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kinase

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  1. Hi, I was playing with CRON-o-Meter and was wondering if these all the micronutrients to be on optimal nutrition? (excluding aminoacids)
  2. kinase

    OMG! Obesity paradox stupidity

    The "Obesity paradox" its right there on the top of the list like others of the form of "sitting is bad for you". Yeah its probably because of lack of exercise, not the position your body is in while you are on your desk.
  3. Interesting blood glucose reading from lunch. The meal was 4 slices of bread and 1 cookie and some 150ml of chocolate milk. I ate the 3 slices of bread with cheese and 1 with butter. I guess it was >80% of calories coming from carbohydrates. I was in empty stomach, it was the 2nd meal of the day and the first meal was a tiny ammount. Im on a moderate CR. I think this response qualifies as a glucose tolerant. I can say I was very hungry when i start eating and only stopped when i felt full. I describe this reading as normal under CR, it took almost 4 hours for the glucose level to normalize and from many readings i've done in the past it shows the insulin resistance effects of a moderate to severe chronic calorie restriction.
  4. kinase

    CR went out of control NEED HELP

    Just want to update everyone, I'm safe and gaining weight and everything is going great. I didnt have time to review all the literature on it, but in order to not destabilize the hormonal porfile caused by starvation, i decided the best way of refeeding would be while supporting the growth hormone secretion, which is suppresed upon refeeding. So I decided to run small distances and hike, in theory it stimulates growth hormone secretion. My appetite increases the days i do exercise and i let myself eat, so far im not gaining any middle section fat, and it's actually a good feeling. Thanks for all the suggestions, they did help.
  5. kinase

    CR went out of control NEED HELP

    Thanks for the advice everyone. I did blood work pre and post CR, and i dont have any nutrition/mineral deficit, or feel weak or anything, i feel good. Keep in mind that my BMI was never mantained above 18 during all my life, even before i even knew what a BMI is, losing or gaining 6 or 5 kg is the difference between being 18 and 15. If i ever go above 18 I would not be on CR, simple as that, i would need to force myself to eat and eat high caloric foods to mantain it, it's complety absurd.
  6. I dont count calories but i try to be constant hungry all the time, but this time i went on overdrive and ended up with just a BMI a little above 15. It's worth knowing that my normal BMI was never maintained above 18 so it's not that bad, but i do look anorexic when i look in the mirror and in my hands and face so I know i really abused this time. So now I want to gain a little bit of weight, I know just eating will make me regain the weight, but I want to be very careful, i dont want to put waist fat and such things, and i want to correctly get out of CR the more safe way possible. I don't want to yo-yo with my body and doing fast changes. Does anyone have good tips to get out CR correctly and gain weight correctly. I have been reading research on anorexic people and it seems they gain fat around the waist and so on in the initial weeks/months and then it turns back normal, i suspect this is because they force feeding these anorexic people to eat and gain weight too fast, the endocrine balance is throw off a little bit.
  7. kinase

    pre-CR biomarkers - NEED HELP

    Thanks a lot!
  8. Hello. I've looked at Tests and biomarkers page and i've made my own list, but I know I'm going to forget something, it's like going to the grocery store, you always forget something. What more data would have you gathered before entering CR knowing what you know today? quick question: - what is the difference between rT3 and T3? Why do we need to test rT3? I'm going to get blood work done in 1 weeks or so.
  9. kinase

    Is 30 years of age too old to start CR

    Thanks for those lifespan curves Gordo, I've seen the pictures of UW study (it's the only pictures i can found from the monkey CR studies), and the lifespan curves don't do justice by how different they look. The CR monkey look really young compared to CON, even if they die not much later. I can only wonder how much phenotypicaly superior juvenille CR onset must be, at least in monkeys. I would never advise someone to do CR starting at age of 15, at least above age 20, minimum.
  10. kinase

    Is 30 years of age too old to start CR

    In that study it is more like comparing a bad diet to a bad-diet but on CR. But one good thing is that in that study all monkeys were started in adulthood, so around my age. The NIA study is more interesting, but I dont seem to find any pictures of the monkeys in that study. Only markers and more markers. I want to see how they look like.
  11. I was thrown into ageing research, biology, CR and such interventions when at age of 27 I found a small tiny "wrinkle" in my face. So before age of 27 I never noticed any age related physical change and i am very picky about everything. So everything that was happening was visually unnoticeable until then. I started to starve myself almost immediatly even before reading the research because I intuintivily suspected that eating less would slow down metabolism and thus slow down the ageing process. Althought I was right, it was for different reasons after finding out about the research. Very sadly I had to abort several times during age 28 and 29 to try different approches, read more about the research, change eating habits and founding more about risks/benefits. I am now a 30 year old male (and that stupid wrinkle is just barely more noticeble) and I feel like I have all the theory, research, risks/benefits and methodology figured out. The main reason I want to do CR is because I havent "reproduced" yet and I feel like I lost an immense ammount of time in school or working on other things that would provide me with financial stability. I can't afford to be on my physical peak all the time while I spend most of my time inside house, with low chances to find some girl and date her. So i am not worried about longevity and living longer per say, just delaying my peak window, given that i will start refeeding if I find a girl I like. But at the same time I feel like I lost the chance to do it, because the better CR results studies on monkeys were with juvenille CR onset. late 20's is not juvenille, is already adulthood. So is 30 years of age already too late? Just to be clear, I am interested in retaining my young phenotype for longer.
  12. I could see this study as an indication that 25% CR is not being enough to suppress the immune system. It would make sense that a suppressed immune system leads to a slow down in immuno-senescence and higher telomere count. We know that anorexic people get randomly sick from time to time and more frenquently than a non-AN. So they do have a compromised immune system. Is there any study showing a greater % of CR and higher telomere count in immune cells?
  13. This all started when I found an article about a method that increased the viability of sperm stem cells by culture them in a low oxygen, high glucose medium. This promoted the stem cells to use glycolysis as their energy source instead of mitochondrial oxidative phosphorylation (OXPHOS) for their energy needs. The article went on to explain that glycolysis produces a lot less ROS than OXYPHO and it prevents a lot of DNA damage. So i went on to look if this was just a specific case but it appears that Haematopoietic SCs, Embryonic SCs, pluripotent SCs, and most adult stem-cells, use glycolysis as their main way to create energy. I couldn't figure out if its because of a predominant hypoxic environment or if this is a trait of stem-cells. When stem-cells go on to differentiate, they go through a metabolic reprogramming and start using the mitonchondrion (OXPHOS). [2] CR is known to cause a shift away from Glycolysis to OXPHOS, so its not clear how this would be beneficial. Could be part of a hormesis response. Its likely that stem-cells do not go through this metabolic shift, only differentiated cells. I tried look for rapamycin and mTOR inihibition and how it effects stem-cells, and it appears some mTOR activation is beneficial in ESCs: But lower mTOR activation is better on the long-run as it prevents stem-cell exhaustion. I was thinking of doing a 1-month intake of rapamycin while on CR to further suppress mTOR activity. I don't know now if this is a good idea. We know that whatever happens here and the shift in metabolism to OXPHOS in cells during starvation will lead to a healthier life, but i can't reconcile this stuff as it appears glycolysis is a lot better to avoid DNA damage as you can see from the sperm cells that reached 40% viability from 5% when using OXPHOS. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575699/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095859/
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