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https://www.youtube.com/watch?v=9nuoKbMNCbo&lc=Ugz6FWkNk7mMWATxO9x4AaABAg Papers referenced in the video: Sirtuins, Healthspan, and Longevity in Mammals https://www.sciencedirect.com/science... Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi.nlm.nih.gov/24011... Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi.nlm.nih.gov/17086... Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice https://pubmed.ncbi.nlm.nih.gov/20974... Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer https://www.nature.com/articles/ncomm... Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://pubmed.ncbi.nlm.nih.gov/34050... The sirtuin SIRT6 regulates lifespan in male mice https://pubmed.ncbi.nlm.nih.gov/22367... SIRT6 in Senescence and Aging-Related Cardiovascular Diseases https://pubmed.ncbi.nlm.nih.gov/33855... Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling https://pubmed.ncbi.nlm.nih.gov/26940... Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 https://pubmed.ncbi.nlm.nih.gov/27101... A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes https://pubmed.ncbi.nlm.nih.gov/33920... Acute Exercise Leads to Regulation of Telomere Associated Genes and MicroR A Expression in Immune Cells https://pubmed.ncbi.nlm.nih.gov/24752... The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men https://pubmed.ncbi.nlm.nih.gov/32919...
Dear colleagues, This Spring, as always, there was the annual Conference on Aging at UR. The keynote speaker was Matt Kaeberlein, of the University of Washington. I was particularly interested in attending his talk -- Prof. Kaeberlein spoke at one of the previous CR Society Conferences that I had attended. Matt's talk both surprised and interested me. Matt did not discuss Calorie Restriction -- but he did discuss studies involving the use of rapomycin as an anti-aging drug. He made the point that the side-effects of rapomycin that have been identified are minor (rapomycin is often used as a drug with transplant patients to reduce the likelihood of organ rejection, due to a lowering of the immune response). Dr. Kaeberlein pointed out that studies had not been done on healthy humans; he clearly would support that, but of course the FDA would not approve of such a study without extensive animal studies first. As we know, studies on fruit flies and rodents have shown both (average) lifespan and (possibly more important) healthspan increases. Dr. Kaeberlein has received approval for a study on large pet dogs. (Small dogs live on average much longer than large dogs, which have comparatively short lifespans.) Owners of large pet dogs can voluntarily enter the study -- some dogs will receive rapomycin, some a placebo. Since pet dogs are cared for by their owners, the cost of the study is greatly reduced from what a comparable study might cost if the dogs were in cages on site. After the talk, I asked Dr. Kaeberlein if he believed that CRON and taking rapomycin might work together synergystically. He told me that there were overlaps in the effects of both anti-aging procedures, but they were not identical. As to whether they would work well together, he answered truthfully that he had no idea -- he said that it would be impossible to get grant money to support such a study. I asked Dr. Kaeberlein if he still was on CR. He isn't; he said that he never had been. He "likes his food". 😋 -- Saul