies in animals and humans have indicated that brown fat can improve glucose and insulin sensitivity, increase fat oxidation, and protect against diet-induced obesity.[41][42] In humans, brown fat typically decreases with percent body fat and age, whereas brown fat typically increases with a higher resting metabolic rate.[43][44][45] Cold exposure also increases brown fat volume, drives glucose uptake, and increases oxidative metabolism in brown fat.[46][47][48][49] Cold-induced glucose uptake in brown fat exceeds the rate of insulin-stimulated glucose uptake in skeletal muscle in healthy humans.[50][51] These findings have made brown fat an exciting therapeutic target for the treatment of obesity and obesity-related disorders. Brown fat may also improve whole-body glucose utilization and insulin sensitivity in humans. In a study involving healthy young men (with or without detectable brown adipose tissue), cold exposure increased resting energy expenditure by 15 percent only in those with detectable brown fat, compared to thermoneutral conditions. This increase was primarily due to the oxidation of plasma-derived glucose (30 percent contribution) and fatty acids (70 percent contribution). Under thermoneutral conditions, both groups displayed normal insulin-induced whole-body glucose disposal. However, after six hours of cold exposure, only the brown fat detectable group had a further increase in glucose utilization when infused with insulin, indicating that brown fat plays a role in glucose utilization.[52] General health effects associated with cold exposure A growing body of evidence suggests that cold exposure affects multiple organ systems, eliciting beneficial effects on aspects of metabolic, cardiovascular, immune, and neurocognitive health, among others. Metabolic health The activation of nonshivering thermogenesis in people with obesity or type 2 diabetes may be an effective therapeutic strategy to aid in weight loss and improve metabolic health.[53] People with higher percent body fat typically have less brown fat; however, cold exposure increases brown fat volume and activity in people with high body fat.[54] A study found that men with type 2 diabetes and overweight had improved insulin sensitivity after cold exposure. The men's brown fat volume and metabolic activity increased, but the levels were much lower than those typically seen in healthy people. The men's peripheral insulin sensitivity increased by approximately 43 percent, and in turn, skeletal muscle glucose uptake increased.[55] A separate study in men with obesity found that brown fat volume was associated with increased fat mobilization and oxidation and corresponded to cold-induced changes in whole-body free fatty acid oxidation and lipolysis (release of fatty acids), signifying increased mobilization of lipids from peripheral tissues and utilization of lipids primarily in brown fat. After five hours of cold exposure, circulating free fatty acid levels increased compared to levels at thermoneutral conditions. However, the day after cold exposure, the men had decreased fasting triglyceride levels and very-low-density lipoprotein levels, suggesting that cold exposure may exert long-term beneficial alterations in lipid metabolism.[56] In healthy adults, brown fat appears to have marked effects on glucose metabolism independent of age, sex, and percent body fat. A study in which participants intermittently put their feet on an ice block wrapped in cloth while sitting in a cold room evaluated the effects of cold exposure. Roughly half of the participants had active brown fat, and they were typically younger and had lower body mass index, body fat mass, and abdominal fat area than the participants with undetectable brown fat. While blood parameters were within the normal ranges for both groups, the brown fat-positive group had lower HbA1c (a measure of long-term blood glucose control), total cholesterol, and LDL-cholesterol compared to the brown fat-negative participants, even after adjusting the data for age, sex, and body fat composition.[57] A retrospective study of more than 52,000 people who had cancer found that people with detectable brown fat had a lower prevalence of cardiometabolic diseases such as type 2 diabetes, coronary artery disease, congestive heart failure, and hypertension than those without detectable brown fat. The study revealed that nearly 10 percent of the participants had detectable brown fat. The prevalence of type 2 diabetes, coronary artery disease, hypertension, or congestive heart failure was lower in those with brown fat compared to those without. Although the researchers adjusted the analysis to accommodate the potential influence of cancer and various treatment characteristics, these data were obtained from a population of people with cancer who may already have metabolic alterations due to the disease. Nevertheless, the study implicates brown fat in supporting cardiometabolic health.[58] Future research in nonshivering thermogenesis, mainly brown fat biology, will likely uncover ways to maximize the thermogenic capacity of brown fat to reach clinically significant improvements in metabolic health. Immune function Cold exposure may boost certain populations of immune cells. When healthy young men were exposed to cold multiple times over a period of six weeks, their CD25 lymphocytes increased after three weeks, while CD14 monocytes increased after six weeks. Other types of immune cells, such as leukocytes and neutrophils, did not change.[59] Another study demonstrated that cold exposure increased numbers of white blood cells, including cytotoxic T lymphocytes, a specialized type of immune cell that can kill cancer cells. The white cell counts remained elevated at two hours of cold exposure. The participants' natural killer cells (white blood cells of the innate immune system) also increased.[60] A separate study noted similar findings.[61] A study comparing regular winter swimmers who practiced more than once per week to non-habitual swimmers showed that resting concentrations of some white blood cells such as leukocytes and monocytes were higher compared to the non-habitual swimmers.[62] Additionally, a study found regular winter swimming may decrease respiratory tract infections by 40 percent.[63] These studies bolster anecdotal claims shared among communities of winter swimmers that they experience fewer colds and influenza. While these studies indicate that cold exposure can boost some immune cells in younger people, future studies are needed to determine the effects in older people and whether the increase in immune cell number is associated with improved health. Antioxidant enzyme activation A normal byproduct of energy metabolism and exercise is the production of reactive oxygen species. Excess concentrations of reactive oxygen species can promote muscle damage, fatigue, immune dysfunction, DNA damage, and cellular senescence. Cold exposure appears to activate endogenous antioxidant enzymes by functioning as a hormetic stressor. When healthy young men underwent 20 three-minute cryotherapy sessions, red blood cell concentrations of the antioxidant enzyme glutathione roughly doubled after ten sessions of cryotherapy but decreased slightly below baseline by the final session. Another antioxidant enzyme, superoxide dismutase, increased by approximately 43 percent compared to baseline by the final session.[64] Similarly, a study in healthy men found that a single three-minute whole-body cryotherapy increased superoxide dismutase activity by 36 percent and glutathione peroxidase activity by 68 percent, compared to levels three days before the cryotherapy session.[65] Additional research may reveal whether the increase in antioxidant enzymes upon cold exposure has any effect on protecting against DNA damage, cellular senescence, or immune dysfunction. Inflammation Chronic inflammation is a key driver of the aging process and is associated with many age-related diseases, including arthritis.[66] Inflammation also occurs after periods of exercise. Research indicates that cold exposure may decrease inflammation in people with inflammatory conditions and in those who have undergone exercise training.[65][67] Arthritis Arthritis is an inflammatory degenerative joint disorder that can cause pain and reduced mobility.[68] Destruction of cartilage within the joints can drive arthritis. There is currently no cure for arthritis, but some treatments include pain relievers, anti-inflammatory drugs, exercise, and joint surgery.[69] Cold exposure may be an effective treatment to reduce inflammation and pain associated with arthritis. Cold exposure may decrease pain in people with rheumatoid arthritis by decreasing inflammatory signaling molecules. In healthy people, five days of cold exposure decreased the pro-inflammatory protein IL-2 and the inflammatory E2 series of prostaglandins while increasing the anti-inflammatory protein IL-10.[69] A study involving people with rheumatoid arthritis compared the effects of multiple sessions of different cold therapy modalities, including localized cryotherapy, whole-body cryotherapy at -76ºF (-60ºC), or whole-body cryotherapy at -166ºF (-110ºC). All of the participants received individual physical therapy or engaged in low-impact group exercise. Pain, assessed using a visual analog score, decreased in all treatment groups. Compared to baseline, the pain score decreased by 11 points with local cryotherapy, three points with whole-body cryotherapy at -76ºF (-60ºC), and 24 points with whole-body cryotherapy at -166ºF (110ºC).[70] A separate study compared whole-body cryotherapy to traditional rehabilitation in postmenopausal women. Roughly half of the women received whole-body cryotherapy, and the remainder underwent a traditional rehabilitation program. After the treatments, both groups exhibited similar improvements in pain and disease activity, fatigue, time of walking, and the number of steps over a distance of 50 meters.[71] The pro-inflammatory molecules IL-6 and TNF-α decreased in both groups. Some of the pain-alleviating effects of cold exposure, particularly in whole-body cryotherapy, may also be due to increased norepinephrine since inflammation itself causes pain. In fact, spinal injection of compounds that induce a release of norepinephrine alleviates pain in human and animal studies.[72][73] Exercise-associated inflammation A study in male athletes found that whole-body cryotherapy altered immunological parameters such as muscle enzymes and cytokine levels. The men maintained their regular training regimen, which involved both resistance and aerobic exercise, and underwent two-minute cryotherapy sessions once daily for five days. Compared to baseline, the men's circulating C-reactive protein (a marker of inflammation) concentrations remained stable, but IL-10, an anti-inflammatory cytokine, increased, and the pro-inflammatory cytokines IL-2 and IL-8 decreased. In addition, creatine kinase and lactate dehydrogenase, which are markers of muscle damage, decreased.[74] Elite marathon runners who underwent whole-body cryotherapy after a running session had lower C-reactive protein levels than runners who underwent passive recovery. The two modalities were completed immediately after the exercise and at 24, 48, 72, and 96 hours afterward. C-reactive protein peaked at 24 hours after running in both groups. However, compared to pre-exercise levels, C-reactive protein increased by 123 percent with whole-body-cryotherapy and 515 percent with passive recovery at 24 hours. At 72 hours post-exercise, the C-reactive protein levels returned to baseline levels with whole-body cryotherapy, but levels persisted with passive recovery. The pro-inflammatory mediator IL-1 beta and the anti-inflammatory mediator IL-10 peaked one hour post-exercise in both recovery groups. However, whole-body cryotherapy was associated with a greater decrease in IL-1 beta and a greater increase in IL-1ra, a cytokine inhibitor that reduces the pro-inflammatory response, one hour post-exercise compared to passive recovery.[75] Elite tennis players who engaged in whole-body cryotherapy had decreases in the pro-inflammatory cytokine TNF-alpha and increases in IL-6, a cytokine that exhibits both pro- and anti-inflammatory properties and plays a role in muscle repair. These inflammatory alterations were associated with improvements in stroke effectiveness.[67] It is important to note that these anti-inflammatory qualities of cold exposure on exercise and athletic performance, while probably beneficial in some contexts, may add some level of nuance or complexity to any discussion of the practice's effects. Microbiome The microbiome is composed of all of the microorganisms that reside both on and within the human body. Studies in mice suggest that cold exposure can alter the composition and activity of the gut microbiome to improve energy metabolism and support thermogenesis. Upon cold exposure, the composition of gut microbiota in mice is altered to support the activation of nonshivering thermogenesis in part by increasing the uptake of carbohydrates and lipoprotein-derived triglycerides.[76][77][78] Conversely, mice lacking gut microbiota have impaired nonshivering thermogenesis and decreased insulin sensitivity.[79] Translational studies are needed to evaluate the impact of the gut microbiome on the activation of nonshivering thermogenesis in humans. Brain effects of cold exposure Cold exposure elicits the release of norepinephrine into the brain and may activate the cold shock protein RBM3. Some studies suggest that cold exposure may improve mood and cognition, decrease depression, and protect against neurodegenerative disease. Mood and cognition One of the most consistent and profound physiological responses to cold exposure is a robust release of norepinephrine into the bloodstream as well as in the locus coeruleus, the brain's main source of norepinephrine.[80][14] Norepinephrine is a key player in the mood and cognitive-enhancing effects of cold exposure. As described above, norepinephrine is a neurotransmitter involved in vigilance, focus, attention, and mood.[81] Generally, lower norepinephrine activity is associated with inattention, decreased focus and cognitive ability, low energy, and poor mood.[82][83] Pharmacological depletion of norepinephrine can lead to depression.[84] In fact, both ADHD and depression are sometimes treated with norepinephrine reuptake inhibitors, but these drugs carry some risks.[85] After adults who had been diagnosed with depression underwent ten cryotherapy sessions, they showed marked reductions in their depressive symptoms and improved quality of life, mood, and disease acceptance, suggesting that whole-body cryotherapy is beneficial for mental well-being and quality of life.[86] In addition, some anecdotal evidence suggests that cold exposure improves mood and may help treat depression. Findings from a case report suggest that a 68ºF (20°C) cold shower for two to three minutes preceded by a gradual adaptation period can relieve depressive symptoms when performed once or twice daily over the course of several weeks to months.[87] A separate case report demonstrated that cold water swimming once or twice a week improved mood and reduced depressive symptoms in young women.[88] These reports are anecdotal and involve exercise as a confounding factor. However, studies in animals suggest a mechanism by which cold exposure may improve mood. More direct evidence is needed to link cold exposure as a strategy for the potential treatment of cognitive and mood disorders, but it is an interesting and promising area of inquiry. Brain aging Nerve synapses facilitate neuronal communication and memory formation. Synapse loss occurs with normal brain aging and is accelerated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease and after traumatic brain injury.[89][90][91] Hibernating animals also experience synapse loss during their period of hibernation, but synapse restoration occurs upon arousal. Studies in hibernating animals demonstrate that induction of cold shock proteins, particularly RBM3, is important for synaptic regeneration after hibernation.[92][93][94] Interestingly, synaptic regeneration after cold exposure has also been observed in mice, which are not hibernating animals. Briefly cooling mice to a body temperature similar to that of some hibernating animals promoted synapse reassembly and temporarily increased RBM3 in the animals' brains. After repeated application of the procedure, RBM3 expression increased and persisted for several weeks. In the same study, mice predisposed to have Alzheimer’s disease lost the ability to upregulate RBM3 and subsequently lost the ability to reassemble synapses. The upregulation of RBM3 in the mice promoted sustained synaptic protection, prevented behavioral deficits and neuronal loss, and prolonged survival.[25][26] An in vitro study using human astrocytes, a type of brain cell, found that decreasing the culturing temperature from 37°C (normal human body temperature) to 35°C activated RBM3.[95] The extent to which RBM3 protects against neurodegeneration in humans, however, is still not entirely understood. It is plausible that therapeutic strategies that increase norepinephrine, such as cold-water immersion and whole-body cryotherapy, may lower inflammation and facilitate attenuation of what is otherwise a major contributor to the aging process in the brain. Additional studies are needed in humans to determine the degree to which RBM3 may be activated upon cold exposure and determine the potential for RBM3 to protect against neurodegeneration. Cold exposure exerts variable effects with exercise Cold exposure is widely utilized as a therapy to improve muscle recovery and increase performance. Numerous studies have investigated the effects of cold exposure after exercise or athletic competition, with mixed results. The inconsistent findings in these studies are likely due to the nature of the exercise (endurance versus resistance) and the time of the cold exposure with respect to exercise (pre-exercise, immediately after exercise, or later). Studies suggest that cold exposure immediately after resistance training may blunt muscle adaptations, while cold exposure after endurance exercises such as cycling or long-distance running may improve muscle recovery and performance. Timing influences the effects of cold exposure with exercise Immediately after exercise, blood concentrations of pro-inflammatory proteins and reactive oxygen species increase.[96] Conversely, concentrations of anti-inflammatory proteins peak within the first hour post-exercise, likely to restrict the magnitude and duration of the preceding inflammatory response.[97] These physiological responses play roles in mediating beneficial adaptations to exercise.[98] However, excessive exercise-induced inflammation can promote muscle damage, fatigue, and immune dysfunction, the extent of which varies according to the duration and intensity of exercise.[99] Cold exposure immediately after exercise may diminish the beneficial training adaptations by blunting the immune response. A study in young elite athletes evaluated the effect of ice pack application after sprint interval training. After the athletes exercised, they applied ice packs to their hamstring muscles for two sessions lasting 15 minutes with a 15-minute rest between each session. The athletes' blood concentrations of anabolic hormones (associated with repair and synthesis) increased immediately after exercise, but after ice pack application the hormones decreased and the catabolic hormone (associated with breakdown) IGFBP-1 increased, compared to recovery without cold exposure.[100] Use of cryotherapy, cold-water immersion, or ice packs immediately after training may undermine certain beneficial effects of having acute periods of low-grade inflammation. The peak anti-inflammatory response appears to occur up to one hour after activity, and some inflammation and immune activation before that point may be beneficial. Cold exposure may diminish the effects of resistance exercise The type of activity one engages in also influences the outcome of cold exposure on athletic performance and recovery. Resistance training, also referred to as strength or weight training, notably increases strength and skeletal muscle mass, but some studies indicate that cold exposure immediately after training can blunt these adaptations. One study compared the effects of cold water immersion to active recovery and found that cold water immersion after resistance training attenuated long-term gains in muscle mass and strength in physically active men. Half of the men underwent cold water immersion, while the others completed active recovery within five minutes of completing a training session. Both groups of men saw an increase in muscle mass, but the active recovery group gained more muscle mass than the cold-water immersion group, suggesting that cold water immersion partially blunted muscle hypertrophy. Additionally, the type II muscle fibers (required for very short-duration, high-intensity bursts of power) increased in the active recovery group but not in the cold water immersion group. Biomarkers that are usually associated with hypertrophy (muscle growth), including the activation of satellite cells and mTOR signaling (a regulator of growth), decreased in the cold exposed group.[101] Additionally, studies suggest that cold water immersion after resistance exercise may interfere with regenerative processes and blunt muscle performance.[102][103] These detrimental effects may be in part due to alterations in protein synthesis via suppression of ribosomal biogenesis. Ribosomes are cellular machinery that translate genetic information into protein. When healthy athletes underwent brief cold water immersion sessions, their upstream signaling and activation of ribosomal biogenesis decreased, suggesting that cold water immersion immediately after resistance training may blunt protein synthesis and muscle mass gain.[104] Delaying cold water immersion by at least one hour after resistance exercise may improve recovery, however. When healthy young men underwent whole-body cryotherapy one hour after plyometric exercise (squat jumps and leg curls), their performance measures improved up to 72 hours after the treatment. The men's perceived pain sensation at rest and during squat decreased with cryotherapy, and their knee torque development (a measure of force produced) was greater.[105] This study only utilized one training session, so additional studies investigating the long-term effects of cold exposure after frequent exercise may help determine whether delayed cold exposure after resistance training is beneficial. While these studies suggest that cold exposure immediately after resistance training can blunt muscle adaptations, many studies have found cold exposure (both cold water immersion and whole-body cryotherapy) has no detrimental effects on muscle strength, endurance, or mass.[106][107][108][109][110][111] The conflicting results could be due to a variety of factors, including type of cold exposure (ice pack versus cold water immersion versus whole-body cryotherapy), duration of cold exposure, or the type and duration of resistance training. For now, it seems prudent in the context of strength training to exercise caution in the timing of cold exposure immediately after exercise. Cold exposure and endurance exercise Cold exposure generally elicits positive effects in the setting of endurance exercise. This may be due to the fact that the adaptations that occur are more specific to endurance activities or due to the timing that the cold exposure was done post-exercise. A meta-analysis of nine randomized controlled trials found that cold water immersion improved muscle soreness to a greater extent compared to passive recovery. The studies included in the analysis utilized cold water immersion within one hour of the end of exercise in a water bath at temperatures of 41° to 59°F (5° to 15°C) for anywhere between 5 and 20 minutes. They involved a single session of exercise, including running, cycling, or jumping, and included only one cold water immersion after the exercise session. The immersion in cold water ranged from lower limbs to immersion of the whole body, excluding the head and neck. The results of each study were pooled, and the mean difference between cold water immersion compared to passive recovery favored cold water immersion for an improvement in muscle recovery. When subgroups were analyzed, the mean difference in reduced muscle soreness in studies using water temperatures between 34° and 59°F (11° and 15°C) was approximately 50 percent greater than studies using temperatures between 41° and 50°F (5° to 10°C).[112] Another meta-analysis evaluated the effects of cold water immersion for the recovery from team sports-related activities such as soccer or volleyball. The analysis pooled data from 23 studies comprising 606 participants and determined the mean difference of neuromuscular performance (jump performance and sprint times), subjective measures of fatigue, muscle soreness, and biochemical markers, following either cold water immersion or passive recovery performed no less than 24-hours post-exercise stressor. Passive recovery primarily included seated rest. A majority of the studies evaluated the effects of cold water immersion 24 hours following an exercise stressor, while six studies extended the research to 72 and 90 hours following an exercise stressor. The temperatures for cold water immersion ranged between 41° and 59°F (5° and 15°C), with most studies applying cold water between 50° and 54°F (10° and 12°C). Cold-water immersion lasted anywhere between one and 15 minutes, with shorter immersion times typically repeated three to five times. Neuromuscular recovery improved with cold water immersion compared to passive recovery when performed 24 hours following the exercise stressor. However, cold water immersion had minimal effects on enhanced recovery one hour, 48 hours, and beyond 90 hours following the exercise stressor. Cold-water immersion improved the perception of fatigue, defined as a reduction in physical or functional performance, 72 hours following the exercise stressor compared to those in passive recovery. Cold-water immersion did not enhance the perception of fatigue at any other time points. Muscle soreness and clearance of creatine kinase (a marker of muscle damage) were not altered with cold water immersion. The reviewers concluded that cold water immersion can attenuate decrements in neuromuscular performance 24 hours following team sports, but studies evaluating recovery beyond 48 hours are needed to determine whether the perceived recovery leads to enhanced performance in games or training.[113] Cold exposure may be especially beneficial in the context of running to accelerate recovery and reduce soreness.[114][115][116] Cold exposure may mitigate high levels of pro-inflammatory proteins post-exercise, which can cause acute performance deterioration and muscle damage. This can be problematic for training even several days later since there may be a greater risk of injury due to residual soreness and changes in muscle function. For example, a study of 11 runners who regularly participated in marathons found that whole-body cryotherapy decreased the inflammatory response that coincides with enhanced muscle recovery. The men completed an approximately 45-minute treadmill run once a month, followed by either a passive recovery or whole-body cryotherapy. The recovery modalities were completed immediately after the race and again at 24, 48, 72, and 96 hours after. The runners' C-reactive protein (a biomarker of inflammation) peaked at 24 hours after running in both groups. However, compared to pre-exercise levels, C-reactive protein increased by 123 percent with whole-body cryotherapy and 515 percent with passive recovery at 24 hours. At 72 hours post-exercise, the C-reactive protein levels returned to baseline levels with whole-body cryotherapy but levels persisted with passive recovery. No difference was observed in the inflammatory cytokine TNF-alpha. Additionally, the cytokines IL-6 and IL-10 increased immediately after exercise regardless of the recovery modality with no observed differences in response between groups. Whole-body cryotherapy was associated with a greater decrease in the pro-inflammatory cytokine IL-1 beta and a greater increase in the anti-inflammatory cytokine IL-1ra one hour post-exercise compared to passive recovery.[75] Whole-body cryotherapy may also alter the inflammatory process in endurance athletes involved in other sports such as tennis and rowing.[65][67] Elite tennis players who engaged in whole-body cryotherapy experienced reduced levels of the pro-inflammatory cytokine TNF-alpha and increased IL-6, a cytokine with both pro- and anti-inflammatory properties that plays a role in muscle repair. These inflammatory alterations were associated with improvements in stroke effectiveness.[67] The performance enhancements that endurance athletes experience from post-exercise cold exposure may even be sustained over a prolonged time period. A study in elite cyclists who engaged in frequent cold water immersion sessions over a 39-day training period demonstrated improvements in performance. The cyclists experienced a 4.4 percent increase in average sprint power, a 3 percent enhancement in repeat cycling performance, and a 2.7 percent increase in power over the 39-day training period. While these improvements seem minimal, they may be substantial for elite athletes.[117] Cold exposure safety concerns As described above, cold exposure poses some health risks, especially in unsupervised or uncontrolled conditions. The most common risk associated with cold exposure is hypothermia, a condition in which a person's core body temperature drops below 95°F (35°C).[118] Symptoms of hypothermia include rapid breathing, shivering, pale skin, confusion, and drowsiness.[118] If hypothermia occurs in a large body of water such as a lake or ocean, it can impair respiration and may lead to drowning. Other risks of cold exposure include afterdrop and frostbite. Afterdrop refers to a drop in core body temperature after exiting cold water and is common among open-water swimmers. Immediately after exiting cold water, the cooler blood from peripheral tissue returns to the central circulation, inducing a drop in core body temperature and subsequent hypothermia[119] Frostbite occurs when the skin freezes. It is common on peripheral tissues such as the fingers, toes, nose, ears, cheeks, and chin.[120] Exposing skin to air temperatures less than 10°F (-12.2°C) can cause frostbite. As a result, a person can develop frostbite in 30 minutes or less when the wind chill is -15°F (-26°C) or lower.[121] While whole-body cryotherapy involves standing in temperatures as low as -289˚F (-178˚C), sessions typically last only a few minutes and users are instructed to wear socks, gloves, and a hat to minimize the possibility of developing frostbite. Cold exposure is contraindicated in the setting of alcohol consumption and hypothyroidism, due to their capacity to decrease cold tolerance and increase the likelihood of adverse events.[122][123][124][125] Caution should be exercised when alternating from hot to cold exposure (a common practice among sauna users), as dramatic changes in blood pressure could occur.[126] Conclusion A growing body of evidence demonstrates that cold exposure may serve as a hormetic stressor that switches on a host of protective mechanisms that reduce inflammation, activate antioxidant enzymes, improve athletic performance and promote recovery, and boost the immune system to protect against age-related diseases. Post-exercise cold water immersion may also increase PGC-1 alpha, a protein that promotes mitochondrial biogenesis. 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  10. Shanghai residents question human cost of China's COVID quarantines SHANGHAI (Reuters) -Lu, 99, was a long-time resident at Shanghai's Donghai Elderly Care hospital, her loved ones secure that she was getting round-the-clock care at the city's largest such centre. That was before COVID-19 struck China's biggest city last month, the country's worst outbreak since the virus emerged in Wuhan in late 2019, infecting multiple patients, doctors and care workers at the 1,800-bed facility. Orderlies posted cries for help on social media, saying they were overwhelmed. Relatives told Reuters that there had been several deaths. Lu, whose relatives asked that she be identified only by her surname, had coronary heart disease and high blood pressure. She caught COVID and, though she had no symptoms, was being transferred to an isolation facility, her family was told on March 25. © Reuters/ALY SONG FILE PHOTO: COVID-19 outbreak in Shanghai She died there seven days later, the cause of death listed as her underlying medical conditions, her granddaughter said. Among the questions she has about Lu's final days was why elderly patients had to be quarantined separately, away from the care workers most familiar with their conditions under China's quarantine rules. Her frustrations reflect those of many with China's no-tolerance COVID policy. Everyone testing positive must quarantine in specialised isolation sites, whether they show symptoms or not. Shanghai has become a test case for the country's strict policy. Home quarantine is not an option and, until public outrage prompted a change, Shanghai was separating COVID-positive children from their parents. From March 1 to April 9, China's financial hub reported some 180,000 locally transmitted infections, 96% of which were asymptomatic. It reported no deaths for the period. A Donghai staffer who answered the phone on Sunday declined to answer questions, directing Reuters to another department, which did not respond to repeated calls. Asked for comment, the Shanghai government sent a local media report with a first-person account of life at one of the quarantine centres. The unidentified author said he wanted to dispel fears that such sites were terrible, saying he received ample meals and medicine but recommending people bring earplugs and eye masks. Video: China sees highest COVID cases since Wuhan (Reuters) Play Video China sees highest COVID cases since Wuhan The authorities did not offer further comment. The United States has raised concerns about China's COVID approach, advising its citizens on Friday to reconsider travel to China "due to arbitrary enforcement of local laws and COVID-19 restrictions." Beijing dismissed the U.S. concerns as "groundless accusations". 'DIDN'T DARE BELIEVE IT' When Lu was being quarantined, the family asked, "Who is going to care for her? Will there be care workers, doctors?," her granddaughter said. "My grandmother is not someone who can live independently. "If the care worker had COVID and no symptoms, why couldn't they stay together?," she said. "The chaos and tragedies happening in Shanghai this time really boil down to cruel policies." A relative of Donghai patient Shen Peiying, who gave his surname as Qiu, said he believes the quarantine policy contributed to the April 3 death of the bedridden 72-year-old. She had not caught COVID, he said, citing test records he saw on China's health app. After weeks of little communication, staff rang to say Shen had died from a chest infection. Qiu has refused to consent to her cremation, citing such unanswered questions as what care she received after her regular care worker was quarantined. "If they were all in quarantine, who was there to take care of the patients?," Qiu said. Shanghai is doubling down on the quarantine policy, converting schools, recently finished apartment blocks and vast exhibition halls into centres, the largest of which can hold 50,000 people. Authorities said last week they have set up over 60 such facilities. These steps, including sending patients to quarantine sites in neighbouring provinces, have been greeted by the public with a mixture of awe at their speed and horror over conditions, prompting some Shanghai residents to call for home quarantine to be allowed. While Chinese state media has shown hospitals with just two or three patients per room, patients like those sent to Shanghai's giant exhibition centres say they live side by side with thousands of strangers, without walls or showers and with ceiling lights on at all hours. Videos on Chinese social media have shown hastily converted quarantine sites, including a ramshackle vacant factory where a number of camping beds were placed, a site made out of shipping containers and a school with a poster saying blankets and hot water were not available. A source verified the first video. Reuters could not independently verify the others. Management of such sites has been a concern. One viral video last week showed patients at a site called the Nanhui makeshift hospital fighting for supplies. Reuters could not reach the facility on Sunday for comment. Among those posting on social media was Shanghai resident Li Tong, who asked for help after his wife was sent there. He said things got better when more staff arrived to organise the patients but that he was shocked by what the videos showed and what his wife told him. "I didn't dare believe it, that Shanghai in 2022 could be like this," he said.
  11. UK hits record COVID-19 levels; nearly 5 million infected
  12. China doubling down on bizzare lockdown strategy?? Unbelievable...
  13. Myocarditis risk higher after Covid infection than Pfizer or Moderna vaccination, CDC finds No surprise to me, but maybe to the antivaxer...
  14. Gordo

    War in Ukraine

    I wonder if anyone in Russia will ever be held accountable for this: