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Todd Allen

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About Todd Allen

  • Birthday 08/21/1964

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  1. Todd Allen

    Olive oil? Healthy or not?!

    If only we could get kids to drink more fat free soda and stop drinking so damn much EVOO we might end this catastrophe of youth with diabesity and heart disease!
  2. I doubt they were achieving optimal nutrition. CR with poor nutrition even when voluntary as in anorexia doesn't produce good results for adults either.
  3. AKG and AAKG are widely available and fairly inexpensive. Rejuvant is just a slow release form of AKG. Hard to imagine much increased value in that as one can buy cheap bulk powder and dose on whatever schedule one believes is optimal.
  4. Maybe both. I asked my doctor for an antibody test but she said of the ones she could order neither appeared to her to be sufficiently accurate to be actionable.
  5. Todd Allen

    Hit or miss: the new cholesterol targets

    From that link: Sounds like high blood sugar may be the bigger issue here. No mechanism mentioned for high cholesterol being problematic rather it looks like it is the triglyceride lowering aspect of Fenofibrate which is relevant.
  6. Todd Allen

    Hit or miss: the new cholesterol targets

    She probably read this paper: Mortality over two centuries in large pedigree with familial hypercholesterolaemia: family tree mortality study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31037/
  7. Todd Allen


    I think John Brown is a forum spambot.
  8. Todd Allen

    Hit or miss: the new cholesterol targets

    Yes, there is a lot of evidence that low HDL is a serious risk factor but unfortunately trials of drugs which raise it and even niacin failed to show benefit. Low HDL is probably an indicator of metabolic derangements such as insulin reistance and hyperinsulinemia and artificially fixing it without addressing the underlying issues doesn't seem to help.
  9. Todd Allen

    Hit or miss: the new cholesterol targets

    https://sci-hub.tw/https://jamanetwork.com/journals/jama/article-abstract/2767861 Does excluding those who died within 150 days sufficiently correct for the bias caused by the practice of not prescribing statins to those perceived to be near the end of life? What would the results be if they excluded those who died within a year or two or five? Heart disease develops over decades and statins at best have a modest impact on the rate it progresses. Is it credible that they have a dramatic impact when taken for the last few years of life? Or is this result an artifact of the rules by which this data was produced and processed? Observational studies of this nature at best find correlation and other methods such as RCTs are better for evidence of causation. The ALLHAT-LLT Randomized Clinical Trial found the opposite. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2628971
  10. https://ebm.bmj.com/content/early/2020/07/20/bmjebm-2020-111413.full Abstract Drug treatment to reduce cholesterol to new target levels is now recommended in four moderate- to high-risk patient populations: patients who have already sustained a cardiovascular event, adult diabetic patients, individuals with low density lipoprotein cholesterol levels ≥190 mg/dL and individuals with an estimated 10-year cardiovascular risk ≥7.5%. Achieving these cholesterol target levels did not confer any additional benefit in a systematic review of 35 randomised controlled trials. Recommending cholesterol lowering treatment based on estimated cardiovascular risk fails to identify many high-risk patients and may lead to unnecessary treatment of low-risk individuals. The negative results of numerous cholesterol lowering randomised controlled trials call into question the validity of using low density lipoprotein cholesterol as a surrogate target for the prevention of cardiovascular disease. Discussion This analysis highlights the discordance between a well-researched clinical guideline written by experts and empirical evidence gleaned from dozens of clinical trials of cholesterol reduction. It further underscores the ongoing debate about lowering cholesterol in general and the use of statins in particular. In this analysis over three-quarters of the cholesterol lowering trials reported no mortality benefit and nearly half reported no cardiovascular benefit at all. The widely held theory that there is a linear relationship between the degree of LDL-C reduction and the degree of cardiovascular risk reduction is undermined by the fact that some RCTs with very modest reductions of LDL-C reported cardiovascular benefits while others with much greater degrees of LDL-C reduction did not (MEGA, ALLIANCE, SEAS, ODYSSEY FH 1 and 2, SPIRE 1 and 2).5–9 23 This lack of exposure–response relationship is illustrated in figure 3, where the scatter plot and the calculated correlation coefficient (R) suggest there is no correlation between the percent reduction in LDL-C and the absolute risk reduction in cardiovascular events. Moreover, consider that the Minnesota Coronary Experiment, a 4-year long RCT of a low-fat diet involving 9423 subjects, actually reported an increase in mortality and cardiovascular events despite a 13% reduction in total cholesterol.24 What is clear is the lack of clarity of these issues. In most fields of science the existence of contradictory evidence usually leads to a paradigm shift or modification of the theory in question, but in this case the contradictory evidence has been largely ignored simply because it doesn’t fit the prevailing paradigm.25 26
  11. Todd Allen

    Keto Diet

    I've been keto for 4 years. I've had good results and expect to be keto or near keto for the foreseeable future perhaps the rest of my life. While I've found it to be a decent approach for lowering body fat it isn't a magic bullet and I have to exercise restraint to avoid over indulging in very calorie rich foods which make me gain fat even in the absence of carbohydrates. I've also made effort to maintain a nutritionally complete diet of minimally processed whole foods gently cooked in healthful ways. My reason for the keto dietary approach is somewhat unusual as it isn't just about weight management but I have a rare genetic supposedly progressive and untreatable neuromuscular wasting disease known as SBMA or Kennedy's disease. It is a predisposition for metabolic issues such as type 2 diabetes and while eating keto I have reversed my neuropathy and muscle wasting and the comorbidities of diabetes I was developing.
  12. Todd Allen

    whole genome sequencing

    I realize we don't know how to interpret most of it now but I like the idea of having my data and being able to check it whenever I read a paper studying genes. The non-coding DNA has been called junk but is now known to have functions such as coding for RNA. Telomeres are also part of this junk. I expect a lot more of it will become relevant with time.
  13. 2000 IU daily in winter tapering off March and April resuming on days of low sun in November.
  14. Do you know you don't already have it? from: https://en.wikipedia.org/wiki/Human_betaherpesvirus_5
  15. Todd Allen

    whole genome sequencing

    Anyone familiar with this service or similar offerings? https://nebula.org/whole-genome-sequencing/ I'm thinking about ordering the 30x WGS for $299 plus one month of analysis for $20 and downloading my 100 GB of data for future analysis through whatever low cost options pop up. It looks sufficiently legit and cost worthy to me but looking for others thoughts before I pull the trigger and then learn there were better options.