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About mccoy

  • Birthday 01/01/1960

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  1. Some aspects of the NIH study would suggest that the beneficial effecgts of a KD in rats is correlated to the dietary restrictio inherent in those. The control group, as far as I understood, is fed ad-libitum, so there is no isocaloric state: Apparently, the KD group was fed an hypocaloric diet, which is the same as traditional CR, barring the different macronutrients ratios. ttwo more differences, one negative (glucose intolerance) the other positive (lesser weight loss) of KD: But I expect that there was a weight reduction, although not at the same levels of CR. Some outputs of the mTORC cascade are the same in both traditional CR and KD regimens. My take as related to humans is that KD (traditional KD with low protein) takes to bottom the insulin signal, and that's not always a good thing. IGF-1 is decreased as well, testosterone is bound by higher SHBG so free T drops down, muscular development is thwarted, bodyweight drops. That's good in overweight people who also accept a loss of musculoskeletal tissue. Bodybuilders also loose weight and muscle mass while on a strict KD, that's why it's prevalently used to shred before contests. The only way to ensure preservation of muscle tissue during KD is use of androgens (and exercise). I'm aware of people like Dom d'Agostino, who are absolute exceptions, researchers who experiment on themselves and also make anple use of costly exogenous ketones. Bottom line, the research is still at its inception and there is apparently no definite proof that KD may extend longevity in humans. It may also be dangerous, if lipids and inflammation parameters are not checked. Barring particular conditions, I find it a very unconvenient way to hypothetically gain better longevity and healthspan, unless we desire to practice stoicism and eliminate many foods from our table...Also, if we pursue celibacy that's a good method, considering the absolute crash in free testosterone. N:B: I tried a KD diet and experienced unwanted weight loss and total loss of libido. Advantage was a more controlled fasting blood glucose. I appreciated though the mental discipline inherent in avoiding simple sugars.
  2. That study to me appears too far-fetched. Untrained grip strenght is a function among other things of genetic hand size and pattern of muscle and tendons insertions, plus the neurological genetic pattern (innervation and neurological recruitment of fibers), quantity and ratios of various muscle fibers.... How can the above genetic factors iunfluence CVD hazard? I can really find no logical answer to that.
  3. Yes, the push-ups proficiency level seems to have been adopted as a general qualitative proxy for a combination of aerobic plus resistance exercise. Obviously, the conclusions are valid insofar as the proxy reflects accurtely the underliyng mechanistic principles. Which are????? Proxy: Ability to keep the body rigid while doing brisk arm resistance exercise which imply some level of previous training and no upper-limb related injuries or inflammations.... Mechanistic principle: max VO2? tolerance to lactic acid? slow twitch fibers in upper arms? Are they really the fundamental elements of CVD hazard?
  4. mccoy

    Vegan specimens and protein

    Guys, next time around that I'll have my blood drawn I'm going to request an IGF-1 value, so that we know for sure if systemic IGF-1 is overly increased in my case. By the way, we all know that IGF-1 like so many other parameters seems to have an optimum, too low is bad too high likewise. My reasoned feeling is that, if bodybuilding is done giving priority to an healthy balanced diet, no drugs, no supplements, no caloric nor proteic abuse, no overtraining, then it's not going to be detrimental to longevity. Whereas if done competitively, like many other sports in today's world, it may have deleterious effects.
  5. mccoy

    Vegan specimens and protein

    Gordo, I believe that Todd's arguments are valid. By pumping muscles, I'm opposing the natural trend towards myopenia with increasing age. Plus the glucose sink. Plus the hormetic stress. Plus the enhanced digestive function. Plus enhanced cognitive function. How much is too much pumping? In natural bodybuilding, there is a defined threshold by which overwhelming muscularity is avoided. Drug induced superphysiological hypertrophy may actual be of detriment to health and longevity, whereas the natural resistance-induced muscularity provides usually benefits. The higher exercise-induced IGF-1 appears to be local rather than systemic, and we know that local IGF-1 in muscle and nervous tissue is beneficial. Higher T is also notoriously provided by sun exposure. Such natural boosters may be beneficial in opposing the natural decline in physiological androgens. Diet wise, I keep eating an healthy diet and presently am avoiding all the usual supplements like protein isolates, BCCAs and others because in my case they just do not work. There are flip sides, like the increased hunger causing an increased intake of carbs and a consequent higher fasting blood glucose. Since I feel very good with lifting weight and hypertrophic muscles, I'm going to make this specific gamble, trying my best not to get injured (first and foremost rule). After all, I remember you described doing things contrary to longevity, like taking Aya or going canoeing in perilous waters. Dean also described engaging in parachuting, which is an highly hazardous activity.
  6. A simple supplement with those huge benefits, seems too good to be true....
  7. mccoy

    Exercise optimization

    Thanks Todd, already heard it, very good podcast!
  8. alex2, good job on the amoutn of determining the glycerol content and nice website indeed. I'd be a little reluctant now to ingest glycerol if not in minimal amounts, because of its known laxative effects which I felt in one of the latest FMDs I led. I didn't ingest any of it for bodybuilding purposes, since the same and better effect of muscle hydration is probably achieved by use of creatine.
  9. mccoy

    Exercise optimization

    Re: protein requirement, by this time I think it's impossible to determine by the scientific literature how much we really need. The official RDA=0.8 g/kg/d is debated because of the N-balance method used and, even if it were right, it only provides us a wide statistical distribution (Rand et al, 2002), from which a cautious value has been adopted: Also, the above does not probably reflect isocaloric conditions (I'll write about the consequences on CR in another thread). Present reccomendations for bodybuilders who seek hypertrophy is 2.2 g/kg/d, so almost thrice the RDA. But of course hypertrophy implies raw material for MPS. Strength: we know it's different from hypertrophy, whereas the latter requires necessarily an active mTOr with high phosphorylation and availability of amminoacids for MPS, the former does not , or at least requires just the material needed for metabolic balance. Gladiators: which were the amounts of barley soup they ate? this may be more a case of type of protein (mostly plant-based) than of amount of them (potentially unlimited). Moreover, gladiators pursued fighting efficiency, which requires explosive strength, not hypertrophy. But, bottom line, in consideration of the confused state of knowledge from literature (which may reflect the complexity of the issue), I'm going to adopt intuitive eating and trial and error.
  10. mccoy

    Exercise optimization

    Ah yes, FFMI, my bad I didn't spot the difference! I concur with the reasonings in the site you linked, my natty limit would have been most probably 80 kg in my twenties, with a few more years of effort. Now My FFM is 20.5 but I would never hope to realistically rise above 22 and there would be no reason I also concur on this. The following seems to be a reference article which dates back to 1995, I wonder if it hasd been updated since. Send to Clin J Sport Med. 1995 Oct;5(4):223-8. Fat-free mass index in users and nonusers of anabolic-androgenic steroids. Kouri EM1, Pope HG Jr, Katz DL, Oliva P. Author information Abstract We calculated fat-free mass index (FFMI) in a sample of 157 male athletes, comprising 83 users of anabolic-androgenic steroids and 74 nonusers. FFMI is defined by the formula (fat-free body mass in kg) x (height in meters)-2. We then added a slight correction of 6.3 x (1.80 m - height) to normalize these values to the height of a 1.8-m man. The normalized FFMI values of athletes who had not used steroids extended up to a well-defined limit of 25.0. Similarly, a sample of 20 Mr. America winners from the presteroid era (1939-1959), for whom we estimated the normalized FFMI, had a mean FFMI of 25.4. By contrast, the FFMI of many of the steroid users in our sample easily exceeded 25.0, and that of some even exceeded 30. Thus, although these findings must be regarded as preliminary, it appears that FFMI may represent a useful initial measure to screen for possible steroid abuse, especially in athletic, medical, or forensic situations in which individuals may attempt to deny such behavior.
  11. mccoy

    Exercise optimization

    Genny, my age is now 58, my current BMI is 23.3 on the average and my max BMI when I had to interrupt my serious training (at age 28) because of mysterious pains was 25. Of course it was natty training. Probably naturals with favourable genetic predisposition may reach a BMI of 27, which is the value around which Torre Washington seems to hover. I'm sure that BMI 25 can be reached by naturals beause that was my case! My case is pretty specific, in that I had to completely stop training at age 30, only being able to do some running. I was able to restart training at 56, so now I'm suffering the drawbacks of a long layoff and of age-related anabolic resistance.
  12. mccoy

    Back to CE but...

    I must regretfully say here that today I had elevated frontal temperature and heatbeat and a general feeling of weakness. FWIK, it might be due to overtraining and maybe concomitant overeating. no other symptoms are present.
  13. I had stand-up problems when a young boy, I remember, sometimes I fainted and fell down. Maybe very low pressure. What about fats? I presume you eat in the region of 15-20%. Very good blood sugar values though, especially the postpradial ones.
  14. Gordo, according to all the research I went through, true or false that it is, no vitamin D is produced in winter at non-tropical latitudes. There might be other benefits though from solar radiation, actually, I'm pretty sure there are.
  15. If the doubts will be proven to be true, then Sarah Knauss is going to hold the record at 119 years.