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Mike41

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  1. Mike41

    Keepin' the carbs LOW!

    Michael Rae was not so concerned about gluten but WGA and lectins as mentioned above. I do recall that he believed extensive cooking of whole grains adequately could reduce these concerns. AFAIK the concerns here are primarily of wheat, barley and rye. Oats and quinoa appear to be more benign. see this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705319/#__sec13title 7. Conclusion In the present review, we describe how the daily consumption of wheat products and other related cereal grains could contribute to the manifestation of chronic inflammation and autoimmune diseases. Both in vitro and in vivo studies demonstrate that gliadin and WGA can both increase intestinal permeability and activate the immune system. The effects of gliadin on intestinal permeability and the immune system have also been confirmed in humans. Other cereal grains containing related prolamins and lectins have not been so extensively studied and, therefore, more research investigating their impact on intestinal permeability and inflammation is required. It would be interesting to further elucidate the role of other prolamins on zonulin release and intestinal permeability. In CD and gluten-sensitive individuals, adverse reactions to the intake of wheat, rye and barley are clinically apparent; however, it is important to gain better insights on the effects of the consumption of these cereal grains in other groups of patients and in healthy individuals. It would be of high interest to investigate the effects of the withdrawal of cereal grain products from the diet on inflammatory markers and intestinal permeability in healthy subjects and patients suffering from inflammation-related diseases and measure the same parameters in a rechallenge trial. Ideally, in such an intervention study, the diet must be completely controlled and combined with the appropriate substitution of foods in the cereal grain-deprived diet so that small dietary variations and alterations in energy intake can be avoided and cannot potentially influence inflammatory markers. Until now, human epidemiological and intervention studies investigating the health effects of whole grain intake were confounded by other dietary and lifestyle factors and, therefore, well-designed intervention studies investigating the effects of cereal grains and their individual components on intestinal permeability and inflammation are warranted
  2. Mike41

    Keepin' the carbs LOW!

    Our own Michael Rae is on record supporting some of the positions that Dr. Breseden expresses above in Todd’s post. That has always made me a bit suspicious of some whole grains. The Irritating effects are certainly there in the case of celiac. Could it be that many of us have some vulnerabilities
  3. Mike41

    Problems with Olive Oil

    --Dean --------- [1] Circulation. 2019;139:2422–2436 Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality An Individual-Level Pooled Analysis of 30 Cohort Studies Matti Marklund, Jason H.Y. Wu, Fumiaki Imamura, Liana C. Del Gobbo, Amanda Fretts, Janette de Goede, Peilin Shi, Nathan Tintle, Maria Wennberg, Stella Aslibekyan, Tzu-An Chen, Marcia C. de Oliveira Otto, Yoichiro Hirakawa, … See all authors Originally published11 Apr 2019 https://doi.org/10.1161/CIRCULATIONAHA.118.038908 Abstract Background: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. Methods: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance–weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). Results: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15 198 incident cardiovascular events occurred among 68 659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88–0.99), 0.78 (0.70–0.85), and 0.88 (0.79–0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88–1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86–0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. Conclusions: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention. ----- [2] Omega-6 Fatty Acids and Cardiovascular Disease Are We Getting Closer to the Truth? Thomas A.B. Sanders Originally published20 May 2019 https://doi.org/10.1161/CIRCULATIONAHA.119.040331 Circulation. 2019;139:2437–2439 Thanks Dean! Based on this one could choose walnuts as a preferred source of healthy fats. Also it is a whole unprocessed food and loaded with polyphenol and nutrition and Fibre unlike olive oil. Also Taste better
  4. Mike41

    Keepin' the carbs LOW!

    True, but I don’t think he recommends this for people in general just to be clear. It is an intervention for a serious condition.
  5. No, but I cited many articles and I can cite more on top of them. Many of those guys had no vested interest. Also, I could object if vegan authors write something on the benefits of vegan diets. That can be seen as a bias and it is, money-related or agenda-related. The same is true about carnivorous authors, keto-authors like Dom D'Agostino, and so on. This is another deep rabbit hole. My bottom line is that nutritional science is almost hopeless. It's largely based on degrees of belief. Barring a few exceptions.That is why I'm not so much concerned presently on literature. I follow my own system of belief, based on many factors, including literature, but assigning it a variable weight broccoli, kale, lentils, chickpeas have not seen any industry funding for those! https://www.foodpolitics.com/tag/sponsored-research/
  6. J Am Coll Nutr. 2016 Nov-Dec;35(8):717-731. Epub 2016 Jun 22.The Potential Role of Yogurt in Weight Management and Prevention of Type 2 Diabetes.Panahi S1, Tremblay A1,2.Author information Angelo Tremblay serves on the Yogurt in Nutrition Initiative for Health Advisory Board for Danone Institute International and on the board of the Danone Institute of Canada. His research has been funded, in part, by Dairy Farmers of Canada, the Dairy Research Institute of the United States, Wyeth Consumer Healthcare, and Nestlé. Need I say more?
  7. We humans are quite arrogant about our science and smartness. But we live in a mysterious universe and we ain’t anywhere near understanding it! Biology is know known to have quantum effects like tunneling which is too damn bizarre and logic defying for any one to understand cause no one understands quantum physics. NO ONE! https://www.nytimes.com/2019/09/07/opinion/sunday/quantum-physics.html?referringSource=articleShare “I think I can safely say that nobody really understands quantum mechanics,” observed the physicist and Nobel laureate Richard Feynman https://youtube.com/watch?v=Bjh9n2Cw0TY&feature=share
  8. Totally agree. It’s a risk factor for some and not for others. Some people are virtually immune from developing CAD and would not benefit from extreme lowering, whereas people who already have it clearly do benefit form very low levels
  9. Interesting because two of the most respected members seem to be in a disagreement on this very fundamental dietary issue FAT!
  10. Low fat diets do generally raise triglycerides and lower HDL levels, but if the they are WFPB diets and very low fat that can have a profound ldl lowering effect. As for lipids it’s a mixed bag and not sure what to make of it. Ornish and Esseltyne have both claimed hdl is lower. They describe it as needing less garbage trucks in the case of HDL Not everything that raises HDL is good for you. For example, if you increase the amount of fat and cholesterol in your diet (e.g., an Atkins diet), you may increase your HDL, because your body is trying to get rid of the extra “garbage” (fat and cholesterol) by increasing the number of available garbage trucks (HDL), if you are genetically able to do so. Eating a stick of butter will raise HDL in those who are able to do so, but that does not mean that butter is good for your heart. It isn’t
  11. Mike41

    Olive oil? Healthy or not?!

    That depends. Also high fat is a definition that needs to be defined and that is a controversy in itself.
  12. Mike41

    Olive oil? Healthy or not?!

    But now with your own submission we have more evidence that high fat diets may increase insulin resistance so the gamble appears to be shifting wouldn’t you say?
  13. Thanks McCoy for this interesting hypothesis. It appears to be Another plus for a high whole food carb low fat diet. Considering this emerging concept coupled with the whole TMAO situation where we see animal based foods increasing levels; The Ornish/esseltyne/pritikin studies which were small but still showed significant reversal of CAD appear to have unknowingly been quite consistent with major risk factors like TMAO, insulin resistance, LDL, plant polyphenols etc. I could also mention THE CHINA STUDY slammed here years ago when I posted it, but it was certainly on the right page it appears more and more as time goes on.
  14. Mike41

    Exercise not too much!

    Kenneth Cooper founder of the Cooper institute and so called father of aerobics and who trained astronauts for NASA has said for decades that exercise is a two edged sword. He long ago also said jogging more than 15 -20miles a week is not a good idea for non athletes. And the only reason it may be a good idea for athletes is about performance not long term health. https://www.cooperinstitute.org/2015/06/how-much-of-a-good-thing-is-too-much/
  15. https://pubmed.ncbi.nlm.nih.gov/33284677/ falls in older folks and vitamin d. Have to wonder how well they controlled for confounder. Sicker people more likely to take supplements ?
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