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Ron Put

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  1. Fair points. But still: Cardiovascular responses to cold exposure "Cold temperatures have adverse effects on the human cardiovascular system. Animals develop hypertension and cardiac hypertrophy during exposure to cold. Cold exposure activates the SNS which, in turn, increases the activity of the RAS (Fig. 3). The RAS suppresses eNOS expression and decreases NO production which contributes the development of CIH. The RAS also mediates the cold-induced increase in ET-1 production. Cold exposure up-regulates ETA but down-regulates ETB receptors. This unique pattern of changes in the ET system may be involved in the development of CIH. The relationship of the SNS, the RAS, the ET system and the NO system in the development of CIH is summarized in Figure 3. The mechanism of CICH may be different from that of CIH. The development of CICH is disassociated with CIH and is independent of the SNS and the RAS. The protooncogene c-myc is up-regulated in the hearts of cold-exposed rats, which may mediate CICH. The potential role of thyroid hormones in the cold-induced up-regulation of c-mycneeds to be evaluated. CIH and CICH are prototypic models of environmentally-induced hypertension and hypertrophy, which are induced without surgical intervention, genetic manipulation or large doses of drugs or hormones."
  2. Ron Put

    Olive oil? Healthy or not?!

    This is a fair point. I was thinking I should plant my own olive tree 🙂 But on the other hand, I eat about 2-3 grams of supposedly organic olive leaves powder a few times a week, and since it appears to be considerably denser in beneficial stuff like oleuropein than olive oil (EVOO too), I figure it still provides some of the benefits, without the fat. As to Todd's question above, it is a valid one, but the best-studied diet is that of the 1950s Okinawans, who were also the longest living population within Japan and in the world. They consumed no olive oil at all and their diet consisted of less than 10% fat. No red wine either. My own fat intake is far above 10%, mainly from nuts and flax, and some from cacao nibs. It's worth noting that the Sardinians, especially those in the "Blue Zone," consumed very little olive oil and almost no fish until the 1950s. Both the Okinawans and the Sardinians ate very little meat and animal products (a little goat cheese for the Sardinians).
  3. I just did it and this was my experience. The first time it was "WOW! What the fk!" But after a couple tries and not holding the lifted leg too far off the ground, I did about 15 seconds. Strangely, I am right-handed, I would jump off from the right leg, yet I could get to a bout 20 seconds on my left leg, and between 12-15 on my right leg. I feel humbled....
  4. The Telegraph makes this sound ominous, but the fact is that Sweden has a significantly lower number of infections than other European countries that imposed strict lockdowns and still insist on imposing much more restrictive measures. Also, The Telegraph does not appear to be aware that Belarus is in Europe, unless they have adopted the position that it is already a province of Russia... 🙂 Speaking of infections and mortality rates, Italian scientists long ago noted that they've had unusually mild flu seasons and that a portion of this year's Covid deaths are attributable to that. Tegnell has made a similar point: Sweden’s high coronavirus death toll could be linked to mild flu seasons, chief scientist says “When many people die of the flu in the winter, fewer die in heat waves the following summer. In this case, it was Covid-19 that caused many to die,” Anders Tegnell, Sweden’s chief epidemiologist, told Swedish newspaper Dagens Nyheter earlier this week. ’What has now been seen is that the countries that have had a fairly low mortality for influenza in the last two, three years, such as Sweden, [also] have a very high excess mortality in Covid-19,” he said, according to a translation provided in The Times newspaper. “Those which had a high flu mortality rate, such as Norway, during the last two winters, have fairly low Covid mortality. The same trend has been seen in several countries. This may not be the whole explanation but part of it.” It's worth noting that the average age of death from Covid in the US is higher than the average life expectancy age. And to keep this in perspective, Michael Levitt from Stanford and others noted that if we counted flu and common cold deaths in the way we attribute Covid-19 death, flu and the common cold would be also responsible for close to 200,000 annual deaths in the US (but in addition killing a lot more people under 20). Not quite the 200 million dead as claimed by Biden recently, but still... 😄
  5. Yeah, just as clear as it is that most commonly circulating viruses behave in a very similar manner, as repeatedly pointed out. Another clickbait headline to scare those who are ignorant and would shrug off the flu and the common cold, but will hide under the bed at the mention of Covid-19. (Sigh.) Here is an example related to a common influenza variant: H5N1 Influenza Virus as a Etiological Agent in Parkinson's Disease "There is a significant literature (mostly based on cases from the Spanish Influenza outbreak of 1918) that has documented Parkinson’s disease occurring, following exposure to influenza. Viruses (including influenza) have also been proposed to be an etiological agent for PD based on the appearance of otherwise non-explained clusters of parkinsonism. ..."
  6. The positive dieting conclusion appears to hold for dieting early in life (to me it's crazy that someone in their teens or 20s can let themselves become obese). Later in life, going on a diet may not be so helpful: Weight change across adulthood in relation to all cause and cause specific mortality: prospective cohort study Conclusions Stable obesity across adulthood, weight gain from young to middle adulthood, and weight loss from middle to late adulthood were associated with increased risks of mortality. Of course, this does not address the type of diet or the reasons for it. If one goes on a diet of steak, eggs and bacon, which is what Atkins was and which is what for many keto is, and avoids healthy carbs, then the chances of keeping over sooner rather than later would increase accordingly, with the corresponding weight reduction. Similarly, if one is diagnosed with several comorbidities and then goes on a successful diet (and most would choose keto over whole grains, fruits, and vegetables), then again, mortality may very well increase.
  7. Ron Put

    Olive oil? Healthy or not?!

    mccoy, I am not arguing that olive tree products, including EVOO, do not contain beneficial properties, including secoiridoids. What I am arguing is that it given the considerable evidence that the fat in olive oil is detrimental, it is prudent to choose a healthier alternative, such as olive leaf powder. I appreciate that it tastes like somewhat bitter sawdust and it doesn't compare to the aroma or flavor of good EVOO, but then to many carrots have similar appeal when compared to the Lady M cake I mentioned above 🙂 Based on what I read, olive leaves are in fact not only less processed and devoid of harmful fat, but also have a better whole profile than oil and higher amounts of secoiridoids, as well as all the other goodies found in the olive fruit, such as oleuropein. Cardioprotective and neuroprotective roles of oleuropein in olive Various methods have been developed for qualitative and quantitative occurrence of phenolic and secoiridoid compounds analysis, from the most simple techniques to the more sophisticated such as TLC (Capasso et al., 1992), reversed phase HPLC (Ficarra et al., 1991, De Laurentis et al., 1997), GC–MS, FAMS or TMS (Baracco et al., 1995). In the fruits, phenyl acids, flavonoids and secoiridoids have been reported, the phenolic compounds representing 1–3% (w/v) Brenes et al., 1993. In the leaves, 19% (w/w) is oleuropein and 1.8% (w/w) flavonoids, of which 0.8% is luteolin 7-glucoside (Le Tutour and Guedon, 1992).
  8. You didn't miss the headlines. More of a reading comprehension issue....
  9. Because it's not bacon and cheese like keto (AKA Atkins) and it is neither palatable, nor easy for most people. Much easier to cut out grains, fruits, and vegetables....
  10. Ron Put

    Ashwagandha

    Yep, I agree. I checked myself for the common heavy metals after the ConsumerLab brouhaha about cacao, which boosted their subscriptions. Nothing. Even though I used to eat 30-40 grams of cacao nibs for years, and tons of cacao powder before that. I've also been eating Indian-sourced spices for years, in quantities much higher than the average consumer. In most cases, this is much ado about nothing.
  11. LOL, cold again. It constricts your arteries, which is one major reason more people die during the cold months. Lab rats are one thing, the Spaniards and the Norwegians are quite another. You'd think the climate would have a dramatic effect if this theory was true, at least like diet, right? But if anything, the colder it is, the faster they die, even with more money to spend on health care....
  12. Ron Put

    LDL CHOLESTEROL AND LONGEVITY

    Tom summarizes my thoughts on the subject, exactly. There are studies that show that reduction in weight among obese people increases mortality. Reduction in alcohol consumption in heavy drinkers also increases mortality. I'd guess that if I search, I'll find something that says that reduction in smoking results in increased mortality too. These all have an explanation, of course....
  13. Ron Put

    Olive oil? Healthy or not?!

    I am with Mike on this one. The above video summarizes much of what I read and what prompted me to stop consuming olive oil at home. Since I did, my total cholesterol has dropped by a third, to less than 140, and my LDL is at about 70 (and VLDL at 6). Since then I've upped my intake of EPA and DHA (from algae) so I am hoping to see a further drop in LDL. I'll also see if I can check the size of the particles, for good measure. I do add olive leaf powder every other day or so, which appears to provide greater benefits than olive oil, without the fat hit. I don't understand why some here are so obstinate 🙂 Ironically, last night I ate about two tablespoons of good EVOO at one of the better Italian restaurants where I live, with some focaccia, a couple of salads, and a couple of glasses of red. And a dark chocolate dessert to boot 🙂 So, I still indulge, but try to do it only while eating out.
  14. It baffles me how so many continue to believe that this coronavirus is somehow dramatically different from other viruses. The fact is that similar effects are observed in other viral infections, both from corona and influenza viruses -- do a search. Heck, a good number of deadly cancers are caused by a virus. I understand why scientists may try to confirm that this in the case with this coronavirus, I can also understand the click-bait headlines such confirmations generate. But do we have to get every single one pasted here too?
  15. Unfortunately, viruses don't really get "wiped out" by temporary lockdowns. When restrictions are lifted, they come back to run their course. Just as Tegnell and a number of other epidemiologists pointed out from the start, but were drowned out by the hysteria and political propaganda: Sweden spared European surge as coronavirus infections stay low As we are getting more evidence that this coronavirus likely circulated among world populations considerably earlier than assumed, it lends further support to studies like the one out of Pennsylvania, which claimed that the initial wave of infections peaked in mid-March and the number of infected was 25-30 times greater than officially acknowledged (the CDC recently adjusted its own estimate to 24 times greater). This also means that the mortality rate is rather similar to that of the flu, despite the crazy way Covid-19 deaths are counted. As Michael Levitt and others point out, if flu and common cold deaths were counted as Covid-19 deaths are, the toll would be fairly similar. COVID-19 may have been in Los Angeles as early as last December, UCLA-led study suggests All this makes the lockdowns rolling out across the Western world in late March and April look idiotic, as they crashed the economies of the liberal democracies for no good reason. Yet in the "progressive" US states the authorities are still forcing everyone to wear masks outdoors, the media is still spreading fear, and businesses are still forced to stay closed. My guess is that the drunk Left will try to maintain this until the election, reason and the economy be damned, as fear wins elections over almost everything else. FOUR STYLIZED FACTS ABOUT COVID-19 First: across all countries and U.S. states that we study, the growth rates of daily deaths from COVID-19 fell from a wide range of initially high levels to levels close to zero within 20-30 days after each region experienced 25 cumulative deaths. Second: after this initial period, growth rates of daily deaths have hovered around zero or below everywhere in the world. Third: the cross section standard deviation of growth rates of daily deaths across locations fell very rapidly in the first 10 days of the epidemic and has remained at a relatively low level since then. Fourth: when interpreted through a range of epidemiological models, these first three facts about the growth rate of COVID deaths imply that both the effective reproduction numbers and transmission rates of COVID-19 fell from widely dispersed initial levels and the effective reproduction number has hovered around one after the first 30 days of the epidemic virtually everywhere in the world. We argue that failing to account for these four stylized facts may result in overstating the importance of policy mandated NPIs for shaping the progression of this deadly pandemic.
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