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  1. It would be good to start differentiating between quoting news/data from countries like the UK that primarily vaccinated with a less effective vaccine against the delta variant, vs the US or Israel that mostly used a more effective Pfizer or Moderna vaccine particularly among the more susceptible older folks. It's really an apples vs oranges comparison.
  2. Nuts and protein both may not give you the expected listed calories on the product label: The truth about counting calories https://www.popsci.com/health/calorie-counting-apps-accuracy/
  3. BrianA

    Starting a CR Diet

    If you like having more brain cells vs. less brain cells, avoid alcohol: Drinking any amount of alcohol causes damage to the brain, study finds https://www.cnn.com/2021/05/19/health/alcohol-brain-health-intl-scli-wellness/index.html
  4. It would be interesting just to try a walk after eating the exact same meal that caused a spike, and see what happens. If it helps, you can consider then getting a slow walking-speed treadmill, I use one at my sit/stand/walk desk after breakfast and lunch while doing work on my computer.
  5. Gordo the deaths always lag cases by 3 to 4 weeks. Takes a while for people to progress through the stages of infection/test -> hospitalization -> death. Same pattern repeats every time there is a new upsurge in cases throughout the pandemic.
  6. BrianA

    Whole Body Vibration Therapy for Bone Health

    Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats https://www.aging-us.com/article/202907/text
  7. Strain on NHS as tens of thousands of staff suffer long Covid https://www.theguardian.com/society/2021/apr/03/nhs-feels-strain-tens-thousands-staff-long-covid "At least 122,000 NHS personnel have the condition, the Office for National Statistics disclosed in a detailed report that showed 1.1 million people in the UK were affected by the condition. That is more than any other occupational group and ahead of teachers, of whom 114,000 have it. Patient care is being hit because many of those struggling with long Covid are only able to work part-time, are too unwell to perform their usual duties, or often need time off because they are in pain, exhausted or have “brain fog”."
  8. It's possible for anyone with the ApoE4 Alzheimer's risk-increasing allele that choline may be beneficial: Droplets of Unsaturated Fats Burden Human ApoE4 Astrocytes https://www.alzforum.org/news/research-news/droplets-unsaturated-fats-burden-human-apoe4-astrocytes "Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers" "Choline is a component of Souvenaid, a medical food designed by Nutricia of Danone Research to enhance the formation and function of synapses. In the LipiDiDiet clinical trial, people with AD who consumed this yogurt-like drink once a day for two years had slightly less shrinkage of the hippocampus than did controls. The trial failed to meet its primary outcome, but follow-up data suggested that Souvenaid might help people who continue consuming the drink for three years." https://www.alzforum.org/news/conference-coverage/non-av-non-tau-drugs-tweak-markers-cognition-alzheimers-huntingtons "At three years, the cognitive benefit on the CDR-SB widened for those taking Souvenaid, with decline slowing by 45 percent. Likewise, the rate of hippocampal atrophy diverged further between the groups, slowing by 33 percent for those on Souvenaid. The Cohen’s d effect sizes were 0.31 and 0.27, respectively, for CDR-SB and hippocampal atrophy. Both were significant at the 0.01 level or better."
  9. There was also evidence found of cognitive damage in this much larger study from the UK back in October. This was done via online cognitive testing / questionnaire, with a pattern of increasing cognitive damage as Covid severity increased, but even in "mild" cases some cognitive damage was detected. At the higher end of ventilated patients, approximately 8.5 IQ points were estimated lost. Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study https://www.medrxiv.org/content/10.1101/2020.10.20.20215863v1.full.pdf
  10. More evidence of brain damage in mild Covid-19 cases, including a pattern of hyperconnectivity that may lead to risk of future issues. "Our findings suggest the new coronavirus affects the brain in individuals who did not require hospitalization, with persistent fatigue, headache, memory problems and somnolence even after two months of their diagnosis. We detected cognitive impairment in these patients, along with white matter abnormalities and hyperconnectivity among distinct resting-state networks. The degree of brain alterations and the severity of cognitive dysfunction raises the attention for the necessity of extensive longitudinal studies of chronic neuropsychiatric symptoms in post-COVID-19 infected individuals. Specific treatment for symptoms and neurorehabilitation strategies may be necessary to improve the quality of life and cognitive function for those with persistent limitations after the acute phase." Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 https://www.medrxiv.org/content/10.1101/2021.03.20.21253414v1.full-text
  11. BrianA

    Sci Fi Movie and Book Recommendations

    Primer is definitely worth a watch. And a rewatch.
  12. See how they run: 'Exercise protein' doubles running capacity, restores function and extends healthy lifespans in older mice https://www.sciencedaily.com/releases/2021/01/210121131934.htm
  13. α‐ketoglutarate delays age‐related fertility decline in mammals https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13291 https://www.lifespan.io/news/alpha-ketoglutarate-delays-age‐related-fertility-decline/
  14. BrianA

    Cake fit for human consumption

    There are some interesting dessert (and other) recipes at this site. The focus is on vegan, gluten-free, processed sugar-free (sweetness typically added via dates), processed oil-free (fats typically added via cashews or other nuts) food: https://plantbasedcookingshow.com/ We've made some of the desserts, muffins, and breads and they generally turn out very tasty. There is an apple pie recipe, haven't tried that one yet: https://plantbasedcookingshow.com/2020/10/03/vegan-apple-pie/
  15. A new company called OneSkin has released a skin product they claim acts as a senolytic, reducing senescent cells and reducing the biological age of skin as measured via methylation clock. Some data charts in this video, where they claim better effects than retinoic acid: