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  1. The guy has dishes out $100 million, what have you done to contribute other than another negative post on the CR forums? It seems to be your default response these days.
  2. In all of the perusing I've done pertaining to longevity, I hadn't yet come across Sergey Young. He has a book appropriately titled "Growing Young" that is soon to be released. His website is here: https://sergeyyoung.com/ His $100 million dollar longevity fund is of interest as well as his X-Prize involvement. I think this conversation will be much appreciated by folks here.
  3. drewab

    Starting a CR Diet

    I wouldn't worry about the question you are asking too much, nor would I advise fasting (though if you really want to do it, please do it medically supervised). There are so many things you can do that will vastly improve your health and position you much closer to your goal weight: Each plenty of whole plant foods including vegetables, fruits, nuts, seeds, whole grains, and legumes (if a particular food item doesn't work for you, then don't eat it). Some high-quality animal proteins are permissible if you'd like in small amounts - I personally have none and this makes it very easy to maintain a BMI of 20.7. Get some vigorous movement 5-6 days per week - jog, lift weights, swim, bike, do yoga, etc... whatever you like and find sustainable. Perhaps 20-30 minutes most days. Additionally, get a lot of NEAT - non-exercises activity thermogenisis. My step count is typically 15000-20000 due in large part to NEAT (don't sit too much and try to be constantly in motion). Practice TRF (time-restricted feeding) - eat all of your calories in a given window of say, 6-10 hours, but work your way up to it. Don't consume any sugar or processed foods, for obvious reasons. Don't consume alcohol (or limit it greatly, to say 1 drink per week maximum). Practice stress reduction - maybe this means meditation, connection with loved ones and friends, time in nature, etc. It will look a little different for each person. Supplement intelligently, if at all. The exact supplements will vary depending on your diet and goals. Get bloodwork done and a thorough evaluation to see how you are truly doing with your health. Stress the body in other ways - cold exposure, activate heat shock proteins, etc. Lastly, December is about 30 weeks away and I wouldn't try to lose more than 30-60 pounds by then. I think this is entirely doable if you stick to the above.
  4. I can't offer any constructive thoughts other than to say keep up the great work! These videos are fascinating and I enjoy watching them. While I'll likely never apply the same level of rigor to my lifestyle that you employ, there are some takeaways that I keep in mind with my simpler regime. Your analysis is sort of like watching an Olympian do their thing compared to someone with a general interested in fitness.
  5. I get up to pee once a night more or less every night. I’ve been doing it for so long that it’s practically unconscious at this point and I fall back asleep nearly instantly. I think it comes with the territory of eating a diet rich in plants (probably 6-7 pounds daily) and with virtually no added sodium. For a period of time I restricted all fluids within a few hours of bed and also included salt about 3-4 hours before bed in the form of hot sauce. This seemed to allow me to retain water overnight and not have to get up to pee. Ultimately I decided that the extra sodium was not worth it (it moved my intake from 400mg a day to 1000-1500mg or so). I think it’s remarkable how clear my pee is on an exclusive WFPB diet without any refined products. Prior to eating this way I was focused heavily on animal products and I did not experience this (though I had a plethora of other health issues).
  6. Hi cTpa, I think that your question is an interesting thought experiment and I believe it will lead to some interesting discussion in this thread. I was seriously ill (not from cancer) and did a complete 180 in my lifestyle just over a decade ago. On that note, if you are interested in reading about it you can do so here as I recently composed a long piece on 10 years of a WFPB (mildly CR'd) lifestyle: https://www.drmcdougall.com/forums/viewtopic.php?f=1&t=61699 To be clear about one thing, I eat a lot of food and in some ways may live more of an 'exercise-induced CR' lifestyle than being a true CRON-ie. Having said that, my bloodwork looks remarkably similar to those adhering to more conventional CR with more normal exercise regimes. Basically, a health crisis early in my life resulted in me going WFPB, engaging in exercise, cold exposure, heat exposure (sauna, steam room, etc.), taking up a meditation/mindfulness practice, tinkering with intermittent fasting, spending a great deal of time in nature, and so forth. Basically, if it's a longevity practice with robust data around it, I try to engage in it. I don't think a great deal would change if I were to get diagnosed with cancer as I think I've probably optimized a lot of what can be done. Having said that, I would almost certainly book a trip to True North Health Center for a medically supervised water-only fast as an intervention. As McCoy mentioned, doing regular rounds of Longo's FMD is probably something I would look to incorporate on a monthly basis. I would research the hell out of whatever condition I had and I also try to make peace with the fact that the outcome may be out of my hands (which I'm sure is easier said than done). I would also quit my job, spend every moment I could with family and friends, and try to see as much of this incredible world as I could. And if I was fortunate enough to survive, then I would resume working and contributing to society once again. I also would very seriously consider conventional medical treatment and would probably take advantage of it in some form. I'm certainly pro-medical establishment and think that an uber-healthy lifestyle is complementary to whatever current standard of care may be in place. The type of cancer, age of diagnosis, survival rates, and so forth, would undoubtedly influence my decision making though. If I was diagnosed with stage IV pancreatic cancer, it would be much different than to be diagnosed with early-stage prostate cancer. I appreciate Dean's openness in sharing his experience here.
  7. I hear you - I have a similar issue but there are a few that I have found that I can tolerate. For example, I can tolerate chickpeas and lentils well (cooking in the Instant Pot seems to make them much easier on the guy). But meanwhile there are many other common legumes that I don't do well with (i.e. kidney beans).
  8. I continue to enjoy your videos Mike! I've noticed that legumes, lentils, and other pulses are notably absent from your diet. Any reason in particular?
  9. I actually make my own hot sauce and I'm not concerned about lead/heavy metal contamination (from a manufacturing point of view at least), though I suppose theoretically some of the ingredients I use could be grown in contaminated soil. Spices are a pretty broad category, so I guess it would depend.
  10. Well, I found part of the answer here from 2015, though I'm not sure if your diet has changed since then? Either way, it looks great to me!
  11. I really enjoyed this video Mike. It's quite interesting to see how your 2006-2013 values compare to your 2015-2020 values. Congratulations on improving your kidney function in a clear and measurable way. I've also got to commend you on your 25 servings per day of vegetables! I had to listen to it twice since for a moment I thought that the 2000/g per day might include all whole plant foods, but it certainly sounds like pure veg to me! Have you ever posted your complete diet anywhere? I would be very interested in taking a look. By the way, your kidney values towards 2006 were the worst included (though certainly comparable to average). Why do you think there weren't as good then?
  12. Well, if you look at the group of Japanese centenarians from above who have a mean age of 106 and a mean BMI of 19.3. That's comparable to many people around here. Personally, I dipped down to a BMI of 19.9 for a while but find myself with more energy closer to 21.0.
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107392/ A notable quote from the publication which looked at centenarian cohorts in Italy, Japan, and Spain include: "Notably, we found no obese male centenarians in any of the cohorts." I think you'll find this chart to be informative too - while there is some variation in BMI between the 3 cohorts, there is a clear trend. So, if you still think it's a good idea to maintain a higher weight to live a long life, then by all means be my guest. But when you actually look at men who've reached the centenarian milestone, think again.
  14. drewab

    Oldest Man 111

    This thread prompted me to look up some of the ages of the longest currently living people. Kane Tanaka is currently the oldest verified person at 118 and is from Japan. More on her can be found here: https://en.wikipedia.org/wiki/Kane_Tanaka What I find remarkable is that unlike many centenarians who were seemingly healthy right up until the end, she clearly is not. It is remarkable to think that she had pancreatic cancer at age 45 and is still alive today. The 10-year survival rate for pancreatic cancer is less than 2% and here she is 73 years later still alive.
  15. drewab

    Effects of two glass of wine a day

    I personally avoid alcohol for the most part (I probably average 6 glasses of wine per year...though in 2020 I bet that number was 12). The increased cancer risk is my primary motivation for doing so. I've included the link below for the info I have included. When I was a young person I witnessed an alcoholic (my grandfather) drink himself to the point of neurological disorder and institutionalization. Death would have been a much preferrable outcome to what I saw. His brain failed before his body, which wasn't long thereafter and he passed away far too young. I don't mind if people have a few glasses of wine and I believe that we should be able to do as we like, but I do know far too many people that have an inappropriate relationship with alcohol (and I'm not even referring to being an alcoholic). John Mackey, founder of Whole Founds, recently had an excellent appearance on the Joe Rogan Podcast, part of which includes commentary on alcohol, which I found particularly enjoyable. Cancer. Excess alcohol consumption may increase the risk of the following cancers:[6] [7] Colorectal cancer – 10-20% increased risk with usual consumption of 50g daily, or 3-4 standard sized drinks daily. Breast cancer – For each 2/3 of a drink consumed daily (10g alcohol) risk increases by 7-10%. Cancer of the oral cavity, pharynx, larynx – Less than 2 drinks daily = 86% increased risk. 3-4 drinks daily = 311% increased risk. Esophageal cancer – Less than 2 drinks = 39% increased risk, 3-4 drinks daily = 93% increased risk. Liver cancer – Less than 2 drinks daily – 19% increased risk, 3-4 drinks daily = 40% increased risk. Stomach cancer – Less certain relationship. May be related to alcohol. Pancreatic cancer – Less certain relationship. May be related to alcohol. Lung cancer – Less certain relationship. May be related to alcohol. Stress urinary incontinence (a sneeze or cough causes leakage of urine): 2.4 times more common among women who consume alcohol.[8] Depression – Alcohol consumption is clearly associated with depression and has biochemical effects that explain how it causes and exacerbates depression. Hemorrhagic stroke (a type of stroke where a blood vessel breaks open) – High levels (more than 4 drinks a day) are associated with over 200% increased risk.[7] Pneumonia – Two drinks a day increase risk by 13%. More drinks lead to higher risk.[7] High blood pressure – Just two drinks a day is linked to 25% increased risk in men. More is linked to higher risks.[7] Heart rhythm problems – More than 2 drinks daily linked to more about 15% increased risk of conduction problems.[7] Pancreatitis – High alcohol consumption strikingly increases risk of pancreatitis. Liver cirrhosis – High alcohol consumption increases risk of the liver cirrhosis and failure. Addiction – 7% of American adults have an alcohol use disorder, which includes alcohol abuse and alcohol dependence.[9] Insomnia – 35-70% of people who chronically drink alcohol have insomnia, a much higher rate than the general population.[10] Heartburn – Alcohol can hamper the function of the sphincter barrier between the esophagus and stomach, leading to acid reflux and heartburn.[11] Leaky gut – Alcohol can disrupt the barrier function of the intestine, allowing large molecules that normally couldn’t be absorbed into your body.[11] Disrupted nutrition – High levels of alcohol consumption inhibits the absorption of a variety of nutrients.[11] Psoriasis – Alcohol may be a trigger for psoriasis exacerbations.[7] Obesity – Alcohol contains lots of calories, and people may not compensate for those calories by eating less food. In fact, alcohol may stimulate appetite. That said, observational data does not link alcohol intake with weight gain.[12] https://nutritionstudies.org/alcohol-16-reasons-to-rethink-your-drink/