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  1. mccoy

    Weight gaining while on CR

    My present obsession is to gain muscle weight at the same time keeping off the anabolic, anti-longevity signals of IIS and mTOR. Easier said than done. When much younger and a gym rat, I was able to build conspicuos muscle by eating lots of ricotta cheese, rich in anabolic whey proteins, and eggs. Plus natural carbs like honey, fruit and fruit juice. The above of course would irremediably trigger the main metabolic pathways we know are NOT conducive to longevity. Now, after having lost much of the former muscle due to forced inactivity, what I'm trying to do (this is an ongoing experiment) is to upregulate mTORC1 in muscle tissues, simply by supplying them with more protein than the minimum required at rest. So I lift weight at 60-70% my maximum load (maximum liftable weight single repetition), trying to stimulate muscle protein synthesis (MPS). Arguably, this is not the same as stimulating growth and reproduction (which would necessarily thwart longevity). Conceptually, we are stimulating the functional requirements of the body, which adapts itself to environmental demands by growing muscle cells, sequestering the excess proteins (amino acids, especially leucine) before they reach organs and other tissues. The above is what I understand at present. I may be wrong, hopefully not too much. The tricky part is to estimate how much additional protein is needed to allow MPS without upregulating IGF-1 and mTOR in non-muscle tissues. That's tricky before we should estimate first our at-rest minimum proteins requirement, then our additional protein requirement because of exercise. It's a biochemical juggler's work. I'm monitoring my weight, my muscles size and estimating my body fat. Without a DEXA scan it's not easy at all. I might have 24 hours urine analysis done, to ascertain the nitrogen balance. More simply I try to keep proteins as low as possible while allowing some MPS. I'm not using free leucine, only natural foods and I'm following instinct. Istinct often will tell me not to feed the body proteins just after exercise, which is the opposite of what is suggested. Experience has taught me to heed instinct first. The muscle growth window may not open soon after exercise, whereas it might remain open later and last more days, not just hours. HUNGER is the telltale, especially hunger for proteins, muscle tissue telling you that it's looking forward to provide MPS.
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