Mike Lustgarten

Thanks Ron. There's also this study, "The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice": https://insight.jci.org/articles/view/127647 Yes, the young group had relatively high hs-CRP. ng/ml = mg/L, and the young group's 2.4 is definitely high for a young group. Also, the young group may not have been as metabolically healthy as possible, based on their HOMA-IR values, as you mentioned.

For men, [an HDL-c of] 50 - 59 seems to be optimal in terms of maximally reduced risk of death for all causes, with significantly increased mortality risk above 60. That data is in ~19 million subjects, see:

A new study for how HDL changes during aging and associations with all-cause mortality risk in 15.8 million people was published in Dec 2020, which is now updated in a new HDL video:

Ha, thanks Ron. I've read that low protein can impact albumin (and have heard it anecdotally, too), but in my data, protein intake isn't significantly correlated with albumin (r=0.18, p=0.37, n=28 blood tests since 2015). If albumin is low on CR, that's going in the wrong direction, as it decreases during aging and relatively lower levels are associated with an increased mortality risk. So I'd figure out within CR how to increase it, whether it's more carotenoids, protein, or something else.

Yep Clinton, and thanks drewab! I have elevated IgE to many legumes, and GI issues as a result, including bloating and pain. I wish that weren't true, though!

Since April 2015 (I've tracked diet every day since then), 8900mg/day.

That's what I thought, but my data suggests the opposite may be true for me-higher salt-->higher HDL-->lower hs-CRP. I'm going to monitor my BP, and keep tracking everything else, to make sure I don't optimize 1 variable while messing up others.

Most people aren't deficient in B12. In contrast, most don't eat green vegetables, and may have suboptimal Vitamin K1 intakes, which may limit health and lifespan:

5 minutes/d of strength training is better than 0 minutes/day. It's a small commitment with huge benefits