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About mccoy

  • Birthday 01/01/1960

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  1. mccoy

    Keepin' the carbs LOW!

    AFAIK, coeliac disease is a morbidity. Even then, not all cereals contain gluten. Healthy people with a balanced immune system are not in the least affected by a moderate amount of cereals, barring cases of imperfect glucose homeostasis.
  2. mccoy

    Keepin' the carbs LOW!

    The known inflammatory properties... Known by whom? By the paleo folks? One thing is to advise against grain consumption to decrease blood sugar concentration, another thing is to make up stories about unexisting detrimental properties of a class of foods.
  3. Kashmi, I'm curious but I cannot see the video you posted.
  4. mccoy

    Reaching optimal health

    Clinton, although I admit I would love to be able presently to bench press 660 pounds. But that, even if possible, would require most probably an anti-longevity strategy.
  5. mccoy

    Reaching optimal health

    Yes, we agree, by strong I didn't mean overreactive, but to avoid misunderstandings I edited: a balanced, well-responding, optimized immune system.
  6. mccoy

    Reaching optimal health

    In my opinion, optimal health includes optimal physical efficiency but only to an extent. Some people may construe physical efficiency as being able to run a marathon or to lift big weights, but we know that optimal health implies physical efficiency in the most common chores of our ancestors: walking and jogging, climbing, farming, moving light objects, occasionally heavier, rarely very heavy and in such a case moving them in group. But of course a degree of physical efficiency must be included in the definition of optimal health. To me these are some of the main parameters defining optimal health. Good metabolism and homeostatic mechanisms (glucose, fats, thermal, weight and so on) Moderate to high physical fitness Unimpeded cognitive faculties Good level of energy and mental alertness across the day A balanced, well-responding, optimized immune system Healthy organs, bones, skins and skeletal tissue. Optimum health also implies that any injuries, except the most serious ones, are healed in a reasonable time. Aging influences optimal health in the measure it influences the above parameters. .
  7. Sibiriak, that's really for specialists in biostatistics. The following quote includes some interesting questions from professor Harrel
  8. Apparently so, even by the anecdotal recounts of pharmacists who are able to follow the trends based on their clients demands. If there has been a competition, among flu, common cold and other seasonal viruses the SARSCOV2 apparently won it big time.
  9. Dr. Steele's curriculum: has anyone read his book yet? Worth it? After researching the forum engine and the google engine, I did not find any previous thread on it
  10. Dean, it's true that I have no more much patience, one effect of aging perhaps. On the other side, here in Europe it's becoming increasingly difficult to find open sci-hub sites. Also, when I answered I had really no time for a detailed research. Anyway, I can find no logical objections in the plots you posted. They are referred to all-cause mortality, they carry error bars and they do not display outlying values, so the explanation is straightforward, as you say. My reading of the plots is that there is a significant, but not a very substantial increase of all-cause mortality, and that depends on age classes. From BMI 27-32 in younger people, from BMI 27-29 up to 74 years, then there really appears not to be a definitely increased mortality for higher BMIs. Such a conclusion is logically more satisfactory. There is usually a trend of increased all-cause mortality with increasing BMI, but it has often large error bars and the RR becomes substantial at higher BMIs. One possible objection is that the control group, especially in women, is thin, it does not appear to exhibit normal or ideal weight, and this ideal or normal weight attributed to the control group should be logically explained anyhow. My previous objection was with the data on T2D, where that steep uptrending line in women constitutes an absolute anomaly which must be explained in detail, eventually confirmed or denied, and surely offering some comments about it, explaining above all why very thin women have been chosen as a control group.
  11. This graph is originally from Willet et al., 1999, Fontana just cites it. The abstract is very concise, almost useless. The full article is not available. We have no guarantees that the article followed the methods outlined by Fontana himself to avoid reverse causation and other spurious correlations. It is probably a prospective cohort study, prone to various biases and errors. We have no description about the control population. Unfortunately, the graph by itself does not say much, other that, according to data we don't know and of which there is no public access, very thin women of unknown habits and health conditions have been taken as a reference (control population). Taking as control population a subgroup with such uncommon characteristics rises some doubts as to the purpose of the study. It says that very skinny women have much less T2D than normoweight women. But what's the prevalence of T2D in that very skinny subgroup? I imagine very, very, low. So the 2-3fold increase in more normal women would not be significant at all in absolute terms, maybe within the range of statistical error. I greatly respect Fontana as a researcher, but of course he wants to prove something in his article, and whatever information helps him to prove that, is useful to the purpose. Maybe it's useless in daily life? Guidelines for Healthy Weight List of authors. Walter C. Willett, M.D., Dr.P.H., William H. Dietz, M.D., Ph.D., and Graham A. Colditz, M.D., Dr.P.H. Article Figures/Media Excess body fat is a cause of cardiovascular diseases, several important cancers, and numerous other medical conditions1 and is a growing problem in many countries. In the United States, for example, the age-adjusted prevalence of obesity increased by approximately 30 percent from 1980 to 1994.2 In this review we consider the assessment of body fat and the definition of a healthy body weight for an adult. We also discuss how clinicians can use this information in caring for patients. Because overt obesity has undisputed adverse consequences for health, our focus is on lesser degrees of adiposity, the consequences of which . . .
  12. I remain a little skeptical, a RR = 2 of T2D for a BMI of 22 in women... But right now I have no time to read the paper.
  13. This article from Ioannidis seems to be the most accessed in the history of scientific publications (3 million views). Why Most Published Research Findings Are False
  14. This is an apropos podcast, John Ioannidis speaks in detail about the various biases in nutrition science articles, not excluding biases from career interests, personal beliefs, the interest of an audience, selective bias, and so on. I didn't know about his 'cookbook' article, where he shows that among 50 ingredients chosen at random in a classic cookbook, most of them have been found carcinogenic in some articles. Bottom line is that, unfortunately, most articles are not very reliable (and it's not very easy to determine the reliable ones). #143 – John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
  15. Ah, yes, thanks for reminding me, that's really a common point that may suggest that the situation is not totally hopeless, although it's undoubtedly confusing. Another strong point common to many regimes is the abundant use of vegetables. That's a start, although a pretty generic one. 100% agreed, although fine-tuning self-experimentation is not an easy thing to do for everyone. This discussion stemmed from a question on Longo's longevity diet and the lack of fruit and dairy products in such a regime. I'll start again from there. Valter Longo has built a conceptual framework according to which fruit and dairy may be detrimental to longevity. Although he's a formidable researcher, this does not mean that he cannot be wrong. More specifically, he's not wrong, but he generalizes a specific approach, simplifying the strategy to make it less difficult to follow. In the process, he forgets about individual propensities and variability. So Longo's solution is but one of the many solutions possible, and one which is easier to follow for some people, less easy for others. Easier also means more likelihood of lifelong adherence. If I give up fresh fruit, I sure avoid a source of simple carbs, but at the same time I give up beneficial nutrients for longevity. Same goes for dairy products which display the benefits of nutrients richness with low quantities of product ingested at a low financial cost. EVOO is high in calories, but rich in some beneficial phytochemicals. We cannot have everything. We must optimize, choose something, discard other thing, apply moderation and discrimination and if possible make extensive use of self-experimentation. Last, the argument of IGF-1. If an individual has parents and family members with a history of cancer, if IGF-1 and insulin are high, then the suggestion to decrease as much as possible animal products, including dairy products, may be the best, especially if the individual already had cancer. Then Longo's diet or even a totally vegan regime with low simple carbohydrates intake might be the best choice. But this is not a generalization as offered by Longo, rather the result of individual situations.