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rudolph marcus

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  1. Hi Saul, Doctors Zeke Emanuel and Dave Campbell discuss the confusion over the WHO's remarks. Aired on 06/09/2020.
  2. rudolph marcus

    Exercise optimization

    What about the BSE proteins that are in abundance in almost all tissues in goat and sheep, and also in their milk, once they are infected with BSE / and prone to cause Creudzfeldt Jacob disease. I don't take the risk and stick to cow milk, due to my allergic reactions . Maybe in Europe a bigger issue but still... Ruud
  3. rudolph marcus

    Rejuvenation drug J147

    Did came across this paper, after reading and searching info about the disappointing message from Pfizer, halting Alzheimer's research. Since I take curcumin lately, trying to relief some discomforting joint pains, I was a bit more interested. https://www.salk.edu/news-release/alzheimers-drug-turns-back-clock-powerhouse-cell/ Have a nice day, Ruud Marcus LA JOLLA—The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful. “This really glues together everything we know about J147 in terms of the link between aging and Alzheimer’s,” says Dave Schubert, head of Salk’s Cellular Neurobiology Laboratory and the senior author on the new paper. “Finding the target of J147 was also absolutely critical in terms of moving forward with clinical trials.” Schubert’s group developed J147 in 2011, after screening for compounds from plants with an ability to reverse the cellular and molecular signs of aging in the brain. J147 is a modified version of a molecule (curcumin) found in the curry spice turmeric. In the years since, the researchers have shown that the compound reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer’s progression in mice. However, they didn’t know how J147 worked at the molecular level.
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