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  1. Maybe it is related to the high stearic acid content of cocoa butter. There is a lot of discussion on longecity about stearic acid's influence on mitochondrial fusion. Also of interest: https://mobile.twitter.com/matthewjdalby/status/1310966867566178307?lang=en
  2. I think the ultra smooth appearance of his face is largely from the webcam quality. There are some other recent videos on Youtube where he looks like a normal mid-to-late 40s man. He has good hair, isn't overweight, and looks like he takes care of himself. That goes a long way to looking youthful. A more impressive example of youthful appearance in middle age is Chuando Tan, a 51 year old Korean who claims no plastic surgery and only once used botox around his eyes. https://www.youtube.com/watch?v=CRwV21mPXy0 I don't think skin youthfulness will be an early indicator of whether or not rejuvenation therapy is working. I have a hunch that things like the loss of subcutaneous fat and cross-linking of skin collagen won't be so quick to recover.
  3. Humans did evolve around fires, breathing in some amounts of smoke on a regular basis. There are likely some hormetic benefits from low-level pollution. At what level of exposure you surpass the hormetic bell curve, is to be determined.
  4. It certainly would be curious to know which is more damning: maintaining a close relationship with a figurehead who made uncouth sexual comments, or severing connection with the face of the company and most renowned person in the entire field of research. I guess the SENS board knows what the donors care about...or at least they think they do.
  5. tea

    Exercise optimization

    I recently suffered from a few bouts of tendonitis, and a lot of reading and my own experience has led me to believe that prolonged inactivity is rarely helpful, and the only real way to overcome those injuries is through loading-induced tissue remodeling. This is the tendonitis rehab protocol I found: If your pain is at a 10, you should not be exerting yourself at all. If your pain is an 8, you can push to an RPE 2. And likewise if your pain is only at a 2, you can push yourself to an RPE of 8. Pain during exercise is ok, but should not exceed a 3 or 4. And pain the following day is ok, but if it doesn't return to baseline within 48 hours you know that you were pushing at too high of an intensity. Supposedly this is the strategy used by some NBA team physical therapist. I can't say with certainty that this protocol is scientifically sound, but I like the simplicity of it and at least for most tendonitis type injuries, research supports that loading is the best path to pain reduction.
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    Exercise optimization

    In case anyone needs some empirical evidence that bodybuilding, strength training, and exceptional longevity can go hand in hand - look only to the life of Manohar Aich, India's earliest Mr Universe winner and possibly the shortest champion. He lived to be 104 and was regularly squatting 600-750 lbs. https://www.outlookindia.com/website/story/manohar-aich-the-father-of-indian-bodybuilding/296960
  7. From what I understand, this study is not claiming that the highest flavonol intake increases mortality - just that the reduced risk of mortality plateaus beyond a certain point. I think this is a very understudied point of research. If polyphenols are functioning through hormesis with a bell-curve effect of health benefits, you have to wonder how these effects night interact with the hormetic effects of exercise, antioxidants, and herbal supplements. Someone taking too much could very well be in a worse position than someone living the bare minimum healthy lifestyle and getting 500-1000mg flavanols through chocolate and wine everyday. "Results from our study indicate that for total flavonoid intake, risk of all-cause and CVD mortality was lower for flavonoid consumption until intakes of approximately 500 mg/d, after which higher intakes afforded no added benefit. This threshold was higher, approximately 1000 mg/d for cancer-related mortality. That the thresholds for each of the flavonoid subclasses approximately sum to the threshold for total flavonoid intake is consistent with the idea that all are important and afford added benefit. Interestingly, these threshold levels exist well within daily dietary achievable limits: one cup of tea, one apple, one orange, 100 g of blueberries, and 100 g of broccoli would provide most of the flavonoid subclasses and over 500 mg of total flavonoids. In this population it is likely that tea, chocolate, wine, apples, and pears were the main food sources of flavonoids15."
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    Spicy food and dementia risk?

    Strange that the study didn't differentiate between fresh, dried, and processed chilis, as well as disregarded capsaicin content of the chili consumed, considering that was their proposed MOA for inhibiting bdnf and neuron survival. In China, fermented or roasted chili paste in peanut oil is an incredibly popular condiment. My guess would be this kind of processed condiment made up a significant portion of the 50g consumed, so it isn't all that surprising that higher consumption might not be a good thing. The higher chili intake was also associated with lower income.
  9. How much do you take? A lot of the kyolic studies I've seen use pretty large dosages of 1200 to 2400mg, which would be 4 to 8 capsules. And just out of curiosity, have you ever tried amla for blood pressure?
  10. 3 grams of glycine before bed has improved my sleep quality. If you have trouble falling asleep, I can highly recommend lemon balm extract (I use Cyracos). And if you want vivid dreams, but possibly disrupted sleep, then magnesium-l-threonate before bed.
  11. Does anyone have any personal experience with either of these? Devices for LLLT (low level laser therapy) and hydrogen water production via electrolysis have gotten rather cheap lately, costing ~$20-100. Obviously both of these will arouse the suspicions of skeptics, but I believe both have been studied robustly enough to assuage doubts of their effectiveness for some conditions. I recently got a Tendlite-type device which I have been using for tendonitis, some localized inflammation issues, and tentatively for optimizing testosterone production. I also have a hydrogen water generator (1.7 ppm) coming. I'll update with my experiences. Some relevant discussion: https://www.molecularhydrogeninstitute.com/human-studies https://www.longecity.org/forum/topic/86247-hydrogen-water-as-a-much-cheaper-alternative-to-mk677/ https://redlightman.com/blog/red-light-triples-testicle-health-function/ https://selfhack.com/blog/my-review-of-lllt/
  12. tea

    The Intermittent Fasting Advantage

    I mistakenly had the wrong study linked. But the title study used an 8 hour feeding window. That's the equivalent of not eating after 2pm assuming someone wakes up at 6am, which is a little more intensive fasting than no eating after dinner. Regardless of sample being overweight, I would have expected some favorable outcome on body mass or insulin resistance. However, the study group actually lost a significant amount of lean body mass, not fat mass.
  13. tea

    The Intermittent Fasting Advantage

    Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and ObesityThe TREAT Randomized Clinical Trial have you guys seen this study?
  14. Is anyone able to access this newly published article?: Effects of bag-in-box packaging on long-term shelf life of extra virgin olive oil I tried the usual sci-hub route, but for some reason I have no luck accessing the full text. Curiously, all of the olive oils they tested showed very little drop in total phenolic content after as long as 24 months storage.
  15. Does anyone know how well bag-in-box packaging preserves the polyphenol content of olive oil? I'm tempted to purchase a 3 or 5 liter bag of some Oilala Coratina, but it would probably last me a few months and I imagine that is considerable time for the polyphenol content to plummet, even in BIB's "vacuum seal" packaging.