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All, At the recent CR conference, Dr Richard Miller from the University of Michigan gave a great talk on the Interventions Testing Program, a NIA-sponsored, rigorous, multi-center effort to investigate the potential of various drugs, supplements and nutriceuticals to extend lifespan in mice. Dr. Miller shared with us some results which have now been published. Here is a good summary of the latest results. It looks like the most promising interventions were metformin+rapamycin, acarbose, and 17-α-estradiol (in males only). I'm not planning on running out to take any of these, but I find acarbose interesting. It works by blocking the breakdown of carbohydrates, and suppressing hunger - in many ways like eating extra dietary fiber (a controversial topic itself) as discussed here on the Dietary Fiber - Health Promoter or Anti-CR Hunger-Suppressor? thread. --Dean