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  1. yes interesting read even if your not interested in the particular drug, but are interested in how science is so often skewed! it may very well be that statins are effective not so much for lowering cholesterol but for other effects https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832 4.4. Conclusions ClinicalTrials.gov is an important open source that reports trial results in a structured way and enables the inclusion of unpublished data in reviews. Our review did not yield evidence that PCSK9 inhibitors decreased the risk of individual targeted and unintended serious diseases. However, in the clinical outcomes studies, alirocumab decreased the risk of all-cause serious morbidity but not of all-cause mortality, whereas evolocumab did not affect the risk of all-cause serious morbidity but probably increased the risk of death. Differences in numbers of events in articles and on ClinicalTrials.gov deserve more attention. Preventive therapies require elaborate safety analysis before massive use. Regulatory agencies had a special interest in new-onset DM and neurocognitive disorders when reviewing PCSK9 inhibitors. Systematic reviews based on articles about PCSK9 inhibitor trials found no increased risk for these conditions. In addition, no differences in all-cause serious adverse events (SAE) and all-cause mortality between intervention and control groups were found. Hence, alirocumab and evolocumab were considered to be safe and found their way to the market and international treatment guidelines [73,74]. The published results of two large clinical outcomes trials later confirmed the safety profile. Although our review based on ClinicalTrials.gov data confirmed the initial findings for new-onset DM, neurocognitive events, and all-cause SAE for evolocumab and alirocumab, we found an increased risk of all-cause mortality for evolocumab. ClinicalTrials.gov reported the number of deaths for 3.0 years of follow-up of the FOURIER-trial while the article reported deaths until 2.2 years of follow-up. The number needed to harm was 213. For a preventive therapy, this reflects an unacceptable lack of safety, which questions whether evolocumab should be recalled from the market. In addition to being safe, preventive medications should also have unambiguous health benefits. Several systematic reviews based on composite outcome data from articles reported a reduction in the risk of cardiovascular events. Therefore, PCSK9 inhibitors are considered to be effective in improving cardiovascular health. In contrast to trial results reported in articles, trial results registered on ClinicalTrials.gov enable an analysis of individual cardiovascular events. The attending physicians of the trial participants need to record all SAE including (potentially fatal) targeted cardiovascular diseases and (potentially fatal) non-cardiovascular events. The disorders are coded according to the regularly updated, clinically validated dictionary for medical terminology MedDRA, which is imposed by regulatory authorities for use in pharmaceutical trials. We found that PCSK9 inhibitors did not reduce the risk of myocardial infarction, stroke/TIA, and heart failure.
  2. Thank you Dean for your input. It is unfortunate that the data is scarce as far as any long term clinical trials
  3. Dean I would love to hear your take in general on the low fat heart disease reversal hypothesis that is supported by Ornish, pritikin group and Dr. esseltyne etc. assuming of course that you have pondered this. Bottom line are fat sources like walnuts a heart healthy plus in your opinion which would contradict the likes of Dean Ornish etc. who insist low fat, 10-15% fat are indeed powerful medicine for reversal of coronary disease including limiting so called heart healthy fats.
  4. Oats and diet in my case are totally useless. My ldl is 100 even with 40 mg of Crestor the highest dose of the most potent statin. Anyway thanks for keeping us updated and I ordered your recommended product
  5. Hi Dean thanks for this information. BTW how long is your wife going to take this before she gets tested for ldl? If it’s anything like a statin it should work quickly.
  6. Mike41

    Random Lectures and talks you liked

    Fascinating stuff. Another very interesting link with the major killers and causes of morbidity in the world.
  7. https://www.sciencedaily.com/releases/2016/06/160627095006.htm is ldl really a problem when it’s high?? https://www.hopkinsmedicine.org/health/conditions-and-diseases/high-cholesterol/older-adults-and-high-cholesterol-what-you-need-to-know
  8. Mike41

    Sci Fi Movie and Book Recommendations

    Dean have you read aldous huxley’s “The Doors of Perception “? https://en.wikipedia.org/wiki/The_Doors_of_Perception the link is regarding that and explores the topic in general. I think penfield and wilders research along with scores of genius’s from Plato ,the cave allegory, on certainly indicate that we see a very thin slice of reality. We are basically the blind leading the blind IMO.
  9. Some are saying this animal to human transmission is just one more reason to go vegan. They claim animal farming etc. increases the probability of this sort of pandemic
  10. BOO! Conspiracy theories aside, if you want polyphenols they are quite available in whole plant foods and you’ll save yourself a lot of calories.
  11. Mike41

    ALS, Exercise and Genetics

    My take on exercise is keep it simple. Hunter gatherer simple. Be active and avoid extremes!
  12. Exactly! Oil is refined food. It’s sugar basically healthwise!!! I’m so tired of the olive oil bullshit! The endothelial function, the diabetic connection etc.
  13. My mother is 92, never had heart issues or dementia. Her only problem is bad knees. She only takes blood pressure meds. Her cholesterol has Been around 250 ish for decades and she refused to take statins decades ago. She never drank or smoked. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367420/ based on the above massive study total cholesterol levels between 210-249 were best. In conclusion, U-curve relationships between TC and mortality were found, regardless of sex and age. TC ranges associated with the lowest mortality were 210–249 mg/dL in each sex-age subgroup, except for the youngest groups of men, aged 18–34 years (180–219 mg/dL), and women aged 18–34 years (160–199 mg/dL) and 35–44 years (180–219 mg/dL). Inverse associations in the range <200 mg/dL were more than 3-fold stronger than positive associations for cholesterol levels ≥200 mg/dL, except for the youngest adults. Positive associations in the upper TC range were strongest for youngest adults and weakened with advancing age. TC levels <200 mg/dL may not necessarily be a sign of good health. Identification and proper management of diseases associated with lower TC levels might improve survival.
  14. Share HealthyHey Nutrition Amla Extract 50:1 - Equivalent to 25g Amla Powder - Natural Vitamin C - 500mg - 60 Veg. Capsules Dean Are extracts equivalent to the dried powders. The above product claims quite a difference. If the extract in the study was similiar you would need 50 gms of powder!!