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I wonder if any of you guys has been listening to this episode of Peter Attia's drive. I've listened it twice and there are a few interesting concepts expounded there, when and how leucine triggers mTor in muscles, for how long, what's the best distribution of protein and with what quantities according to Layman's muscle-centric model. The DIAAS score, the 3 governing EAAS (Leucine, Lysine, Methionine), the underestimation of nitrogen requirement by the nitrogen-balance studies (Randd's model adopted as the official RDA) and the ideal 1.6 g/kg/d quantity of protein which is twice the adopted RDA. The effect of plant-based protein and the low absorption degree of some of them, like whey protein. The invalidation of the metabolic window concept for people who have been training after 6 months. The need of more protein adequately distributed for non-young individuals and more. I already knew Don Layman and especially the fact that his studies have been financed by the big protein corporation, but at 1:55 he explains why he had to fall back on this kind of financing. In this episode, we discuss: 0:00:00 - Intro 0:00:08 - Don’s background: from growing up on a farm to studying nutritional biochemistry 0:04:39 - Don’s philosophy on nutrition, muscle, and metabolism 0:18:10 - The controversial relationship between saturated fat and atherosclerosis 0:26:30 - The basics of protein and amino acids 0:33:46 - Origin and limitations of the current recommended dietary allowance (RDA) for protein intake 0:43:44 - Protein sources: determining quality, absorption rates, and how to track intake 0:51:35 - Leucine, lysine, and methionine: three important essential amino acids 0:57:35 - The vital role of ruminant animals in the production of quality protein 1:04:55 - The differing needs and impacts of dietary protein for a 16-year old compared to a 65-year old 1:12:50 - Consequences of protein deficiency in childhood 1:19:50 - Muscle protein synthesis: ideal timing, small meals vs. big meals, and more 1:27:51 - Protein needs of children 1:33:07 - How important is timing protein intake around training? 1:37:27 - The role of leucine in fatty acid oxidation by muscle 1:41:07 - High protein diets for fat loss: Results from Don’s clinical trials 1:55:24 - Influence of industry funding on nutrition studies 2:01:26 - Don’s thoughts on plant-based and synthetic “meats” 2:10:05 - Problems with epidemiological studies of dietary protein

Hi, I've gone on a calorie restriction diet because I've been diagnosed with a tongue cancer, I've been on a calorie restriction diet for 11 days today, and am at around 800 calories a day at the moment. I've read and heard that the lower the protein the better potential to halt cancer progressing. The only problem is that I am only 111lb weight 5ft 9" male and don't want to lose any more weight. I'm on a 2:1 fat to protein (in grams) zero carb ketogenic diet. It's said that 0.6g protein per kg is the least amount I could eat a day for my weight (that would be 30g), but some sources say that the protein amount is actually calculated for the average healthy weight you should be for your height, so that would mean 30g a day would be far too low? the charts give my lowest healthy weight at 128lb, so for 0.6g protein per kg this would be = 35g protein as the lowest I could go? Any thoughts?

Hi all! First of all, I am a strict ethical vegan, so please might I ask you to take that into consideration in any dietary advice you might elect to offer me in response to this post. Just to be clear, that means I will not, for ethical reasons, consume any animal products, no products manufactured or harvested with slave labor or other forms of manifest exploitation, and no products that are known to cause widescale ecological devastation (date palm oil, avocados, etc.). It makes things a tad challenging, but I find that part of feeling good means not knowingly doing evil stuff with respect to my caloric intake. I make no judgments about what other folks choose to consume. Thanks awfully for your consideration! <3 First time poster but have been doing CR for about 3 months now and am happy to say I've lost 35 pounds. I have a bunch more to lose to get down to a <21 BMI, but I'm making good progress at around 2 pounds per week (which is, as of this writing, the upward limit of what is a safe, sustainable pace based on my best understanding from reading several CR books both old and new). I'm currently working through Dr. Fontana's book "Path to Longevity" and he brings up the issue of protein consumption. He has several different bits of data about it: first he says that the FDA recommends 0.6g/kg of body weight or more to avoid deficiency. Then he says 0.83g/kg of body weight is what is optimal and sufficient for most people based on a European study and he indicates that this is what centenarian Okinawans typically eat. He then says later on that an optimal ratio of 1:10 for protein to carbs is best for longevity in a variety of mammals and suggested that Okinawans were eating about 9% of their calories from protein. So all of this leads me to do maths to see where I'm at. I'm using the CRONometer app and I"m using the macronutrient ratios of 24.5% protein to 43.5% net carb to 32% fat. I modified that slightly off of a post my partner showed me from CR Society, I think from one of Dean's dissertations/treatise which indicated that the aggregate mean ratios were something around that among CR Society folks polled. I tweaked the numbers slightly to get the total grams of protein required per day to display 1 gram per kilogram of my CURRENT weight. I am currently at 317.6 pounds which, at 38 years old and 6'4", is much too much for longevity and risk of disease and what have you, so I'm continuing to lose steadily. My goal weight is about 156-160 pounds which lands me at around 19-19.5 BMI or so. So what I'm wondering is: should I be looking to eat 0.83grams of protein per kilogram of my GOAL weight of 160pounds which is about 72.5kg and therefore about 60.2g of protein per day (which is handy because it's about 30g per meal since I only eat two meals a day and that's about the upper limit of what the human metabolism can usefully extract from a single meal, at least according to the references that Dr. Fontana cites). OR, should I instead be eating 0.83 grams per kilogram of my current weight of 317.6 pounds which is about 119.5g of protein? I know too much protein leads to oxidative stress, inflammation, and susceptibility to a host of diseases. I know too little leads to muscle wasting and metabolic insufficiencies. At around 120g of protein and only eating 2 meals a day, I would have to get about 60g per meal or have 30g per meal and two snacks where somehow I get an additional 30g per snack and do not get much else in the way of calories (not easy to do), and the difficulty of doing that strikes me as a likely indicator that it's too much protein. However, I do not want to make assumptions about this and go to lower protein and find that I become ill. I should note that in order to lose 2 pounds per week, I am eating at a 998 kcal deficit per day (some days a bit more if I just don't feel hungry and have less than or equal to about 150kcal left for the day). Typically I'll go a few days where I only lose 0.2 pounds or so, then have a day where I suddenly drop 1.5-2 pounds. I have at no point felt ill or weak or faint other than the first 2 or 3 days of CR where I think I was adjusting to the lower calorie intake. I think the removal of nearly 1k kcal from my diet makes the protein percentage be much higher (~25%) of my diet than if I were eating maintenance-levels of protein, in which case it would be closer to the 10%-ish level Fontana describes. Anyway, that's my question and the context in which it's being asked. Thank you for any insight you can share!