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The Observer

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  1. The Observer

    Fasting - The Movie

    Why would they feature Montreal Healthy Girl from youtube in the trailer? She is a quack naturopath that can cure pretty much everything with her imagination, probably even bring back the dead. Very fishy!
  2. The Observer

    The Sorry State of AI

    That's because we reached the moon, cured polio, smallpox, so people thought everything is possible. But we were extremely ignorant back then. Reaching the moon is not nearly at the same level of complexity as making flying cars for everyone.. Just like curing polio with a simple vaccine is not even remotely comparable to curing cancer. And yet people thought so. Scientists simply had insufficient knowledge back then. Only when you have sufficient grasp of the subject, you can make more reliable predictions. Today we understand cancer fairly well and not many are claiming it will be eradicated any time soon. The cure will come gradually (just like driverless cars) and finally materialize sometime in the second half of this century (probably, I guess, I hope).
  3. The Observer

    Exercise increases all cause mortality

    I believe the benefits of exercise are well documented. Everything from reducing stress and inflammation, blood pressure, etc... However, I do wonder about the muscle mass and aging. Having bigger muscles means more maintenance, more micro-tearing, more growth, more energy/calories needed. More, more, more, and consequently the machinery should break down sooner. So I wonder if muscle mass is really a good thing regarding the pace of aging (ignoring the obvious fact muscles keep you from breaking bones at older age).. I mean, different studies have also confirmed that taller people die sooner than short individuals. I don't know. Just my layman's logic. Will also cite something from the above link (perhaps something for Dean to think about): Also this talk, worth the watch:
  4. The Observer

    Nuts and Mortality

    Just found out one is supposed to soak them before eating, and I quote: Apparently 6-12 hours will do the trick. Sounds a bit over the top to me, but are you guys soaking your nuts?
  5. The Observer

    Valter Longo interviewed by Rhonda

    Ah, nothing scientific really. I just though about minimizing the hours of feeling hunger, maximizing the sleeping hours during the fast and go to bed on a empty stomach only once. And since I am a night owl who likes to sleeps-in in the morning, and lunch being my favorite meal by far, this is what I came up with. Perhaps I could extend it to 48 hours, but I already lost quite a bit of weight and I have been continuously adding different diet changes and CR/fasting practices to my lifestyle, so I do not want to venture too deep into this rabbit hole. One can easily become obsessed, if it's not already too late for that. Perhaps many of us here are already too far gone. Maybe Dean saved himself in the nick of time.
  6. The Observer

    Valter Longo interviewed by Rhonda

    Thanks for the links, Gordo. It inspired me to undergo a 40 hour water only fast. It's perfect for me.. I ate my last meal in the evening, 4 hours before going to sleep. I also slept a bit longer due to obvious reasons, a total of 18 hours over the 2 days.. And since you do not suffer during sleep, plus I did not feel hunger in those initial 4 hours and also the first 2 hours after waking up on day 1, this means a total 18+4+2=24 hours of free ride and only 16 hours of suffering. Doable! I've been doing 24 hour water only fasts once a week in the last 5 months or so, but I will now incorporate one 40 hour fast (instead of 24 hour) once a month into my lifestyle.
  7. The Observer

    Valter Longo interviewed by Rhonda

    But autophagy happens while fasting, not while refeeding, right? It was funny how Rhonda wanted to talk about autophagy and mitophagy on several occasions during the interview, but Longo was like "Yeah, that to, it happens and it's good.... let's move on".
  8. The Observer

    Valter Longo interviewed by Rhonda

    Great! Now all we need is for one of you Americans to go through this 5-day FMD diet that Valter is offering through the Prolonfmd.com website and then present an extensive photo diary here, together with pictures of every meal (I presume they send you a package with fresh food every day), ingredients breakdown, your personal feelings, etc. Do we have a volunteer? edit: Ah, it's not really fresh food. ProLon® meals come in 5 small boxes (one for each day) that include plant-based energy bars, soups, a variety of snacks, drinks, and supplements, all studied and carefully designed to nourish your body and promote positive changes. edit2: Actually someone already went through such a similar experiment and made a thorough report.. Quite an interesting read.. Here's a link: https://www.quantifiedbob.com/2016/04/fasting-mimicking-diet/
  9. The Observer

    Fasting

    Satchin Panda just finished me off with 4 devastating words, which were "No coffee or tea". Recently I switched full throttle to 16/8 Time Restricted Feeding, but apparently every kind of drink, except for pure water, wakes all sorts of clocks in your body, when drinking outside your eating period. I'm referring to this super interesting and informative talk of his (he specifically answers this question during Q&A at 36:30): Even fracking green tea without sugar is supposedly off limits !!! Folks, this is really not good news.
  10. The Observer

    Forever Young - by Humanity Death Watch

    It would be interesting to hear what you guys think of these modern day messiah's.. What usually happens with me is I "discover" one of them and then slowly start losing respect for them over the years. Like for-instance Ben Goetzel you mentioned up there.. I still like the guy, but after watching the following interview, I started questioning everything he ever said. I just cannot take him serious anymore. Statements like "We can achieve AGI in 6-8 years if we really really try" (said that a few years ago). The interview: And then the father of them all, Kurzweil. Same thing. At first I really liked him, but then watching him using the same Gawd damn sentences in every speech (like "Hold on to every calorie because the next hunting season may not work out so well) and his non-intelligent answers to a more complex questions. It seems to me all he's doing is selling Moore's law. He took the ideas of FM2030 and ran with it. And what about him taking 200 supplements a day to reprogram himself, or bringing a version of his father back to life in 10 years time using his father's writings and memories about him. Also his inventions are not that impressive to me. And his prediction record, which is supposed to be some ~85% accurate. I read The age of spiritual machines and I literally threw it away as garbage paper. David Sinclair? I really hate this guy. To me, he is a proper snake oil salesman. How he talks about resveratrol and mouse studies, knowing very well it does not translate to humans, and how he is trying to make it personal to earn himself a sympathy vote and sell more of his products. I remember his TED talk where he is describing how his mother died and he says something like "When I got the phone call that my mother is close to death, I immediately grabbed all the resveratrol (or was it some other chemical?) stock I had and flew to her bed side".. I mean, really? You truly and honestly did that? You believed it will do her any good? What kind of scientist says that? So, yeah, in it for the money, and he has since switched his attention to selling another chemical I believe. Because surely one single magic chemical will do wonders for us humans. Who else? I almost lost a little bit of respect even for our most beloved leader Aubrey when I saw him completely naked in one of his documentaries - I believe it was The immortalists - but then I remembered this is just who he is, a eccentric and sincere person, plus he really knows what he's talking about. So yeah, I like Aubrey. Of course I also like Musk and Craig Venter. Ok, enough rambling from me.
  11. Matt, you and I are the same, down to the teeth. Blood brothers, perhaps. Reading your experiences regarding your peers and what others say about you, it's like reading my own words. I just turned 38 recently. On 22nd of July (Hi Gordo ). My brother is 27 and we look about the same age, but certainly no more than 3-5 years apart. I had a BMI of about 18 for most of my life and I was always the smallest. Having no wrinkles I also did a quick research on skin aging, because I recently ran into one of my classmates from high school and his facial skin must have looked ~20 years older than mine. I guess he is on the opposite extreme of the spectrum. Info sites like this one: http://www.womens-health-advice.com/skin-care-questions/aging-first-signs.html ... which also suggest I should be in late twenties or ~30, since I noticed my skin getting a bit dry on the forehead only in the last 2 years or so. I do avoid sunlight exposure more than my brother, but then again he exercises a lot more. Now visiting this forum the last couple of months I came to the conclusion that CR probably does not work, so I don't know what to think now. After all the research, is anecdotal evidence really all we are left with to cling our hopes on?
  12. The Observer

    Will Low IGF-1 / Growth Hormone Extended Human Lifespan?

    The answer: Yes to GH, no to IGF-1, perhaps? http://onlinelibrary.wiley.com/doi/10.1111/acel.12519/full Reduced growth hormone (GH) signaling has been consistently associated with increased health and lifespan in various mouse models. Here, we assessed GH secretion and its control in relation with human familial longevity. We frequently sampled blood over 24 h in 19 middle-aged offspring of long-living families from the Leiden Longevity Study together with 18 of their partners as controls. Circulating GH concentrations were measured every 10 min and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) every 4 h. Using deconvolution analysis, we found that 24-h total GH secretion was 28% lower (P = 0.04) in offspring [172 (128–216) mU L−1] compared with controls [238 (193–284) mU L−1]. We used approximate entropy (ApEn) to quantify the strength of feedback/feedforward control of GH secretion. ApEn was lower (P = 0.001) in offspring [0.45 (0.39–0.53)] compared with controls [0.66 (0.56–0.77)], indicating tighter control of GH secretion. No significant differences were observed in circulating levels of IGF-1 and IGFBP3 between offspring and controls. In conclusion, GH secretion in human familial longevity is characterized by diminished secretion rate and more tight control. These data imply that the highly conserved GH signaling pathway, which has been linked to longevity in animal models, is also associated with human longevity. So how would one go about lowering GH secretion? Would fasting do the trick or does fasting only lowers IGF-1?
  13. The Observer

    Motivation for Practicing CR?

    Just found this short video presentation https://www.youtube.com/watch?v=h7fs33Jewsg of Michael from 2010 (I apologize if I just violated his privacy by posting this, in which case feel free to remove the link or delete the whole post) and in it he emphasizes how every calorie is toxic and the fewer calories you consume, the longer your lifespan is extended. Oh, how I wish this would be a scientific fact of life. I would go berserk practicing CR. I truly would, especially since it implies (or at least that's how I took it) some substantial gains in terms of additional years of life. But I reckon we cannot really confirm that today. Wonder if Michael still stands by this words today and if so, what is he basing them on. After all, the publication of the NIA monkey study results came out in 2012? and therefore after his presentation I linked. If someone can point me to the right direction, perhaps a link? Anyways. It seems to me you guys, Dean and Michael, are/were somewhat on the opposite sides of the spectrum, when it comes to CR optimism. That is, unless he too evolved his opinion over the years. You two must have had some epic battles over the years. I glanced over some of them, but that's about it. Must go search through the forum archives right away. :P
  14. The Observer

    Motivation for Practicing CR?

    Thank you for your extremely thorough answer, Dean. I almost feel like I stole hours of your life away from you, and we all know how special time is for us futurists waiting for LEV. Then again, I've been browsing the forum and I get the feeling you probably don't mind discussing these things and even repeating yourself for the gazillionth time to a noob such as myself. I can sense your passion emanating through your words, not to mention your knowledge that is truly impressive. But where does this leave me? I've stumbled across CR every now and then during the last decade. Mouse studies, monkey studies, IGF-1, autophagy, sedentary vs active lifestyle, ~18 vs ~23 BMI... At first you find mostly positive arguments about all these things, but then when you look into them, they start falling off one by one. It seem to me each of these coins have two sides and the end total is close to null. Even autophagy. I did put my last money on autophagy because it really sounds like a scientifically bullet proof method for at least a moderate amount of life extension. But now you (almost) took even autophagy away from me, by pointing out the possible negative side effects of autophagy. And then there is my personal experience. Like I said I am quite different. As a child I rejected food and was always the smallest, always lagging behind. I probably hit puberty only at the age of ~18 and today, comparing my skin to other people and researching the web, I would say I must be more like 28-30 biologically, having no wrinkles whatsoever, not the actual 38. Well, perhaps I am 50 inside, who knows. :D I just don't know what to think of it all. Or looking at celebrities like Jared Leto, who I think also attributes his youthful appearance to his eating habits. Anyway, for now I'm staying with my current plan, which is one 24-hour fast, 1-2 CR days and 4-5 normal eating days every week, which should allow me to settle at around 20-21 BMI. Will add one slightly off topic question I've been obsessing about lately: When do you guys think humanity will conquer or bring under control major diseases like cancer, dementia and cardiovascular diseases? I've been following scientific progress in medicine and I personally believe this date to be around 2050, which should then help many of us, who are younger than ~65 today, live to be 100+ and drastically increase our chances of catching the Longevity Escape Velocity train. Do you think this date to be overly optimistic? 10x. May all of you live long and prosper. Edit: P.S.: I completed the survey and selected for being a long time practitioner of mild-CR (21-30 years), even though I practiced it unknowingly and unwittingly.
  15. The Observer

    Motivation for Practicing CR?

    [Admin Note: Observer (the OP) and others - I apologize for moving this post around. After (nearly) completing a long response, I realize just how interesting Observer's questions are, and how they deserve their own thread in the CR Practice Forum. Thanks Observer! I'll be posting a detailed response shortly. - Dean] Great, now you guys somewhat discouraged me in throughout this thread. Just when I was getting a little bit more serious about starting a proper CR regime, after ~10 years of hesitation. But now you convinced me CR probably doesn't do much for us humans, compared to just eating/exercising healthy and staying slim. I am currently on some mild-CR plan with one 24-hour fast every week and my BMI is 21.5. Was planning on lowering it down do 19-20, but now I don't see a reason for doing it anymore. :( Before I believed I would gain at least 5-8 additional years, especially because of my own anecdotal evidence. I am somewhat a unique human specieman in that I was basically on CR for most of my life, unknowingly.. I simply rejected food, never liked sweets and was always semi-anorexic. As a result (I guess) I was developing slower as a child and always looked much younger than my peers. Even now in my late 30's people think I look 25-30 and I do agree my biological age must be closer to 30. Then again, what do I know? Now reading your posts Dean, you seem like a reasonable individual and you convinced me that we probably cannot gain more than ~2 years through CR and possibly even shorten our lifespan.. So the obvious question is, why do you - and others - even continue practicing it? Why not simply live healthy lives? I'm thinking perhaps I should only concentrate on fasting and autophagy that comes with it? What are your thoughts on that Dean, if you don't mind answering?
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