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Mechanism

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  1. Mechanism

    Movie Recommendations

    Hi Dean, I just saw the theory... I mean history... of time travel. It was a good recommendation, I love cerebral cinema. Thanks.
  2. Doctors get rare diseases... and statisticians get rare odds! May your next improbability drive event be a good one!
  3. Saul, I'm glad you stayed healthy on placebo- congratulations on your apt to get the real thing!
  4. Thank you Gordo. I heard good things about it. Reason also had mentioned it here: https://www.fightaging.org/archives/2021/01/ageless-the-new-science-of-getting-older-without-getting-old/ , referring to the story about it at The Guardian: https://www.theguardian.com/science/2021/jan/03/observer-magazine-do-we-have-to-age-biologist-andrew-steele
  5. Mechanism

    Lost your marbles yet??

    Wow, now that’s a wonderful turn of events! Happy New Year... and live long and prosper!🖖
  6. Mechanism

    LDL: What's Optimal For Health And Longevity?

    This point is often confused. What the research supports is that “changes in HDL cholesterol caused by diet or drug treatments can no longer be directly linked to changes in CVD, and therefore, the LDL cholesterol–raising effect should be considered on its own.” (1) The context here is caution in the context of coconut oil until more research is done, since coconut raises HDL as well as LDL. (There are many other arguments pertaining to coconut oil on both sides of the debate, but this is not the focus of this post). But in that context the Presidential Advisory from the AHA was essentially taking the position that we cannot be as confident that raising HDL via diet will compensate for the increase in LDL. In contrast, elevated HDL achieved via weight loss and exercise does have a consistent favorable profile. [“because coconut oil increases LDL cholesterol, a cause of CVD, and has no known offsetting favorable effects, we advise against the use of coconut oil.”]. The basis of this skepticism of a rise in HDL outside of established benefit via lifestyle intervention was described earlier in (1): “However, unlike LDL cholesterol, genetic variation that affects HDL cholesterol is not associated with expected differences in CVD unless LDL cholesterol or triglyceride is also affected by the genetic variants84 or reverse cholesterol transport is impaired.85 Still, these genetic studies, often called mendelian randomization, may not be capturing important loci for the protective effect of HDL that may be reflective in HDL cholesterol raising by dietary fats compared with carbohydrates. Although increases in HDL cholesterol by some pharmacological treatments have not decreased CVD,86,87 this does not directly pertain to the effects of dietary fat because the underlying mechanisms of effects of drugs such as a cholesterylester transfer protein inhibitor and nicotinic acid are probably not the same as those affected by dietary fats and carbohydrates. The HDL field is working toward a functional approach to CVD risk prediction and treatment. For example, a small experimental study showed that consumption of saturated fat reduces the anti-inflammatory potential of HDL and impairs arterial endothelial function. In contrast, the anti-inflammatory activity of HDL improves after consumption of polyunsaturated fat.” An editorial in Circulation by Frank Sacks (2) subsequently reaffirmed this position, ie, “Although coconut oil increases plasma HDL cholesterol, it is impossible to know if this is a beneficial mechanism in cardiovascular disease.7 Although HDL cholesterol is a robust risk marker for cardiovascular disease, genetic studies and HDL-raising drugs have not so far supported a causal relationship between HDL cholesterol and cardiovascular disease. HDL, the lipoprotein, is composed of a huge array of subparticles that may have adverse or beneficial actions.7,8 It is unknown which, if any, foods or nutrients that raise HDL cholesterol do so in a way that reduces atherosclerosis and coronary events. Thus, effects on cardiovascular disease of foods or nutrients cannot be judged from changes in HDL cholesterol.” As the Harvard Heart letter noted (3) , the track record for HDL raising drugs is particularly dismal with “To date, five major clinical trials that sought to raise HDL levels with drugs have failed to lower heart disease risk” Lipidologist Dr. Thomas Dayspring & others have speculated it is more of an HDL function story, still poorly characterized as of now. (1) https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000510 (2) https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044687 (3) https://www.health.harvard.edu/heart-health/rethinking-good-cholesterol Further reading (primary sources of said publications): Sacks FM, Jensen MK. From high-density lipoprotein cholesterol to measurements of function: prospects for the development of tests for high-density lipoprotein functionality in cardiovascular disease.Arterioscler Thromb Vasc Biol. 2018; 38:487–499. doi: 10.1161/ATVBAHA.117.307025LinkGoogle Scholar & Furtado JD, Yamamoto R, Melchior JT, Andraski AB, Gamez-Guerrero M, Mulcahy P, He Z, Cai T, Davidson WS, Sacks FM. Distinct proteomic signatures in 16 HDL (high-density lipoprotein) subspecies.Arterioscler Thromb Vasc Biol. 2018; 38:2827–2842. doi: 10.1161/ATVBAHA.118.311607LinkGoogle Scholar
  7. Sad to hear the news. While death is inevitable, our daily choices do much to impact the quality of our lives while we are here.
  8. McCoy! Great to hear from you. Hope you and family are all well- and into Covid round 2+ ( if there ever was a lull). yes, that’s a lot of EVOO- if nothing else places into context concerns re: FMD. Indeed, the initial reports may have been I. Part from using refined oil and without vitamins ( summary of those details here, worth the read for anyone not familiar): https://www.oliveoiltimes.com/world/uc-davis-researcher-advises-opt-out-of-olive-oil/51579 Regarding dosing in PREDIMED, “Participants in the group assigned to a Mediterranean diet with extra-virgin olive oil received 1 liter of the oil per week per household, with the recommendation to consume at least 4 tablespoons per day of extra-virgin olive oil per person” though real consumption was less (https://www.nejm.org/doi/full/10.1056/NEJMoa1800389). I owe my initial introduction to EVOO to Michael. Though I think it is possible to have a healthy diet without EVOO, if choosing an oil, EVOO is the best bet. MR’s choice? “I insist on verifiably superior EVOO qualities: high (≥76%) oleic acid content (for oxidative stability, and see above on DHA-accelerated aging hypothesis: olives from different cultivars and regions can vary from 55-83% oleic acid); low peroxide value (<9, and preferably <6 meq/kg), and high (≥350 mg/kg) total phenolics, assayed using caffeic acid equivalents. ” His own take on the literature and I do not disagree is: “The epidemiology strongly suggests 2-3 T/d. I get an average of 5-6 tsp (ie, 2 T or just a bit shy of it); I also get a lot of additional MUFA from nuts (also on 'the list'), Peruvian olives, and occasional avocado, tho' of course EVOO is not just a MUFA source.” By contrast, Valter Longo - hedging his bets a bit the other way [ I won’t mention the flawed / lower quality low-far vegan school of thought data as not to invoke the ire of MR... though I would not dismiss it out of hand either] as a compromise, as detailed in his Longevity Diet book), has advised in the ballpark of 3T/d. There is no perfect data out there but as a whole foods purist (I still prefer nuts!) I have been thoroughly persuaded harm, if any, is minor in the context of a healthy diet/lifestyle and that evidence and statistics favor moderate EVOO as a net positive in the vast majority of diets via in large part from polyphenols, MUFA, and substitution effect for low quality / high GL carbohydrates & “true” nasty refined elements. Mechanism
  9. I was a skeptic at first too Ron (a great health and scientific literacy quality I might add), but looking deeper into the matter, I ultimately came to the conclusion that while yet unproven, there are likely additional benefits ( not by oleic acid alone)! For a sense of perspective, if faced with a choice I would prioritize keeping EVOO (vs refined lower quality OO) much higher than the need for cold exposure . This, even and perhaps especially for those with substantial metabolic dysfunction & metobesity for whom there remains the greatest plausibility for material CE health outcome benefits. The work since this 06’ classic paper (1) has done much more to support than to undermine the evidence: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1538-7836.2006.01963.x (1) Pacheco YM, López S, Bermúdez B, Abia R, Muriana FJ. Extra-virgin vs. refined olive oil on postprandial hemostatic markers in healthy subjects. J Thromb Haemost. 2006 Jun;4(6):1421-2. doi: 10.1111/j.1538-7836.2006.01963.x. PMID: 16706995.
  10. Glad you are doing well Saul. Stay healthy and stay safe!
  11. Thanks for the update Saul. I am very happy to hear you are doing well both health wise and also with a wonderful sense of purpose you have always had - teaching math at the University of Rochester. And with an excellent attendance rate too I recall. Many ease up CRON a bit with age because of the evidence keeping a little extra reserve may prove helpful in the event of an injury or metabolic insult, with some evidence to this effect. Obviously it depends on personal circumstances. I am curious, what made you decide to get “more strict on CRON?” I presume you still follow your biomarkers along with your doctors including the “CR-sympathetic” nephrologist you referred to in the past. You have always been understandably proud of your outstanding lipid panel ratios. Wishing you well, Mechanism PS- I will declare Covid in “a new era” when Kriplalu re-opens. No word yet, AFAIK.
  12. McCoy recently posted re: this fantastic interview- much more detail then the comparatively superficial TED Talk: https://peterattiamd.com/jamesokeefe/
  13. That’s great about the temperature. Hang in there.
  14. Sorry to hear about Mom. I’m glad it had been mild for you, and at least Dad is over it most quickly so will be better able to look out for her too. I don’t think anybody has the answers but I’m sure it will be studied. A shorter course need not mean fewer antibodies. Be well and best to Mom, Mechanism
  15. Hope your family, and you with the exposure, do well Matt. You have statistics in your favor for a milder course.
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