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Brett Black

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Everything posted by Brett Black

  1. - Some media articles interviewing an author of the new study and also referencing previous studies showing links between B12 and B6 supplementation and cancer: https://www.sciencedaily.com/releases/2017/08/170822175515.htm https://www.theatlantic.com/health/archive/2017/08/b12-energy/537654/
  2. In my experience it's uncommon to find B12 tablets less than 100µg, which is over 40 times the RDI and almost twice the dose shown in this study to be linked to a doubling of lung cancer risk. My impression is that 1000µg B12 tablets may actually be the most commonly available dose - over 400 times the RDI. So it wouldn't surprise me to find people taking such doses.
  3. Some studies examining the evidence(or lack thereof) for routine 6-monthly dental check-ups: --- ---
  4. Sure, that may be a possibility, but obviously it's speculation. My past reading on these and related issues suggested to me that there is a lack of quality evidence surrounding common dental hygiene practices in general. Thus speculation and hypothesis may be necessary guiding forces unfortunately. If I recall correctly, other comments on the Longecity thread mentioned bacteremia resulting from teeth brushing and even eating. So bacteremia induction may not require unusual/unaccustomed gum stresses. Of course, even if bacteremia is a common daily occurence resulting from everyday living, that doesn't mean it's desirable. Here's a study that showed bacteremia from toothbrushing alone, with powered toothbrushing inducing more bacteremia than manual toothbrushing:
  5. Longecity discussion of these issues: http://www.longecity.org/forum/topic/74225-flossing-may-be-harmful-or-at-least-useless/
  6. This meta-analysis concludes that there is a lack of scientific evidence to support routinely recommending flossing:
  7. Flossing may cause gum tissue trauma leading to oral bacteria transmission into the bloodstream ("bacteraemia"):
  8. Some longecity posts relevant to this thread: Cytomegalovirus dramatically alters immune system http://www.longecity.org/forum/topic/76392-cytomegalovirus-dramatically-alters-immune-system/ Working Towards a Way to Clear Cytomegalovirus http://www.longecity.org/forum/topic/72824-working-towards-a-way-to-clear-cytomegalovirus/ Impact of Lifelong Cytomegalovirus Infection on Aging http://www.longecity.org/forum/topic/74524-impact-of-lifelong-cytomegalovirus-infection-on-aging/ Are All Those Memory T Cells Present in the Elderly in Fact Due to CMV Exposure? http://www.longecity.org/forum/topic/68778-are-all-those-memory-t-cells-present-in-the-elderly-in-fact-due-to-cmv-exposure/
  9. Here's a patent that describes treatment with widely used and available antiviral drugs to reduce the impact of CMV infection on the immune system:
  10. Brett Black

    The Ultimate Purpose of Life

    Who says the meaning/purpose in my(and your?) life is "merely" "subjective" "arbitrary" "preference"? My meaning, all meaning, is part of the very fabric and essence of existence. And, I am, after all, existence itself. Claiming any of this is arbitrary, assumes that there could be some alternative way things could be - but this is nonsense. What is, is what is - end of story. No imaginary God could claim any greater. It's kind of pathetic to see how self-denying...self-negating...most everyone is. Like a bunch of sick ascetics or something. Are you all gonna start whipping yourselves soon too? I suppose it's an outgrowth of social control. Now God's gone, society has had to fashion a new method to maintain control: the postmodern "that's only your opinion!" to keep people in line works nicely. The ultimate in low self-esteem is hammered into you - you can't even trust your own meaning, purpose, LIFE. Ha! No thanks - I retain my godhood. Furthermore: egoism combined with empathy can combine to form something like Peter Singer's "Point of View of the Universe" - there need be no contradiction there. I feel your pain, and because I don't like being in pain I don't want you to be in pain. Simple. Empathy aligns with the apparent reality of other beings' capacity to feel pain/pleasure, making empathy an accurate, instinctual-level, representation/reflection of reality. Then, right = pleasure and wrong = pain. "Right" and "wrong" being more complex manifestations/representations of pleasure/pain.
  11. Brett Black

    Why Don't UK Vegans/Vegetarians Live Longer?

    The lack of mortality benefit seen in the EPIC-Oxford vegetarians/vegans might be due to bias from the "healthy volunteer" effect among the non-vegetarians/vegans. It looks like the vegetarians/vegans still managed around half the expected death rate of the general population[1]: --- Dean, do you know about www.veganhealth.org? It's got to be one of the best science-based websites relating to veganism. Here's a veganhealth.org page that collected mortality data of vegans from several studies: http://www.veganhealth.org/articles/dxrates
  12. Brett Black

    So Why Don't We Brew Our Chocolate?

    Do you eat rice or rice-derived products? There have been some concerns raised about arsenic levels in rice, e.g.: http://www.consumerreports.org/cro/magazine/2012/11/arsenic-in-your-food/index.htm
  13. Brett Black

    Target anti-aging post-prandial blood sugar / lipids?

    Interesting recent study investigating many variables (including gut microbiota) that may impact glycemic response to meals, suggesting that the use of stock glycemic index food tables may provide limited predictive power:
  14. Brett Black

    IGF-1 Tradeoff: Performance vs. Longevity

    My impression is still that evidence for IGF-1 impact on human longevity is inconsistent and unclear. I think the reviews from the experts agree with that position. I'm not sure speculations about IGF-1-related longevity in humans, currently largely extrapolated from mice, worms and yeast, through unspecified "anti-aging" mechanisms, should enter the equation when better human evidence supports protection or risk for specific pathologies of aging. When we look beyond mice, the lack of observed longevity benefits in IGF-1 deficient human Laron dwarfs and CR'ed rhesus monkeys adds further uncertainty about the translatability to humans. IGF-1 genetic association studies may not be applicable to diet-induced IGF-1 levels in adults if longevity benefits mainly derive from exposure during develpomental years of life. Another element of potential importance for some CR practitioners is that impaired glucose tolerance may be a significant CVD and stroke risk factor. This is not necessarily an either/or situation, as one doesn't require CR or lower protein diet to maintain a superb CVD risk profile. There may be alternative ways to lower risk of cancer too, like a plant-based diet, which has been shown to blunt the dietary protein/IGF-1/cancer association. One option is to look at the IGF-1 issue from a personal risk factor perspective: those with higher risk for cancer maybe should opt for lower IGF-1, those with higher risk for cardiovascular and cerebrovascular diseases and concern for maintaining bone, brain and muscle health maybe should opt for higher IGF-1.
  15. Slightly off topic, but I know you have expressed concerns about BPA leaching into food from packaging in the past, and I know you also drink(or at least drank) wine, so I thought this might interest you too: A discussion about the study findings and some comments from posters claiming to have in-depth technical knowledge of industrial-scale wine production methods and where and how phthalates might be getting into the wine: https://www.reddit.com/r/science/comments/2d5pwd/phthalates_a_class_of_environmental_contaminant/
  16. Brett Black

    IGF-1 Tradeoff: Performance vs. Longevity

    There is no clear evidence of longevity benefits of lower IGF-1 in humans, the current evidence is contradictory. Laron dwarfism in humans, which results in congenitally low IGF-1 (and which resembles the longevous genetically-modifed IGF-1 deficient rodent models) has not been observed to result in unusually long lives. Among other things, lower IGF-1 may reduce risk of cancer mortality, and since many(most?) common laboratory mice strains have high mortality due to cancer (think 90%) this may largely explain the benefit seen in mice. However, lower IGF-1 may, among other things, increase risk of mortality from cardiovascular diseases, and whilst cardiovascular mortality is not a significant threat in mice, it is in humans. Basically, the benefits and detriments of higher or lower IGF-1 may be species, strain and disease specific. There is also evidence that the lifespan benefits seen in mice from lower IGF-1/GH may only be realized when they are kept low during early life (equivalent perhaps to the childhood/adolescent years in humans.) Some of the issues reported by and personally concerning calorie restriction practitioners (e.g. bone health, impaired glucose tolerance) might benefit from increased IGF-1. Just generally IGF-1 and its anabolic growth and repair-inducing effects may oppose many of the common and serious quality-of-life problems associated with aging including cognitive decline, muscle wasting, cardiovascular dysfunction, skin aging etc and I think it is something that should be considered very carefully. Dean (and anyone else interested), I can't recommend highly enough reading the first paper I have linked to below. It contains a wealth of very interesting and potentially important information regarding IGF-1 and its relation to lifespan, healthspan and disease in both humans and rodents. "Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348498/ --- "Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring" http://www.impactaging.com/papers/v4/n9/full/100484.html --- "Functionally significant insulin-like growth factor I receptor mutations in centenarians" http://www.pnas.org/content/105/9/3438.full ---
  17. Brett Black

    Time to Stock Up on Cranberries!

    Dried plums ("prunes") have been shown to increase IGF-1 and this has been suggested as a mechanism underlying the benefits to bone health. I'm not convinced that lower IGF-1 is beneficial for aging and long-term health in humans, in fact I actually believe it may be preferable to maintain higher levels (the pros/cons of IGF-1 might be dependent upon each individual's particular risk factors.) There is substantial evidence of IGF-1 benefiting and protecting bone, brain, muscle and cardiovascular health in humans. However, I know that lower IGF-1 is favored by many CR practitioners and therefore it may be important for them to be aware of this effect of dried plums.
  18. Brett Black

    CR-induced elevated cortisol and sleep

    I'd be concerned about mirtazapine, it has shown to be carcinogenic in both mice and rats. I was under the impression that, toxicologically, seeing carcinogenic effects in two species is often considered a potentially serious sign. The fact that both species also developed the same type of cancer and the dose may not have been sufficiently high in mice just adds to that concern. Yet it still obviously got FDA approval... http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=20642
  19. Brett Black

    Best source for nuts

    You made some other comments about the possible significance and meaning of various aesthetic qualities of walnuts over here too: https://www.crsociety.org/topic/11315-great-source-for-walnuts/ What I'm wondering (and part of the driving reason for my previous post) is: what are you basing this information/interpretation on? And, how confident are you and should we be that this information/interpretation is accurate and/or useful? Even though it was quoting an entire post it was still a short quote and gave quick and easy context (rather than having to read through the thread, or scroll back up and search etc).
  20. Brett Black

    Best source for nuts

    For what reason(s) do you think the walnut on the left is the less desirable of the two?
  21. Brett Black

    Does the Obesity Epidemic have a Mysterious Cause?

    The Carb-Sane Asylum recently made a blog post titled "The Problem with NHANES Dietary Data" with an interesting table showing NHANES overweight/obesity and dietary data: http://carbsanity.blogspot.com.au/2015/10/the-problem-with-nhanes-dietary-data.html Also, a poster at Carb-Sane Asylum pointed out this:
  22. If part or all of the benefits of CR seen in rodents are explained by an underlying evolutionary adaption to surviving famine, then a preferential retention of body fat could be an obvious sign that a particular rodent/strain strongly expresses this adaption. Preferential retention of body fat could be suggestive of the organism attempting to store away energy supplies for the future, with the "plan" of sitting out the famine period in a pro-survival("anti-aging") state whilst living off the stored "rations." There is of course evidence to suggest however, in humans, that too much body fat, particularly visceral fat, may be detrimental, possibly because it is pro-inflammatory. Taken together, I wonder if in humans the much popularly maligned "skinny-fat" body morphology could actually reflect something akin to the successful CR'ed rodents. The skinny-fat combination might ideally reflect a state of lowered caloric intake (skinny) which implies famine, coupled with the pro-survival/anti-aging adaption (fat), along with keeping absolute body fat amounts low enough to avoid the health problems observed in the conventionally overweight/obese. It also makes me wonder if womens' tendency toward proportionally higher body fat, as well as live longer, reflects a similar pro-survival evolutionary strategy. Due to the higher and longer-lasting investment requirements for reproduction in females, evolution may have given females similar pro-famine-survival adaptions like preferential fat accumulation and retention.
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