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  1. The email list system is broken. Posts cannot be searched. Many of the posts do not make it to the messages I receive individually and via the daily mailings. Therefore, I am sending this message, comprised of citations papers that seem to be appropriate to the room of the Forum. I will try to also provide full-text links and a very brief excerpt or within brackets my synopsis of the paper. I apologize for the fact some papers discuss results of studies on the overweight or obese, but feel that some benefits seen in such subjects bears on a continuum of benefits accrued by CR and provide incentive to folks who are overweight or obese. Below are today's papers. Altered consolidation of extinction-like inhibitory learning in genotype-specific dysfunctional coping fostered by chronic stress in mice. Campus P, Maiolati M, Orsini C, Cabib S. Behav Brain Res. 2016 Aug 6. pii: S0166-4328(16)30505-8. doi: 10.1016/j.bbr.2016.08.014. [Epub ahead of print] PMID: 27506654 http://linkinghub.elsevier.com.sci-hub.cc/retrieve/pii/S0166432816305058 These findings support the conclusion that an experience of reduced food availability strain-specifically affects persistence of newly acquired passive coping strategies by altering consolidation of extinction-like inhibitory learning. The interaction of fasting, caloric restriction, and diet-induced obesity with 17β-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse. Yang JA, Yasrebi A, Snyder M, Roepke TA. Mol Cell Endocrinol. 2016 Aug 6. pii: S0303-7207(16)30298-2. doi: 10.1016/j.mce.2016.08.008. [Epub ahead of print] PMID: 27507595 http://linkinghub.elsevier.com.sci-hub.cc/retrieve/pii/S0303720716302982 [This paper suggests that steroidal environment and energy state negatively regulate KNDy (Kisspeptin/Neurokinin B/Dynorphin) gene which plays an important role in the https://en.wikipedia.org/wiki/Hypothalamic%E2%80%93pituitary%E2%80%93gonadal_axis] Effects of dietary supplementation with EPA and/or α-lipoic acid on adipose tissue transcriptomic profile of healthy overweight/obese women following a hypocaloric diet. Huerta AE, Prieto-Hontoria PL, Fernández-Galilea M, Escoté X, Martínez JA, Moreno-Aliaga MJ. Biofactors. 2016 Aug 10. doi: 10.1002/biof.1317. [Epub ahead of print] PMID: 27507611 http://sci-hub.cc/doi/10.1002/biof.1317 α-lipoic acid, especially in combination with EPA, upregulated the expression of genes associated with lipid catabolism while downregulated genes involved in lipids storage. Association of the TNF-alpha -308 G/A polymorphisms with metabolic responses secondary to a high protein/low carbohydrate versus a standard hypocaloric diet. De Luis DA, Aller R, Izaola O, Romero E. Nutr Hosp. 2016 Jun 30;33(3):267. doi: 10.20960/nh.267. Spanish. PMID: 27513494 [i have no access to this paper's full texts.] Carriers of -308 GG promoter variant of TNF-alpha gene have a better metabolic response than -308 GA obese with a high protein hypocaloric diet.
  2. Hi CR Society Friends! For my first post here, I'd like to ask our community if anyone has come across published research similar to that which is currently being discussed in the "Fasting for CR Benefits?" topic in this forum. That topic, which I highly recommend, is discussing the University of Wisconsin-Madison study on fasting driving the positive effects of a CR diet in mice. So as to not sidetrack that topic, anyone familiar with studies that, for example, have compared time restricted feeding (TRF) windows (16:8 versus 18:6?), particularly in relation to CR, is more than welcome to discuss them here. One study (Sutton et al., 2018) randomized men with prediabetes into an early TRF (6 hour feeding period, with dinner before 3 p.m.) or a control schedule (12 hour feeding period) and later crossed the groups over to the other schedule. The early TRF significantly improved some aspects of cardiometabolic health (even without any weight loss). My criticism of that study is that there were two (potentially confounding) variables (early versus later eating as well as a 6 versus 12 hour feeding window) that differed in the experimental and control groups. The study begs for a follow-up (which I haven't found) comparing only early versus late TRF. Nonetheless, the results are noteworthy. I'd very much appreciate reading anyone's thoughts or knowledge on such topics. Thanks!
  3. Hi CR society, I was wondering if anyone knew if 5:2 was better than a 10% reduction in consumed calories and if any studies have been done on this. Since I normally eat 2000 calories a day, CR would take me to about 1800 calories, which adds up to 12600 calories a week. However, with 5:2, this would be something like 11,200 calories a week since I'd eat 600 on my fasting days. Thanks for the time you take to answer my inquiry.
  4. I have embarked upon a quest to lengthen my telomeres. Intermittent Fasting is one technique I am utilizing in my effort. The type of Intermittent Fasting I am practicing is water fasts on Tuesdays and Thursdays. Has anyone had their telomeres measured? Does anyone have any input and/or suggestions regarding my objective?
  5. The 5:2 Diet is a form of intermittent fasting popularized by BBC health journalist Dr. Michael Mosley. A documentary and radio interview with him are now available online →
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