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BrianA

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  1. This study used hospitalized patients from the original variant. Blood markers of brain cell damage higher over short term in COVID-19 patients than in Alzheimer's patients, study finds https://www.sciencedaily.com/releases/2022/01/220113092128.htm
  2. "In a large cohort of military service members followed over many years, infection with Epstein-Barr increased the likelihood of developing multiple sclerosis, or MS, by more than 32-fold, a team of scientists led by Harvard University’s Neuroepidemiology Research Group reported in the journal Science on Thursday." Strong new evidence suggests a virus triggers multiple sclerosis https://www.statnews.com/2022/01/13/strong-new-evidence-suggests-virus-triggers-multiple-sclerosis/
  3. New study shows immune system issues several months after covid, in "long covid" patients. The good news for vaccinated individuals is other studies have shown vaccination significantly cuts down on long covid risk. "Here, we studied individuals with LC compared to age- and gender-matched recovered individuals without LC, unexposed donors and individuals infected with other coronaviruses. Patients with LC had highly activated innate immune cells, lacked naive T and B cells and showed elevated expression of type I IFN (IFN-β) and type III IFN (IFN-λ1) that remained persistently high at 8 months after infection. ... In summary, our data indicate an ongoing, sustained inflammatory response following even mild-to-moderate acute COVID-19, which is not found following prevalent coronavirus infection. The drivers of this activation require further investigation, but possibilities include persistence of antigen, autoimmunity driven by antigenic cross-reactivity or a reflection of damage repair. These observations describe an abnormal immune profile in patients with COVID-19 at extended time points after infection and provide clear support for the existence of a syndrome of LC." Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection https://www.nature.com/articles/s41590-021-01113-x?s=09
  4. BioNTech now has an AI-based system to study emerging variant sequences, to predict 2 months ahead of time which ones might likely become high-risk variants. BioNTech and InstaDeep Developed and Successfully Tested Early Warning System to Detect Potential High-Risk SARS-CoV-2 Variants https://investors-biontech-de.translate.goog/news-releases/news-release-details/biontech-and-instadeep-developed-and-successfully-tested-early/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en-US
  5. Here's a new CDC study with more evidence that covid increases diabetes incidence, this time in children under 18. Unlike flu or other "it's just the flu" diseases. Summary What is already known about this topic? SARS-CoV-2 infection is associated with worsening of diabetes symptoms, and persons with diabetes are at increased risk for severe COVID-19. SARS-CoV-2 infection might also induce newly diagnosed diabetes. What is added by this report? Persons aged <18 years with COVID-19 were more likely to receive a new diabetes diagnosis >30 days after infection than were those without COVID-19 and those with prepandemic acute respiratory infections. Non–SARS-CoV-2 respiratory infection was not associated with an increased risk for diabetes. What are the implications for public health practice? The increased diabetes risk among persons aged <18 years following COVID-19 highlights the importance of COVID-19 prevention strategies in this age group, including vaccination for all eligible persons and chronic disease prevention and treatment. Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged <18 years — United States, March 1, 2020–June 28, 2021 https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm?s_cid=mm7102e2_w
  6. Here's a study from Germany that quantifies the average amount of organ damage from covid on unvaxxed individuals from 2020 who had a mild course, not hospitalized. Looks like around 2% loss of function on lungs/heart/kidneys roughly, plus leg vein damage, and I'd assume the slight loss of IQ reported in the UK studies. So nothing too major, but OTOH it's not nothing. Hamburg City Health Study: Even a mild course of COVID-19 leaves traces on organs https://www-uke-de.translate.goog/allgemein/presse/pressemitteilungen/detailseite_115521.html?_x_tr_sl=auto&amp;_x_tr_tl=en&amp;_x_tr_hl=en-US
  7. This study was done with hospitalized patients from the original variant back in 2020, but still interesting that the virus can potentially reduce adiponectin levels through fat cell infection. The coronavirus may cause fat cells to miscommunicate, leading to diabetes https://www.sciencenews.org/article/coronavirus-covid-diabetes-fat-cells-blood-sugar
  8. This may be part of what drives the "long covid" response in some people: COVID-19 can trigger self-attacking antibodies https://www.sciencedaily.com/releases/2021/12/211230130944.htm
  9. Well there was that little "blip" of a Civil War 150 years back... but yes, I expect the next civil war would be fought over memes this time around. Thanks Facebook
  10. BrianA

    Thread of monumental disappointment

    Here's some good news, another billionaire has stepped up to fund rejuvenation research: Brian Armstrong, the CEO of Coinbase: Lifespan News – Coinbase CEO vs Aging NewLimit is using new technology to address epigenetic alterations. https://www.lifespan.io/news/lifespan-news-coinbase-ceo-vs-aging/
  11. This is very interesting, it seems SARS-CoV-2 can spread quite well via an additional direct cell-to-cell mechanism, which can help keep it hidden from the immune system and antibodies in the blood. I'm quite curious if this may be part of what's behind the "long covid" phenomenon, as the scientists here note that this mechanism also allows the virus to invade cells that don't even have the much-discussed ACE2 receptor. SARS-CoV-2 goes 'underground' to spread from cell to cell https://www.sciencedaily.com/releases/2021/12/211223113127.htm
  12. Interestingly I read yesterday Omicron has been shown to be able to infect mice fairly well, whereas Delta and prior variants couldn't. Now here is another paper showing Omicron's particular mutations and the large overall jump in mutations may indicate it jumped from mice to humans (after we assume first a previous variant jumped from humans to mice). Evidence for a mouse origin of the SARS-CoV-2 Omicron variant https://www.biorxiv.org/content/10.1101/2021.12.14.472632v1.full.pdf
  13. Hospital loads still climbing in South Africa, in comparison to Delta trend https://imgur.com/ii9A7ee
  14. Helping to explain how Omicron can spread so quickly, study finds it replicates 70x faster than Delta in first 24 hours post-infection, likely making individuals contagious within 24 hours, and probably before they have any noticeable symptoms. On the plus side, it replicates more in the throat than the lungs.
  15. Here's some good news, just need the FDA to stop wasting time and approve this. Every day they delay, people are dying. Pfizer says Covid-19 pill near 90% effective in final analysis https://www.cnbc.com/2021/12/14/pfizer-says-covid-19-pill-near-90percent-effective-in-final-analysis-.html
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