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Ron Put

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  1. Ron Put

    I kindly ask you to delete my account.

    Yeah, the powers that be should be kind enough to oblige Fernando.
  2. Ron Put

    Resveratrol latest tips from sinclair

    About six months ago started taking about 1400 resveratrol daily. I may have been suckered by the latest wave of Sinclair product pitches, but since I don't see a significant downside, I added it to my daily pills: This is the one I take.
  3. Ron Put

    Exercise Effects

    I like hiking. It clears my mind and it is far less damaging to joints than running. You just need a steep enough hill and a good pace to get to a decent heart rate, plus the occasional burst of running uphill to get into the over 150 zone. But reading through this thread, I was reminded of a recent study (I believe also posted here) which may help explain some of Tom's observations (or not :): Undulating changes in human plasma proteome across lifespan are linked to disease "Strikingly, we observed a prominent shift in multiple biological pathways with aging (Fig. 3g). At young age (34 years), we observed a downregulation of proteins involved in structural pathways such as the extracellular matrix (ECM). These changes were reversed in middle and old ages (60 and 78 years, respectively). At age 60, we found a predominant role of hormonal activity, binding functions and blood pathways. At age 78, key processes still included blood pathways but also bone morphogenetic protein signaling, which is involved in numerous cellular functions, including inflammation24. Pathways changing with age according to linear modeling (Fig. 1g) overlapped most strongly with the crests at age 34 and 60 (Fig. 3f), indicating the dramatic changes in protein expression occurring in the elderly might be masked in linear modelling by more subtle changes at earlier ages. Altogether, these results suggest that aging is a dynamic, non-linear process characterized by waves of changes in plasma proteins that are reflective of a complex shift in the activity of biological processes."
  4. Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands Question Are plasma concentrations of vitamin B12 associated with risk of all-cause mortality among adults from the general population of the Netherlands? Findings In this population-based cohort study including 5571 adults, higher plasma concentrations of vitamin B12 were associated with a 25% increased adjusted risk of all-cause mortality per 1-SD increase. Meaning These findings suggest that higher plasma concentrations of vitamin B12 are associated with all-cause mortality, independent of traditional risk factors.
  5. Thanks, Mechanism! Macadamia nuts are on order, next to my walnuts, almonds and Brazil nuts (one a day) I like MyFoodData, the top item for vegan foods lowest in methionine is Beer! :) I just ran across this, which among other things discusses median protein and specifically, leucine, intake: Knowledge Gained from Studies of Leucine Consumption in Animals and Humans "Food intake surveys underestimate nutrient intakes because of underreporting and my analysis of the UK adult National Diet and Nutrition Survey (8), trimmed of under-reporters (i.e., energy intakes <1.35 × predicted basal metabolic rate), indicates median and 90th percentile intake values for protein of 1.25 and 1.61 g · kg−1 · d−1(14.2 and 17.3% energy) and 108 and 138 mg/kg leucine at 8.3% (9) of the protein intake. Modeling the more recent UK National Diet and Nutrition Survey protein intakes of 17.6% food energy (10) for a physically active 70-kg young man (physical activity level = 2.2) indicates a protein intake of 2.41 g · kg−1 · d−1 or 200 mg · kg−1 · d−1of leucine. Our studies of 90-kg body builders (11) indicated protein intakes up to 3.05 g · kg−1 · d−1(28% protein calories) of a mainly animal protein diet [8.6% leucine (9)]; i.e., a food leucine intake of 262 mg · kg−1 · d−1(∼7 × the recommended dietary allowance). Although little is known about the long-term health impact of these high-protein intakes, it can be assumed that such intakes are widespread."
  6. Ron Put

    Jeanne Calment was a fraud?!!

    Thanks, Dean. The Russians are probably the best in the world at using disinformation in less than obvious ways and they have been doing it for much of the 20th century. Sometimes they target seemingly inconsequential subjects, such as this, but the broad goal is to simply undermine trust in democratic and civil institutions, which provide wedge opportunities to be exploited later. The use of Western "celebrities" like de Grey, or Angela Davis, or Depardieu is another common thread. Crazy, stupid, but I guess it works on occasion. "S. Jay Olshansky, a gerontologist at the University of Illinois at Chicago, told me, “I did not find the paper to be of a very high quality. If I were the editor, I would not have accepted it.” Many readers were confounded: why had de Grey decided to bestow the imprimatur of academic respectability on Zak’s work? Outlandish conspiracy theories proliferated. Was de Grey, an “international adjunct professor” at the Moscow Institute of Physics and Technology, somehow in league with the Russians? Was it Big Pharma? Was it Putin? Or was there a plot involving the Lifeboat Foundation, a techno-survivalist organization to which de Grey and Zak both belonged, which had been infiltrated by Russian spies? “These are bad guys, playing nasty games,” Robert Young, a consultant for Guinness World Records and a director of the Gerontology Research Group, which maintains a database of supercentenarians, told me. “This is a manufactured controversy—we don’t even consider the case to be disputed. ... ... As the controversy continued, Zak’s theories became increasingly baroque. As soon as one idea was disproved, he came up with another. Calment’s late-life height, it turned out, was really a hundred and forty-three centimetres, reflecting the loss of stature that one would expect. The caption that the validators had used for the photo of Jeanne and Yvonne—“Which one is which?”—seemed to come from the slogan for a brand of soap. Zak eventually dropped the fibroma argument.”
  7. Interesting, thanks! "One study from the same group of University of Rochester researchers found that low-level alcohol consumption actually enhanced the performance of the glymphatic system, while another found that sleeping on your side rather than your back or stomach can produce similar effects." I have been reducing my alcohol consumption, but maybe I shouldn't.... :)
  8. Mechanism, thank you for the great post! It really helps sort it all out in one place and make better sense of it all. I am not sure I have any hope of getting my protein intake down to the levels discussed, while still getting a balanced diet. Here is a snapshot of my protein intake over the last three months: Virtually all of my protein is from plant sources (I eat cheese very rarely) and mostly from flax, nuts and seeds, legumes and cacao nibs. But, I average close to 70g of fiber daily, so I wonder if having a diet high in fiber reduces the absorption of plant protein, which I believe is a little less bioavailable than animal protein anyway?
  9. Ron Put

    The Ultimate Purpose of Life

    mccoy, I think part of the problem is that you, as many others, lapse into anthropomorphism when trying to understand the universe. Just like religions ascribe all sorts of human traits to their gods, even when they otherwise insist that they are transedentent. Religious folks are pushing really hard to give legitimacy to the various "intelligent design" arguments by equating them to theoretical physics, with the goal of creating enough confusion so that "intelligent design" seems reasonable to casual observers. A bunch of casual geeks have also become excited by watching Youtube videos with funny math purportedly "proving" the extreme likelihood of this being a Matrix world. But they are not the same. The simulation narrative is the stuff of fantasists, metaphysics, science fiction and the occasional philosopher freely expounding, not of science. As you can see from the calculations of the few actual physicists who bother to address this nonsense spread on the internets, such simulation would violate some fundamental laws. Just like walking on water would. String Theory may or may not turn out to be correct, but it is built upon strong mathematical framework foundations, just like other competing theories. It makes testable predictions, just like other theories in physics. It's just that currently we lack the technology to achieve the extremely high-energy processes necessary to prove or falsify its predictions. No different than something like Relativity. There are currently experiments which may provide some answers about the validity of aspects of string theory. I already mentioned one: Here is another opportunity, made possible by the detection of gravitational waves in 2015 (a full century after the prediction made by Einstein): "Researchers from the Max Planck Institute for Gravitational Physics (Albert Einstein Institute/AEI) in Potsdam found that hidden dimensions – as predicted by string theory – could influence gravitational waves. In a recently published paper they study the consequences of extra dimensions on these ripples in space-time, and predict whether their effects could be detected." https://phys.org/news/2017-06-hints-extra-dimensions-gravitational.html I suppose one can argue that the Abramic sects have made predictions too . Both Christianity and Islam foretold the imminent apocalypse and judgment day, and both predictions were proven wrong long ago. But true believers keep believing, so I doubt I would really convince anyone....
  10. Ron Put

    Flatulence study

  11. I am still curious though, has anyone come across some sort of a standard definition of what constitutes a diet "low in methionine" or "low in BCAAs" as it applies to humans? For methionine, I remember seeing a human study which deemed "low" to be anything 1.3g per kg or less. But I haven't seen anything defining what "low" means for BCAAs. I can't even find what is the average intake based on SAD, or any other population.
  12. Ron Put

    The Ultimate Purpose of Life

    Uhm, it wasn't me, it was some dumbass theoretical physicists from Oxford.... ( https://advances.sciencemag.org/content/3/9/e1701758 ) And I really don't think that the Oxford folks are misguided, but I do have an inkling that some here are mightily confused. Oh, boy.... I thought I should note that while I found the video mesmerizing on the big screen and it generally tracks based on sort of current knowledge, it is done by a talented freelance videographer who does veer occasionally into pop-sci areas. But if this is what someone takes out of it, who am I to judge ;) I am starting to feel like I am at a Kansas Board of Education hearing, circa 2005.... :D
  13. Ron Put

    Intermittent Fasting and green tea...

    I haven't seen a specific study, but assuming that tea and coffee are similar in their effect, it appears that at least coffee helps induce autophagy, which is the main reason for intermittent fasting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111762/
  14. Yes, animal protein appears to generally beat plant protein in BCAAs, unless one eats pumpkin seeds by the pound: "Amount of BCAAs in prepared foods: PLANT FOODS: beans (2 g/cup); pumpkin seeds (1.5 g/oz); nuts (1 g/oz); quinoa (1 g/cup) ANIMAL FOODS: milk, nonfat (10 g/cup); cheese (5 g/100 g); chicken, turkey, pork, beef, fish (4 g/3 oz); egg (1 g/egg) Breast milk: 2 g/liter" http://www.nutrientsreview.com/proteins/amino-acids/branched-chain-bcaa.html
  15. Ron Put

    Americans Report Eating Less Meat

    Maybe we shouldn't base our global policy views on Amazon Prime movies. :) As modern medicine and hygiene made inroads in rural China in the 20th century, infant deaths dropped dramatically and the population exploded, more than doubling in less than 50 years. The subsistence farming most rural Chinese were engaged in was not able to provide enough food, so there were repeated famines every decade or two, through the 1960s. The Great Leap, which forced industrialization, certainly contributed much, but one cannot, and should not, overlook the population explosion. Yes, in this case China did the right thing, as far as social policy goes. The implementation, like many acts of the Chinese government, is another matter. Keep in mind that the policy affected city dwellers, with rural Chinese and minorities largely exempted. Infanticide, however, was not nearly as widespread as the anti-abortion crowd in the US has claimed. Most of the reduction in birthrates was achieved through birth control and probably very often, abortion (which is what really riles up the religious and where the “millions of babies killed” nonsense come from). At the end, far, far more adult, sentient Chinese have died from famine during the 20th century, than baby girls have been drowned in buckets. Again, population explosions are often the result of transfers of knowhow and aid, which ensure survival and rapid procreation without the balance of family planning. Religion is the main reason for the decoupling of family planning. In terms of religiosity, the US is more akin to the Third World than to the First, and unfortunately at times this is reflected in its global projection, with stuff like the Mexico City policy, which every Republican president resurrects in order to appeal to the Bible Belt. https://www.voanews.com/africa/africa-record-largest-population-growth-over-next-40-years And I don’t even understand the logic in the argument that because carnivore predators kill to eat, so should I. Predators kill humans too. Humans enslave, torture and kill humans, as well as animals. I’ve even been in a village where ritual cannibalism was supposedly still practiced. None of it leads to the conclusion that I should do these things. Cheers.