Jump to content


  • Content Count

  • Joined

  • Last visited


About mccoy

  • Birthday 01/01/1960

Profile Information

  • Gender

Recent Profile Visitors

1,045 profile views
  1. Well, that's an example of application of the prudential principle... The decisional aspect remains: LDL-p and trygs in the low percentiles to keep CV hazard low.
  2. Well, objectively, his credentials are such that we are guaranteed he's not a charlatan. I agree that not everything he says may hold for everyone, especially so the alleged very inexorable need for many hours of sleep. But the details he delves into are incredible. Also, pls provide other references on sleep, I know about Kirk Parsley and none else, I'd like to dive more into this fascinating subject.
  3. My take is that if Dr. Peter Attia, a lowcarber himself, reasons that LDL and Trygs must be kept in the lower percentiles for longevity, then SAFAs must be potentially hazardous, unless the individual can show that hir lipid panel remains good (at least LDL-p and tryglicerides, if we are deniers about other parameters). Some guys tolerate fats pretty well, others simply don't.
  4. mccoy

    Romaine Lettuce vs. Cabbage Slaw

    One useful reference is Dr fuhrman's ANDI score, which is probably what you wish, micronutrients density per calorie. I think that does not consider specific content like sulphoraphane or other phytochemicals. But it is a good suggestion, the veggies with higher scores are the best as far as micronutrient/calories ratio is concerned. It is not complete and some entries are not present in all countries. Also, I believe you should pick the most convenient solution for you as a base, then also rotate a little when possible. Some of thsoe entries cannot be eaten in large amounts raw. Also, oxalates are high in many.
  5. Thanks for sharing, Matt, Keith Baar has been active in research on muscle hypertrophy, I'm going to see this tonight on the threadmill!
  6. I think I remember that he said there are genetic variations where one phenotype has early optimum sleeping times (early bird), whereas another sleeps better late (night owl). And the middle ground. And that of course presently society favours the early birds phenotype.
  7. mccoy

    Muscle power vs strength

    Clinton, right, you can lift a huge weight explosively even if the lifting velocity seems low, since you must overcome a huge resistance. Thinking it back, it may be the type of muscle fibers recruited in such explosive lifting that gave some advantage dscribed in the article, but the association with overall mortality should be perhaps explored more thoroughly to eliminate possible (probable) confounding factors. Yes, unfortunately joints and tendons seem to be the weak point after a certain age. To me, it's a continuos struggle, how to train to minimize pains, when to stop determined exercises and for how long when a certain tendon starts to ache, and so on. Lots of patience but worth it. So far I've been successfull this way to avoid long setbacks.
  8. mccoy

    Muscle power vs strength

    I'm not very convinced of that explanation, maximizing power requires a certain weight, not very small, which must be lifted explosively. Such explosive (very fast) application of strenght may not be ideal for joints and tendons health though. I don't know if the original paper discusses the mechanistic, or hypothized mechanistic aspect. Also, an association of death hazard and more explosive versus less explosive lifting appears conceptually strange.
  9. I've been listening to many of the numerous interviews with professor Walker, he's been very busy disseminating his ideas in the interwebs. All the info he provides is extremely interesting and convincing, within the limits of practicality I'm trying to apply his suggestions. The necessity and balance of both deep, stage 4 sleep and REM sleep is clearly explained. Personally, I have a very fragmented sleep, with very frequent brief awakenings in the night. I've been like this all my life. Probably there si soem adaptation mechanism in the brain which escapes research, since so far I suffered no particular problems with that. I did suffer problems when my sleep was very irregular because of commuting, double jobs and so on. I remember that impaired my digestive system for a few years.
  10. This is the specific post by Dr. fuhrman, with papers citations, with age groups and quantities Optimal IGF-1 levels A meta-analysis analyzed ten studies on IGF-1 levels and all-cause mortality. The authors found a “U-shaped” association, meaning that IGF-1 levels on the low end and the high end of the spectrum were associated with increased risk of premature death.14 The lowest risk was at the 55th percentile of serum IGF-1, and increased in both directions for all-cause, cancer, and cardiovascular mortality.14 This data suggests that we should aim for an IGF-1 level near the lower to middle for healthy people in our age range. A few studies, primarily in European populations, have attempted to define average IGF-1 levels for healthy people in different age ranges:15-17 Age: Average Serum IGF-1 (ng/ml) 21-30 158-230 31-40 135-220 41-50 121-193 51-60 98-150 61-70 85-140 71-80 85-95 80+ 85-90 These numbers are somewhat lower than the average IGF-1 levels reported in several other studies in U.S. and European populations. The European Prospective Investigation into Cancer and Nutrition (EPIC) study reported an average serum IGF-1 level of 200-210 ng/ml, suggesting that this is a typical level for adults on a Western diet.18 The amount of animal products consumed by most Americans drives their IGF-1 into this danger zone (above 200), increasing their risk of cancer. Two studies comparing adults on a vegan (or raw vegan) diet (9-10 percent of calories from protein, no animal protein) to those on a Western diet (16-17 percent of calories from protein) found the Western diet average IGF-1 level of 200 ng/ml and vegan average lower than 150 ng/ml. One of these studies also evaluated IGF-1 in non-vegan endurance runners, and their average was about 175.19-20 The average age of subjects in these studies was in the mid-50s. Low IGF-1 levels associated with an increased risk of disease or mortality are generally about 70-80 ng/ml or lower.15,21-26Studies in elderly men (average age 75) have found increased risk of cardiovascular events and deaths from cancer in high IGF-1 groups, approximately 190 ng/ml.22-23 In the Nurses’ Health Study, premenopausal women with IGF-1 levels higher than 207 had a substantially higher risk of breast cancer.2,7 In the Physicians’ Health Study, there was an increase in prostate cancer risk once IGF-1 increased above 185 ng/ml.28 Taking all of this information into account, for most adults, keeping IGF-1 below 175 ng/ml is likely important, and below 150 ng/ml should be even more protective. Serum IGF-1 levels below 80 ng/ml may be detrimental, especially after the age of 75. Restricting animal protein during most of one’s adult life to maintain a relatively low, but not excessively low IGF-1, is an important objective for those desiring superior health and life extension. Protein assimilation can decline in the elderly. The use of greens, seeds and beans in the Nutritarian diet, to assure protein adequacy with aging, prevents the excessive lowering of IGF-1 in the elderly, often seen with other plant-based diets. The attention to micronutrient completeness and plant protein adequacy on a Nutritarian diet makes it the most scientifically supported diet-style to push the envelope of human longevity.
  11. Then, there is the issue of optimal IGF-1 levels for older people, 'in their last decades', which appears to be another different aspect...
  12. Sibiriak, then you agree that Longo seems to have oversimplified the issue. The above suggestions from MR should be evaluated with attention. 152 ± 41 ng/mL is not a low concentration, higher than the 140 average value cited by Longo. Whereas, when MR goes That in statistical terms means a value probably located around the 30th percentile of the general population distribution per age group. Or the mean minus SD. SO, in the plot I posted above and again posted here, that means one value which is found between the yellow line and the pale blue line underneath it. For example, if we take the 50 years age group, according to teh above suggestions, our IGF-1 should be located in the 100-150 ng/mL range. Which is what Fuhrman in the original OP cited, without an age specification though. Then we should cross-check by the IGF-1:IGFBP-3 ratio...
  13. mccoy

    The thread on keto (and low carb) diet

    Todd, yours is an example of healthy keto diet, with a regimen designed after careful study of the literature and you are often monitoring your blood values. From the Longo-Hyman conversation it is evident that many of the objections raised by Longo are due to the fact that the general public is not so well learned and is not followed by qualified professionals. Do you remember Jerry Brainum's video, he starts recounting about the boy in the gym who said he was following a keto diet. When Jerry asked him if he was in ketosis, the boy didn't know what to answer. That's an example applicable probably to a high percentage of teh public.
  14. mccoy

    The thread on keto (and low carb) diet

    Sibiriak, since my wife has a family history of T2 and T1 diabetes, she's measuring her glycemia pretty often after whole meals. Her fasting glucose is all right but after meals she often displayed 2 hours peaks at the border of frank diabetics according to teh ADA guidelines 2018 (> 140 mg/dL). It turns out that, always within a meal context, some vegetables which I wouldn't have associated with high glycaemia, like zucchini, have actually spiked blood glucose. Also, pumpernickel bread, which everyone says it's the best, low GI bread. Whole grains of farro wheat caused similar spikes. Pasta, which should cause lesser peaks than ground cereals, spiked gluocse just the same. The quantity is of course relevant, but I'm speaking usual portions here. Whereas surprisingly melba toast with jam at breakfast did not cause significant spikes, as well as low-calories ice cream (with carbs). One Apples, legumes, most vegetables even in hearty protions, did not spike blood glucose. The above measures have been repeated multiple times so they are not the result of random events. It would seem that Segal and Elinav have it right, the response to carbs ingestion is apparently an highly individual issue and general rules are often reversed. Unfortuntately those accurate, continuos glucometers dispensed to T1 diabetics are not available to the public in general (that I know); that would be a formidable tool to monitor one's glycemic signal throughout the day and design one's regimen accordingly. We also know that a strong confounding factor here may be due to cortisol peaks, which apparently inhibit pancreas insulin production and are sometimes seen even at night, or in particular stressful situations. They might cause anomalous glycemic peaks not seen in more quiet conditions. Takehome lesson seems to be that glucose homeostasis is a pretty complex issue, function of individual repsonse and individual hormonal status , as complex after all as everything else in the body. Hard to define in a single, general rule. After all Shawn Baker, the zero-carbs carnivore, displayed fasting glucose at the verge of pure diabetes...
  15. mccoy

    The thread on keto (and low carb) diet

    Mike, as a whole I agree with you but what about prediabetic guys? Many otherwise very healthy cereals even when cooked as whole grains may spike glycemia in some subjects. That's very individual but it happens, and I almost could not believe that but witnessed the results personally. That's why in diabetics and prediabetics a keto diet might be a useful tool to reset glucose homeostasis. I know about Brenda Davis and her low fat vegan experiments with the Marshalese, but the situation there was disastrous to begin with.