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  1. Strain on NHS as tens of thousands of staff suffer long Covid https://www.theguardian.com/society/2021/apr/03/nhs-feels-strain-tens-thousands-staff-long-covid "At least 122,000 NHS personnel have the condition, the Office for National Statistics disclosed in a detailed report that showed 1.1 million people in the UK were affected by the condition. That is more than any other occupational group and ahead of teachers, of whom 114,000 have it. Patient care is being hit because many of those struggling with long Covid are only able to work part-time, are too unwell to perform their usual duties, or often need time off because they are in pain, exhausted or have “brain fog”."
  2. It's possible for anyone with the ApoE4 Alzheimer's risk-increasing allele that choline may be beneficial: Droplets of Unsaturated Fats Burden Human ApoE4 Astrocytes https://www.alzforum.org/news/research-news/droplets-unsaturated-fats-burden-human-apoe4-astrocytes "Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers" "Choline is a component of Souvenaid, a medical food designed by Nutricia of Danone Research to enhance the formation and function of synapses. In the LipiDiDiet clinical trial, people with AD who consumed this yogurt-like drink once a day for two years had slightly less shrinkage of the hippocampus than did controls. The trial failed to meet its primary outcome, but follow-up data suggested that Souvenaid might help people who continue consuming the drink for three years." https://www.alzforum.org/news/conference-coverage/non-av-non-tau-drugs-tweak-markers-cognition-alzheimers-huntingtons "At three years, the cognitive benefit on the CDR-SB widened for those taking Souvenaid, with decline slowing by 45 percent. Likewise, the rate of hippocampal atrophy diverged further between the groups, slowing by 33 percent for those on Souvenaid. The Cohen’s d effect sizes were 0.31 and 0.27, respectively, for CDR-SB and hippocampal atrophy. Both were significant at the 0.01 level or better."
  3. There was also evidence found of cognitive damage in this much larger study from the UK back in October. This was done via online cognitive testing / questionnaire, with a pattern of increasing cognitive damage as Covid severity increased, but even in "mild" cases some cognitive damage was detected. At the higher end of ventilated patients, approximately 8.5 IQ points were estimated lost. Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study https://www.medrxiv.org/content/10.1101/2020.10.20.20215863v1.full.pdf
  4. More evidence of brain damage in mild Covid-19 cases, including a pattern of hyperconnectivity that may lead to risk of future issues. "Our findings suggest the new coronavirus affects the brain in individuals who did not require hospitalization, with persistent fatigue, headache, memory problems and somnolence even after two months of their diagnosis. We detected cognitive impairment in these patients, along with white matter abnormalities and hyperconnectivity among distinct resting-state networks. The degree of brain alterations and the severity of cognitive dysfunction raises the attention for the necessity of extensive longitudinal studies of chronic neuropsychiatric symptoms in post-COVID-19 infected individuals. Specific treatment for symptoms and neurorehabilitation strategies may be necessary to improve the quality of life and cognitive function for those with persistent limitations after the acute phase." Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 https://www.medrxiv.org/content/10.1101/2021.03.20.21253414v1.full-text
  5. BrianA

    Sci Fi Movie and Book Recommendations

    Primer is definitely worth a watch. And a rewatch.
  6. See how they run: 'Exercise protein' doubles running capacity, restores function and extends healthy lifespans in older mice https://www.sciencedaily.com/releases/2021/01/210121131934.htm
  7. α‐ketoglutarate delays age‐related fertility decline in mammals https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13291 https://www.lifespan.io/news/alpha-ketoglutarate-delays-age‐related-fertility-decline/
  8. BrianA

    Cake fit for human consumption

    There are some interesting dessert (and other) recipes at this site. The focus is on vegan, gluten-free, processed sugar-free (sweetness typically added via dates), processed oil-free (fats typically added via cashews or other nuts) food: https://plantbasedcookingshow.com/ We've made some of the desserts, muffins, and breads and they generally turn out very tasty. There is an apple pie recipe, haven't tried that one yet: https://plantbasedcookingshow.com/2020/10/03/vegan-apple-pie/
  9. A new company called OneSkin has released a skin product they claim acts as a senolytic, reducing senescent cells and reducing the biological age of skin as measured via methylation clock. Some data charts in this video, where they claim better effects than retinoic acid:
  10. What COVID-19 Reinfection Means for Vaccines https://www.scientificamerican.com/article/what-covid-19-reinfection-means-for-vaccines/
  11. Cases in some countries seem to be taking off again, kind of a 3rd wave. Some countries like israel and Spain are now at per-capita case loads higher than the US peak. Israel heads to a second lockdown as coronavirus cases soar https://www.washingtonpost.com/world/middle_east/israel-heads-to-a-second-lockdown-as-coronavirus-cases-soar/2020/09/13/4f473fe6-f5a7-11ea-85f7-5941188a98cd_story.html
  12. Lasting Covid damage in a lot of people seems to be real. Tim Spector, professor of genetic epidemiology at King's College London, said about 600,000 people have some sort of post-Coronavirus illness https://www.ibtimes.sg/long-covid-run-man-who-tested-positive-coronavirus-march-says-6-months-still-unwell-51455 45% of of a group of 26 competitive athletes show either current myocarditis or evidence of prior heart injury. Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://jamanetwork.com/journals/jamacardiology/fullarticle/2770645 Redefining Covid-19: Months after infection, patients report breathing difficulty, excessive fatigue https://edition.cnn.com/2020/09/13/health/long-haul-covid-fatigue-breathing-wellness/index.html 74% of hospitalized patients reporting continuing symptoms after 12 weeks Patient outcomes after hospitalisation with COVID-19 and implications for follow-up; results from a prospective UK cohort. https://www.medrxiv.org/content/10.1101/2020.08.12.20173526v1
  13. Looks like some long term neurological damage in 55% of Covid-recovered individuals in this study from China. They didn't find much correlation between severity of the disease and these results, although my understanding is all of these study participants came from a local hospital, so were hospital-admitted individuals I think. Cerebral Micro-Structural Changes in COVID-19 Patients – An MRI-based 3-month Follow-up Study https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30228-5/fulltext
  14. Research is starting to develop some ideas on how to use drugs to tweak body temp pathways. Linking calorie restriction, body temperature and healthspan https://www.scripps.edu/news-and-events/press-room/2020/20200908-conti-temperature.html Metabolic adaptation to calorie restriction https://stke.sciencemag.org/content/13/648/eabb2490
  15. Here's a table with the AGE content of many foods. Anyone have any other good links for this kind of data? I was surprised walnuts have a lot, is that from the roasting process commercial walnuts have to go through, and would raw organic type walnuts be lower in AGE content? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704564/table/T1/