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Everything posted by Clinton

  1. Clinton

    Regaining Health with CR Diet

    Good advice McCoy! Thomas, I hope you post back here with your progress.
  2. Clinton

    Could a person weigh less on a ketogenic diet?

    I've believed (s)he's been trolling for a while now, but offered some advice just in case.
  3. Plant Based Diet; beans, greens and lots of nuts with other fruits & veggies is awesome. Intermittent Fasting (16-8). Keep track of nutrients on chronometer app and only supplement what you can’t adjust for with improved diet (obviously you will require vitamin D3 and B12). Exercise in many different ways and sleep well; eat enough to support physical activity. Fernando - 2 things; 1-You are probably too young for caloric restriction. 2-if caloric restriction is not done intelligently and carefully it will be detrimental.
  4. Clinton

    "Green" Powders

    Fred, I put just 1/4 tsp of Greens+ in each of my nut-berry-buckwheat-kefir meals of the day. I purposely try to avoid products that are fortified with vitamins (Greens+ isn’t fortified), rather get the vitamins (A’s from carrots, cooked tomatoes, salsa, V8,etc.) (E’s from walnuts, almonds, avocados). But Greens+ has some green plants/veggies and spirulina including lots of other polyphenols & ingredients that in small doses should be beneficial (milk thistle, ginseng, ginkgo, red beet root, bee pollen, royal jelly, licorice root). It makes a nice addition to that meal to essentially add some green veggies. Clinton
  5. Clinton

    TMAO & Cardiovascular Disease

    Tom, I’m also doing the 16-8 five days per week and 1 meal on two non-consecutive days (500 cals). Combining that with optimal nutrition and resistance training 3 days per week. Clinton
  6. https://joshmitteldorf.scienceblog.com/2019/07/01/money-in-aging-research-part-i/ Karl, Josh Mitteldorf on his blog recently wrote 2 entries on money in aging and many of the main players. You might want to check and see if you find any new companies mentioned, Clinton
  7. When I consider metformin and rapamycin, I come back to 2 truths. 1-We don’t have evidence that I am aware of that EVEN CR extends lifespan in humans. 2-I’m not aware of any supplement or combination of supplements has extended lifespan in mammals greater than CR (ref S.Spindlers studies). When you think about #1 and #2 -logically you've got to come to the conclusion that if you want to slow aging at the moment supplements are hopeless.
  8. Sounds like you’ve covered almost everything- that’s pretty impressive to have children eating what you have already described. A couple of other ‘must consume’ foods on my list are nuts; in particular walnuts and almonds. 1oz (1/4cup) of mixed nuts per day will get the job done. Next item is a form of cooked tomato or food that contains tomato paste for bioavailable lycopene. Salsa and even V8 juice are decent to this end. I also think ground flaxseed is very useful- loaded with ALA form of omega 3’s, fibre, minerals- you can sprinkle this on cereal or sneak it into pancake mix and kids don’t seem to mind.
  9. Clinton

    Cronometer results for the FMD

    Thanks Dean, Great suggestion on taking less than 1 per day - that amount would also get me just above RDA level as well, Clinton
  10. Clinton

    Cronometer results for the FMD

    I am personally supplementing with 100micrograms of selenium ( NOW brand). Without it I am under RDA levels - anyone else supplementing as well? Clinton
  11. Thanks for the Sinclair Interview post, Gordo - was nice to hear about what he's working on.
  12. I’m sure you can maintain a little lower than 10% sustained - but I get your point- maintaining the physique of a skinned rabbit indefinitely isn’t likely optimal.
  13. Referring to 'this' as reversing aging in humans reminds me of how 'Eugene Goostman' https://en.wikipedia.org/wiki/Eugene_Goostman passed the Turing Test https://en.wikipedia.org/wiki/Turing_test wrt artificial intelligence. A bunch of 'ooo ooo, ahhh, ahhh, jumping up and down and finger pointing, followed with sensational headlines in non-academic circles.
  14. Thanks Ron, If/when you get a urine test results for cadmium I’d be interested to know your results. I’m thinking that going with raw organic nibs and more than adequate minerals discussed above that 1-2 TBSP per day is likely safe and beneficial - that’s the amount I’m planning to add to my smoothie(s)
  15. Ron, How much cacao nibs do you consume per day?? thanks, Clinton
  16. Thanks Sibiriak - excellent post & references. So we know that cacao nibs have less cadmium than powder (but amounts vary by brand/source) and that adequate calcium, iron, zinc & magnesium intake also helps to mitigate cadmium risk. I was able to find some information online regarding cadmium in some popular brands but not of one I was interested in on Amazon (Sevenhills Wholefoods, organic, raw); I am not a member of ConsumerLabs. Essential Living Foods Cacao nibs which have been tested and reported 'low' (according to quick searching) in cadmium are approx 4x the price of the Sevenhills brand. Having said that, assuming your calcium/iron/zinc/magnesium intake is adequate, I wonder if the benefits for cacao nib consumption outweighs the risk; especially if you are not willing to have (urine) testing for cadmium done? (just curious of opinions on this)
  17. Just ordered some raw organic cacao nibs to add into my smoothies!
  18. Yes - I was concerned about the cadmium. I was eating Lindt chocolate 85% cacao.
  19. Todd - I’m sure you mentioned this previously, but what are you showing in your photo (exactly) - thanks, Clinton btw one of my (personal) regrets was following Vince Giuliano’s blog for a while, when as an engineer (by day) and a guy that didn’t study biology- led me to assume dark chocolate (cacao) (among many other poor influences) was a good thing.
  20. Clinton

    Aging focused human trials of rapa analogues

    Tom and Saul, Thanks very much for above information!!
  21. Clinton

    NAD supplement?

    Interesting - so CRISPR trials have already started and Church has said in an interview from 2017 that in 5-10yrs they'd be 'perfected' ... based on that and some of the timing comment in your post, Sibiriak, I'd guess it should be useful and available by or before 2030. In the meantime I will try to maintain nutrition, stay hungry, and lift heavy things.
  22. Clinton

    NAD supplement?

    This is from a June 14, 2016 interview from Life Extension Foundation Fahy interviewing George Church: Fahy: There are several very exciting stories in aging intervention these days. In 2013, the Sinclair lab at Harvard came out with the revelation that the aging of mitochondria (which are the producers of usable energy within cells) is driven in significant part by reduced levels of one particular molecule in the cell nucleus: oxidized NAD (NAD+). The team showed that they could correct mitochondrial aging just by giving old mice nicotinamide mononucleotide (NMN), which is a vitamin-like substance that can be converted into NAD+, for one week. This resulted in phenomenal overall rejuvenation, including reversal of signs of muscle atrophy, inflammation, and insulin resistance. Now your lab showed that there is a very exciting gene engineering alternative involving TFAM (Transcription Factor A, Mitochondrial). Why is TFAM important, and what have you done with it? Church: TFAM is a key regulatory protein that is in this pathway of NMN and NAD+. It allows cells to manufacture the NMN precursor on their own, so you don't have to manufacture it outside the cell and then try to get it into the cell from outside. Ideally, you don't want to have to take NMN for the rest of your life, you want to fix the body's ability to make its own NMN and buy yourself rejuvenation for at least a few decades before you have to worry about NMN again. In order to accomplish this on a single cell level, we've used CRISPR to activate a TFAM activator, and we made it semi-permanent. (See sidebar: Gene Editing with CRISPR) Fahy: With this technique, you were able to increase TFAM levels in the cell by 47-fold. This resulted in restored ATP levels, increased NAD+, and an increased NAD+ / NADH ratio. It also increased total mitochondrial mass and reversed several other age-related changes. Church: Yes. We have a number of ways to measure mitochondrial function and age-related losses of those functions. When we activated TFAM, these changes returned to what you would expect of a younger cell state. And we built this anti-aging ability into the cell, so it's self-renewing and eliminates the need to take pills or injections. Church stated the above 3 years ago and if this were (actually) avaliable it would seem to be a more upstream and direct way of addressing NAD+ decline than taking exogenous NMN or N(R)
  23. Clinton

    Aging focused human trials of rapa analogues

    Gents, Depending on what you're already aware of wrt rapamycin, I suggest taking a look at Dr.Alan Green's website; In just a few minutes you can get an understanding of some of the 'basics': https://rapamycintherapy.com/ He provides a very nice summary of rapamycin therapy which he offers as anti-aging treatment (with other drugs such as metformin as part of the 'Koschei Formula' - developed by Blagosklonny). This is NOT a long read and Alan has really summarized this topic well imho - by the way - also imo one of the KEY things to understand and what even many medical professionals completely miss when discussing rapamycin is that, similar to 'the dose makes the poison'; in this case the 'frequency makes the poison'. I.E. the elimination half life of rapamycin is stated on AG's website as 62hrs (+/- 16hrs). Normally to suppress the immune system rapamycin is taken by organ recipients daily (this is repeatedly taken at 0.4x the half life); however AG's anti-aging approach as you will see (and that of Blagosklonny) is to take rapa at much longer intervals for example perhaps once per week - please read about this - I found it quite interesting. The 2 other papers that I strongly recommend are: (again these are not long or overly complicated) "From Rapalogs to Anti-Aging Formula" Mikhail V. Blagosklonny "Koschei the Immortal and Anti-Aging Drugs" MV Blagosklonny I'd love to hear people's 'take' on this; I've been very tempted to actually go on the 'Koschei Formula' and contacted Dr.Alan Green howver in the end decided against it due to a few factors (essentially I'm not willing to 'tinker' with my meat suit with an entire suite of prescription drugs just yet since I'm still 44yrs old ... however I think I'd be willing to roll the dice if I was 25yrs older). Clinton
  24. Clinton

    Who would live longer?

    Fernando, I don’t understand your question. An active person should outlive an inactive person if all other variables are equal.
  25. Clinton

    Allulose - any takers?

    Thanks Tom, In the first paper you posted, one of the upstream compounds they examined was glucosamine - it's extremely safe, cheap and can buy at any walmart/costco. Vince Giuliano has an excellent summary of it's effects here: http://www.anti-agingfirewalls.com/2014/06/09/glucosamine-for-longevity/ He states: "Glucosamine appears to have a comparable or greater effect on mortality reduction and lifespan extension than Meformin, Rapamycin, 2DG, Veganism, and Resveratrol in nematodes and rodents." This paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823/ States (emphasis mine): "d-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extendsCaenorhabditis eleganslife span by impairing glucose metabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of mitohormesis, GlcN promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expression of the nematodalamino acid-transporter 1(aat-1) gene. Ameliorating mitochondrial ROS formation or impairment ofaat-1-expression abolishes GlcN-mediated life span extension in an NRF2/SKN-1-dependent fashion. Unlike other calorie restriction mimetics, such as 2-deoxyglucose, GlcN extends life span of ageing C57BL/6 mice, which show an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expression of several murine amino-acid transporters, as well as increased amino-acid catabolism. Taken together, we provide evidence that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet.” https://academic.oup.com/ajcn/article/91/6/1791/4597416 "Conclusions: For most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased total mortality."