Todd Allen

I've got quart bags and gallon bags. I have little need for bigger ones.

I use reusable silicone food storage bags. They come in many shapes and sizes. Plenty of places online carry them.

This supercentenarian did not talk about his genes or the exceptional longevity of family. Rather he claims to have been very lucky. If you get hit by a meteor great genes don't matter.

It's not really rapa or nothing. Most agree there are fundamentals such as diet, sleep, exercise, stress management, toxin avoidance, positive relationships, etc. which can get one pretty far despite a lack of agreement on the precise details. I didn't mean to say no one should self experiment with rapa but rather I think getting this particular vet to prescribe it for your dog and buying pills from him is a really bad idea. Especially if one doesn't have the capacity to verify what exactly is in the capsules one might get. Does he expect repercussions if his pills do nothing and people's dogs still age and die at the same rate? I have more confidence a major brand horse paste will have the ingredients claimed. I am also mocking the FDA and I place no value on anything that corrupt incompetent agency says or does.

According to the FDA, you are not a horse. And probably not a dog either. So all you longevity peeps don't go getting any bright ideas about achieving escape velocity with dog paste...

$105 for 12 0.5 mg capsules or $112 for 12 3.0 mg capsules. Considering the empty capsules cost maybe $0.20 and filling them can be automated suggests to me the pricing has little to do with costs. I'm guessing the calculation is that even at $10 the market would be tiny so let's make as much per customer as possible.

Yikes! I just found this: https://helpingpetslivelonger.com/ I don't think Matt has any connection to it other than providing data and visibility but it does illustrate how easy it can be to cash in on any longevity related research.

Indeed, I was a bit swayed by your arguments but hoped you were overstating your case. Unfortunately now I'm increasingly inclined to believe you were right on the money. I also am less concerned about Matt's research with rapa and dogs. If it leads to him profiting from pet foods, supplements or medicines then I will reconsider but for the moment I have the impression he is more interested in science then self enrichment.

https://www.thelongevitynewsletter.com/p/david-sinclair-matt-kaeberlein

This is Nick Norwitz. pic taken from:

You started with a statement about people becoming insulin resistant on a ketogenic diet. I believe practically the polar opposite and that LMHRs are in general exquisitely insulin sensitive. Our viewpoints are so completely divergent that discussion is pointless. Is it even possible for either of us to provide sources or evidence for our beliefs that the other is likely to accept or even seriously consider? The years of covid have left me jaded about the value of discussing strongly held divergent views. It generates a poor return on the invested time and energy.

Yes you have long and repeatedly made your preference for ignorance and dogma versus science abundantly clear.

That was not the point of the study. The point was as TomBAvoider described, the mainstream understanding of lipid metabolism as embraced by the pharma driven health care system would not have predicted this result. The result however is in alignment with the lipid energy model hypothesis put out by Dave Feldman and associates. Our choices are made based on our conceptual frameworks or models of reality. It is import to investigate when our models fail to predict testable outcomes. Medical and especially nutritional "science" far too often dismiss failures of their models to make predictions as paradoxes. Science riddled with paradoxes is not science.

Yes, I was being facetious. Although my desire was to be sarcastic and ridicule your position. You acknowledge that LDL can drop for a bad reason: cancer. I assume you are aware LDL can drop for other bad reasons too. You seem to believe oreos are an unhealthy food choice. And yet you jumped to the conclusion that Nick's drop in LDL was a good thing despite no other positive data suggesting an improvement Nick's health from the intervention which lowered his LDL.

Exactly! The oreos caused the cancer which lowered his LDL. And thus his risk of dying from CVD is reduced. Problem fixed!