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  1. tea

    The Intermittent Fasting Advantage

    I mistakenly had the wrong study linked. But the title study used an 8 hour feeding window. That's the equivalent of not eating after 2pm assuming someone wakes up at 6am, which is a little more intensive fasting than no eating after dinner. Regardless of sample being overweight, I would have expected some favorable outcome on body mass or insulin resistance. However, the study group actually lost a significant amount of lean body mass, not fat mass.
  2. tea

    The Intermittent Fasting Advantage

    Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and ObesityThe TREAT Randomized Clinical Trial have you guys seen this study?
  3. Is anyone able to access this newly published article?: Effects of bag-in-box packaging on long-term shelf life of extra virgin olive oil I tried the usual sci-hub route, but for some reason I have no luck accessing the full text. Curiously, all of the olive oils they tested showed very little drop in total phenolic content after as long as 24 months storage.
  4. Does anyone know how well bag-in-box packaging preserves the polyphenol content of olive oil? I'm tempted to purchase a 3 or 5 liter bag of some Oilala Coratina, but it would probably last me a few months and I imagine that is considerable time for the polyphenol content to plummet, even in BIB's "vacuum seal" packaging.
  5. People taking famotidine had significantly reduced mortality as evidenced by Chinese data. I've seen several publications speculating that melatonin should be protective, and aspirin is for the obvious anti-platelet effects preventing the covid induced stroke. Doesn't seem random at all to me. I'm sure he's taking a bunch of other drugs like beta blockers, statins, etc, but this list seems specifically to be adjunctive to his covid treatment.
  6. I don't understand how you can see one study claiming masks have no significant effect on transmission, and argue that that refutes the large body of counter evidence showing that masks do indeed reduce virus transmission. Efficacy of face mask in preventing respiratory virus transmission: A systematic review and meta-analysis It doesn't take much critical thinking to understand that droplet transmission and inhalation is reduced by covering your mouth - that's not even a debatable topic, so why would it be a bad thing to require masks? And your claims that asymptomatic people are highly unlikely to spread the virus is also unfounded. Do you really believe that there is no droplet or aerosol spray from laughing and talking? Have you ever felt spit hit your face while having a simple conversation with someone? That's a pretty common occurrence. Do you realize that asymptomatic people are also normal humans, prone to sneezing and occasionally coughing, from allergies or photic reflex?
  7. tea

    Exercise optimization

    Both of those athletes did not take up their sports until they were already elderly. Not exactly a lifetime of intense exercise or practice. Miyazaki didn't even start running until his 90s. Also, what makes you think they do "far more exercise than what's recommended"? I imagine they both practice for their sports, but certainly not a comparable amount to that of young competing athletes.
  8. Yes, the comparison to "Saccharomyces yeast-based fermentate EpiCor®, which is composed of the fungal cell walls as well as secreted metabolites produced during the fermentation. The aqueous extract of the dried fermentate has well-documented immune activating, anti-inflammatory, and antioxidant properties" is interesting, I had not read that before. I have some epicor open right now, but never noticed much benefit for my seasonal rhinitis. My main issue lies with the lack of testable biomarkers in mycelium products. Maybe it has epicor like bioactives in it, or maybe it doesn't, but I'm not going to trust the speculation until there is more conclusive evidence, and I'm not buying a mushroom product for just polysaccharides and beta glucans. When you can buy 1000 grams of lab tested cordyceps with 0.3% adenosine for $40, similarly priced lb of 4:1 organic cordyceps militaris, or organic reishi and lions mane extracts from Terrasoul - why would you deliberately choose to pay $45 for 60 grams of something that's best show of clinical efficacy required dosing 6 to 9 grams with speculation that 12 grams may have been even better?
  9. This person wasn't selling products available to me or anyone in the United States. I don't even know what particular mushroom companies he worked with. I had just read some insightful posts from him online discussing mushroom quality and bioactivity and his companies' research, so I reached out to him with some questions because I was searching for sources for high quality mushrooms. He directed me to some reputable, large-scale-production suppliers in China that I could source from, because I was struggling to navigate the Alibaba mushroom minefield. Also, cs-4 liquid culture mycelium is not the same as other mycelium products, and has been proven to have comparable or higher levels of most of the active compounds found in wild cordyceps. And this is without even being a concentrated extract. that is not quite the same as a mycelium product that has to be concentrated 10, 20-fold just to show a high percentage of polysaccharides and can't be standardized to anything else. CS-4 has like 30 years of research behind it, many clinical trials. It is the exception to mycelium products not the rule. I think we can dismiss to some extent the "mushrooms in China are full of pollution". It's very easy to find certified organic mushrooms grown far from areas of high pollution, and also, cordyceps militaris is grown indoors in labs, and liquid culture mycelium is grown in labs in huge sealed vats, not out in the open. But be afraid of pollution all you want and purchase impotent US grown products. Would you refuse to use Indian grown Ashwagandha or curcumin extracts? Do you you scoff at the idea of drinking high quality Chinese teas? If so, I'm sorry.
  10. I was in touch with a researcher and manufacturer based in China/Japan around 6 years ago before all the "starch mushroom" info was everywhere on reddit and the internet, and this was the reply I received. **Activated cordyceps mushroom mycelium preparation of the CS4 strain. Other ingredients: Vegetarian capsules (pullulan) and organic myceliated brown rice. "This is from their label. Myceliated brown rice is the answer to the problem. In the USA they grow Cordyceps Sinensis on rice, in China Cs4 it is cultured by fermentation, a completely different growing method. In China only the cordyceps is processed and there is no substrate of brown rice as a growing base. Also in China the strain has to be certified and Government checked every year to ensure that the strain is genuine. I would doubt firstly that Mushroom Harvest even has the correct strain and secondly 90% of what you are taking is brown rice flour, not the fruiting body of CS4 which is what you are after. Simply it’s a crap product and most retail products from producers in the USA are the same. We tested many of them and basically they would only be useful as an animal supplementary food at high doses say 2kg per day for pigs. In China they use rice to grow Cordyceps militaris, once mature the fruiting body is separated from the growing base. The fruiting body is then freeze dried and powdered, the rice substrate is sold to pig farmers." This was coming from someone with no bias who worked with medicinal mushrooms for decades. I believe wholeheartedly Stamets is selling mycelium because it's cheap and they can easily grow it, not because it's better in any way.
  11. "Preliminary data with these small samples of 3 breast cancer patients per dose cohort group showing dose-related trends lead to the testable hypothesis that 6 grams of Tv may lead to faster immune recovery after radiotherapy." 6 to 9 gram dosages of mycelium extract showing significant effects aren't exactly the same as the 1gram per serving offered in those capsules. I'm curious what the extraction ratio is. For all I know, it could be something like 10:1 wherein you would have to consume 50, 100 grams of raw mycelium to get those same effects. But also, I absolutely do not support RealMushrooms or a handful of the other companies reselling Nammex products at ridiculous prices. Nammex sells their mushroom powders in bulk for like $50/kg, only to be resold for nearly $1 a gram in some cases.
  12. In general, I don't really trust Paul Stamets or his overpriced products. After some digging and no links being provided on any of their own websites, I found the actual study: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2681-7 Only an in-vitro study, which they leave out of their advertisements. Yes, mycelium has some immunological effects, but it's important to note that the vast majority of studies with mycelium deal with some kind of extract. And this product is certainly an extract, considering it is 55% polysaccharides, but are mycelium polysaccharides a better option that astragalus extract standardized to polysaccharides? A bottle of NOW astragalus extract standardized to 70% polys can be had for like $10. And polysaccharides are not exactly the gold standard metric for bioactive compounds, nor the truly interesting component of mushrooms. And then again, just showing immunological effects is a pretty easy thing to do. Even oatmeal consumption has demonstrated pretty robust immunological effects, proven through more than just in-vitro. Speaking from experience, I've gone through probably a kg each of both mycelium powders and fruiting bodies, and every time, the mycelium products taste almost exactly like the bland substrate they are grown on, and the fruiting bodies tastes like mushrooms.I just don't see much benefit to deliberately choosing a mycelium product over similarly priced fruiting bodies.
  13. To the best of my knowledge, thermal imaging cameras for prevention and detection of infection are useless, simply a technological scarecrow. Even with expensive stationary cameras, the technology isn't accurate enough to accurately gauge and detect fevers. I can't imagine how inaccurate drone cameras will be, used at a distance in sun-exposed outdoor settings.
  14. tea

    Walking and All-Cause Mortality

    i imagine that cushioning in the feet is mostly muscle, it doesn't seem to me like there is much subcutaneous fat to speak of. I am younger ,but at least for me, I had developed foot pain (morton's neuroma) and found myself with sore feet quite often after walking/standing. I made the switch to "minimalist shoes" some time ago and have subsequently been pain free, even after walking as much as 15 miles in a day. I think strengthening the muscles/connective tissues in the foot is helpful, and using highly cushioned/arched shoes prevents some of the natural adaptations that might otherwise toughen up your feet. another thing worth mentioning. i'm not sure what your trainers are, but true "weightlifting shoes" are flat, little cushioning, and no heel. for curiosity's sake you could try switching to barefoot or socks on a soft surface or mat and see if that helps.
  15. Do you know at what level of oxygen saturation they will consider admittance necessary?