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Showing results for tags 'Senescent cells'.
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Michael R posted a topic in CR Science & TheoryAll: Diet quality may play into this, and the fact that the 27.4 ± 2.5 kg/m2 average BMI in the controls includes some significantly overweight people. And it's n-12, and only in the colon, where narrow diet effects might be most strongly observed (note that dietary influences on colorectal and GI cancers are more consistent than other tissues). But it seems pretty good evidence that human CR suppresses SC accumulation rather strongly, consistent with CR's tranlatability.
Anyone jumping up and down yet? http://www.ebiomedicine.com/article/S2352-3964(17)30116-0/fulltext "Cell senescence is increasingly recognized as a major contributor to the loss of health and fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; oxidative phosphorylation efficiency is decreased and reactive oxygen species production is increased. In this review we will discuss how the turnover of mitochondria (a term referred to as mitophagy) is perturbed in senescence contributing to mitochondrial accumulation and Senescence-Associated Mitochondrial Dysfunction (SAMD). We will further explore the subsequent cellular consequences; in particular SAMD appears to be necessary for at least part of the specific Senescence-Associated Secretory Phenotype (SASP) and may be responsible for tissue-level metabolic dysfunction that is associated with aging and obesity. Understanding the complex interplay between these major senescence-associated phenotypes will help to select and improve interventions that prolong healthy life in humans."