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  1. I'm skeptical of their main finding, since every study I've ever seen of the effects of weight loss from reduced energy intake has reported a loss of bone mineral density and evidence of bone resorption, with the differences by protocol being the magnitude of the effect. And intuitively, I'd expect fasting or very-low-calorie days to lead to more bone resorption in the context of net energy deficit than "continuous" energy restriction; here, instead, they report that neither did. And the increase in IGF-1 on "continuous" energy restriction is very surprising and contrary to other reports.