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Everything posted by tea

  1. Maybe it is related to the high stearic acid content of cocoa butter. There is a lot of discussion on longecity about stearic acid's influence on mitochondrial fusion. Also of interest: https://mobile.twitter.com/matthewjdalby/status/1310966867566178307?lang=en
  2. I think the ultra smooth appearance of his face is largely from the webcam quality. There are some other recent videos on Youtube where he looks like a normal mid-to-late 40s man. He has good hair, isn't overweight, and looks like he takes care of himself. That goes a long way to looking youthful. A more impressive example of youthful appearance in middle age is Chuando Tan, a 51 year old Korean who claims no plastic surgery and only once used botox around his eyes. https://www.youtube.com/watch?v=CRwV21mPXy0 I don't think skin youthfulness will be an early indicator of whether or not rejuvenation therapy is working. I have a hunch that things like the loss of subcutaneous fat and cross-linking of skin collagen won't be so quick to recover.
  3. Humans did evolve around fires, breathing in some amounts of smoke on a regular basis. There are likely some hormetic benefits from low-level pollution. At what level of exposure you surpass the hormetic bell curve, is to be determined.
  4. It certainly would be curious to know which is more damning: maintaining a close relationship with a figurehead who made uncouth sexual comments, or severing connection with the face of the company and most renowned person in the entire field of research. I guess the SENS board knows what the donors care about...or at least they think they do.
  5. tea

    Exercise optimization

    I recently suffered from a few bouts of tendonitis, and a lot of reading and my own experience has led me to believe that prolonged inactivity is rarely helpful, and the only real way to overcome those injuries is through loading-induced tissue remodeling. This is the tendonitis rehab protocol I found: If your pain is at a 10, you should not be exerting yourself at all. If your pain is an 8, you can push to an RPE 2. And likewise if your pain is only at a 2, you can push yourself to an RPE of 8. Pain during exercise is ok, but should not exceed a 3 or 4. And pain the following day is ok, but if it doesn't return to baseline within 48 hours you know that you were pushing at too high of an intensity. Supposedly this is the strategy used by some NBA team physical therapist. I can't say with certainty that this protocol is scientifically sound, but I like the simplicity of it and at least for most tendonitis type injuries, research supports that loading is the best path to pain reduction.
  6. tea

    Exercise optimization

    In case anyone needs some empirical evidence that bodybuilding, strength training, and exceptional longevity can go hand in hand - look only to the life of Manohar Aich, India's earliest Mr Universe winner and possibly the shortest champion. He lived to be 104 and was regularly squatting 600-750 lbs. https://www.outlookindia.com/website/story/manohar-aich-the-father-of-indian-bodybuilding/296960
  7. From what I understand, this study is not claiming that the highest flavonol intake increases mortality - just that the reduced risk of mortality plateaus beyond a certain point. I think this is a very understudied point of research. If polyphenols are functioning through hormesis with a bell-curve effect of health benefits, you have to wonder how these effects night interact with the hormetic effects of exercise, antioxidants, and herbal supplements. Someone taking too much could very well be in a worse position than someone living the bare minimum healthy lifestyle and getting 500-1000mg flavanols through chocolate and wine everyday. "Results from our study indicate that for total flavonoid intake, risk of all-cause and CVD mortality was lower for flavonoid consumption until intakes of approximately 500 mg/d, after which higher intakes afforded no added benefit. This threshold was higher, approximately 1000 mg/d for cancer-related mortality. That the thresholds for each of the flavonoid subclasses approximately sum to the threshold for total flavonoid intake is consistent with the idea that all are important and afford added benefit. Interestingly, these threshold levels exist well within daily dietary achievable limits: one cup of tea, one apple, one orange, 100 g of blueberries, and 100 g of broccoli would provide most of the flavonoid subclasses and over 500 mg of total flavonoids. In this population it is likely that tea, chocolate, wine, apples, and pears were the main food sources of flavonoids15."
  8. tea

    Spicy food and dementia risk?

    Strange that the study didn't differentiate between fresh, dried, and processed chilis, as well as disregarded capsaicin content of the chili consumed, considering that was their proposed MOA for inhibiting bdnf and neuron survival. In China, fermented or roasted chili paste in peanut oil is an incredibly popular condiment. My guess would be this kind of processed condiment made up a significant portion of the 50g consumed, so it isn't all that surprising that higher consumption might not be a good thing. The higher chili intake was also associated with lower income.
  9. How much do you take? A lot of the kyolic studies I've seen use pretty large dosages of 1200 to 2400mg, which would be 4 to 8 capsules. And just out of curiosity, have you ever tried amla for blood pressure?
  10. 3 grams of glycine before bed has improved my sleep quality. If you have trouble falling asleep, I can highly recommend lemon balm extract (I use Cyracos). And if you want vivid dreams, but possibly disrupted sleep, then magnesium-l-threonate before bed.
  11. Does anyone have any personal experience with either of these? Devices for LLLT (low level laser therapy) and hydrogen water production via electrolysis have gotten rather cheap lately, costing ~$20-100. Obviously both of these will arouse the suspicions of skeptics, but I believe both have been studied robustly enough to assuage doubts of their effectiveness for some conditions. I recently got a Tendlite-type device which I have been using for tendonitis, some localized inflammation issues, and tentatively for optimizing testosterone production. I also have a hydrogen water generator (1.7 ppm) coming. I'll update with my experiences. Some relevant discussion: https://www.molecularhydrogeninstitute.com/human-studies https://www.longecity.org/forum/topic/86247-hydrogen-water-as-a-much-cheaper-alternative-to-mk677/ https://redlightman.com/blog/red-light-triples-testicle-health-function/ https://selfhack.com/blog/my-review-of-lllt/
  12. tea

    The Intermittent Fasting Advantage

    I mistakenly had the wrong study linked. But the title study used an 8 hour feeding window. That's the equivalent of not eating after 2pm assuming someone wakes up at 6am, which is a little more intensive fasting than no eating after dinner. Regardless of sample being overweight, I would have expected some favorable outcome on body mass or insulin resistance. However, the study group actually lost a significant amount of lean body mass, not fat mass.
  13. tea

    The Intermittent Fasting Advantage

    Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and ObesityThe TREAT Randomized Clinical Trial have you guys seen this study?
  14. Is anyone able to access this newly published article?: Effects of bag-in-box packaging on long-term shelf life of extra virgin olive oil I tried the usual sci-hub route, but for some reason I have no luck accessing the full text. Curiously, all of the olive oils they tested showed very little drop in total phenolic content after as long as 24 months storage.
  15. Does anyone know how well bag-in-box packaging preserves the polyphenol content of olive oil? I'm tempted to purchase a 3 or 5 liter bag of some Oilala Coratina, but it would probably last me a few months and I imagine that is considerable time for the polyphenol content to plummet, even in BIB's "vacuum seal" packaging.
  16. People taking famotidine had significantly reduced mortality as evidenced by Chinese data. I've seen several publications speculating that melatonin should be protective, and aspirin is for the obvious anti-platelet effects preventing the covid induced stroke. Doesn't seem random at all to me. I'm sure he's taking a bunch of other drugs like beta blockers, statins, etc, but this list seems specifically to be adjunctive to his covid treatment.
  17. I don't understand how you can see one study claiming masks have no significant effect on transmission, and argue that that refutes the large body of counter evidence showing that masks do indeed reduce virus transmission. Efficacy of face mask in preventing respiratory virus transmission: A systematic review and meta-analysis It doesn't take much critical thinking to understand that droplet transmission and inhalation is reduced by covering your mouth - that's not even a debatable topic, so why would it be a bad thing to require masks? And your claims that asymptomatic people are highly unlikely to spread the virus is also unfounded. Do you really believe that there is no droplet or aerosol spray from laughing and talking? Have you ever felt spit hit your face while having a simple conversation with someone? That's a pretty common occurrence. Do you realize that asymptomatic people are also normal humans, prone to sneezing and occasionally coughing, from allergies or photic reflex?
  18. tea

    Exercise optimization

    Both of those athletes did not take up their sports until they were already elderly. Not exactly a lifetime of intense exercise or practice. Miyazaki didn't even start running until his 90s. Also, what makes you think they do "far more exercise than what's recommended"? I imagine they both practice for their sports, but certainly not a comparable amount to that of young competing athletes.
  19. Yes, the comparison to "Saccharomyces yeast-based fermentate EpiCor®, which is composed of the fungal cell walls as well as secreted metabolites produced during the fermentation. The aqueous extract of the dried fermentate has well-documented immune activating, anti-inflammatory, and antioxidant properties" is interesting, I had not read that before. I have some epicor open right now, but never noticed much benefit for my seasonal rhinitis. My main issue lies with the lack of testable biomarkers in mycelium products. Maybe it has epicor like bioactives in it, or maybe it doesn't, but I'm not going to trust the speculation until there is more conclusive evidence, and I'm not buying a mushroom product for just polysaccharides and beta glucans. When you can buy 1000 grams of lab tested cordyceps with 0.3% adenosine for $40, similarly priced lb of 4:1 organic cordyceps militaris, or organic reishi and lions mane extracts from Terrasoul - why would you deliberately choose to pay $45 for 60 grams of something that's best show of clinical efficacy required dosing 6 to 9 grams with speculation that 12 grams may have been even better?
  20. This person wasn't selling products available to me or anyone in the United States. I don't even know what particular mushroom companies he worked with. I had just read some insightful posts from him online discussing mushroom quality and bioactivity and his companies' research, so I reached out to him with some questions because I was searching for sources for high quality mushrooms. He directed me to some reputable, large-scale-production suppliers in China that I could source from, because I was struggling to navigate the Alibaba mushroom minefield. Also, cs-4 liquid culture mycelium is not the same as other mycelium products, and has been proven to have comparable or higher levels of most of the active compounds found in wild cordyceps. And this is without even being a concentrated extract. that is not quite the same as a mycelium product that has to be concentrated 10, 20-fold just to show a high percentage of polysaccharides and can't be standardized to anything else. CS-4 has like 30 years of research behind it, many clinical trials. It is the exception to mycelium products not the rule. I think we can dismiss to some extent the "mushrooms in China are full of pollution". It's very easy to find certified organic mushrooms grown far from areas of high pollution, and also, cordyceps militaris is grown indoors in labs, and liquid culture mycelium is grown in labs in huge sealed vats, not out in the open. But be afraid of pollution all you want and purchase impotent US grown products. Would you refuse to use Indian grown Ashwagandha or curcumin extracts? Do you you scoff at the idea of drinking high quality Chinese teas? If so, I'm sorry.
  21. I was in touch with a researcher and manufacturer based in China/Japan around 6 years ago before all the "starch mushroom" info was everywhere on reddit and the internet, and this was the reply I received. **Activated cordyceps mushroom mycelium preparation of the CS4 strain. Other ingredients: Vegetarian capsules (pullulan) and organic myceliated brown rice. "This is from their label. Myceliated brown rice is the answer to the problem. In the USA they grow Cordyceps Sinensis on rice, in China Cs4 it is cultured by fermentation, a completely different growing method. In China only the cordyceps is processed and there is no substrate of brown rice as a growing base. Also in China the strain has to be certified and Government checked every year to ensure that the strain is genuine. I would doubt firstly that Mushroom Harvest even has the correct strain and secondly 90% of what you are taking is brown rice flour, not the fruiting body of CS4 which is what you are after. Simply it’s a crap product and most retail products from producers in the USA are the same. We tested many of them and basically they would only be useful as an animal supplementary food at high doses say 2kg per day for pigs. In China they use rice to grow Cordyceps militaris, once mature the fruiting body is separated from the growing base. The fruiting body is then freeze dried and powdered, the rice substrate is sold to pig farmers." This was coming from someone with no bias who worked with medicinal mushrooms for decades. I believe wholeheartedly Stamets is selling mycelium because it's cheap and they can easily grow it, not because it's better in any way.
  22. "Preliminary data with these small samples of 3 breast cancer patients per dose cohort group showing dose-related trends lead to the testable hypothesis that 6 grams of Tv may lead to faster immune recovery after radiotherapy." 6 to 9 gram dosages of mycelium extract showing significant effects aren't exactly the same as the 1gram per serving offered in those capsules. I'm curious what the extraction ratio is. For all I know, it could be something like 10:1 wherein you would have to consume 50, 100 grams of raw mycelium to get those same effects. But also, I absolutely do not support RealMushrooms or a handful of the other companies reselling Nammex products at ridiculous prices. Nammex sells their mushroom powders in bulk for like $50/kg, only to be resold for nearly $1 a gram in some cases.
  23. In general, I don't really trust Paul Stamets or his overpriced products. After some digging and no links being provided on any of their own websites, I found the actual study: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2681-7 Only an in-vitro study, which they leave out of their advertisements. Yes, mycelium has some immunological effects, but it's important to note that the vast majority of studies with mycelium deal with some kind of extract. And this product is certainly an extract, considering it is 55% polysaccharides, but are mycelium polysaccharides a better option that astragalus extract standardized to polysaccharides? A bottle of NOW astragalus extract standardized to 70% polys can be had for like $10. And polysaccharides are not exactly the gold standard metric for bioactive compounds, nor the truly interesting component of mushrooms. And then again, just showing immunological effects is a pretty easy thing to do. Even oatmeal consumption has demonstrated pretty robust immunological effects, proven through more than just in-vitro. Speaking from experience, I've gone through probably a kg each of both mycelium powders and fruiting bodies, and every time, the mycelium products taste almost exactly like the bland substrate they are grown on, and the fruiting bodies tastes like mushrooms.I just don't see much benefit to deliberately choosing a mycelium product over similarly priced fruiting bodies.
  24. To the best of my knowledge, thermal imaging cameras for prevention and detection of infection are useless, simply a technological scarecrow. Even with expensive stationary cameras, the technology isn't accurate enough to accurately gauge and detect fevers. I can't imagine how inaccurate drone cameras will be, used at a distance in sun-exposed outdoor settings.
  25. tea

    Walking and All-Cause Mortality

    i imagine that cushioning in the feet is mostly muscle, it doesn't seem to me like there is much subcutaneous fat to speak of. I am younger ,but at least for me, I had developed foot pain (morton's neuroma) and found myself with sore feet quite often after walking/standing. I made the switch to "minimalist shoes" some time ago and have subsequently been pain free, even after walking as much as 15 miles in a day. I think strengthening the muscles/connective tissues in the foot is helpful, and using highly cushioned/arched shoes prevents some of the natural adaptations that might otherwise toughen up your feet. another thing worth mentioning. i'm not sure what your trainers are, but true "weightlifting shoes" are flat, little cushioning, and no heel. for curiosity's sake you could try switching to barefoot or socks on a soft surface or mat and see if that helps.