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Showing results for tags 'Hormesis'.
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Tonight I was hacking potatoes to cook'em in the oven and I noticed that they were very green, on the outside and a little in teh inside as well. I always cook potatoes with the skin. It occurred to me that somewhere I read green potatoes may be toxic because of an high concentration of solanin, as belied by the high concentration of green clorophyll. Now, if you guys read the wiki voice for solanine, it's apparent that it is a natural pesticide produced by the plant, a toxin. We know that these defensive plant-produced chemicals display an hormetic behaviour, that is, at low enough doses they trigger beneficial reaction in the human body. Now, when I think 'hormetic', then I must have it. Let's say I collect hormetic foods. I already threw away the diced green potatoes because they were meant to be my son's breakfast for tomorrow. But I'm going to keep the bag, cooking half a green potato twice a week with all the skin and enjoying the hormetic properties of solanine. In the past I remember I tasted some very bitter green potatoes, cooked in the oven with their skin. I cannot recall toxic effects,l not even mild ones. Probably I'm accustomed to plant-derived toxins after 40 years of vegetarian regimen. Anyhow, I'm determined to take fully advantage of the toxicity of solanine (at hormetic doses). These are some data from http://www.nutritionmyths.com/are-green-potatoes-toxic/ Also, A Review of Important Facts about Potato Glycoalkaloids by Marita Cantwell This means that with my present weight of 66 kg I might experience toxicity symptoms by eating 200 g or less of green potatoes with their skin. One tenth of that is 20 grams and that's probably an hormetic dosage for myself, surely a far higher dose in the past did not cause me toxic symptoms. Toxicity from proper potatoes would not manifest before eating 2 kg of'em. Disclaimer: the hormesis region is not the same for everyone. In particular, some people are very susceptible to poisononing from vegetable toxins, like lectins from beans, gluten from wheat, solanine from potatoes. I do not suggest the above experimentation to anyone without a proper medical supervision, or without a consolidated attunement to the reactions of one's own body. Also, experiments should begin with very low dosages.
There are many factors, which act as stressors on the body, and seem to contribute to improved health outcomes. Some of these include: Exercise Fasting Cold exposure Caloric restriction Heat exposure Particular foods that exert hormetic effects (ie. cruciferous vegetables) Some of the above are not without their controversies, but it's interesting that mild sleep deprivation (a mild stressor) doesn't elicit a hormetic effect. Or perhaps it does? Has anyone else had this curious thought before and unpacked it a little?
As I've indicated many times in the past, one should ignore studies on interventions in aging in nematode worms (C. elegans), fruitflies (Drosophila), and all other non-mammalian species: they age and anti-age too differently to be given any credence until at least translated into mice. One of the most remarkable broad categories of such findings is the remarkable number of "hormetic" interventions reported to increase maximum LS in C. elegans, despite the fact that no such interventions with the pseudo-exception of CR have done so in mice. A remarkable new study turned up in a professional-oriented science news outlet by Al Pater finally gets to the bottom of this: it's not just (as I had assumed) an interspecies difference, but a freakin' experimental artifact! Apparently, researchers performing LS studies in C. elegans routinely dose the animals with low levels of 5-fluorodeoxyuridine (FUdR), a drug usually used in chemotherapy as an alternative to 5-fluorouracil, "a thymidylate synthase (TS) inhibitor. Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidine, which is a nucleoside required for DNA replication." By interfering with cells' ability to replicate their DNA, these drugs drugs work to shut down cancer by preventing them from replicating — and ferocious, unregulated cell replication is the very definition of cancer. Of course, many kinds of normal cells have occasional need to replicate too, which is why you get the awful side-effects of these drugs. Well, apparently (and I assume that my eyeballs must at least have passed over this info on a few occasions, but it never registered — I probably figured "those worm guys know what they're doing"), FUdR is also routinely used at low dose to sterilize the worms and prevent them from laying eggs, both because the new "born" C. elegans mess up their worm counts when they later conduct survival studies, and because reproduction itself reduces the lifespan of C. elegans. This has been thought harmless because FUdR That may be the biggest understatement to appear in a scientific abstract since Watson and Crick's "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material" in their landmark paper proposing the double helical structure of DNA as the structural basis of genetic inheritance (Nature 171: 737-738 (1953)). Even studies in mice don't always translate directly to humans -- look at all the failed cancer drugs that cure the disease in mice -- but they're a much better start. Now we know one more massive reason why. Reference 1: Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22. PubMed PMID: 26854551.
The Latest In Anti-Aging Research: The Power Of The Toxins In Vegetables They talked a lot about calorie restriction - I think more than they discussed the good "toxins in vegetables" (and fruits) http://tinyurl.com/od4myej Questions after show. Much much shorter to read but I did like the (long) show above. http://tinyurl.com/qbvrwhh David