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Ron Put

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  1. Ron Put

    Does CR keeps you looking younger?

    It's hard to judge one's own age, but presumably, CR should make one appear younger. Appearance does present health status in broad terms and I would think that all things equal, CR would improve enough health aspects to improve one's general appearance.
  2. Ron Put

    Anyone tried January.AI?

    I am not sure about the accuracy, since I don't have a way to test blood. The sensor may be reading a bit higher, based on A1C, and my fasting blood glucose is usually within the 80s in lab tests. But as you point out, it's the curve and pattern that's more interesting. On the first screenshot in my previous post, the peak between 15:00 and 18:00 was a somewhat strenuous hour-long hike/trail run, which pushed me to 131 at its peak. The following peaks are pizza, cocktails and stuff like that, followed by a late-night munchies snack. Mostly junk food/refined carbs, and I was sort of happy that it never pushed me over 130. I am not insulin resistant (my last insulting lab test was 3.9, at the same time as the fasting glucose of 82). But yesterday I did a glucose challenge, which pushed me way over. I fasted until about 15:00 (so 15 hours or close), with black coffee and green tea as the only consumables. At about 15:00 I drank a solution of 75g of glucose provided by January.ai. Orange, nasty sweet-tasting liquid 🙂 In an hour I peaked to 174, then by the second hour I was down in the 110s and I crashed, hitting 50s about three and a half hours later, still fasting until then. At that point I ate and then dosed off until about 22:00 (I never just dose off). When I woke up I ate some more and continued snacking until about 01:00. In other words, the glucose challenge really screwed me up 😞 Here is a screenshot of what happened during the first 3 and a half hours after the glucose drink, from the LibreLink app: And here is a longer period that shows the crash after 3 and a half hours, and then bounces from food intake and probably my body trying to recover from the glucose challenge: Interestingly, my Garmin watch registered noticeably increased stress (measured mostly from HRV, I think) as soon as I drank the glucose. It's similar to what I see if I drink alcohol. Here is a shot, the orange is the stress after the glucose: I don't remember if you did a glucose challenge while using the sensor, mccoy. If so, what was your experience?
  3. Thanks, Saul! I'd assumed RBC and albumin would go in tandem on CR. I wonder what others on CR are seeing,, and what it means, if anything?
  4. That's what I assumed, thanks. But what about albumin?
  5. Ron Put

    The Singularity May be Closer than It Appears

    It's quite amazing, although I think the Medium piece was a bit optimistic in its interpretations. Sentience presumes self-awareness and feelings, such as fear of death. A dog has them, and so does a cow, a chicken, or a lamb, which is why I do not eat animals. Humans don't until some time after birth, which is why I think the state should have no say in personal carrying-to-term decisions (had to throw this in 😄 ). I see nothing above or in the LaMDA piece that indicates sentience. In fact, I'd be worried if it exhibited fear of death, for obvious reasons. But so far nothing indicates that it does, and hopefully, by the time it does, we'll have a way of addressing it safely. A more immediate concern is that Google develops and shares know-how with China, which has no qualms about using it for political control and exports it to other authoritarian states. Heck, the Left in the US has shown that it has no qualm about using similar tech to suppress free discussion internally. This is a much more immediate issue, IMO.
  6. Ron Put

    Anyone tried January.AI?

    Well, I am trying it. It's a way to get the first-gen Libre CGM without a prescription in the US. The price is reasonable ($288 with the current discount) and it includes two sensors and an app that hopefully will provide some insights. I've spent three days with it so far. On all three days, I ate mostly at restaurants and mostly food I don't normally eat. It included Indian (including white rice, and bread), Italian (including pasta with pesto, bread), and American (including breaded, fried Brussels sprouts, a sugary cocktail, and a whole mushroom pizza without cheese). I figured this is kind of a trial by fire (or refined carbs). I was pleased that my glucose never went over 130, despite all the refined carbs. What I am less pleased about is that my average glucose is 103. This translates to A1C of about 5.2, so it's not widely off the mark. My A1C is usually about 5. My lab blood test of about 10 days ago shows fasting glucose of 82 (my insulin result was 3.9, so I am unlikely to be insulin resistant). So far, the Libre patch has not gone this low, generally ranging between 95 and 115, with occasionally reaching the low 80s and the high 120s. Here is a screenshot from LibreLink (fasted until about 15:30 yesterday, ended up with the munchies close to midnight and ate 150g or so of Black Garlic with almonds and walnuts...😞) I've set the desirable band to be 70-130 and I was 77% within it. I noticed that Kambucha seems to cause a spike to about 120 or so. I am still waiting for the January.ai app to gather enough data, but here is an example of an insight it offered: Note that the "garlic" is actually Black Garlic, which is rather sweet and I expected it to spike up, but it actually caused a dip. I am pretty happy so far with the app and the info, although who knows what the sensor accuracy is.
  7. Interesting, thanks. I believe this is one example they are pointing to: https://www.snpedia.com/index.php/rs107251
  8. I've been puzzled why my albumin and RBC are low, with my latest albumin test at 4.1g/dL. But it's been pretty low since I started testing, generally between 4.1 and 4.4. My Beta Carotene intake was about 30000 micrograms per day during the last three months, according to Cronometer. It was about 1000 micrograms per day lower during the three months before my previous test, when it was measured at 4.3. So, I am not sure that it correlates so well for me. This is based on an average of 1850 calories per day.
  9. Ron Put

    REQUEST TO GUIDE IN OPTIMIZING NUTRITION

    Interesting sources, Amar. It works well, it seems. I do use non-fortified nutritional yeast daily and it's a great source of B-2 and B-3, but stuff like cannellini beans and sweet potatoes may help too. The purslane is a new discovery for me, I didn't know it was so nutritious. Why so much oil, if you don't mind me asking?
  10. Ron Put

    Random Lectures and talks you liked

    AI is here, and it's taking over 😉
  11. The only "proposal" is from a Russian disinformation campaign, AFAIK. Build up Russian national pride while tearing down the credibility of Western science and government authorities, and all that. Calment was pretty well studied and her history is well known. If it was a conspiracy, it must be a very wide-ranging one, involving the whole town and local authorities, as well as the number of scientists who investigated her.
  12. I am tempted, as CGMs are not available without prescription in the US. I was going to get a prescription, but for $288 January.AI is rather comparable to the monthly cost of the CGM alone, and it appears to provide a pretty good app from what I can tell. Did anyone here try it?
  13. Interesting, thanks. I am a bit skeptical of the great emphasis on circadian rhythm, at least at the individual level. There is great variability in the lifespan of professionals with highly irregular schedules, once the apparent confounding stuff is taken into account. I am not arguing that it doesn't matter, but other factors appear to have a greater effect. Such as inflammation (and all the stuff it goes with, such as obesity, poor diet, and self-destructive habits).
  14. Keep in mind that different devices and manufacturers measure differently and accuracy varies wildly. EliteHRV.com has an app that can be used with a chest strap and it'd be a good way to get an idea of where you are. And as Michael points out, overtraining will often drop HRV significantly (as will sitting on the couch 🙂
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