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drewab posted a topic in CR Science & TheoryValter Longo's work has been discussed around here quite frequently as of late, particularly his work on the fasting mimicking diet. In typical Rich Roll fashion, he goes long form and tries to gain deep insight into Longo's understanding of nutrition, longevity, and health. Rich says that he considers it one of his most important conversations to date.
Sorry everyone. It appears Valter Longo has patented intermittent fasting. So you all gotta pay up. Seriously. Pretty crazy. Here is the abstract from the patent, which was just granted last month: Methods and diets for lowering glucose and/or IGF-1 levels US 9237761 B2 ABSTRACT A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and/or IGF-I levels, and/or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake/level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity. I'm no patent attorney, but it would seem like there should be sufficient "prior art" to invalidate this patent. --Dean
Hi everyone, Many people have been asking, both here and elsewhere, about the safety and efficacy of various time-restricted eating schemes. This is of particular interest to me since, for reasons that are irrelevant to most here (an unusual constellation of health challenges), I have been finding conventional CR (=the same, low energy intake per day) unworkable. Before I continue, I should emphasize that the best bet for health and longevity, based on the science we have (which is limited), is indeed conventional CR. But for those who want to try time-restricted eating, I'm wondering about the relative merits of two approaches, and I'd appreciate feedback. I've been thinking this through mostly on my own, and find myself unable to reach a conclusion. Experimental evidence is so limited, I think it's more helpful to reflect a bit on mechanisms, or even evolution. (More helpful doesn't mean very helpful, though....) Type 1: Longo/FMD. The evidence for benefit in both lab animals and humans is limited, but is at least somewhat compelling. It seems unlikely that there's any antiaging benefit per se, beyond that which would have obtained with the same overall ("longish-period averaged") reduction in calories. Type 2: "Inverted FMD". If the Longo approach involves having non-CR signaling patterns (high mTOR, IGF1, insulin, etc.) be the norm, with a sudden several-day period of CR signaling patterns being the exception, "inverted FMD" would be CR, perhaps somewhat mild, as the norm, with a several-day, or week-long period of "feast" signaling. (Credit where credit is due: James Clement is the one who suggested this pattern of eating as possibly better than the Longo pattern.) Type 1 vs. Type 2. Type 2 seems to me to be more like the pattern of eating under which we evolved – scarcity as the norm, with the occasional feast when the tribe came upon a bunch of food – but that doesn't say much about its benefits, though it might suggest that the body would be more adapted to it. Hm.... what we really need is more science on this. Does anyone here know Longo? I've emailed him a couple times and not gotten a response. A small trial comparing the two approaches could be helpful (though only slightly of course, since the main interest of many here is effect on mortality, for which we still don't have great biomarkers). Brian
Hi all, I have enjoyed consuming content on this forum. Thank you to all members who actively post. Please know that many lurk in the background and benefit from the exchange of knowledge. I am about to embark on my first FMD using the Prolon box. I have previously completed water only fasts. I will compare FMD changes in biomarkers to those of other fasting interventions (water, self-hacked FMD, etc.) I was planning to track the enclosed at onset and immediately post FMD, any suggestions on others? IGF FBS Ketones hs-CRP ESR Homocysteine CBC --- Microbial load (uBiome) Organic Acids Test (Great Plains, urine)