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Found 7 results

  1. A recent interview with Brian Delaney with information on: Benefits of vegan over animal diet regarding mTor Calorie restriction in its various forms mTor considerations with hormone replacement Brian's work and role in the Age Reversal Network
  2. GhostofCircleKnight

    5:2 or daily -10%

    Hi CR society, I was wondering if anyone knew if 5:2 was better than a 10% reduction in consumed calories and if any studies have been done on this. Since I normally eat 2000 calories a day, CR would take me to about 1800 calories, which adds up to 12600 calories a week. However, with 5:2, this would be something like 11,200 calories a week since I'd eat 600 on my fasting days. Thanks for the time you take to answer my inquiry.
  3. Hi! I got interested in calorie restriction diet for health benefits and I'm wondering can I do it long term, even if I'm only 18 years old? Can it effect my growth in any way? Should I wait until I turn 25 because by then I'm fully grown? Thanks in advance!
  4. Not sure this has been posted.. So here's a study of transgenic mice made to overexpress telomerase. In the control mice it seems that this led to more tumors, but CR decreasing it back to levels similar to that of WT controls and WT CR. Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts. These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing “health span” and extending mouse longevity. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053760
  5. sirtuin

    CR / IF + BCAAs (leucine) ?

    I'm curious what the group's opinion is on using supplemental branched chain amino acids (leucine in particular) to limit the catabolic effects that calorie restriction and fasting have on muscle tissue. With intermittent fasting / calorie restriction I believe growth hormone is elevated, which is itself implicated in certain cancers. I believe that the drop in mtor / igf-1 might provide some protection against this in the context of calorie / protein restriction. However, I'm not sure what the effect is when supplementing branched chain amino acids / leucine, which strongly activate mtor/igf-1, over the rise in growth hormone produced with CR / IF. Is supplementing BCAAs / Leucine a smart hack around the catabolic effect of CR / IF on muscle tissue, or does this negate the anti-aging benefits and introduce new risks?
  6. Hi everyone, My name is Caroline Edwards and I am currently writing an e-book on the quest for longevity as a part of my final project at university. In the book, I focus on how and why we age, what we can do to live longer, and what positive and negative impacts an ageing population might have on our society. In the chapter covering posible methods to combat ageing I mention calorie restriction and the science behind it. Therefore, I would love to find an experienced CR dieter from the UK, ideally London, who has been practicing the CR diet for long enough to have felt the benefits. I would like to learn more about how you practice it on a daily basis, how much time your dedicate to it, your motivations behind it, and so on. Is that you? Then I would love to hear from you. Please send me a message in here or send an e-mail to: Carolineedwards@hotmail.dk It would be a very big help for me and my project. Thanks! - Caroline
  7. I recently picked up some Acetyl-L-carnitine (500mg) combined with racemic Alpha Lipoic Acid (150mg), after reading many reports of benefits with energy / memory / mitochondrial function, which seems like a helpful component of an anti-aging strategy. While my body fat % is quite low, I've been eating an ad libitum diet for most of my life, if not a fairly high calorie diet while exercising and lifting weights / gaining muscle. I've been dialing down on my methionine / caloric intake over the past few weeks toward a mild CR diet, and came across this article: Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span: http://www.ncbi.nlm.nih.gov/pubmed/18486188 What are your thoughts on this article? Are there other supplements / foods that nudge genetic expression toward a beneficial CR profile?