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  1. Mechanism


    Keep it up Saul.
  2. Mechanism

    How much salt?

    Thank you Michael. Also great to see you here.
  3. Mechanism

    Healthiest Greens?

    There are no more "healthiest greens" than are "nicest notes" in an orchestra. It's the portfolio or symphony that makes the diet - and the presence and amplitude of each note impacts what other notes would best compliment it. There are certainly more nutritionally dense greens and those have better supportive data or a stronger apparent effect size per calorie - typically from limited epidemiological studies which are with few exceptions the best we have for definitive outcomes. Other work also supports the concept of dietary diversity, which also can serve to dilute the bad and ensure some of the good- just as is described by modern portfolio theory around the concept of a well-balanced investment mix. Michael summarized nicely here- and the literature has not changed all that much since then: "...specific foods that have been documented in long-term, well-designed prospective epidemiological studies or clinical trials to reduce the risk or improve the outcomes in actual diseases or mortality: short-term results using unvalidated surrogate markers don't count at all, and even results with well-validated disease risk factors (glycemia, blood lipoproteins, etc) must be treated with some caution and do not meet this bar when taken in isolation. On the list: raw vegetables; leafy greens; cruciferous vegetables (broccoli, cauliflower, mustard greens, cabbage, etc); Allium vegetables (onions, garlic, etc); carrots; green vegetables; citrus (including the peel -- but eat organic and wash thoroughly); cooked tomatoes; nuts; green tea; coffee [added fall 2012]; moderate (3-10 oz/d) wine, taken with a meal." [and EVOO] Source: https://www.longecity.org/forum/topic/51743-michaels-quotidian-diet/
  4. Nice detective work Dean.
  5. Observations: -Truly practiced CR for the most part. Few today based on the posts, but I'd also expect selection bias that the more motivated including "silent lurkers" are more likely to attend a formal conference. -Better educated, analytical, and more likely to be in technical fields (AI, chemistry, CPA, basic biology, etc, one attorney). -Interesting filming. Lots of shots of food.
  6. The same arguments that apply to unknowns also apply to unknowns regarding complete absence of any animal sources of nutrition. There is much we have yet to understand. Though not a vegan myself, still, I empathize with the vegan philosophy, and hope mankind will continue to move in that direction, collectively.
  7. Sibiriak advice, as usual is very sensible. I'll give you my two cents but keep in mind my goals are not the same. Yes CGMs in US require prescription. Yes, the higher BMI you target the less "room" you have without pharmacotherapy, or for a given level of pharmacotherapy Peter Attia targets <135 mg/dL post-prandially always and ideally <130. I am more stringent: the closer to 100-115 the better, but this is not realistic for most individuals: you have to like what you eat, and your metabolic state, BMI, genetics, etc will all have an impact. Impact of PUFA/MUFA depends on total calories, genetics, and what is being substituted out but as a rule-of-thumb, MUFA typically mildly reduces LDL, PUFA to a greater extent. Which is worse: postprandial peaks vs. lipid profile depends on genotype to a degree, and especially the extent of departures. For all the controversies on cholesterol there is good reason to be conservative and follow guidelines - or in many cases more stringently if possible. For example for BP a BP of 110/70 or lower, to a point, is typically better than 120/80 but there are always exceptions to all the rules, eg, lower BP may be associated with mortality and cognitive decline - part of this association is from confounding but at the same time if you have impaired cerebral perfusion from atherosclerosis later in life, a beneficial rule-of-thumb may be a liability for that situation. Bottom line, check with your doctor or get several second opinions when in doubt since medicine is so personalized. Many doctors are not versed at all in this arena, so your own due diligence and research is very helpful as a quality check and source of dialogue for these conversations with your team.
  8. Sibiriak your quote by Dean & summary sums it up nicely. Other avenue is lowering carbs & substituting with MUFA sources. That’s pretty much it, the rest is following CGM and lipid panels to ascertain personal data.
  9. Sibiriak, I agree "33%!" Actually, I couldn't agree with you more Sibiriak, and I found the statistic equally alarming for the same reason. It seems to me too much dialogue is an attempt to win over the other party to our own way of thinking rather than objectively and constructively trying to find truth, balance, and wisdom ( & mutual respect on matters of differences of preference). Moreover, the situation you illustrated is even worse than that - not a matter of persuasion but for the matter of public opinion you cited, it comes down to fooling ourselves. Overconfidence in one scenario or another in the absence of definitive smoking gun evidence either way is a recipe for disaster. Not only for the general public but saliently in politics. Humility, mindfulness, and a science and evidence-based balanced approach - and with positive respectful values to go with it - would go a long way towards addressing many of the problems of modernity.
  10. Mechanism

    Random Lectures and talks you liked

    Saul, enjoyed your discussion of your long academic career & digressions into life and Fermat's Last Theorem, etc BTW, if you didn't know, good news, your favorite place https://kripalu.org/ - it's official, doors open 8/19.
  11. Mechanism

    Whole Body Vibration Therapy for Bone Health

    Hi Kenton! Great to hear from you. Though I was completely joking of course - for your interest: 1) Agree though in principal just about anything can be biohacked, especially if the car of the future mostly or exclusively will be self-driving with no distraction safety concern: Eg, strap on bioengineered suit simulating load in a micro-chamber. The next great CR patent- but not before mega-muffins go industrial scale. 2) Aware of the C Elegans data, mammals if affected at all, may go the other way: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536001/ Best CR strategy: Eat real food, not too much (BMI/kcal), mostly plants/nutrition & exercise +/- sleep, stress, etc. Beyond those, the rest (if they help it all) is having a little orthorexic fun frosting on the cake... Of course you knew all that Kenton, you've been in the CR gig long before it got hip!
  12. Mechanism

    Random Lectures and talks you liked

    My favorites are talks, documentaries and interviews. In that spirit, what do Saul, Dean, James Cain, & Richard Miller share in common unrelated to CR? https://m.youtube.com/channel/UCkC6C9Xj8vxOyOT8EXcStQg/videos (@ KAUST?)
  13. Mechanism

    Whole Body Vibration Therapy for Bone Health

    Hey, you never know, CR-mobile may also come equipped with cryo-seat setting for the Deans of the world. Maybe even delicious-smelling car fragrance to kick up the ghrelin in-transit.
  14. Mechanism

    Whole Body Vibration Therapy for Bone Health

    Despite the long thread and a multitude of other publications there remains much to work out respect to both safety and efficacy, but the literature continues to grow. A recent publication of interest: Wen J, Bao M, Tang M, He X, Yao X, Li L. Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats. Aging (Albany NY). 2021;13(8):12031-12045. doi:10.18632/aging.202907 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109117/ Abstract Dysfunction of bone marrow mesenchymal stem cells (BMSCs), osteoblasts and osteocytes may be one of the main causes of bone loss in the elderly. In the present study, we found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed. Osteogenic differentiation capacity of BMSCs from aged rats decreased while adipogenic capacity increased. The mineralization capacity, ALP activity and osteogenic proteins expression of osteoblasts from aged rats decreased. Additionally, osteocytes from aged rats up-expressed sclerosteosis protein, a negative regulator of bone formation. To inhibit osteogenic cell senescence, we use low magnitude vibration (LMV) to eliminate the senescent osteogenic cells. After LMV treatment, the number of osteogenic cells staining positively for senescence-associated-β-galactosidase (SA-β-Gal) decreased significantly. Besides, the expression of anti-aging protein SIRT1 was upregulated significantly, while p53 and p21 were downregulated significantly after LMV treatment. Thus, the LMV can inhibit the senescence of osteogenic cells partly through the Sirt1/p53/p21 axis. Furthermore, LMV was found to promote bone formation of aged rats. These results suggest that the inhibition of osteogenic cell senescence by LMV is a valuable treatment to prevent or delay osteoporosis. Regarding the protocol, from the study "For rats, a vertical whole-body vibration at 0.3 g and 90 Hz was performed for 30 minutes, once daily, 5 days a week until 12 weeks for subsequent analysis." Same settings for the cells. Functional outcome measures are really needed of course. This is tricky with rodents, and we can only infer so much to human musculoskeletal pathology given interspecies differences, but it is a good place to start. RCT's in humans would be best and are very much needed. The underlying aging biology described here is of interest, and may also lend itself to additional new targeted therapies.
  15. If CR appears to work better in some mouse models at sub-thermoneutral temperatures, one may hypothesize that part of the seemingly greater efficacy may be there are simply more cancers to suppress: https://pubmed.ncbi.nlm.nih.gov/32716858/ Camparing absolute life extension under both conditions in one experiment along with cause of death pathology is most helpful disentangling the variables.