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About mccoy

  • Birthday 01/01/1960

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  1. This morning my BG is down to more encouraging territory, 93 mg/dL. The morning high values may be due to measurement errors or to unusual hormonal spikes (cortisol mainly, or glucagon, or norepinephrine or HGH or others). My dietary carbs levels are always in the region of 50-100 g/d-. Lactose and carbs from nonstarchy vegetables and nuts, mainly. I'm losing some bodyweight though, that I hate. Hard to gulp down many calories when restricting both carbs and animal fats.
  2. Seriously, AGE has been shown to decrease BP up to 15 mm Hg in good responders (after some time), plus it seems to inhibit the progression of CAC score and so on. Cannot find now the main article I consulted, I'm going to paste something relevant. My BP still is under 120/80, but some further reduction wouldn't hurt I suppose.
  3. mccoy

    How many people are actively on a CR diet?

    But why you don't simply follow the 750 kCals, 5-days fast mimicking diet by Valter longo? Once a month it would constitute a powerful tool for longevity and healthspan. And the 3 weeks off you might follow something similar to his longevity diet, with controlled calories, Adequate refeeding is just as important as the restriction itself, or more. What does it mean on and off? Do you binge during the off periods? Too much of a restriction for too long may be detrimental, not beneficial.
  4. This is a very interesting podcast, Katherine Eban, an investigative journalist, explains the hidden facts about the lab leak hypothesis. I listened with interest to the details of last year's Lancet article, by which I too have been fooled. Not a peer-reviewed article, where the authors lied about the declared lack of any conflict of interest. Bottom line: the lab leak hypothesis is very plausible, but not proven. The zoonotic hypothesis has not been proven yet.
  5. Guys, I'm posting about AGE (Aged Garlic Extract). I was checking my BP, and systolic 120-125 was a value I didn't like much. I ordered AGE but didn't take it. I rechecked my BP, 15 days ago and today. 114-115. Good. My conclusion is that AGE is an extremely powerful supplement, the mere fact of it sitting on a shelf in my house has decreased my BP by 10 mm Hg, LOL.
  6. mccoy


    It's always interesting to read (or read again) MR's posts. Presently, there is the ongoing TAME clinical trial on 1500 mg/day of metformin, led by Barzilai. Maybe it's going to be the first, officially recognized antiaging drug. Or maybe not.
  7. This morning I measured my fasting BG by a strip glucometer, and it read 107 mg/dL.😬😬 Not very encouraging. I was expecting a decrease in the base level after about 3 weeks of low carb regime, although it may be a spurious number, I didn't repeat the measure but I'll do another measurement in a few days.
  8. mccoy

    CAr stop

    This was the full low-carb meal. A huge plate of vegetables and one small buffalo mozzarella. All lavishly sprinkled with EVOO (a little balsamic vinegar on the mozzarella).
  9. mccoy

    CAr stop

    I love this car stop on the highway, the ladies serving at the restaurant seem to be happier the bigger the mound of vegetables on your plate. There is spinach, turnip greens, asparagus, broccoli, mushrooms, peppers, and black olives. I don't know how but I managed to eat it all.
  10. I'm keeping up with the new low-carb regime. Cholesterol optimization involves eating loads of vegetables and nuts + EVOO, oleic acid and phytosterols which are all supposed to be mild inhibitors of cholesterol synthesis, but I still eat some saturated fatty acids which may detrimentally impinge upon lipids balance. I can worry about it later. One effect I think I'm experiencing is mild tiredness and sleepiness during the day. Maybe I should have been more gradual in the change, but momentum is momentum, I'm not missing at all carbs. Bodyweight has decreased but not much.
  11. Dean, yes, it would be also useful to test different kinds of fruit, in combination with nuts or yogurt. Or, for example, after a full meal (sliced banana with cacao powder). Moderation appears to govern as well. Fact is that, after a full breakfast I'm not so able to exercise efficiently, except for walking or household chores and gardening. Might contribute to the purpose but is not always possible due to my present workload. That is my concern as well, this new regimen is probably not sustainable for a long time.
  12. These are cited a lot during Peter Attia's podcasts, they seem to be the breakthrough in blood lipids control.
  13. I've taken my first step towards Glucose-cholesterol optimization. Last year I remember my fasting glucose was at 85-90 mg/dL. Recently it raised to 100-105. A significant 15 mg/dL increase in the baseline which started to worry me, since FG is a usually stable baseline of the blood-glucose homeostatic system, sort of a setpoint whose upward variations may suggest something wrong going on. So I installed a Continuous glucose monitor device (CGM), where I could see the effects of ripe fresh fruit eaten at the morning. I used to do that, eating just fruit at the morning since it's so easily digested. But this kind of meal results in a high glucose peak, which peters out after an hour but probably has a negative effect on me at this point. It was customary to me to eat large amounts of fruit in the morning alone since it is healthy food so easily digested. But this as I've observed mya have overly stimulated the pancreas beta cells. I also observed the effects of a moderate-carbs diet, around 60-100 mg/dL of net carbs. It's not strictly low-carb, defined at 50 mg/dL, sure not keto, defined at about 20 mg/dL (these values may change individually fo course). Obviously, I didn't see spikes after eliminating honey, fruit, all simple sugars. I saw large humps with a prolonged effect when eating non negligible amounts of cereals though. So I discarded all cereals, eating only 50 grams of legumes, whose effect is negligible. After 2 weeks of this moderately low carb diet my baseline decreased from about 105 to about 95 mg/dL. My aim now is to go on as long as I can, at least a few months, after which I might resume a more various diet. I also must make the effort to reach enough calories not to loose weight, about 2700 seemingly. This is an example of my daily regimen now. Breakfast: cacao and nonfat yogurt or greek yogurt, with lowcarb dairy dessert, sometimes a few berries, 50 grams max but not always. Stevia/erithritol sweetener. lunch/dinner: large dishes of salads and other vegetables with 40 grams hi-polyphenols EVOO, many nuts and seeds, a few legumes or nonfat cottage cheese or tofu, peanut butter, sometimes a little parmesan cheese, a lowcarb sweet at the end (quest bar, lowcarb chocolate). Sometimes some lowcarb product such as gluten pasta and so on. This is the cronometer report for last week: 58% fats, 20% carbs, 22% protein Lipids composition: saturated fats are about 19% of total fats, this constitutes the cholesterol optimization. CArbs composition, cronometer slightly overestimates some carbs, I think the real number is about 10-20% less. Proteins are probably too many, I'll have to adjust but it's not easy when the choice is so restricted. My fasting IGF-1 and insulin are very very low, so it shouldn't impact too deleteriously on the overall health. All micronutrients are green bars, I make sure I take B-complex vitamins by ingesting 20-25 grams of nutritional yeast per day.
  14. This is the link of the other thread, where I'm going to post my dietary changes which I think to mantain for the next few months.
  15. Dean, yes, as much as I love fresh fruit I had to conclude that, at least in my case, I should temporarily refrain and continue my lowish-carb experiment (not extreme keto). I'm going to post the details in the other thread, the glucose-cholesterol optimization. After these 2 weeks my glucose baseline went down of about 10 mg/dL (from 106 before to 96 after) measured with a strip glucometer with 7% MARD.