Ron Put

I listen to Attia and I find his show and opinions useful, but he is not a researcher and a many of his guests make claims that may not all stand up to scrutiny, perhaps because they have axes to grind, or stuff to promote and sell. I am not sure that this generalization is necessarily true. Old-age frailty is not necessarily due to not lifting weights when 30, but is more likely a consequence of genetics, life-long habits and subtle changes that may not raise to "pre-existing conditions" but have an impact on mobility, ability and desire to engage in activities that would stave off frailty, etc.. Perhaps there is correlation with overall mass, but weightlifters or even folks with Attia's physique are far rarer among the very old than those with slighter builds. I probably would not suggest CR at 30, especially for someone who is healthy and fit. While I am a vegan nowadays for moral reasons, I have observed significant measurable health benefits since I stopped consuming animal flesh, and then slowly moved away from animal products. I would venture a guess that high-amounts of animal protein are not the secret to longevity.

Hi, mccoy. If I recall correctly, TMG may bump up LDL-C and TGs, while glycine may have the opposite effect.

BMI of 18.5 is totally fine, as long as you are healthy, and your doctor says so, right? Healthier than the vast majority of the population. You don't need to go to the gym to maintain good muscle mass and bones. Do push ups, pull ups, squats, planks... You can do these spread throughout the day, one set of something at the time and focus on one area each day. Start with whatever you can do and increase the reps as you can, every week or two. The key is consistency. Once you get into a rhythm, it will get both easier, and you will start seeing results. Do a DEXA scan every year or so to track how muscles and bones look and progress. Presumably, you don't have a visceral fat issue that plagues most of the population, especially as you appear to run. I am curious what exactly is your relationship with food and do you track nutrients with something like Cronometer? Are you male or female (I read through really quickly, may have missed it)?

What Mike said. I forget, how old are you, Alex? Methinks most healthy people should stay away from pills that may/are likely to cause more harm than good in the long run. At some point, science will come up with a way to extend health-span and/or lifespan, but nothing I am aware of yet fits the bill today, IMO. Eat whole (plant) foods, in moderation, go for a run/hike outdoors, sleep well and yes, don't forget to do some wight-bearing exercises, and unless you have some unique issues, you will do better than most.

There is still a lively debate about the primate studies and their methodology and interpretation, and I would not discard CR as a health-span, or even life-extending hack. If anything, CR would make people more attractive in tight jeans and make coach air travel less unpleasant... CR is still being studied, see for instance this CALERIE result: Calorie restriction trial reveals key factors in enhancing human health The question for me personally is that I am unsure how do we define CR. My BMI varies between 18.5 and 19, rarely shoots up to 19.5 before I dial it down. Am I on CR? I don't know, but if asked, I would have to say no, since this is where I was when I was 20, and if I reduce my calories even 15% my BMI would likely drop to 17 or so. But if you ask some of my old school friends who are at 30+ BMI, they would respond that I am on a severe CR. Go figure.

Or, you may regret it... There are still some serious questions about the long term effects of these drugs in healthy people, and long term keto also seems like a bad deal for most healthy people, from what I have read. But keto is a religion for some nowadays, and an industry for others.

I enter my food fairly religiously, not so much to count calories, but to track nutrients. I try to eat a fairly wide variety of foods, presumably my microbiome is happier because of it.I also travel (with a small rechargeable food scale) a fair bit to different parts of the world and food variety is often forced on me, not that I mind it. One important caveat: since I try to consume mostly whole foods, I enter the NCCDB, USDA, ESHA and similar values rather than the label values, as rightly or wrongly, I place more trust in such agencies. As a side note, perhaps the poll should be updated, as 8 years is a long time and technology and apps change...

I am with Klaper on Omega-3s, I guess:

First, high fat/low carb will likely level your glucose but it will eventually increase your insulin resistance. I didn't see your insulin measurement, without which fasting glucose is far less meaningful. It's why all the CGM-pushing companies promote high fat/low carb, since all they measure is glucose and flatlining it keeps the subscriptions going. Your A1C will likely take longer to move, if it does much. You lipid numbers are kind of up there, consistent with the high fat diet. How much B-12 are you taking? No, you are not going to die just because your number is 1,117 pg/mL, but maybe ease of on the dose you are supplementing with. Try adding a little glycine to help a bit with homocysteine.

Bleh... And from Nutrition Source (Harvard): "Bottom Line At this time, non-industry funded research on collagen supplements is lacking. Natural collagen production is supported through a healthy and balanced diet by eating enough protein foods, whole grains, fruits, and vegetables and reducing lifestyle risk factors."

Unlikely, IMO. I just di a quick search: Slippery Slope: Diet Drugs No Help for Heart And see this, too: Long-term Victoza use linked to higher blood glucose levels, study claims

In addition to 500 mcg daily B-12, I've been using glycine to keep my homocysteine in check and so far it appears to work better than just B-12. BTW, for me at least it doesn't seem like increasing B-12 affects homocysteine beyond certain level.

Hi, Saul! Just curious, what is "excellent" and are you on any medication that affects cholesterol?

I am open to any other suggestions for the cause 🙂 I don't have any other issues that pop up on the tests, with thyroid, kidney and liver values all good, low inflammation markers, low PWV, no tissue injuries and no other drugs/supplements. But even if the lipo(a) value is off because of a lab error or methodology, my lipids are definitely significantly worse than when I was not supplementing with Omega-3, and they get worse with increasing the dose. I am wondering if the results showing supplementation benefits are because study subjects already have metabolic and lipid issues, while in my case I started Omega-3 supplementation while at what I consider to be optimum numbers for someone my age. To boot, my Lp-PLA2 activity has also increased with supplementation 😞 Of course, it may be simply correlation, but this is my second try with Omega-3 supplements, and both had negative effects on my lipid markers. And this time it got worse as I doubled the dose. I guess I'll know if elimination of Omega-3 supplementation improves my results in about three months.

Like most things Vice, the review is semi-idiotic. I would not go by the not-so-healthy looking "Hey Man" columnist thinks about diets. And I didn't' really want to know about the size and buoyancy of his stool. For what it's worth, countless people in the developing world subsist on lentils and other legumes, and if more Vice readers ate 300+ grams a day, it's likely the UK obesity rate would go down significantly, and their Covid mortality would likely have been much lower. But I do question the wisdom of the bucketful of supplements, too.

thanks for the suggestion, Igor. I considered the possibility of a lab problem, but when I went back and checked and all three apo(a) tests were done by Labcrorp. While this doesn't eliminate the possibility, it reduces the likelihood. Other lipid markers are off too, like my Free Fatty Acids, which have literally doubled at 0.7 mEq/L from before supplementation. Also, my Insulin has doubled at 7.2 ulU/mL, which supports my theory (high free fatty acids prime one for insulin resistance). I've eliminated Omega-3 supplementation and will retest in about three months to see if it has had an effect. I plan to keep most other things the same.

Thanks, Saul. My guess is that animals with sufficiently developed nervous system to be able to navigate complex environments are self-aware, with the capacity to process pain and fear death. As to the mirror tests, IMO sensory attributes may be different across and even within species. For instance, most humans are self-aware even though they cannot perceive their own sonar reflections. Which, as you know, is why I have decided not to eat animals, including fish.

It amazes me that so many think that this is crazy, but find the average 45 year old with a BMI of 29 to be "normal." And don't get me started on the obese "models" that are increasingly popping up on ads and billboards to virtue-signal to the militant woke brigades... That's the real crazy.

Thanks, drewab. Go Bobi! I hope nowadays people spay and neuter their pets, instead of burying puppies in holes.

I just completed a four-month experiment where I took 900mg of EPA+DHA each day. In the six months period prior, I was taking half of that amount, or 450 mg. Prior to that I was not taking any. The results confirmed my suspicions that supplementation with Omega-3s is detrimental to my blood markers. Back when I cut out olive oil and was not supplementing other than eating flax seed every day and based on Chronometer, my Omega-3 to Omega-6 consumption was roughly 1:1, my total cholesterol had dropped to the mid-140s. After listening to a bunch of lectures and reading studies, I took an Omega test and my score was sort of low, so I tried supplementing, but my cholesterol went up. I stopped Omega-3 supplementation for a while because of it, and it leveled off. So, I kept hearing about the great benefits of Omega-3 supplementation on shows like Atta's and Rhonda Patrick's, and decided to try again, And like clockwork, my total cholesterol goes up as does my LDL-C, and they are dose dependent, apparently. Supplementing with 900mg of Omega-3s: C-Total: 185 mg/dl HDL-C: 66 mg/dl LDL-C: 109 mg/dl VLD-C: 10 mg/dl Apo B: 82 mg/dl Lipoprotein(a): 75 nmol/L 450mg of Omega-3s: C-Total: 164 mg/dl HDL-C: 65 mg/dl LDL-C: 90 mg/dl VLD-C: 9 mg/dl Apo B: 76 mg/dl Lipoprotein(a): 39 nmol/L No supplementation with Omega-3s: C-Total: 138 mg/dl HDL-C: 63 mg/dl LDL-C: 69 mg/dl VLD-C: 6 mg/dl Apo B: 64 mg/dl Lipoprotein(a): 21.8 nmol/L The Lipoprotein(a) is the weirdest, as everything I read is that it is relatively stable through one's lifetime and needs to be tested only once. Apparently not, in this case. For what it's worth, my doctor claims that he sees variations, so maybe I am misreading something. I have started questioning the methodology of the studies, as I have noticed that those interviewed are generally connected with the industry, either involved in selling supplements, or promoting tests by entities they have interest in. Then there is the Levels type company consultant or employee, who pushes the high fat diet because that's what keeps the CGMs at a flatline and the subscriptions going. It's an experiment involving a single subject, of course, and I may just be weird. Or wrong. But in any case, I am done with Omega-3 supplements.

This is w seriously useful post, Brian! Thanks! I just checked my dog's medications and the price difference is staggering! My hat off to Cuban for doing this.

Albumin transfusions are common and often life-saving, but I am not sure about the long term effects, and would exercise great caution before there is better human data and in healthy subjects.

Of course, this kind of thinking makes many all warm and fuzzy, until one reflects that the industrial revolution and maximizing profits were instrumental in providing the technology and the funds to have cleaner water, scientific, technological and health advances, enabled the population explosion (responsible for most of the environmental impact), and the lifting of billions out of poverty. And, maximising of profits has driven a rapid, unseen hereto increase in the average human lifespan. And yes, the primary focus on aging research is also for profits.

Can you point to how you can tell? A quick search finds the study, but I can't get access easily, and I have not seen anything about taking age into account. A correlation may emerge for a variety of reasons, from age to socio-economic status and overall health status in specific areas. After all, a while back this paper from Germany claimed higher death rates in areas with higher vaccination areas. Of course, it got no headlines or discussion in the mainstream media, and it was censored. The only way one would have heard about it was from attacks on it -- it reminds me of the way we find out of contemporaneous criticism of early Christianity, through the works of Christian apologists attacking books burned long ago and thus forever lost to history. Of course, regardless of the validity of the stats, the main point is that the state should not be allowed to mandate vaccination with what are in fact experimental and non-sterilizing vaccines, and coerce compliance. And please stop calling those who disagree with you "anti-vaxers." People make choices for a variety of reasons, and if someone has reservations about a particular vaccine does not mean that they are against all vaccines. It's akin to the "newspeak" employed by all fascist/communist movements (it's why "liberal" has a different meaning in the US than in the rest of the world).

I mentioned elsewhere my experience. It was what I imagine is deep, profound meditation. I don't meditate purposefully and never have. Shrooms placed me in a deeply introspective state, an exploration of myself of sorts. Speaking of drugs, I've pretty much stopped drinking (my health tracker lights up in a bad way every time I do, showing lower HRV, higher stress, higher RHR, higher stress, even after a single glass of wine...)