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Ron Put

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  1. Well, well.... This is a study that seeks a headline and presents the data accordingly (and in fact it made headlines in all the major media). It picks a period that is generally marked by a declining mortality rate, as the "flu" season, which accounts for a large portion of the annual deaths, especially among the elderly, usually peaks between December and early February. I don't feel like pulling the data for the US to show the manipulative nature of this, but here is what I had posted for the EU, which applies to this nonsense as well: We should also keep in mind that approximately 6 million people die annually in the US, so we should keep the 60,000 or so excess death in perspective. Just as importantly, reported deaths from strokes and heart attacks are way, way down, which suggests that many who were frightened by the media and their "leaders" and skipped going to the emergency room, and then died in their homes, ended up counted as "possible" Covid-19 deaths. This politicized mess will take years to clean up, assuming that an impartial body does the final tally.
  2. Ron Put

    Path to Longevity (new book) by Luigi Fontana

    You are likely right, and in a way, I hope so. I had posted something elsewhere, which supports your bioavailability claim. I consume very little rice anyway. My muscle mass is nothing like Clinton's or mccoy's, but it's proportionately very high, given my mid-18 BMI nowadays. I don't like gyms, but do rotate 125 push-up days (sets of 25) with 40-50 pull-up days (sets of 10), do some Pilates, do 3-4 minute continuous planks every other day, etc.. Again, I don't look like Clinton and Mccoy, or Ronnie Coleman, but I look better than most people my age (which admittedly, is not hard :) The bottom line, moderate vegan protein can maintain muscle mass, as long as one does engage in strength exercise.
  3. Hm, but it is about random damage and it's presented as something groundbreaking: "However, the list of proposed hallmarks is missing the stochastic non-enzymatic modification of long-lived macromolecules. In this review, we summarized all evidence that it is in fact one of the primary, causative hallmarks." I perused the paper and it is a good overview, but I just don't see anything new in it, or at least in the part that they state is new. Nothing to do with it being Russian. And please don't assume that because I find the current leadership of Russia poisonous to its neighbors and to the world community, I hold anti-Russian views. On the contrary, I am a Russophile, in that I admire Russia's very significant cultural and scientific contributions to our world, and I have many close Russian friends. If anything, I feel disappointed and sad about Russia, because I really thought that things may have been different if the West had acted differently after the fall of the USSR. The US has not had a coherent strategic vision since the mid-1990s when Clinton essentially put Harvard's Institute for Int'l Development in charge of America's Russia policy and USAID, with little to no oversight. People like Summers propped up budding oligarchs like the Chubais clan and paved the way for Russian nationalism and distrust of Western "experts." And successive US administrations have not done better. The US should have promoted transparency in Russia, and helped integrate Russia into the world community, but it failed to do so. Swiss, German and British banks viewed Russia (and much of Eastern Europe) as a place they could make a lot of money and not play by the rules applicable within Western Europe. It was a recipe for disaster and we got it, in the shape of Putin and Russian nationalism. Anyway, I am digressing and this is not the place for it, but I find what happened in Russia really depressing, even though I like visiting.
  4. Funny, I think of InquilineKea as a "she." Maybe like Alicia Vikander in Ex Machina :D LOVE the paper though??! The paper talks about random damage, which I also have thought of as a given, in general, in addition to direct damage. But what do I know? The de Grey reference is, if anything, a negative, IMO.
  5. Ron Put

    Path to Longevity (new book) by Luigi Fontana

    I agree, but I don't even know how someone who eats even a varied vegan diet (me, nowadays) can stay at RDA levels. I am purposefully trying to limit protein (actually, mostly to keep methionine low) and I am at 131% of RDA. I seem to remember that Dean, who I believe also tries to keep protein low, is at around 1g or so per kg. If my memory is right, the average American is closer to 1.5g.
  6. P.S. I did a quick search on linoleic acid and it appears that higher concentrations reduce inflammation, which seems to be supported by my rather low HSCRP value of 0.02. Omega-6 fatty acids do not promote low-grade inflammation The individual response may also be based in part on genes (I am T/T at rs174550, which jives with the theory): Effects of linoleic acid on inflammatory response depend on genes
  7. Another note, which may be of interest to vegans and vegetarians: I had the Cleveland HeartLab OmegaCheck test done and the results were a bit surprising, to me. The whole blood EPA+DPA+DHA value was 5.2, a bit below >5.5, the value above which they find the lowest risk of sudden cardiac death. This is despite the fact that I have been trying to maintain a roughly 2 to 1 ratio of Omega-6 to Omega-3, based on Cronometer data. As I am vegetarian, thus the Omega-3 was provided primarily by a daily dose of flax. According to Cronometer, my average daily intake of Omega-3 over the last year was 11.1g and Omega-6 was 16.5g. My blood test results are: Omega-3: EPA: 1.4 (range 0.2-2.3) DPA: 2.1 (range 0.8-1.8) DHA: 1.7 (range 1.4-5.1) Omega-6: Arachidonic Acid: 11.7 (range 8.6-15.6) Linoleic Acid: 31 (range18.6-29.5) So, my DPA is higher than their range, which is good. Linoleic Acid is also higher, I am not sure if it's good or bad. The bottom line is, flax doesn't seem to do it for me in terms of EPA and DHA, so I have started taking 600 DPA and 300 EPA daily, in the form of algae oil supplement. When I retest my amylase in about a month or so, I will probably redo the OmegaCheck and see if the algae oil helps (it should).
  8. Hm, society has to figure out how to handle the "ultra-rich" if they live forever, as someone with such predatory practices as Bezos would eventually own all of us. Jonathan Swift addresses the issue in Gulliver's Travels, where the Struldbruggs (who turn immortal at 80, identified with a red dot on their forehead) are officially declared "dead" at that time and dispossessed from their wealth, so that they don't eventually own everything, just by virtue of a limitless time horizon. On the other hand, the liberal democracies seem to be heading towards "1984," so who knows what Big Brother might decide to do :)
  9. This is from the latest Found My Fitness email: We've just posted a brand-new article about Neu5Gc – a nine carbon sugar molecule that's the subject of controversy among lots of folks in the nutrition community, especially as it pertains to concerns about red meat consumption and the development of atherosclerosis. You can read the new article on Neu5Gc here. Neu5Gc, short for N-glycolylneuraminic acid, is a sialic acid that's produced by most mammals – but not humans. Oddly, trace amounts of the compound show up in human urine, suggesting that we get it from the foods we eat, especially red meat, eggs, and milk. The problem may lie in the fact that Neu5Gc is very similar in structure to Neu5Ac, a sialic acid produced in the human body. The body's biochemical pathways treat Neu5Gc as if it were native. But the body's immune system, it is thought, says, "not so fast." It recognizes Neu5Gc as foreign and produces antibodies to it. The upshot is that foods that contain Neu5Gc – animal products – might provoke an immune response. This immune response may trigger inflammation, potentially providing a unique dietary link between consumption of animal products and chronic disease. An odd quirk of dietary Neu5Gc is that it tends to accumulate preferentially in the linings of blood vessels or hollow organs – and even some types of cancer. Herein lies the controversy. Some studies suggest that the body’s immune response to Neu5Gc is the missing link between animal product consumption and increased risk for diseases such as atherosclerosis and cancer. Cell culture and rodent studies have shown that Neu5gc promotes inflammation, which can drive the pathogenesis of diseases like atherosclerosis and cancer. In fact, long-term exposure to Neu5Gc (approximately 21 months) produced a fivefold increase in the incidence of cancers in mice. Hold on. The data from the cell culture and rodent studies are interesting. But translating these findings to humans presents a few challenges. Humans and rodents are vastly dissimilar organisms, especially when it comes to Neu5Gc metabolism. Unlike mice, we absorb very little of it from our diets, and we eliminate it pretty quickly. But there are issues with the study designs used to assess the effects of Neu5Gc, too, that make it hard to translate the data to humans. It's true: Some studies show links between eating animal products and an increased risk of atherosclerosis and cancer. But others have shown that this risk is largely mediated by other lifestyle factors – such as smoking, heavy alcohol consumption, physical inactivity, or being overweight or obese. While consuming very large quantities of red meat might not be optimal for health, avoiding the iron-rich food altogether could raise other health concerns. For example, women who avoid red meat are at risk for developing anemia, which can have far-reaching effects, especially if they are pregnant, because iron is critical for fetal brain development. The bottom line is that the jury's still out when it comes to Neu5Gc's effects on human health.
  10. Has anyone here who is sort of on CR and high fiber diet tested their amylase? I am really curious if such habits elevate amylase values (without elevating lipase).
  11. Ron Put

    Nuts and Mortality

    I can testify to that :) But, since I have been tracking both sleep patterns and blood pressure, I have found measurable patterns that coincide with how I actually feel. With marijuana, I sleep like a log, do not dream, but my Fitbit score remains high, usually in the 80s (for what it's worth). My resting heart rate remains in the high-40s to low 50s range, which is normal for me. With alcohol, my sleep pattern is disrupted: I fall asleep easily, but often wake up after a few hours and I am more restless throughout the night. My Fitbit score generally dips significantly and my resting heart rate goes up significantly (3-5 beats higher, on average), and it takes a couple of days to return to normal. While I still drink wine when I go out, I try to do it as little as possible and have actually stuck to water now that the restaurants are open again. Bad for the restaurant and the waiter (I try to tip a little more :) but I feel better. Of course, YMMV.
  12. Here is another study, from Germany, which supports the study from Karolinska Institutet and Karolinska University Hospital in Sweden on T-cell Covid-19 immunity. SARS-CoV-2 T-cell epitopes define heterologous and COVID-19-induced T-cell recognition This is the first work identifying and characterizing SARS-CoV-2-specific and cross-reactive HLA class I and HLA-DR T-cell epitopes in SARS-CoV-2 convalescents (n = 180) as well as unexposed individuals (n = 185) and confirming their relevance for immunity and COVID-19 disease course. SARS-CoV-2-specific T-cell epitopes enabled detection of post-infectious T-cell immunity, even in seronegative convalescents. Cross-reactive SARS-CoV-2 T-cell epitopes revealed preexisting T-cell responses in 81% of unexposed individuals, and validation of similarity to common cold human coronaviruses provided a functional basis for postulated heterologous immunity[9] in SARS-CoV-2 infection. This one seems to use a different methodology and the Swedish study above found about 30% T-cell immunity in addition to those who had antibodies. Either way, when combined with the recent models estimating 20%-45% immunity needed for herd immunity, this is very good news.
  13. Ron Put

    Nuts and Mortality

    This is a part of the reason why I decided to cut it out. I have no moral objections to drugs, of any kind, since I don't believe it's my business to tell other adults what they can do with their own bodies, no matter how harmful. Heck, alcohol abuse kills more people than meth. But I personally don't put stuff in my body without having a reasonable idea of what it is. Pot is legal where I live and I buy brands that use clean extraction methods and are organic (although the plant is hardy enough that is almost never sprayed with anything, AFAIK). I started switching to pot as I aged and noticed that the daily glass or two of wine started disrupting my sleep and sometimes giving me headaches. So I thought pot is a good solution to obtaining a good night's sleep. And it worked for a long while, helping me sleep through the whole night as heavy as a log. But as my body got used to it, I needed more puffs. I noticed that I stopped dreaming, or at least that I never remembered my dreams. I continued reading about pot use and while there is very limited research and mostly the studies that are out there don't show any of the serious harm associated with tobacco, there is some emerging evidence that ultimately it's not completely harmless. So, I actually stopped it about a month ago, and while I do wake up a couple of times in the middle of the night, I fall right back to sleep, so I don't miss it. And I dream a lot now :) Since I got my blood tests, there are two which differentiate between non-smokers and smokers: cyanide and CEA. I am slightly above the non-smoker level for both, although not close to the smoker levels. Which is the reason I attribute the slightly elevated results to the vaping. I am not worried about it, of course, but I am curious and will repeat both tests next year. If the cyanide is still elevated, however slightly, then the 30g+ of almonds and 30-50g of flax may be blamed :)
  14. Ron Put

    Nuts and Mortality

    My cyanide blood test shows 0.050 mg/l According to the lab: Normal: Non-smoker: <0.025 Smoker: 0.410 Exposed: Levels of 0.200 are non-toxic Levels of 0.500 to 1.000 are associated with tachycardia and flushing Toxic: Levels of 1.000 to 2.500 are associated with obtundation, coma and respiratory depression above 2.5 Levels of 3.000 and above are associated with death. My guess is that the slightly elevated levels are due to the vaping of pot for better sleep, rather than with almonds or flax consumption. So, the pot is out.
  15. Ron Put

    Receptor makes mice strong and slim

    LOL. It's not a rule, but it has been known to happen -- sometimes too much of a good thing is not so good. Shooting up testosterone will also increase lean mass and muscle, at least for a while, but in the end, it will come back to bite you. Not saying this is the same, just that we don't really know.