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mccoy

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About mccoy

  • Birthday 01/01/1960

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  1. Peter Attia interview with Navdep Chandler, a specialist in metabolism who underlines the role of ROS (reactive oxygen species) in cellular signalling. bottom line is that too many antioxydants (usually by supplements) can have a detrimental effect by inhibiting ROS signalling. the interview also contains an extensive discussion on metformin and longevity
  2. mccoy

    Back to CE but...

    At last we had a little snow, just around freezing point, absolutely nothing like siberia or Canada but I enjoyed walking outside in a sleevless polo shirt. Mostly I walked under a patio and only shortly under the snow. I find that, once full thermogenesis kicks into, cold is not perceived very much, unless it's windy. In more extreme temperatures it's probably better to don long sleeved shirts, unless your name is Wim Hof.
  3. This is a pretty interesting episode of the stemtalk series, with John Ioannidis, the professor who led the critical analysis on the PREDIMED study which turned out not to be a randomized study (although the results hold the same after a reassessment). https://www.ihmc.us/stemtalk/episode-77/ Ioannidis talks about some more or less surprising aspects of the world of medical literature. Nutritional epidemiology is criticized because of food questionnaires of uncertain value and the presence of many correlated variables (confounders). Signal to noise ratio is pretty low. Discussion on the difficulties of an objective assessment of the 'best' diet. More on the drawbacks of scientifical medical literature, like vested interests, repetition, favouring quantity over quality and so on. I wonder if there is some quick index to assess the quality of a paper without havign to consult specialists in the field.
  4. mccoy

    Coratina EVOO

    Oilalà sent me the lab report but it's relative to last year's crop, apparently the complete analyses are provided on january. TP as Tyrosol is 744 ppms and they expect it to be even higher this year, I don't know how they know that. Most probably the method is the colorimetric one cited by Michael, altough to be sure we should look at the relevant regulations cited in the certificate. Acidity is very low and the price is reasonable, although pretty high relative to local producers (12 euro per liter). I'm going to order 10 or 20 liters.
  5. mccoy

    CR with ZeroCarb

    An interesting excerpt from a Mc Dougall's talk on eskimos. From the cited articles, eskimos suffer(ed) premature death by atherosclerosis and other CV diseases, plus osteoporosis and parasitic infections. An example of evolutionary adaptation but not an example of health and longevity...
  6. Speaking of statins, I don't know if you guys came across it, the last episodes of Peter Attia's podcast with Tom Dayspring as a host deal with statins and they seem to provide very valuable info. The whole series of podcasts on applied lipidology lasts about 7 hours (I've been listening to all of'em) but statins, pros and cons, alternatives, are treated in one of'em specifically. https://peterattiamd.com/tomdayspring4/ The podcast notes are packed full with info and pictures. A really good job.
  7. mccoy

    98.6 F (37.0 C) is old school

    Last two weeks, 2400 kCal. BMI= 23.2. My temp is lingering around 36.7 °C today. Frontal IR temperature and ear temperature are probably not comparable measurements.
  8. mccoy

    Coratina EVOO

    Exactly, the article is not a scientific paper, written in Italian and this is the link, he makes no reference to analytical methods. This year Oilalà is selling its Coratina EVOO with an advertised amount of about 700 ppms TP. I asked for the certificate but they didn't send it to me yet. I'm reluctant to buy without having seen the original lab report.
  9. mccoy

    Systemic mTOR activation

    OK thanks Michael, so ipertrophy of adipocites suggests an anergy excess which is necessary, but not sufficient, to the upregulation of systemic mTOR.
  10. mccoy

    98.6 F (37.0 C) is old school

    I made a few IR measurements on my forehead, in the center and at 5 cm of distance, as in the Ng et al. article above cited. The results though were pretty different from the article. So far my frontal temps ranged from 36.4 to 36.7 °C in normal conditions (lack of fever and other symptoms). the devices were evidently different ones and no direct comparison is possible. I checked my values across my wife's and they were not significantly different so I'm probably not a statistical outlier. An obvious way to proceed if we want to check our temperature changes when not feeling in shape would be to record the baseline temps and baseline variations across the day when in very good shape. It's easy then to check the deviation from the baseline and decide whether our sickness has significantly influenced our immune system (fever or no fever and how significant). Inter-individual variability in this way is eliminated, whereas the intra-individual variability (time of day, environmental temperature, natural oscillations) is easily accounted for.
  11. mccoy

    98.6 F (37.0 C) is old school

    Always from the above article, the statistical distribution of 1000 measurements in adults without any inflammatory conditions. Interestingly enough, the study was carried out after the SARS outbreak in South east Asia. Device was held 5 cm from the center of forehead. Ethnicity was Chinese.
  12. mccoy

    98.6 F (37.0 C) is old school

    The below summary suggests a rather low range of normal temperture for a hand held infrared termometer. I'll have to find out in my case, AFAI rememeber, it's usually higher than the cited range, I emphasyzed the relevant part. The article is not very recent though, today's devices might be more state of the art.
  13. mccoy

    98.6 F (37.0 C) is old school

    Also, the normal temperature population data should be updated to modern measuring devices. I've not been using the classic mercury termometer for years. Many people are using the non-contact infrared thermometer, which is pointed on the forehead or temple.
  14. The data are not too clear. 6000 kCal when in health? That's a quantity not even many bodybuilders ingest. And 300 kcal when at rest? Why such a wild range?
  15. mccoy

    CR vs. common illness

    My recent cold, which I complained about in another thread, was actually pretty mild but for the running nose in the first two days and a lesser thermogenesis. What I realized though, that it was an occasion for the body to inhibit systemic mTOR, stunt my bodyweight growth (proliferation) and impose some restriction (manteinance). When I have such episodes from spring to fall I usually start a fast mimicking diet, whereas in the winter I don't. It turns out that the body evidently wanted to enter a period of mantainance. I had little hunger. After 12 days, the bodyweight still keeps at a level 2.5 kg less than the inception of the cold. It's a negative aspect from the POV of bodybuilding, but probably a very positive one from the POV of longevity.
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