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drewab posted a topic in Chitchathttps://nutritionfacts.org/video/coconut-water-and-depression/ Here is Dr. Greger's latest video in the world of nutritional science. Don't let the name 'Coconut Water and Depression' mislead you. Watching a video like this is profoundly disturbing on so many levels. Misallocation of research funds, animal abuse, misreporting of research, and much more. Take a look, but first a warning, you may find it disturbing.
Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona. Dr. Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.
Depression sucks. It's about the worst thing that can happen to otherwise sweet charming talented lovely people. It wrecks lives. It ruins relationships. It kills careers. Unless you've been there -- stuck with it -- you really don't know what it's like. Day in, day out we sad shits who grovel in deep depression often feel little desire to get out of bed and face another damned cold blue lit day. Maybe you know someone. Or you're there, too. Depression, that is, for no reason. No tragedy happened to cause this. Just -- the disease. Current drugs do not work. They zombify you alright, and they poke out the eyes of your libido and make your hair fall out and your steps dizzy and drugs turn your stomach to shit. But they don't stop the pain. They're placebo, and most were pushed by pharma dollar companies based on flimsy, crappy studies. More lies of capitalists. Negative study outcomes are suppressed, squashed, left unpublished if they don't support the stock values or whatever the fuck. The message to depressed people is to take to our stupid drugs, ye losers, and take some expensive longterm CBT while you're at it. Yeah. While new drug therapies appear promising, these new drug promises are similar to the old drug promises: "Meet the new boss/ Same as the old boss." And so we're titilated with the slow drip drop of "advancing" modern medicine. New drugs coming soon for depression! Oh, maybe "in five years" the mantra echoes off. Hence we see very sick, deeply suffering, desperate, often suicidal human beings doing their best and trying nearly anything to find relief. You know the story. It's a long, slow, life-sapping battle, and most artists and performers I know -- many many of whom are very depressed people -- would trade even their precious arts for lasting relief. But maybe, we hope once again, we needn't trade away our talents for more expensive body-numbing fakes. Anyway, here's a novel idea using virtual reality. Looks nice: http://bjpo.rcpsych.org/content/2/1/74 It's kind of a role playing idea. From Futurism: "The virtual therapy session is divided into two parts. First, patients see through a perspective of an adult avatar, or what is termed as “embodiment.” They’re next asked to comfort a crying child with expressions of compassion whether through words or gestures. The child will then respond positively to the compassion showed by their avatar and stop crying. "Then, the scenario gets reversed. Patients now embody the crying child being consoled by an adult avatar in the first part of the session. As the child, the compassionate words or gestures that they expressed at the beginning of the therapy as adult avatars will be played back to them. This then makes them feel less self-critical, which is very common among people who suffer from anxiety and depression."
All, Dr. Greger had another fascinating video out today on the link between inflammation and depression, and why an anti-inflammatory diet might be effective for treating depression. Apparently, it has long been known that systemic inflammation and depression are pretty highly correlated. And apparently, based on several studies cited in the video, you can induce depression in people by increasing the inflammation level in their bodies. Researchers have made an argument for why evolution might have set it up this way. Throughout our evolutionary history, systemic inflammation has been almost exclusively associated with infections of some sort, many of which are contagious. When we develop an infection, and our body responds with an inflammatory response, it would have been 'good' for our kin (and therefore our genes, which they share), if we felt crappy, and all we wanted to do is curl up in a corner and avoid contact with other people - in order not to infect them. So, the evolutionary theorists say, we developed a mechanism by which systemic inflammation triggers a depressed mood. Fast forward to today. We've pretty much defeated pathogenic infections, but still feel like curling up and dying when we get an infection - not much we can do about that. But in addition, despite few pathogenic infections, the bodies of most people are still inflamed continuously these days, largely as a result of the crappy diet most people eat. So the same depressive response to inflammation that used to provide a survival advantage, now simply makes us depressed, as a result of the food we're eating. Not surprisingly, Dr. Greger goes on to advocate an anti-inflammatory diet centered around whole plant foods. He says meats in general, and even fatty fish, are proinflammatory for a variety of reasons, including endotoxins. He says that may be why the early hopes for fish and fish oil as a treatment for depression haven't seemed to pan out in larger studies. I thought the most interesting graphs in the whole video are shown below, taken from . In this study, researchers injected into human subjects an endotoxin derived from E. Coli, and then measured both their blood markers of inflammation and their mood over the next few hours. As their bodies mounted an inflammatory response to the endotoxin (as indicated by the IL-6 and TNF-a markers of inflammation), subjects reported a depressed mood. As the inflammation subsided, so did the depressed mood. The correlation between the inflammation and the depressed mood was high, and wasn't observed in the subjects injected with a placebo. I thought it was a really thought provoking video, and a reasonable explanation for the mystery of why depression might have evolved and persisted in our highly social species. Maybe the fact that CR practitioners generally eat a highly anti-inflammatory diet, and have low levels of inflammation as measured by blood tests like C-reactive protein (CRP), may explain why, after the initial weight loss period when toxins may be released from the fat we're losing, triggering inflammation and therefore depressed mood, CR practitioners generally report being in very good moods - quite in contrast to the expectation most people have that CR would make you permanently irritable. Finally, I don't want to oversimplify true clinical depression - which is an incredibly complex and debilitating condition. The kind of "depression" Dr. Greger is talking about in this video and that may be associated with chronic inflammation might be better characterized as "depressed mood", as opposed to true clinical depression. For more info on some of the complexities of clinical depression, including its genetic component, check out this short video on the science of depression. --Dean ------------  Brain Behav Immun. 2010 May;24(4):558-63. doi: 10.1016/j.bbi.2009.12.009. Epub 2010 Jan 4. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Eisenberger NI(1), Inagaki TK, Mashal NM, Irwin MR. Free full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856755/ Although research has established links between feelings of social isolation and inflammation, the direction of these effects is unclear. Based on the role that proinflammatory cytokines play in initiating "sickness behavior," which includes symptoms such as social withdrawal, it is possible that inflammatory processes heighten feelings of 'social disconnection.' Here, we examined whether exposure to an inflammatory challenge increased self-reported feelings of social disconnection. In addition, because both inflammatory processes and feelings of social disconnection contribute to depressive symptoms, we also explored whether increases in feelings of social disconnection played a role in the link between inflammation and depressed mood. Participants were randomly assigned to either receive endotoxin, an inflammatory challenge, or placebo. Proinflammatory cytokines (IL-6, TNF-alpha) were collected at baseline and then hourly for 6h. Participants completed self-reports of sickness symptoms ("fatigue"), social disconnection ("I feel disconnected from others"), and depressed mood ("unhappy") hourly. Results revealed that endotoxin led to significant increases (from baseline) in IL-6 and TNF-alpha levels as well as feelings of social disconnection and depressed mood. Moreover, controlling for increases in social disconnection eliminated the relationship between exposure to inflammatory challenge and depressed mood. This study demonstrates that inflammation can have social psychological consequences, which may play a role in cytokine-related depressive symptoms. Copyright 2009 Elsevier Inc. All rights reserved. PMCID: PMC2856755 PMID: 20043983