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Thanks for sharing the report. Unfortunately Tricarico was not ready to ship to USA and refunded my order. I may try to track down an early harvest Picual or Cornicabra from Spain this year (they often seem to report 500-900 mg/kg polyphenols). I did try Bryan Johnson's Blueprint olive oil at a gathering recently; while the color was a very vibrant green I found the taste to be not significantly more robust than my 2022 harvest Oilala Coratina.

I'm pretty sure the low-mg dosage of most reputable lithium orotate supplements is reflecting the amount of elemental lithium. The bottle I have says "each capsule provides 1000mcg elemental lithium". Some products on Amazon clarify and say "130mg lithium orotate / 5mg elemental lithium"

Interesting. Do you know how it could be so much lower? I can't imagine harvest conditions changed enough to cut the phenolic content in half...perhaps they altered their testing method. I've come across a lot of other Italian Coratina oils that claim very high phenolic content. For example, this one https://www.agricolatricarico.it/products/baginboxdongiovanniolioextraverginebiologico-bboxdg claims 866 mg/kg. I just ordered 3L on ebay, though not sure it will actually ship to me.

Rebuttal: https://academic.oup.com/ajcn/article/103/6/1557/4569627?login=true More recent krill research seems to indicate reduction in atherosclerotic risk. See: https://drc.bmj.com/content/3/1/e000107.short https://academic.oup.com/nutritionreviews/article/75/5/361/3078064?login=true https://cms.galenos.com.tr/Uploads/Article_49041/ejcm-9-150-En.pdf https://academic.oup.com/nutritionreviews/article/78/9/699/5740623?login=true https://lipidworld.biomedcentral.com/articles/10.1186/s12944-015-0162-7 https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700098

Any thoughts on sourcing an olive oil rich in DMB? DMB seems to be a promising molecule for reducing TMAO and inflammation. Not sure how much truth there is, but this article claims: “You don’t want most extra-virgin olive oil from Italy, because it doesn’t have much DMB in it,” he says. Instead, opt for oil from Turkey, Spain, Greece, or California. Other DMB-rich foods include balsamic vinegar, watermelon, and red wine."

You're correct, I tested it during exercise a few times and it basically just doesn't register heart rate variability well enough to be useful. It still works well for resting heart rate, and heart rate trends over time. The one I bought is no longer available on Amazon, but it's basically identical to this one: https://www.amazon.com/LCW-Temperature-Thermometer-Tracking-Waterproof/dp/B08HQRGZYJ/ I'm sure there are better ones out there in the same price range, and I can't really recommend cheaper smart watches unless you just want a 24-hour resting HR monitor. The battery life is very impressive though, most new cheap models easily last 10+ days on a charge. It's too bad there aren't a bunch of Chinese Oura ring competitors popping up, like there are with smart watches. Probably will see that within the next year or two.

Those are good points. The cheap Chinese watch I bought actually tests blood pressure every 10 minutes, and HR and body temperature are recorded every minute and logged in an app. I'm not optimistic about the blood pressure accuracy and I haven't tried to validate it yet against a cuff, but I did validate the heart rate monitor multiple times and it reads the same as both my pulse oximeter and Apple Watch Series 3. I will try some more extensive HR and BP validation tomorrow during exercise and see how it performs, but so far I'm satisfied with a $30, 24-hour heart rate monitor.

At the very least, Samsung Galaxy 3 watches have demonstrated high accuracy for BP measurements in a clinical setting, after calibration. Models sold outside the US have the blood pressure feature enabled, but it's blocked on the US sold products. There are currently dozens of smart watches capable of reading SpO2, temperature, and blood pressure on Amazon for >$50, and I assume they all have pretty similar tech inside. I'll get one soon and do some testing. Validation of Blood Pressure Measurement Using a Smartwatch in Patients With Parkinson's Disease

Just glancing at the sample menus, it's not exactly surprising. They were eating stuff like English muffins, strawberry fruit spread, and added sugar Greek yogurt in the higher carb groups, and trading those calories for olive oil and macadamia nuts, AND added 200+ grams of salad in the low carb group.

It's not about avoiding selenium altogether, but avoiding a massive selenium overdose. A single brazil can easily have 200% of the RDA. I was actually starting to doubt the old "dangerous brazil nut" lore myself, until I found this study (using just 3 to 6 nuts, 3x per week): Selenium status in preschool children receiving a Brazil nut–enriched diet Study highlights: "These children were asymptomatic, but at risk for toxicity"..."Children not receiving a supplemented diet had normal levels of selenium." That being said, 6 brazil nuts three times a week is a pretty big dose for a preschooler. Assuming a normal sized adult, that would be maybe 15 to 30 brazil nuts, 3 times a week, for a minimum of 7 months as per the study. And despite the long term high level consumption, none of the preschoolers demonstrated any toxicity symptoms.

The microcystin risk and heavy metal contamination is really a non-issue with spirulina. Spirulina has had GRAS recognition for years. Aphanizomenon flos-aquae is the algae that is much more frequently contaminated with cyanotoxins. However, is spirulina even suitable as a staple food? I don't think I would be comfortable consuming 100+ grams of it a day. Is 10+ grams of phycocyanin even healthy? I wouldn't want to be the lab rat there.

Slower, deeper breaths might have some stress reducing and HR/BP lowering effects. As long as you're not changing your blood oxygenation though, I really doubt it matters. I wouldn't want to wear a mask while I sleep, but don't see any real concern when you're awake and can consciously adjust your respiratory rate if you feel any oxygen starvation.

Maybe it is related to the high stearic acid content of cocoa butter. There is a lot of discussion on longecity about stearic acid's influence on mitochondrial fusion. Also of interest: https://mobile.twitter.com/matthewjdalby/status/1310966867566178307?lang=en

I think the ultra smooth appearance of his face is largely from the webcam quality. There are some other recent videos on Youtube where he looks like a normal mid-to-late 40s man. He has good hair, isn't overweight, and looks like he takes care of himself. That goes a long way to looking youthful. A more impressive example of youthful appearance in middle age is Chuando Tan, a 51 year old Korean who claims no plastic surgery and only once used botox around his eyes. https://www.youtube.com/watch?v=CRwV21mPXy0 I don't think skin youthfulness will be an early indicator of whether or not rejuvenation therapy is working. I have a hunch that things like the loss of subcutaneous fat and cross-linking of skin collagen won't be so quick to recover.

Humans did evolve around fires, breathing in some amounts of smoke on a regular basis. There are likely some hormetic benefits from low-level pollution. At what level of exposure you surpass the hormetic bell curve, is to be determined.

It certainly would be curious to know which is more damning: maintaining a close relationship with a figurehead who made uncouth sexual comments, or severing connection with the face of the company and most renowned person in the entire field of research. I guess the SENS board knows what the donors care about...or at least they think they do.

I recently suffered from a few bouts of tendonitis, and a lot of reading and my own experience has led me to believe that prolonged inactivity is rarely helpful, and the only real way to overcome those injuries is through loading-induced tissue remodeling. This is the tendonitis rehab protocol I found: If your pain is at a 10, you should not be exerting yourself at all. If your pain is an 8, you can push to an RPE 2. And likewise if your pain is only at a 2, you can push yourself to an RPE of 8. Pain during exercise is ok, but should not exceed a 3 or 4. And pain the following day is ok, but if it doesn't return to baseline within 48 hours you know that you were pushing at too high of an intensity. Supposedly this is the strategy used by some NBA team physical therapist. I can't say with certainty that this protocol is scientifically sound, but I like the simplicity of it and at least for most tendonitis type injuries, research supports that loading is the best path to pain reduction.

In case anyone needs some empirical evidence that bodybuilding, strength training, and exceptional longevity can go hand in hand - look only to the life of Manohar Aich, India's earliest Mr Universe winner and possibly the shortest champion. He lived to be 104 and was regularly squatting 600-750 lbs. https://www.outlookindia.com/website/story/manohar-aich-the-father-of-indian-bodybuilding/296960

From what I understand, this study is not claiming that the highest flavonol intake increases mortality - just that the reduced risk of mortality plateaus beyond a certain point. I think this is a very understudied point of research. If polyphenols are functioning through hormesis with a bell-curve effect of health benefits, you have to wonder how these effects night interact with the hormetic effects of exercise, antioxidants, and herbal supplements. Someone taking too much could very well be in a worse position than someone living the bare minimum healthy lifestyle and getting 500-1000mg flavanols through chocolate and wine everyday. "Results from our study indicate that for total flavonoid intake, risk of all-cause and CVD mortality was lower for flavonoid consumption until intakes of approximately 500 mg/d, after which higher intakes afforded no added benefit. This threshold was higher, approximately 1000 mg/d for cancer-related mortality. That the thresholds for each of the flavonoid subclasses approximately sum to the threshold for total flavonoid intake is consistent with the idea that all are important and afford added benefit. Interestingly, these threshold levels exist well within daily dietary achievable limits: one cup of tea, one apple, one orange, 100 g of blueberries, and 100 g of broccoli would provide most of the flavonoid subclasses and over 500 mg of total flavonoids. In this population it is likely that tea, chocolate, wine, apples, and pears were the main food sources of flavonoids15."

Strange that the study didn't differentiate between fresh, dried, and processed chilis, as well as disregarded capsaicin content of the chili consumed, considering that was their proposed MOA for inhibiting bdnf and neuron survival. In China, fermented or roasted chili paste in peanut oil is an incredibly popular condiment. My guess would be this kind of processed condiment made up a significant portion of the 50g consumed, so it isn't all that surprising that higher consumption might not be a good thing. The higher chili intake was also associated with lower income.

How much do you take? A lot of the kyolic studies I've seen use pretty large dosages of 1200 to 2400mg, which would be 4 to 8 capsules. And just out of curiosity, have you ever tried amla for blood pressure?

3 grams of glycine before bed has improved my sleep quality. If you have trouble falling asleep, I can highly recommend lemon balm extract (I use Cyracos). And if you want vivid dreams, but possibly disrupted sleep, then magnesium-l-threonate before bed.

Does anyone have any personal experience with either of these? Devices for LLLT (low level laser therapy) and hydrogen water production via electrolysis have gotten rather cheap lately, costing ~$20-100. Obviously both of these will arouse the suspicions of skeptics, but I believe both have been studied robustly enough to assuage doubts of their effectiveness for some conditions. I recently got a Tendlite-type device which I have been using for tendonitis, some localized inflammation issues, and tentatively for optimizing testosterone production. I also have a hydrogen water generator (1.7 ppm) coming. I'll update with my experiences. Some relevant discussion: https://www.molecularhydrogeninstitute.com/human-studies https://www.longecity.org/forum/topic/86247-hydrogen-water-as-a-much-cheaper-alternative-to-mk677/ https://redlightman.com/blog/red-light-triples-testicle-health-function/ https://selfhack.com/blog/my-review-of-lllt/

I mistakenly had the wrong study linked. But the title study used an 8 hour feeding window. That's the equivalent of not eating after 2pm assuming someone wakes up at 6am, which is a little more intensive fasting than no eating after dinner. Regardless of sample being overweight, I would have expected some favorable outcome on body mass or insulin resistance. However, the study group actually lost a significant amount of lean body mass, not fat mass.

Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and ObesityThe TREAT Randomized Clinical Trial have you guys seen this study?