Mike Lustgarten

In an earlier video, I presented data for apigenin's ability to increase levels of NAD+. In addition to apigenin's impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link, NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT... https://www.youtube.com/watch?v=iTYZN7xS3OY&feature=youtu.be Paper links: Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7: https://pubmed.ncbi.nlm.nih.gov/29108... Apigenin Ameliorates the Obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice: https://onlinelibrary.wiley.com/doi/a... Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice: https://pubmed.ncbi.nlm.nih.gov/32857...

No worries Ron, I understand. Have you measured your biological age using Levine's tool? Also, your fiber intake is great, but I shoot for higher Vitamin K (>1500 mcg/d) and C (> 1000 mg/d). Have you tried mixing cacao with Medjool dates? I make my homemade chocolate like that, it's delicious!

Which foods affect biomarkers is likely individual-for you, cutting fat intake seems to be better, at least for CRP. For me, as you saw in the video, the opposite seems to be true, which is interesting because I'd been mostly low-fat (~15% cals from fat or less) for most of my life.

Discussed in the video: What's my biological age on blood test #6 in 2020? What's my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake, cardiovascular fitness (RHR, HRV), and diet composition with my biological age?

-Not true: few (not most!) of the centenarians from Nir Barzilai's studies have HDL > 100,. Average HDL for female and male centenarians was HDL 52 and 48, respectively: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087084/

Even better than associations for LDL or LDL particle size is a coronary artery calcium score, which will tell you how much calcification that you have. Getting that done is on my list for 2021.

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.

I think the data is clear that if you have CVD, lower LDL is then better, which explains the AHA's position. But for the rest of the population that doesn't have CVD? Low LDL in that case may be problematic, at least based on the evidence in the video.

LDL is arguably the most debated biomarker in terms of what's optimal for health. In the video, I present data showing that 100 - 140, not 50 - 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.

That's great, Ron!

White blood cells (WBCs) comprise many different cell types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Neutrophils, lymphocytes, and monocytes account for ~99% of WBCs, and accordingly, in the video I propose optimal ranges for these cell types in terms of health and longevity.

Thanks Iporuru, we agree to disagree for this, I prefer to prepare everything and then record off the top of my head, which is authentic. I'm not a fan of videos or presentations where people read from a script.

Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 - 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y - 115yr olds that additionally suggests HDL in the 55 - 60 mg/dL range as optimal. In addition, I show my own HDL data over the past 15 years (n=34), the correlation for HDL with my diet, and how I plan on consistently increasing my 15-year average HDL of ~44 mg/dL to the 50's.

Sorry to hear that, @Iporuru!